Tertatolol (BioDeep_00000018232)
human metabolite
代谢物信息卡片
1-(tert-butylamino)-3-(3,4-dihydro-2H-1-benzothiopyran-8-yloxy)propan-2-ol
化学式: C16H25NO2S (295.160591)
中文名称: 特他洛尔
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(C)NCC(COC1=CC=CC2=C1SCCC2)O
InChI: InChI=1S/C16H25NO2S/c1-16(2,3)17-10-13(18)11-19-14-8-4-6-12-7-5-9-20-15(12)14/h4,6,8,13,17-18H,5,7,9-11H2,1-3H3
描述信息
Tertatolol (Artex, Artexal, Prenalex) is a medication in the class of beta blockers, used in the treatment of high blood pressure. It was discovered by the French pharmaceutical company Servier and is marketed in Europe.
C - Cardiovascular system > C07 - Beta blocking agents > C07A - Beta blocking agents > C07AA - Beta blocking agents, non-selective
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
同义名列表
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:135244
- PubChem: 36920
- HMDB: HMDB0042026
- DrugBank: DB13775
- ChEMBL: CHEMBL434200
- Wikipedia: Tertatolol
- chemspider: 33875
- CAS: 83688-84-0
- CAS: 34784-64-0
- PMhub: MS000004462
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mohamed M Hefnawy, Yousif A Asiri, Nourah Z Al-Zoman, Gamal A Mostafa, Hassan Y Aboul-Enein. Stereoselective HPLC analysis of tertatolol in rat plasma using macrocyclic antibiotic chiral stationary phase.
Chirality.
2011 Apr; 23(4):333-8. doi:
10.1002/chir.20923. [PMID: 21384438] - Cedric Moro, Fabien Pillard, Isabelle de Glisezinski, Eva Klimcakova, Francois Crampes, Claire Thalamas, Isabelle Harant, Marie-Adeline Marques, Max Lafontan, Michel Berlan. Exercise-induced lipid mobilization in subcutaneous adipose tissue is mainly related to natriuretic peptides in overweight men.
American journal of physiology. Endocrinology and metabolism.
2008 Aug; 295(2):E505-13. doi:
10.1152/ajpendo.90227.2008. [PMID: 18559985] - Cedric Moro, Francois Crampes, Coralie Sengenes, Isabelle De Glisezinski, Jean Galitzky, Claire Thalamas, Max Lafontan, Michel Berlan. Atrial natriuretic peptide contributes to physiological control of lipid mobilization in humans.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2004 May; 18(7):908-10. doi:
10.1096/fj.03-1086fje. [PMID: 15033935] - Jacques Chanard, Olivier Toupance, Sylvie Lavaud, Bruno Hurault de Ligny, Corine Bernaud, Bruno Moulin. Amlodipine reduces cyclosporin-induced hyperuricaemia in hypertensive renal transplant recipients.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2003 Oct; 18(10):2147-53. doi:
10.1093/ndt/gfg341. [PMID: 13679494] - A J Branten, L B Hilbrands, H W van Hamersvelt, R A Koene, F T Huysmans. Renal and systemic effects of atenolol and tertatolol in renal transplant recipients on cyclosporine A.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
1998 Feb; 13(2):423-6. doi:
10.1093/oxfordjournals.ndt.a027840. [PMID: 9509456] - T Lave, C Efthymiopoulos, B Van Overloop, A Gairard, O Crambes, J C Koffel, L Jung. Pharmacokinetics of the enantiomers of tertatolol in the rat after oral and intravenous administration.
Xenobiotica; the fate of foreign compounds in biological systems.
1994 Jun; 24(6):561-8. doi:
10.3109/00498259409043259. [PMID: 7975722] - P Calès, H Caillau, O Crambes, J P Vinel, H Desmorat, I Rocher, L Jung, S Urien, R Brouard, J P Pascal. Hemodynamic and pharmacokinetic study of tertatolol in patients with alcoholic cirrhosis and portal hypertension.
Journal of hepatology.
1993 Aug; 19(1):43-50. doi:
10.1016/s0168-8278(05)80174-6. [PMID: 7905493] - I Berlin, G Deray, P Lechat, G Maistre, C Landault, V Chermat, R Brouard, C Ressayre, A J Puech. Tertatolol potentiates exercise-induced atrial natriuretic peptide release by increasing atrial diameter in healthy subjects.
