Pirprofen (BioDeep_00000182483)

   

human metabolite blood metabolite


代谢物信息卡片


2-[3-chloro-4-(2,5-dihydro-1H-pyrrol-1-yl)phenyl]propanoic acid

化学式: C13H14ClNO2 (251.0713014)
中文名称: 吡洛芬
谱图信息: 最多检出来源 Homo sapiens(blood) 50%

分子结构信息

SMILES: CC(C(O)=O)C1=CC(Cl)=C(C=C1)N1CC=CC1
InChI: InChI=1S/C13H14ClNO2/c1-9(13(16)17)10-4-5-12(11(14)8-10)15-6-2-3-7-15/h2-5,8-9H,6-7H2,1H3,(H,16,17)

描述信息

M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AE - Propionic acid derivatives
C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents

同义名列表

5 个代谢物同义名

2-[3-chloro-4-(2,5-dihydro-1H-pyrrol-1-yl)phenyl]propanoic acid; 2-[3-Chloro-4-(2,5-dihydro-1H-pyrrol-1-yl)phenyl]propanoate; 2-(3-chloro-4-(3-Pyrroli-1-yl)phenyl)propionic acid; Pirprofen; Rengasil



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Kathleen M Knights, Leanne K Winner, David J Elliot, Kushari Bowalgaha, John O Miners. Aldosterone glucuronidation by human liver and kidney microsomes and recombinant UDP-glucuronosyltransferases: inhibition by NSAIDs. British journal of clinical pharmacology. 2009 Sep; 68(3):402-12. doi: 10.1111/j.1365-2125.2009.03469.x. [PMID: 19740398]
  • Philippe Lettéron, Angela Sutton, Abdellah Mansouri, Bernard Fromenty, Dominique Pessayre. Inhibition of microsomal triglyceride transfer protein: another mechanism for drug-induced steatosis in mice. Hepatology (Baltimore, Md.). 2003 Jul; 38(1):133-40. doi: 10.1053/jhep.2003.50309. [PMID: 12829995]
  • M S Mohammed, S S Abdel Hady, M A Mahdy, A I Mohammed. Binding of pirprofen with serum albumin obtained from uremic patients. Die Pharmazie. 1995 Mar; 50(3):226-7. doi: NULL. [PMID: 7732061]
  • T Higuchi, Y Imamura, M Otagiri. Stereoselective inhibition of carbonyl reductase from rabbit kidney by enantiomers of carprofen. Biochemistry and molecular biology international. 1994 Mar; 32(3):531-6. doi: . [PMID: 8032320]
  • D R Brocks, W T Liang, F Jamali. Influence of the route of administration on the pharmacokinetics of pirprofen enantiomers in the rat. Chirality. 1993; 5(2):61-4. doi: 10.1002/chir.530050204. [PMID: 8343343]
  • W T Liang, D R Brocks, F Jamali. Stereospecific high-performance liquid chromatographic assay of pirprofen enantiomers in rat plasma and urine. Journal of chromatography. 1992 Jun; 577(2):317-24. doi: 10.1016/0378-4347(92)80253-m. [PMID: 1400762]
  • F Hallé, F Marfil, A Sioufi, J P Dubois, M Gioud-Paquet, G Lenoir, A M Prieur. Pharmacokinetics of pirprofen in children with juvenile chronic arthritis. European journal of drug metabolism and pharmacokinetics. 1991 Jan; 16(1):29-34. doi: 10.1007/bf03189871. [PMID: 1936058]
  • J Oravcová, V Mlynárik, S Bystrický, L Soltés, P Szalay, L Bohácik, T Trnovec. Interaction of pirprofen enantiomers with human serum albumin. Chirality. 1991; 3(5):412-7. doi: 10.1002/chir.530030506. [PMID: 1756096]
  • A Sioufi, F Marfil, J Richard, D Colussi, J P Dubois. High-performance liquid chromatographic determination of pirprofen and five of its metabolites in human plasma without hydrolysis and in human urine before and after chemical hydrolysis. Journal of chromatography. 1989 Oct; 495(?):195-203. doi: 10.1016/s0378-4347(00)82621-3. [PMID: 2613803]
  • L Zecca, P Ferrario, R Pirola, F Zambotti, N Zonta, F Fraschini. Analysis of pirprofen in cerebrospinal fluid, plasma, and synovial fluid by high-performance liquid chromatography with electrochemical detection. Journal of pharmaceutical sciences. 1989 Sep; 78(9):776-9. doi: 10.1002/jps.2600780916. [PMID: 2585275]
  • M Otagiri, K Masuda, T Imai, Y Imamura, M Yamasaki. Binding of pirprofen to human serum albumin studied by dialysis and spectroscopy techniques. Biochemical pharmacology. 1989 Jan; 38(1):1-7. doi: 10.1016/0006-2952(89)90141-x. [PMID: 2910295]
  • L Zecca, M Broggini, R Pirola, R Campi, P Ferrario, E Bichisao, V Maresca. The diffusion of pirprofen into the cerebrospinal fluid in man. European journal of clinical pharmacology. 1988; 35(1):81-3. doi: 10.1007/bf00555512. [PMID: 3220099]
  • F A Rossi, M Ferrero, G E Balladore, L Zecca, F Fraschini, P Ferrario, E Bichisao, G C Monza, V Maresca. Pharmacokinetics of pirprofen and its pyrrol metabolite in elderly patients. European journal of clinical pharmacology. 1988; 35(4):379-83. doi: 10.1007/bf00561368. [PMID: 3197745]
