Pipamperone (BioDeep_00000182445)

   

human metabolite blood metabolite


代谢物信息卡片


1-[4-(4-fluorophenyl)-4-oxobutyl]-[1,4-bipiperidine]-4-carboxamide

化学式: C21H30FN3O2 (375.2322)
中文名称: 匹泮哌隆
谱图信息: 最多检出来源 Homo sapiens(blood) 36.04%

分子结构信息

SMILES: C1CCN(CC1)C2(CCN(CC2)CCCC(=O)C3=CC=C(C=C3)F)C(=O)N
InChI: InChI=1S/C21H30FN3O2/c22-18-8-6-17(7-9-18)19(26)5-4-12-24-15-10-21(11-16-24,20(23)27)25-13-2-1-3-14-25/h6-9H,1-5,10-16H2,(H2,23,27)

描述信息

D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AD - Butyrophenone derivatives
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
Pipamperone (Floropipamide; McN-JR 3345; R 3345) is a high-affinity antagonist of 5-HT2A receptor (pKi=8.2) and D4 receptor (pKi=8.0) and a low-affinity antagonist of D2 receptor (pKi=6.7)[1].

同义名列表

17 个代谢物同义名

1-[4-(4-fluorophenyl)-4-oxobutyl]-[1,4-bipiperidine]-4-carboxamide; p-Fluoro-gamma-(4-piperidino-4-carbamoylpiperidino)butyrophenone; 1-(3-(4-Fluorobenzoyl)propyl)-(1,4-bipiperidine) -4-carboxamide; 1-(3-(p-Fluorobenzoyl)propyl)-(1,4-bipiperidine)-4-carboxamide; p-Fluoro-g-(4-piperidino-4-carbamoylpiperidino)butyrophenone; p-Fluoro-γ-(4-piperidino-4-carbamoylpiperidino)butyrophenone; Pipamperone dihydrochloride; Pipamperon-neuraxpharm; Floropipamide; Pipamperonum; Pipamperona; Pipamperone; Dipiperon; R-3345; R 3345; McN-JR 3345; Pipamperone



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Sanne M Kloosterboer, Brenda C M de Winter, Soma Bahmany, Linda Al-Hassany, Annet Dekker, Gwen C Dieleman, Teun van Gelder, Bram Dierckx, Birgit C P Koch. Dried Blood Spot Analysis for Therapeutic Drug Monitoring of Antipsychotics: Drawbacks of Its Clinical Application. Therapeutic drug monitoring. 2018 06; 40(3):344-350. doi: 10.1097/ftd.0000000000000502. [PMID: 29505492]
  • Rixt A Wijma, Bart C H van der Nagel, Bram Dierckx, Gwen C Dieleman, Daan J Touw, Teun van Gelder, Birgit C P Koch. Identification and quantification of the antipsychotics risperidone, aripiprazole, pipamperone and their major metabolites in plasma using ultra-high performance liquid chromatography-mass spectrometry. Biomedical chromatography : BMC. 2016 Jun; 30(6):794-801. doi: 10.1002/bmc.3610. [PMID: 26447610]
  • Maria Addolorata Saracino, Anna de Palma, Giancarlo Boncompagni, Maria Augusta Raggi. Analysis of risperidone and its metabolite in plasma and saliva by LC with coulometric detection and a novel MEPS procedure. Talanta. 2010 Jun; 81(4-5):1547-53. doi: 10.1016/j.talanta.2010.02.067. [PMID: 20441937]
  • Linda Hanssens, Gilbert L'Italien, Jean-Yves Loze, Ronald N Marcus, Miranda Pans, Wendy Kerselaers. The effect of antipsychotic medication on sexual function and serum prolactin levels in community-treated schizophrenic patients: results from the Schizophrenia Trial of Aripiprazole (STAR) study (NCT00237913). BMC psychiatry. 2008 Dec; 8(?):95. doi: 10.1186/1471-244x-8-95. [PMID: 19102734]
  • H Kirchherr, W N Kühn-Velten. Quantitative determination of forty-eight antidepressants and antipsychotics in human serum by HPLC tandem mass spectrometry: a multi-level, single-sample approach. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2006 Oct; 843(1):100-13. doi: 10.1016/j.jchromb.2006.05.031. [PMID: 16798119]
  • Ursula Gutteck, Katharina M Rentsch. Therapeutic drug monitoring of 13 antidepressant and five neuroleptic drugs in serum with liquid chromatography-electrospray ionization mass spectrometry. Clinical chemistry and laboratory medicine. 2003 Dec; 41(12):1571-9. doi: 10.1515/cclm.2003.240. [PMID: 14708881]
  • J Martens-Lobenhoffer, W Römhild. Quantitative determination of piritramide in human serum applying liquid chromatography-two-stage mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2003 Jan; 783(1):53-9. doi: 10.1016/s1570-0232(02)00488-9. [PMID: 12450524]
  • T Grobosch, U Lemm-Ahlers. Immunoassay screening of lysergic acid diethylamide (LSD) and its confirmation by HPLC and fluorescence detection following LSD ImmunElute extraction. Journal of analytical toxicology. 2002 Apr; 26(3):181-6. doi: 10.1093/jat/26.3.181. [PMID: 11991536]
  • Gerbrecht E Potgieter, Gerhard Groenewoud, Pierre J Jordaan, Hans K L Hundt, Robert Schall, Michael Kummer, Günter Sewarte-Ross. Pharmacokinetics of pipamperone from three different tablet formulations. Arzneimittel-Forschung. 2002; 52(6):430-4. doi: 10.1055/s-0031-1299910. [PMID: 12109042]
  • H Seno, T Kumazawa, A Ishii, K Sato, O Suzuki. Determination of some butyrophenones in body fluids by gas chromatography with surface ionization detection. Nihon hoigaku zasshi = The Japanese journal of legal medicine. 1993 Oct; 47(5):367-71. doi: NULL. [PMID: 8258900]
  • I Luhmann, S C Szathmary, I Grünert. Determination of pipamperone in human plasma by high performance liquid chromatography. Arzneimittel-Forschung. 1992 Sep; 42(9):1069-72. doi: NULL. [PMID: 1359893]
  • C Köppel, J Tenczer, A Wagemann. Mass spectral characterization of urinary pipamperone metabolites and high-performance liquid chromatography assay for pipamperone plasma levels. Journal of chromatography. 1989 Jul; 491(2):432-8. doi: 10.1016/s0378-4347(00)82862-5. [PMID: 2572602]
  • H Seno, O Suzuki, T Kumazawa, M Asano. Rapid isolation with Sep-Pak C18 cartridges and wide-bore capillary gas chromatography of some butyrophenones. Zeitschrift fur Rechtsmedizin. Journal of legal medicine. 1989; 102(2-3):127-32. doi: 10.1007/bf00200506. [PMID: 2565634]
  • F De Clerck, B Xhonneux, J P Tollenaere, P A Janssen. Dependence of the antagonism at human platelet 5-HT2 receptors by ketanserin on the reaction pH. Thrombosis research. 1985 Dec; 40(5):581-96. doi: 10.1016/0049-3848(85)90297-x. [PMID: 2935970]
  • M P Quaglio, A M Bellini. A gas chromatographic method for the determination of fluanisone, moperone, aceperone and pipamperone in human plasma. Il Farmaco; edizione pratica. 1981 Apr; 36(4):204-14. doi: NULL. [PMID: 6112157]