Cardiology.
1993; 83 Suppl 1(?):16-24. doi:
10.1159/000176015. [PMID: 7903211] - I Berlin, P Lechat, G Deray, C Landault, G Maistre, V Chermat, R Brouard, C Ressayre, A J Puech. Beta-adrenoceptor blockade potentiates acute exercise-induced release of atrial natriuretic peptide by increasing atrial diameter in normotensive healthy subjects.
European journal of clinical pharmacology.
1993; 44(2):127-33. doi:
10.1007/bf00315469. [PMID: 8095894] - J Ribstein, G Du Cailar, R Brouard, A Mimran. Comparative renal and cardiac effects of tertatolol and enalapril in essential hypertension.
Cardiology.
1993; 83 Suppl 1(?):57-63. doi:
10.1159/000176011. [PMID: 7903217] - C Guillet. Overview of novel renal properties of tertatolol.
Cardiology.
1993; 83 Suppl 1(?):64-9. doi:
10.1159/000176012. [PMID: 7903218] - P Shultz, L Raij. Tertatolol: a beta-blocker with unique effects on human glomerular cell function.
Cardiology.
1993; 83 Suppl 1(?):51-6. doi:
10.1159/000176010. [PMID: 7903216] - M Beaufils. Preserving the autoregulation of renal hemodynamics.
Cardiology.
1993; 83 Suppl 1(?):10-5. doi:
10.1159/000176006. [PMID: 7903210] - C Diehm, O Jacobsen, K Amendt. The effects of tertatolol on lipid profile.
Cardiology.
1993; 83 Suppl 1(?):32-40. doi:
10.1159/000176008. [PMID: 7903213] - G Bastian, S Urien, F Brée, P Jolliet, I Rocher, O Crambes, J P Tillement. Stereoselective binding of tertatolol and of 4-hydroxytertatolol to human plasma proteins.
European journal of drug metabolism and pharmacokinetics.
1992 Jul; 17(3):233-6. doi:
10.1007/bf03190151. [PMID: 1362702] - R Tomaszewski, J Kliz. [Tertatolol--characteristics of the drug].
Wiadomosci lekarskie (Warsaw, Poland : 1960).
1992 Mar; 45(5-6):196, 200, 204 passim. doi:
NULL. [PMID: 1360731] - T Lave, C Efthymiopoulos, J C Koffel, L Jung. Determination of tertatolol enantiomers in biological fluids by high-performance liquid chromatography.
Journal of chromatography.
1991 Dec; 572(1-2):203-10. doi:
10.1016/0378-4347(91)80484-t. [PMID: 1687817] - T J Verbeuren, P Mennecier, M Laubie. 5-Hydroxytryptamine-induced vasodilatation in the isolated perfused rat kidney: are endothelial 5-HT1A receptors involved?.
European journal of pharmacology.
1991 Aug; 201(1):17-27. doi:
10.1016/0014-2999(91)90317-j. [PMID: 1838983] - F Fallo, M Gregianin, F Bui, C Macrì, P Folino, F Mantero. Comparison of the antihypertensive and renal effects of tertatolol and nadolol in hypertensive patients with mild renal impairment.
European journal of clinical pharmacology.
1991; 40(3):309-11. doi:
10.1007/bf00315216. [PMID: 1676368] - T Hannedouche, R Brouard, M Godin, D Kleinknecht, F Paillard, J P Grünfeld. Chronic effects of tertatolol on renal function in hypertensive patients with mild chronic renal failure.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
1991; 6(4):252-6. doi:
10.1093/ndt/6.4.252. [PMID: 1679214] - A Nitenberg, D Chemla, F Blanchet, O Guery, J F Prost, C Dutray-Dupagne. Beta blockers induce different intrarenal effects in humans: demonstration by selective infusion of tertatolol and propranolol.
Journal of clinical pharmacology.
1990 Oct; 30(10):930-7. doi:
10.1002/j.1552-4604.1990.tb03573.x. [PMID: 1977772] - D Stephan, M Barthelmebs, J P Krieger, N Decker, C Rochat, J L Imbs. Effect of tertatolol and of its metabolites and structural analogues in isolated perfused rat kidney vasculature.
