Piromelatine (BioDeep_00000182477)

   

human metabolite blood metabolite


代谢物信息卡片


N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-4-oxo-4H-pyran-2-carboxamide

  化学式: C17H16N2O4 (312.111)
中文名称:
  谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=CC2=C(C=C1)NC=C2CCNC(=O)C3=CC(=O)C=CO3
InChI: InChI=1S/C17H16N2O4/c1-22-13-2-3-15-14(9-13)11(10-19-15)4-6-18-17(21)16-8-12(20)5-7-23-16/h2-3,5,7-10,19H,4,6H2,1H3,(H,18,21)


描述信息

C78272 - Agent Affecting Nervous System
Piromelatine (Neu-P11) is a melatonin MT1/MT2 receptor agonist, serotonin 5-HT1A/5-HT1D agonist, and serotonin 5-HT2B antagonist. Piromelatine (Neu-P11) possesses sleep promoting, analgesic, anti-neurodegenerative, anxiolytic and antidepressant potentials. Piromelatine (Neu-P11) also possesses pain-related P2X3, TRPV1, and Nav1.7 channel-inhibition capacities[1][2][3].

同义名列表

5 个代谢物同义名

N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-4-oxo-4H-pyran-2-carboxamide; N-(2-(5-Methoxy-indol-3-yl)-ethyl)-4-oxo-4H-pyran-2-carboxamide; N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-4-oxopyran-2-carboxamide; Piromelatine; Neu-P11



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

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Plant Reactome(0)

INOH(0)

PlantCyc(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Jun Zhou, Deng Wang, XiaoHong Luo, Xu Jia, MaoXing Li, Moshe Laudon, RuXue Zhang, ZhengPing Jia. Melatonin Receptor Agonist Piromelatine Ameliorates Impaired Glucose Metabolism in Chronically Stressed Rats Fed a High-Fat Diet. The Journal of pharmacology and experimental therapeutics. 2018 01; 364(1):55-69. doi: 10.1124/jpet.117.243998. [PMID: 29025979]
  • Jun Zhou, Jin Zhang, XiaoHong Luo, MaoXing Li, Ying Yue, Moshe Laudon, ZhengPing Jia, RuXue Zhang. Neu-P11, a novel MT1/MT2 agonist, reverses diabetes by suppressing the hypothalamic-pituitary-adrenal axis in rats. European journal of pharmacology. 2017 Oct; 812(?):225-233. doi: 10.1016/j.ejphar.2017.07.001. [PMID: 28687198]
  • Jianwu Yu, Jing Wei, Ling Ji, Xutao Hong. Exploration on mechanism of a new type of melatonin receptor agonist Neu-p11 in hypoxia-reoxygenation injury of myocardial cells. Cell biochemistry and biophysics. 2014 Nov; 70(2):999-1003. doi: 10.1007/s12013-014-0009-2. [PMID: 24840226]
  • Meihua She, Xiaobo Hu, Zehong Su, Chi Zhang, Shenghua Yang, Lin Ding, Moshe Laudon, Weidong Yin. Piromelatine, a novel melatonin receptor agonist, stabilizes metabolic profiles and ameliorates insulin resistance in chronic sleep restricted rats. European journal of pharmacology. 2014 Mar; 727(?):60-5. doi: 10.1016/j.ejphar.2014.01.037. [PMID: 24486392]
  • L Huang, C Zhang, Y Hou, M Laudon, M She, S Yang, L Ding, H Wang, Z Wang, P He, W Yin. Blood pressure reducing effects of piromelatine and melatonin in spontaneously hypertensive rats. European review for medical and pharmacological sciences. 2013 Sep; 17(18):2449-56. doi: NULL. [PMID: 24089222]
  • Reinhard Oertel, Lisa Goltz, Wilhelm Kirch. Determination of the novel melatonin agonist Neu-P11 in plasma samples by liquid chromatography-tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2013 Feb; 74(?):66-70. doi: 10.1016/j.jpba.2012.09.020. [PMID: 23245235]
  • R Oertel, L Goltz, W Kirch. Elucidation of Neu-P11 metabolism in urine of volunteers by liquid chromatography-tandem mass spectrometry. Journal of chromatography. A. 2013 Feb; 1278(?):69-75. doi: 10.1016/j.chroma.2012.12.063. [PMID: 23336948]