Picotamide (BioDeep_00000182422)

   

human metabolite blood metabolite


代谢物信息卡片


4-Methoxy-N1,N3-bis[(pyridin-3-yl)methyl]benzene-1,3-dicarboximidate

化学式: C21H20N4O3 (376.15353300000004)
中文名称: 4-甲氧基-N,N-二(3-吡啶甲基)-1,3-苯二甲酰胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=C(C=C(C=C1)C(=O)NCC2=CN=CC=C2)C(=O)NCC3=CN=CC=C3
InChI: InChI=1S/C21H20N4O3/c1-28-19-7-6-17(20(26)24-13-15-4-2-8-22-11-15)10-18(19)21(27)25-14-16-5-3-9-23-12-16/h2-12H,13-14H2,1H3,(H,24,26)(H,25,27)

描述信息

B - Blood and blood forming organs > B01 - Antithrombotic agents > B01A - Antithrombotic agents > B01AC - Platelet aggregation inhibitors excl. heparin
C78275 - Agent Affecting Blood or Body Fluid > C1327 - Antiplatelet Agent
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors

同义名列表

4 个代谢物同义名

4-Methoxy-N1,N3-bis[(pyridin-3-yl)methyl]benzene-1,3-dicarboximidate; 4-methoxy-N1,N3-bis[(pyridin-3-yl)methyl]benzene-1,3-dicarboxamide; Picotamide; Plactidil



