2-Phenylethynesulfonamide (BioDeep_00000182428)
human metabolite blood metabolite
代谢物信息卡片
化学式: C8H7NO2S (181.0197482)
中文名称: 2-苯基乙炔磺酰胺
谱图信息:
最多检出来源 Homo sapiens(blood) 96.72%
分子结构信息
SMILES: C1=CC=C(C=C1)C#CS(=O)(=O)N
InChI: InChI=1S/C8H7NO2S/c9-12(10,11)7-6-8-4-2-1-3-5-8/h1-5H,(H2,9,10,11)
描述信息
Pifithrin-μ is an inhibitor of p53 and HSP70, with antitumor and neuroprotective activity.
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:93704
- PubChem: 327653
- HMDB: HMDB0256545
- ChEMBL: CHEMBL1241268
- chemspider: 290186
- CAS: 64984-31-2
- medchemexpress: HY-10940
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Timothy J Cunningham, Jeffrey Greenstein, Lihua Yao, Itzhak Fischer, Theresa Connors. Heptamer Peptide Disassembles Native Amyloid in Human Plasma Through Heat Shock Protein 70.
Rejuvenation research.
2018 Dec; 21(6):527-534. doi:
10.1089/rej.2017.2049
. [PMID: 29651925] - Li-Peng Shan, Xiao-Hui Chen, Fei Ling, Bin Zhu, Gao-Xue Wang. Targeting Heat Shock Protein 70 as an antiviral strategy against grass carp reovirus infection.
Virus research.
2018 03; 247(?):1-9. doi:
10.1016/j.virusres.2018.01.005
. [PMID: 29355582] - Anshulika Sable, Krishan M Rai, Amit Choudhary, Vikash K Yadav, Sudhir K Agarwal, Samir V Sawant. Inhibition of Heat Shock proteins HSP90 and HSP70 induce oxidative stress, suppressing cotton fiber development.
Scientific reports.
2018 02; 8(1):3620. doi:
10.1038/s41598-018-21866-0
. [PMID: 29483524] - H M Mazhar Asjad, Ameya Kasture, Ali El-Kasaby, Michael Sackel, Thomas Hummel, Michael Freissmuth, Sonja Sucic. Pharmacochaperoning in a Drosophila model system rescues human dopamine transporter variants associated with infantile/juvenile parkinsonism.
The Journal of biological chemistry.
2017 11; 292(47):19250-19265. doi:
10.1074/jbc.m117.797092
. [PMID: 28972153] - Nishikant Wase, Boqiang Tu, James W Allen, Paul N Black, Concetta C DiRusso. Identification and Metabolite Profiling of Chemical Activators of Lipid Accumulation in Green Algae.
Plant physiology.
2017 Aug; 174(4):2146-2165. doi:
10.1104/pp.17.00433
. [PMID: 28652262] - Mohammad Ishaq, Rani Ojha, Kapil Sharma, Gaurav Sharma, Shrawan K Singh, Sekhar Majumdar. Functional inhibition of Hsp70 by Pifithrin-μ switches Gambogic acid induced caspase dependent cell death to caspase independent cell death in human bladder cancer cells.
Biochimica et biophysica acta.
2016 11; 1863(11):2560-2573. doi:
10.1016/j.bbamcr.2016.07.001
. [PMID: 27395830] - Ameya Kasture, Ali El-Kasaby, Daniel Szöllősi, H M Mazhar Asjad, Alexandra Grimm, Thomas Stockner, Thomas Hummel, Michael Freissmuth, Sonja Sucic. Functional Rescue of a Misfolded Drosophila melanogaster Dopamine Transporter Mutant Associated with a Sleepless Phenotype by Pharmacological Chaperones.
The Journal of biological chemistry.
2016 09; 291(40):20876-20890. doi:
10.1074/jbc.m116.737551
. [PMID: 27481941] - Kenji Ishida, Emmitt R Jolly. Hsp70 May Be a Molecular Regulator of Schistosome Host Invasion.
PLoS neglected tropical diseases.
2016 09; 10(9):e0004986. doi:
10.1371/journal.pntd.0004986
. [PMID: 27611863] - Rongping Zhang, Jili Wang, Yanling Hu, Xu Lu, Bo Jiang, Wei Zhang, Chao Huang. Pifithrin-μ Attenuates Acute Sickness Response to Lipopolysaccharide in C57BL/6J Mice.
Pharmacology.
2016; 97(5-6):245-50. doi:
10.1159/000444187
. [PMID: 26881748] - Chao Huang, Jia Wang, Zhuo Chen, Yuzhe Wang, Wei Zhang. 2-phenylethynesulfonamide Prevents Induction of Pro-inflammatory Factors and Attenuates LPS-induced Liver Injury by Targeting NHE1-Hsp70 Complex in Mice.
PloS one.
2013; 8(6):e67582. doi:
10.1371/journal.pone.0067582
. [PMID: 23805318] - Manujendra N Saha, Hua Jiang, Hong Chang. Molecular mechanisms of nutlin-induced apoptosis in multiple myeloma: evidence for p53-transcription-dependent and -independent pathways.
Cancer biology & therapy.
2010 Sep; 10(6):567-78. doi:
10.4161/cbt.10.6.12535
. [PMID: 20595817]