Journal of cardiovascular pharmacology.
1990 Aug; 16(2):338-46. doi:
10.1097/00005344-199008000-00022. [PMID: 1697392] - M Chaignon, R Brouard, M Lucsko, J Guédon. [Renal effects of intravenous tertatolol in essential arterial hypertension].
Archives des maladies du coeur et des vaisseaux.
1990 Jul; 83(8):1219-22. doi:
NULL. [PMID: 1979729] - W Kirch, S Milferstädt, A Halabi, I Rocher, C Efthymiopoulos, L Jung. Interaction of tertatolol with rifampicin and ranitidine pharmacokinetics and antihypertensive activity.
Cardiovascular drugs and therapy.
1990 Apr; 4(2):487-91. doi:
10.1007/bf01857758. [PMID: 1981019] - G Deray, I Berlin, G Maistre, F Martinez, S Legrand, A Carayon, A Prost, A Puech, F Masson, J C Legrand. Beta-adrenoceptor blockade potentiates exercise-induced release of atrial natriuretic peptide.
European journal of clinical pharmacology.
1990; 38(4):363-6. doi:
10.1007/bf00315576. [PMID: 1971599] - E Agnes, J F Prost, M S Laher. Additional benefits of combining beta-blockade and renal vasodilation in the treatment of mild to moderate hypertension: Tertatolol International Multicentre Study results.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension.
1989 Dec; 7(6):S270-1. doi:
10.1097/00004872-198900076-00131. [PMID: 2576668] - F B Gabbai, O W Peterson, J F Prost, R C Blantz. Effect of tertatolol on glomerular hemodynamics in the normal Munich-Wistar rat.
American journal of hypertension.
1989 Nov; 2(11 Pt 2):213S-218S. doi:
10.1093/ajh/2.11.213s. [PMID: 2573366] - O Guery, D Herpin, M Lecasble, J Piron. Tertatolol in hypertension. Long-term therapy in 2,338 patients.
American journal of hypertension.
1989 Nov; 2(11 Pt 2):289S-295S. doi:
10.1093/ajh/2.11.289s. [PMID: 2573378] - A Nitenberg, J F Prost, J M Joussen, F Blanchet, C Dutray-Dupagne. Selective infusion of tertatolol into the renal artery induces a local vasodilator effect in humans. Demonstration by the continuous thermodilution method.
American journal of hypertension.
1989 Nov; 2(11 Pt 2):228S-232S. doi:
10.1093/ajh/2.11.228s. [PMID: 2818875] - N Perico, G Remuzzi. Effects of tertatolol on renal function in the isolated perfused rat kidney.
American journal of hypertension.
1989 Nov; 2(11 Pt 2):223S-227S. doi:
10.1093/ajh/2.11.223s. [PMID: 2573368] - M Beaufils. Alterations in renal hemodynamics during chronic and acute beta-blockade in humans.
American journal of hypertension.
1989 Nov; 2(11 Pt 2):233S-236S. doi:
10.1093/ajh/2.11.233s. [PMID: 2573369] - T J Verbeuren, A G Herman. Pharmacological features of the vasodilation induced by tertatolol in isolated perfused rat kidneys.
American journal of hypertension.
1989 Nov; 2(11 Pt 2):219S-222S. doi:
10.1093/ajh/2.11.219s. [PMID: 2573367] - H A Struyker-Boudier, J F Smits. Antihypertensive action of beta-adrenoceptor blocking drugs. The role of intrarenal mechanisms.
American journal of hypertension.
1989 Nov; 2(11 Pt 2):237S-240S. doi:
10.1093/ajh/2.11.237s. [PMID: 2573370] - NULL. Beta-blockade and renal function in hypertension. Symposium.
American journal of hypertension.
1989 Nov; 2(11 Pt 2):207S-302S. doi:
NULL. [PMID: 2573365] - R Naeije, J P Degaute. Redistribution of cardiac output to the kidneys by tertatolol does not involve prostaglandins.
American journal of hypertension.