  • J Geneve, B Hayat-Bonan, G Labbe, C Degott, P Letteron, E Freneaux, T L Dinh, D Larrey, D Pessayre. Inhibition of mitochondrial beta-oxidation of fatty acids by pirprofen. Role in microvesicular steatosis due to this nonsteroidal anti-inflammatory drug. The Journal of pharmacology and experimental therapeutics. 1987 Sep; 242(3):1133-7. doi: NULL. [PMID: 3116197]
  • A Kalos, I Lazaridis, N Malamas, A Kasfiki, G Drivas, A Germenis, S Grammenon. The effect of pirprofen on renal function in man. Singapore medical journal. 1987 Apr; 28(2):172-5. doi: NULL. [PMID: 3629273]
  • A Sioufi, D Colussi, F Marfil, J P Dubois. Determination of the (+)- and (-)-enantiomers of pirprofen in human plasma by high-performance liquid chromatography. Journal of chromatography. 1987 Feb; 414(1):131-7. doi: 10.1016/0378-4347(87)80031-2. [PMID: 3494738]
  • M Eugène, G Deray, P Cacoub, H Beaufils, A Baumelou. [Acute renal failure and nephrotic syndrome after a treatment with pirprofen]. La Revue de medecine interne. 1987 Jan; 8(1):115. doi: 10.1016/s0248-8663(87)80117-0. [PMID: 3494287]
  • M Bentata Pessayre, P Callard, G Delzant. [Cholestatic and cytolytic hepatitis and acute kidney failure caused by pirprofen]. Annales de medecine interne. 1986; 137(5):445. doi: NULL. [PMID: 3813277]
  • G Danan, P Trunet, J Bernuau, C Degott, G Babany, D Pessayre, B Rueff, J P Benhamou. Pirprofen-induced fulminant hepatitis. Gastroenterology. 1985 Jul; 89(1):210-3. doi: 10.1016/0016-5085(85)90765-6. [PMID: 4007406]
  • M Weiss, T Hess, R Hoigné, J P Dubois. [False-positive porphobilinogen determination test (Hoesch test) after administration of pirprofen]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis. 1985 May; 74(22):598-9. doi: NULL. [PMID: 4012137]
  • D Colussi, F Marfil, A Sioufi. Simultaneous determination of pirprofen and its metabolite, the pyrrole derivative, in plasma by high-performance liquid chromatography. Journal of chromatography. 1985 Apr; 339(1):157-62. doi: 10.1016/s0378-4347(00)84637-x. [PMID: 3874874]
  • L Rooney, M J Kendall, A Main, J Hosie, V A John. Pharmacokinetics of pirprofen in young volunteers and elderly patients. European journal of clinical pharmacology. 1985; 29(1):73-7. doi: 10.1007/bf00547372. [PMID: 3876938]
  • P H Degen, A Schweizer, A Sioufi. Determination of pirprofen in biological material by gas-liquid chromatography with nitrogen-specific and electron-capture detection. Journal of chromatography. 1984 May; 290(?):33-43. doi: 10.1016/s0021-9673(01)93558-7. [PMID: 6736165]
  • J F Domenget, M Laseur, P Blanc, J Fogliani. [Acute renal failure and nephrotic syndrome related to pirprofen]. Presse medicale (Paris, France : 1983). 1984 Feb; 13(5):283. doi: NULL. [PMID: 6229780]
  • F Sörgel, M Hemmerlein, E Lang. [Effect of pirprofen and indomethacin on the effects of oxprenolol and furosemide]. Arzneimittel-Forschung. 1984; 34(10):1330-2. doi: NULL. [PMID: 6335039]
  • J P Schoeller, C Schwarzberg, A Gerardin, D Colussi, A Sioufi, J Hirtz. [Comparative elimination of pirprofen from the plasma and synovial fluid of the knee. 26 cases]. Presse medicale (Paris, France : 1983). 1983 Sep; 12(33):2045-7. doi: NULL. [PMID: 6226019]
  • A Gerardin, R C Luders, W E Wagner. Absorption kinetics and model characteristics of orally administered pirprofen. Journal of pharmacokinetics and biopharmaceutics. 1983 Aug; 11(4):425-33. doi: 10.1007/bf01058959. [PMID: 6668551]
  • H Egger, F Bartlett, H P Yuan, J Karliner. Metabolism of pirprofen in man, monkey, rat, and mouse. Drug metabolism and disposition: the biological fate of chemicals. 1982 Sep; 10(5):529-36. doi: NULL. [PMID: 6128205]
  • P J Morrison, H J Rogers, R G Spector, I D Bradbrook, V A John. Effect of pirprofen on glibenclamide kinetics and response. British journal of clinical pharmacology. 1982 Jul; 14(1):123-6. doi: 10.1111/j.1365-2125.1982.tb04949.x. [PMID: 6809024]
  • R C Luders, D Chao. Effect of pirprofen on protein binding of warfarin and tolbutamide in human plasma. Journal of pharmaceutical sciences. 1981 Dec; 70(12):1370-1. doi: 10.1002/jps.2600701221. [PMID: 7320855]
  • R C Luders, M B Maggio-Cavaliere, H Egger, O B Gum, O Resnick, F Bartlett, M J Gaito, A Soo, C Li. Disposition of pirprofen, a new anti-inflammatory drug. Clinical pharmacology and therapeutics. 1977 Jun; 21(6):721-30. doi: 10.1002/cpt1977216721. [PMID: 862311]