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Bingsheng Li, Ru Huang, Ruixiao Wang, Yuhan Liu, Christian G Stief, Martin Hennenberg. Picotamide inhibits a wide spectrum of agonist-induced smooth muscle contractions in porcine renal interlobar and coronary arteries. Pharmacology research & perspectives. 2021 05; 9(3):e00771. doi: 10.1002/prp2.771. [PMID: 33929093]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Sarah Dawson, Simone Stahl, Nikki Paul, Jane Barber, J Gerald Kenna. In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug metabolism and disposition: the biological fate of chemicals. 2012 Jan; 40(1):130-8. doi: 10.1124/dmd.111.040758. [PMID: 21965623]
  • J L Teeling, C Cunningham, T A Newman, V H Perry. The effect of non-steroidal anti-inflammatory agents on behavioural changes and cytokine production following systemic inflammation: Implications for a role of COX-1. Brain, behavior, and immunity. 2010 Mar; 24(3):409-19. doi: 10.1016/j.bbi.2009.11.006. [PMID: 19931610]
  • Sergio Coccheri. Approaches to prevention of cardiovascular complications and events in diabetes mellitus. Drugs. 2007; 67(7):997-1026. doi: 10.2165/00003495-200767070-00005. [PMID: 17488145]
  • Carola Buccellati, Angelo Sala, Giuseppe Rossoni, Valérie Capra, G Enrico Rovati, Antonio Di Gennaro, Giancarlo Folco, Susanna Colli, Cesare Casagrande. Pharmacological characterization of 2NTX-99 [4-methoxy-N1-(4-trans-nitrooxycyclohexyl)-N3-(3-pyridinylmethyl)-1,3-benzenedicarboxamide], a potential antiatherothrombotic agent with antithromboxane and nitric oxide donor activity in platelet and vascular preparations. The Journal of pharmacology and experimental therapeutics. 2006 May; 317(2):830-7. doi: 10.1124/jpet.105.097170. [PMID: 16399881]
  • Sergio Castellani, Rita Paniccia, Claudia Di Serio, Giuseppe La Cava, Loredana Poggesi, Stefano Fumagalli, Gian Franco Gensini, Gian Gastone Neri Serneri. Thromboxane inhibition improves renal perfusion and excretory function in severe congestive heart failure. Journal of the American College of Cardiology. 2003 Jul; 42(1):133-9. doi: 10.1016/s0735-1097(03)00511-4. [PMID: 12849673]
  • M Y Abeywardena, R J Head. Dietary polyunsaturated fatty acid and antioxidant modulation of vascular dysfunction in the spontaneously hypertensive rat. Prostaglandins, leukotrienes, and essential fatty acids. 2001 Aug; 65(2):91-7. doi: 10.1054/plef.2001.0294. [PMID: 11545625]
  • S Ratti, P Quarato, C Casagrande, R Fumagalli, A Corsini. Picotamide, an antithromboxane agent, inhibits the migration and proliferation of arterial myocytes. European journal of pharmacology. 1998 Aug; 355(1):77-83. doi: 10.1016/s0014-2999(98)00467-1. [PMID: 9754941]
  • S Basili, M Milani, A Longoni, M Vieri, L Iuliano, F Violi. Determinants of fibrinogen in an Italian population suffering from claudication. Lower fibrinogen in the south compared to middle and north of Italy. The ADEP Group. Haematologica. 1998 Aug; 83(8):701-7. doi: NULL. [PMID: 9793253]
  • A Giustina, P Perini, P Desenzani, S Bossoni, P Ianniello, M Milani, G Davì, G Romanelli. Long-term treatment with the dual antithromboxane agent picotamide decreases microalbuminuria in normotensive type 2 diabetic patients. Diabetes. 1998 Mar; 47(3):423-30. doi: 10.2337/diabetes.47.3.423. [PMID: 9519749]
  • P L Malini, E Strocchi, M Zanardi, M Milani, E Ambrosioni. Thromboxane antagonism and cough induced by angiotensin-converting-enzyme inhibitor. Lancet (London, England). 1997 Jul; 350(9070):15-8. doi: 10.1016/s0140-6736(96)12045-6. [PMID: 9217714]
  • F M Pulcinelli, P Pignatelli, M Pesciotti, S Sebastiani, S Parisi, P P Gazzaniga. Mechanism of the persisting TxA2 receptor antagonism by picotamide. Thrombosis research. 1997 Feb; 85(3):207-15. doi: 10.1016/s0049-3848(97)00005-4. [PMID: 9058495]
  • F Violi, M Criqui, A Longoni, C Castiglioni. Relation between risk factors and cardiovascular complications in patients with peripheral vascular disease. Results from the A.D.E.P. study. Atherosclerosis. 1996 Feb; 120(1-2):25-35. doi: 10.1016/0021-9150(95)05657-2. [PMID: 8645368]
  • A Sagripanti, A Ferretti, A Nicolini, A Carpi. Thrombotic and hemorrhagic complications in chronic myeloproliferative disorders. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 1996; 50(8):376-82. doi: 10.1016/s0753-3322(96)89672-7. [PMID: 8952859]
