Pitolisant (BioDeep_00000182488)
human metabolite blood metabolite
代谢物信息卡片
化学式: C17H26ClNO (295.1702816)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 90.91%
分子结构信息
SMILES: C1CCN(CC1)CCCOCCCC2=CC=C(C=C2)Cl
InChI: InChI=1S/C17H26ClNO/c18-17-9-7-16(8-10-17)6-4-14-20-15-5-13-19-11-2-1-3-12-19/h7-10H,1-6,11-15H2
描述信息
C78272 - Agent Affecting Nervous System
N - Nervous system
Pitolisant is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (Ki=0.16 nM).
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:134709
- PubChem: 9948102
- HMDB: HMDB0256619
- DrugBank: DB11642
- ChEMBL: CHEMBL462605
- Wikipedia: Pitolisant
- chemspider: 8123714
- CAS: 362665-56-3
- medchemexpress: HY-12199
分类词条
相关代谢途径
Reactome(0)
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PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Cheng Jiang, Jiancheng Qian, Xin Jiang, Shuohan Zhang, Junxian Zheng, Hongwei Wang. Is pitolisant safe for clinical use? A retrospective pharmacovigilance study focus on the post-marketing safety.
Pharmacology research & perspectives.
2024 Feb; 12(1):e1161. doi:
10.1002/prp2.1161. [PMID: 38174838] - Anca D Buzoianu, Aruna Sharma, Dafin F Muresanu, Lianyuan Feng, Hongyun Huang, Lin Chen, Z Ryan Tian, Ala Nozari, José Vicente Lafuente, Per-Ove Sjöqvist, Lars Wiklund, Hari Shanker Sharma. Nanodelivery of histamine H3 receptor inverse agonist BF-2649 with H3 receptor antagonist and H4 receptor agonist clobenpropit induced neuroprotection is potentiated by antioxidant compound H-290/51 in spinal cord injury.
International review of neurobiology.
2023; 172(?):37-77. doi:
10.1016/bs.irn.2023.06.003. [PMID: 37833018] - Siamak Beheshti, Mohammad Wasil Wesal. Anticonvulsant activity of the histamine H3 receptor inverse agonist pitolisant in an electrical kindling model of epilepsy.
Neuroscience letters.
2022 06; 782(?):136685. doi:
10.1016/j.neulet.2022.136685. [PMID: 35598693] - Stéphane Krief, Isabelle Berrebi-Bertrand, Isabelle Nagmar, Martin Giret, Simon Belliard, David Perrin, Marilyne Uguen, Philippe Robert, Jeanne-Marie Lecomte, Jean-Charles Schwartz, Olivier Finance, Xavier Ligneau. Pitolisant, a wake-promoting agent devoid of psychostimulant properties: Preclinical comparison with amphetamine, modafinil, and solriamfetol.
Pharmacology research & perspectives.
2021 10; 9(5):e00855. doi:
10.1002/prp2.855. [PMID: 34423920] - Magdalena Kotańska, Kamil Mika, Kinga Sałaciak, Lee Wheeler, Jacek Sapa, Katarzyna Kieć-Kononowicz, Karolina Pytka. Pitolisant protects mice chronically treated with corticosterone from some behavioral but not metabolic changes in corticosterone-induced depression model.
Pharmacology, biochemistry, and behavior.
2020 09; 196(?):172974. doi:
10.1016/j.pbb.2020.172974. [PMID: 32565240] - Michel Lecendreux, Giuseppe Plazzi, Patricia Franco, Evelyne Jacqz-Aigrain, Philippe Robert, Thierry Duvauchelle, Jean-Charles Schwartz. Pharmacokinetics of pitolisant in children and adolescents with narcolepsy.
Sleep medicine.
2020 02; 66(?):220-226. doi:
10.1016/j.sleep.2019.10.024. [PMID: 31978866] - Magdalena Kotańska, Kamil J Kuder, Katarzyna Szczepańska, Jacek Sapa, Katarzyna Kieć-Kononowicz. The histamine H3 receptor inverse agonist pitolisant reduces body weight in obese mice.
Naunyn-Schmiedeberg's archives of pharmacology.
2018 08; 391(8):875-881. doi:
10.1007/s00210-018-1516-2. [PMID: 29802412] - Christian Brabant, Yana Charlier, Maria Elisa Serrano Navacerrada, Livia Alleva, Ezio Tirelli. Action of Pitolisant on the stimulant and rewarding effects of cocaine in mice.
European journal of pharmacology.
2016 Nov; 791(?):552-559. doi:
10.1016/j.ejphar.2016.08.027. [PMID: 27568835] - Robert L Hudkins, Rita Raddatz, Ming Tao, Joanne R Mathiasen, Lisa D Aimone, Nadine C Becknell, Catherine P Prouty, Lars J S Knutsen, Mehran Yazdanian, Gilbert Moachon, Mark A Ator, John P Mallamo, Michael J Marino, Edward R Bacon, Michael Williams. Discovery and characterization of 6-{4-[3-(R)-2-methylpyrrolidin-1-yl)propoxy]phenyl}-2H-pyridazin-3-one (CEP-26401, irdabisant): a potent, selective histamine H3 receptor inverse agonist.
Journal of medicinal chemistry.
2011 Jul; 54(13):4781-92. doi:
10.1021/jm200401v. [PMID: 21634396] - Xavier Ligneau, Laurent Landais, David Perrin, Johanne Piriou, Marilyne Uguen, Emmanuel Denis, Philippe Robert, Régis Parmentier, Christelle Anaclet, Jian-Sheng Lin, Aude Burban, Jean-Michel Arrang, Jean-Charles Schwartz. Brain histamine and schizophrenia: potential therapeutic applications of H3-receptor inverse agonists studied with BF2.649.
Biochemical pharmacology.
2007 Apr; 73(8):1215-24. doi:
10.1016/j.bcp.2007.01.023. [PMID: 17343831] - X Ligneau, D Perrin, L Landais, J-C Camelin, T P G Calmels, I Berrebi-Bertrand, J-M Lecomte, R Parmentier, C Anaclet, J-S Lin, V Bertaina-Anglade, C Drieu la Rochelle, F d'Aniello, A Rouleau, F Gbahou, J-M Arrang, C R Ganellin, H Stark, W Schunack, J-C Schwartz. BF2.649 [1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine, hydrochloride], a nonimidazole inverse agonist/antagonist at the human histamine H3 receptor: Preclinical pharmacology.
The Journal of pharmacology and experimental therapeutics.
2007 Jan; 320(1):365-75. doi:
10.1124/jpet.106.111039. [PMID: 17005916]