Phorbolol myristate acetate (BioDeep_00000182365)
human metabolite blood metabolite
代谢物信息卡片
13-(acetyloxy)-1,5,6-trihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyltetracyclo[8.5.0.0^{2,6}.0^{11,13}]pentadeca-3,8-dien-14-yl tetradecanoate
化学式: C36H58O8 (618.4131468)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 75%
分子结构信息
SMILES: CCCCCCCCCCCCCC(=O)OC1C(C)C2(O)C3C=C(C)C(O)C3(O)CC(CO)=CC2C2C(C)(C)C12OC(C)=O
InChI: InChI=1S/C36H58O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30-32,37,40-42H,7-18,21-22H2,1-6H3
描述信息
D009676 - Noxae > D002273 - Carcinogens > D010703 - Phorbol Esters
同义名列表
5 个代谢物同义名
13-(acetyloxy)-1,5,6-trihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyltetracyclo[8.5.0.0^{2,6}.0^{11,13}]pentadeca-3,8-dien-14-yl tetradecanoate; 13-(Acetyloxy)-1,5,6-trihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyltetracyclo[8.5.0.0,.0,]pentadeca-3,8-dien-14-yl tetradecanoic acid; Phorbolol myristic acid acetic acid; Phorbolol-12-myristate-13-acetate; Phorbolol myristate acetate
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yan-Ning Rui, Yawen Chen, Yichen Guo, Caroline E Bock, John P Hagan, Dong H Kim, Zhen Xu. Podosome formation impairs endothelial barrier function by sequestering zonula occludens proteins.
Journal of cellular physiology.
2020 05; 235(5):4655-4666. doi:
10.1002/jcp.29343. [PMID: 31637713] - Hamed Tavakkoli, Morteza Akhond, Gholam Abbas Ghorbankhani, Ghodratollah Absalan. Electrochemical sensing of hydrogen peroxide using a glassy carbon electrode modified with multiwalled carbon nanotubes and zein nanoparticle composites: application to HepG2 cancer cell detection.
Mikrochimica acta.
2020 01; 187(2):105. doi:
10.1007/s00604-019-4064-7. [PMID: 31916024] - Tarfa Albrahim, Moonerah M Alnasser, Mashael R Al-Anazi, Muneera D ALKahtani, Saad Alkahtani, Ahmed A Al-Qahtani. In Vitro Studies on the Immunomodulatory Effects of Pulicaria crispa Extract on Human THP-1 Monocytes.
Oxidative medicine and cellular longevity.
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10.1155/2020/7574606. [PMID: 33628359] - Florian Guenther, Deborah Maus, Sarah Hedtrich, Matthias F Melzig. Serine Protease Mauritanicain from Euphorbia mauritanica and Phorbol-12-myristate-13-acetate Modulate the IL-8 Release in Fibroblasts and HaCaT Keratinocytes.
Planta medica.
2019 May; 85(7):578-582. doi:
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The international journal of biochemistry & cell biology.
2018 02; 95(?):132-142. doi:
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Free radical research.
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10.1080/10715762.2017.1423069. [PMID: 29291631] - Ashwani Koul, Navneet Kaur, Neha Arora Chugh. Folic Acid Modulates DMBA/TPA-Induced Changes in Skin of Mice: A Study Relevant to Carcinogenesis.
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The Journal of biological chemistry.
2017 07; 292(29):12100-12110. doi:
10.1074/jbc.m117.775700. [PMID: 28539358] - Irazú Contreras, Vladimir Paredes-Cervantes, Luis A García-Miranda, Francisco Bernardo Pliego-Rivero, José A Estrada. Leukocyte production of IFN-γ and TNF-α in 8- to 12-y-old children with low serum iron levels.
Nutrition (Burbank, Los Angeles County, Calif.).
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Histochemistry and cell biology.
2013 Dec; 140(6):649-58. doi:
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Inflammation.
2013 Dec; 36(6):1485-93. doi:
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2013 Sep; 57(9):1598-610. doi:
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The Journal of nutritional biochemistry.
2013 Aug; 24(8):1513-9. doi:
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Experimental cell research.
2013 Jul; 319(12):1875-1888. doi:
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Microbes and infection.