1989 Nov; 2(11 Pt 2):241S-244S. doi:
10.1093/ajh/2.11.241s. [PMID: 2573371] - M Rainfray, I Rocher, F Mignon, A Meyrier. Tertatolol in chronic renal failure. A pharmacokinetic study.
American journal of hypertension.
1989 Nov; 2(11 Pt 2):266S-277S. doi:
10.1093/ajh/2.11.266s. [PMID: 2573374] - B Lantz, F Paillard, E Nunez, R Assan. Short tertatolol treatment does not impair the hormone and metabolic responses to exercise and hypoglycemia in diabetics.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
1989 Oct; 21(10):561-5. doi:
10.1055/s-2007-1009288. [PMID: 2572524] - D Stephan, M Barthelmebs, C Rochat, J L Imbs. [Vasodilator effect of tertatolol on isolated rat kidney].
Archives des maladies du coeur et des vaisseaux.
1989 Jul; 82(7):1211-3. doi:
. [PMID: 2573324] - T J Verbeuren, L L Zonnekeyn, J F Prost, A G Herman. Prejunctional beta-adrenoceptors in the isolated perfused rat kidney: a comparative study of the beta-blockers tertatolol and propranolol.
Archives internationales de pharmacodynamie et de therapie.
1989 Mar; 298(?):183-97. doi:
NULL. [PMID: 2569296] - G E Plante, C Prévost, P Sirois, C Rochat, J F Prost. Tertatolol increases glomerular filtration and urinary sodium in anesthetized rats.
The Journal of pharmacology and experimental therapeutics.
1989 Feb; 248(2):741-6. doi:
NULL. [PMID: 2563770] - S Urien, D Morin, I Rocher, J P Tillement. Tertatolol high affinity binding to alpha 1-acid glycoprotein: stereospecificity and consequences on plasma binding in disease states.
Progress in clinical and biological research.
1989; 300(?):453-6. doi:
NULL. [PMID: 2571165] - G Musch, Y Buelens, D L Massart. A strategy for the determination of beta blockers in plasma using solid-phase extraction in combination with high-performance liquid chromatography.
Journal of pharmaceutical and biomedical analysis.
1989; 7(4):483-97. doi:
10.1016/0731-7085(89)80035-4. [PMID: 2577451] - T J Verbeuren, L L Zonnekeyn, J F Prost, C Rochat, J R Thomas, A G Herman. The beta adrenoceptor blocker tertatolol causes vasodilatation in the isolated perfused vasoconstricted rat kidney.
The Journal of pharmacology and experimental therapeutics.
1988 Aug; 246(2):628-34. doi:
NULL. [PMID: 2900328] - F Delaini, N Perico, M Tagliaferri, C Lupini, O Patino, G Remuzzi, S Garattini. Tertatolol ameliorates renal function in rats with chronic renal failure.
The Journal of pharmacology and experimental therapeutics.
1988 Jul; 246(1):287-93. doi:
NULL. [PMID: 2899165] - S Urien, D Morin, A Renouard, I Rocher, J P Tillement. Variation in serum binding of tertatolol mediated by disease-induced modification of alpha-acid glycoprotein concentration.
European journal of clinical pharmacology.
1988; 34(4):381-5. doi:
10.1007/bf00542440. [PMID: 2900145] - D Verotta, L B Sheiner. Simultaneous modeling of pharmacokinetics and pharmacodynamics: an improved algorithm.
Computer applications in the biosciences : CABIOS.
1987 Nov; 3(4):345-9. doi:
10.1093/bioinformatics/3.4.345. [PMID: 2898970] - C Efthymiopoulos, S Staveris, F Weber, J C Koffel, L Jung. Simultaneous quantitative determination of tertatolol and its hydroxylated metabolite in human plasma and urine by gas chromatography-mass spectrometry.
Journal of chromatography.
1987 Oct; 421(2):360-6. doi:
10.1016/0378-4347(87)80417-6. [PMID: 2892852] - C Labrid. [Evaluation of beta-adrenolytic activity. Structure-activity relationship].
Annales de medecine interne.
1987; 138 Suppl 1(?):5-10. doi:
NULL. [PMID: 2884916] - B Lesobre. [Influence of antihypertensive treatment on the metabolism of lipoproteins].
Annales de medecine interne.