  • G Anfossi, S Parisi, I Russo, E M Mularoni, P Massucco, F Cavalot, L Mattiello, M Trovati. Studies on in vitro effect of picotamide on human platelet aggregation in platelet-rich plasma and whole blood. Thrombosis research. 1995 Mar; 77(5):399-410. doi: 10.1016/0049-3848(95)93876-2. [PMID: 7778055]
  • G D'Andrea, F Perini, L Hasselmark, M Alecci, A R Cananzi. Effect of picotamide and aspirin, combined or alone, on platelet aggregation in patients with cerebral infarction. Functional neurology. 1995 Mar; 10(2):91-8. doi: NULL. [PMID: 7557557]
  • M Neirotti, M Molaschi, M Ponzetto, C Macchione, L Poli, F Bonino, F Fabris. Hemodynamic, hemorheologic, and hemocoagulative changes after treatment with picotamide in patients affected by peripheral arterial disease (PAD) of the lower limbs. Angiology. 1994 Feb; 45(2):137-41. doi: 10.1177/000331979404500209. [PMID: 8129189]
  • A Sagripanti, A Cupisti, D Giannessi, U Baicchi, W Bernini, R de Caterina, G Barsotti. [The use of picotamide in nephropathy with mesangial IgA deposits. The effect on thromboxane generation]. La Clinica terapeutica. 1993 Jan; 142(1):47-52. doi: NULL. [PMID: 8472511]
  • A Giustina, S Bossoni, A Cimino, M T Comini, N Gazzoli, G B Leproux, W B Wehrenberg, G Romanelli, G Giustina. Picotamide, a dual TXB synthetase inhibitor and TXB receptor antagonist, reduces exercise-induced albuminuria in microalbuminuric patients with NIDDM. Diabetes. 1993 Jan; 42(1):178-82. doi: 10.2337/diab.42.1.178. [PMID: 8420815]
  • T Fossati, S Parisi, G Abbiati, C Castiglioni. Determination of picotamide in human plasma and urine by high-performance liquid chromatography. Journal of chromatography. 1992 Jun; 577(2):382-6. doi: 10.1016/0378-4347(92)80264-q. [PMID: 1400771]
  • A Saitta, M Bonaiuto, A Mileto. [Evaluation of arteriolar reactivity and blood coagulation parameters during picotamide treatment]. La Clinica terapeutica. 1991 Oct; 139(1-2):9-16. doi: NULL. [PMID: 1837769]
  • P Minuz, C Lechi, E Arosio, P Guzzo, M Zannoni, C Lauciello, A Lechi. Effect of picotamide on platelet aggregation and on thromboxane A2 production in vivo. Thrombosis and haemostasis. 1991 Mar; 65(3):312-6. doi: 10.1055/s-0038-1648141. [PMID: 2048055]
  • F Quarto Di Palo, A Elli, R Rivolta, M Parenti, P Palazzi, C Zanussi. Prevention of chronic cyclosporine nephrotoxicity in renal transplantation by picotamide. Transplantation proceedings. 1991 Feb; 23(1 Pt 2):969-71. doi: NULL. [PMID: 1989347]
  • P Parise, P Gresele, E Viola, A Ruina, R Migliacci, G G Nenci. [Picotamide does not interfere with the anticoagulant activity of warfarin in patients wearing heart valve prostheses]. La Clinica terapeutica. 1990 Dec; 135(6):479-82. doi: . [PMID: 2151435]
  • P Gresele, C Corona, P Alberti, G G Nenci. Picotamide protects mice from death in a pulmonary embolism model by a mechanism independent from thromboxane suppression. Thrombosis and haemostasis. 1990 Aug; 64(1):80-6. doi: 10.1055/s-0038-1647257. [PMID: 2274931]
  • M Berrettini, M De Cunto, P Parise, S Grasselli, G G Nenci. 'In vitro' and 'ex vivo' effects of picotamide, a combined thromboxane A2-synthase inhibitor and -receptor antagonist, on human platelets. European journal of clinical pharmacology. 1990; 39(5):495-500. doi: 10.1007/bf00280943. [PMID: 1963845]
  • P Gresele, H Deckmyn, J Arnout, G G Nenci, J Vermylen. Characterization of N,N'-bis(3-picolyl)-4-methoxy-isophtalamide (picotamide) as a dual thromboxane synthase inhibitor/thromboxane A2 receptor antagonist in human platelets. Thrombosis and haemostasis. 1989 Jun; 61(3):479-84. doi: NULL. [PMID: 2552606]
  • L Vandelli, M Grosoli, E Lusvarghi, A M Cenci, D Campioli, G Grossi. Picotamide, selective inhibitor of thromboxane synthesis in patients on maintenance hemodialysis. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 1989; 4(12):1083-4. doi: NULL. [PMID: 2517331]
  • C Danese, G Sergio, G Giunta, M T Landi, C Renzulli, M G Panciocco, M G De Rossi, M A Perego. Effects of prolonged picotamide therapy on platelet activity in patients with peripheral arterial disease. Current medical research and opinion. 1988; 11(4):221-6. doi: 10.1185/03007998809114239. [PMID: 2975203]
  • J Harkness. Why urinalysis?. The Central African journal of medicine. 1975 Aug; 21(8):178-83. doi: NULL. [PMID: 1150]