2013 Jan; 15(1):18-27. doi:
10.1016/j.micinf.2012.10.005. [PMID: 23108316] - Aeyung Kim, Minju Im, Nam-Hui Yim, Young Pil Jung, Jin Yeul Ma. Aqueous extract of Bambusae Caulis in Taeniam inhibits PMA-induced tumor cell invasion and pulmonary metastasis: suppression of NF-κB activation through ROS signaling.
PloS one.
2013; 8(10):e78061. doi:
10.1371/journal.pone.0078061. [PMID: 24205091] - Anna Majowicz, Sander van der Marel, Anje A te Velde, Sybren L Meijer, Harald Petry, Sander J van Deventer, Valerie Ferreira. Murine CD4⁺CD25⁻ cells activated in vitro with PMA/ionomycin and anti-CD3 acquire regulatory function and ameliorate experimental colitis in vivo.
BMC gastroenterology.
2012 Dec; 12(?):172. doi:
10.1186/1471-230x-12-172. [PMID: 23198878] - Paloma Muñoz-Pacheco, Adriana Ortega-Hernández, María Miana, Victoria Cachofeiro, Arturo Fernández-Cruz, Dulcenombre Gómez-Garre. Ezetimibe inhibits PMA-induced monocyte/macrophage differentiation by altering microRNA expression: a novel anti-atherosclerotic mechanism.
Pharmacological research.
2012 Dec; 66(6):536-43. doi:
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European journal of pharmacology.
2012 Sep; 690(1-3):13-21. doi:
10.1016/j.ejphar.2012.05.020. [PMID: 22683840] - Shenglan Wang, Yi Dai, Kimiko Kobayashi, Wanjun Zhu, Yoko Kogure, Hiroki Yamanaka, You Wan, Wensheng Zhang, Koichi Noguchi. Potentiation of the P2X3 ATP receptor by PAR-2 in rat dorsal root ganglia neurons, through protein kinase-dependent mechanisms, contributes to inflammatory pain.
The European journal of neuroscience.
2012 Aug; 36(3):2293-301. doi:
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Analytical chemistry.
2012 Jul; 84(13):5716-22. doi:
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Chest.
2012 Apr; 141(4):895-905. doi:
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PloS one.
2012; 7(1):e28916. doi:
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Journal of lipid research.
2011 Dec; 52(12):2245-2254. doi:
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Nutrition journal.
2011 Jun; 10(?):64. doi:
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European journal of medicinal chemistry.
2011 May; 46(5):1827-34. doi:
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Plant foods for human nutrition (Dordrecht, Netherlands).
2011 Mar; 66(1):17-21. doi:
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PloS one.
2011; 6(5):e19607. doi:
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European journal of pharmacology.
2010 Dec; 648(1-3):188-94. doi:
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Neuroscience.
2010 May; 167(3):765-73. doi:
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The Journal of pharmacology and experimental therapeutics.
2010 May; 333(2):354-63. doi:
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Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
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European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
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Archives of biochemistry and biophysics.
2009 May; 485(1):30-4. doi:
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The Journal of biological chemistry.
2009 Apr; 284(14):9596-611. doi:
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Journal of pharmacological sciences.
2009 Jan; 109(1):110-8. doi:
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Biochemistry.
2008 Dec; 47(48):12886-99. doi:
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The Journal of pharmacy and pharmacology.
2008 Apr; 60(4):489-97. doi:
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2008 Feb; 283(8):5034-45. doi:
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Prostaglandins & other lipid mediators.
2007 May; 83(3):175-81. doi:
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Acta pharmacologica Sinica.
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The British journal of nutrition.
2006 Jul; 96(1):169-76. doi:
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Prostaglandins & other lipid mediators.
2006 May; 79(3-4):287-97. doi:
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European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2006 Apr; 27(5):518-23. doi:
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Biological chemistry.
2006 Mar; 387(3):319-21. doi:
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Cellular signalling.
2005 Nov; 17(11):1397-411. doi:
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2005 Oct; 138(4):399-412. doi:
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Cellular signalling.
2005 Oct; 17(10):1203-17. doi:
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Free radical research.
2005 Sep; 39(9):995-1003. doi:
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Proteomics.
2005 Jan; 5(1):123-31. doi:
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The Journal of biological chemistry.
2004 Oct; 279(40):41744-9. doi:
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