1987; 138 Suppl 1(?):23-6. doi:
". [PMID: 2884912] - J L Richard, C Martin, B Jacotot. Tertatolol does not affect biochemical markers of atherosclerosis in normo- and hyperlipidemic hypertensive patients.
American journal of nephrology.
1986; 6 Suppl 2(?):100-5. doi:
10.1159/000167342. [PMID: 2879464] - A Salvetti, G Leonetti, G P Bernini, L Rupoli, A R Lucarini, P Sangiorgio, M Mauro, P Di Stratis, A Zanchetti. Antihypertensive and renal effects of tertatolol, a new beta-blocking agent, in hypertensive patients.
American journal of nephrology.
1986; 6 Suppl 2(?):45-9. doi:
10.1159/000167333. [PMID: 2879473] - M Laubie, J F Prost, C Rochat. Renal hemodynamic effects of tertatolol compared with those of propranolol in the conscious dog.
American journal of nephrology.
1986; 6 Suppl 2(?):20-4. doi:
10.1159/000167328. [PMID: 2879468] - T J Verbeuren, A G Herman. Study of prejunctional beta-adrenoceptors in kidneys of normotensive and hypertensive rats using the new beta-adrenoceptor blocking drug tertatolol.
American journal of nephrology.
1986; 6 Suppl 2(?):30-5. doi:
10.1159/000167330. [PMID: 2879470] - M Leeman, R Naeije, J P Degaute, F Brackman, J Thomas, J F Prost. Tertatolol preserves renal perfusion in patients with arterial hypertension after head injury.
American journal of nephrology.
1986; 6 Suppl 2(?):36-9. doi:
10.1159/000167331. [PMID: 2879471] - F Paillard, B Lantz, F Leviel, R Ardaillou. Renal hemodynamic effects of tertatolol in essential hypertension.
American journal of nephrology.
1986; 6 Suppl 2(?):40-4. doi:
10.1159/000167332. [PMID: 2879472] - M Beaufils, B Lantz, F Paillard, G Richet. Effects of tertatolol in hypertensive patients with chronic renal failure.
American journal of nephrology.
1986; 6 Suppl 2(?):50-4. doi:
10.1159/000167334. [PMID: 2879474] - NULL. Recent advances in beta blockade. Therapeutic implications in hypertension. Proceedings of the First International Symposium on Tertatolol, 15th June, 1985, Milano, Italy.
American journal of nephrology.
1986; 6 Suppl 2(?):1-116. doi:
10.1159/000167323. [PMID: 2879463] - M Komajda, B Genevray, Y Grosgogeat. Long-term experience with tertatolol in hypertension.
American journal of nephrology.
1986; 6 Suppl 2(?):106-12. doi:
10.1159/000167343. [PMID: 2879465] - D B Campbell, J C Chignon, J P Devissaguet. Biodisposition of tertatolol in man: a review.
American journal of nephrology.
1986; 6 Suppl 2(?):61-8. doi:
10.1159/000167336. [PMID: 3541611] - B R Walker, A L Erickson, J F Prost, C Rochat, T J Burke. Cardiovascular and renal effects of the beta-blocker SE2395 in conscious normotensive dogs.
Journal of cardiovascular pharmacology.
1985 Nov; 7(6):1193-7. doi:
10.1097/00005344-198511000-00029. [PMID: 2418310] - S Staveris, P Blaise, C Efthymiopoulos, M Schneider, G Jamet, L Jung, J C Koffel. Quantitative determination of tertatolol in biological fluids by gas chromatography-mass spectrometry.
Journal of chromatography.
1985 Apr; 339(1):97-103. doi:
10.1016/s0378-4347(00)84631-9. [PMID: 2862155] - P Brondeau, P Martin-Dupont, J Cambar. [Influence of 3 beta-blockers on the diameter of glomeruli isolated from the renal cortex of rats].
Comptes rendus des seances de la Societe de biologie et de ses filiales.
1985; 179(1):98-101. doi:
NULL. [PMID: 2862977] - R D Holbert, J E Pearson, F M Gonzalez. Effect of sodium acetate infusion on renal function in the dog.
Archives internationales de pharmacodynamie et de therapie.
1976 Feb; 219(2):211-22. doi:
NULL. [PMID: 5975]