2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (BioDeep_00000182292)

   

human metabolite blood metabolite


代谢物信息卡片


2-[6-(5-Chloro-2-methoxyphenyl)-4-hydroxy-2-sulphanylidene-1,2-dihydropyrimidin-1-yl]ethanimidic acid

化学式: C13H12ClN3O3S (325.0287872)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=C(C=C(C=C1)Cl)C2=CC(=O)NC(=S)N2CC(=O)N
InChI: InChI=1S/C13H12ClN3O3S/c1-20-10-3-2-7(14)4-8(10)9-5-12(19)16-13(21)17(9)6-11(15)18/h2-5H,6H2,1H3,(H2,15,18)(H,16,19,21)

描述信息

同义名列表

6 个代谢物同义名

2-[6-(5-Chloro-2-methoxyphenyl)-4-hydroxy-2-sulphanylidene-1,2-dihydropyrimidin-1-yl]ethanimidic acid; 2-[6-(5-Chloro-2-methoxyphenyl)-4-hydroxy-2-sulphanylidene-1,2-dihydropyrimidin-1-yl]ethanimidate; 2-[6-(5-chloro-2-methoxyphenyl)-4-oxo-2-sulfanylidene-1,2,3,4-tetrahydropyrimidin-1-yl]acetamide; 2-[6-(5-Chloro-2-methoxyphenyl)-4-hydroxy-2-sulfanylidene-1,2-dihydropyrimidin-1-yl]ethanimidate; 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide; 2-[6-(5-chloro-2-methoxyphenyl)-4-oxo-2-sulfanylidene-3H-pyrimidin-1-yl]acetamide



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Rachel J Roth Flach, Chunyan Su, Eliza Bollinger, Christian Cortes, Andrew W Robertson, Alan C Opsahl, Timothy M Coskran, Kevin P Maresca, Edmund J Keliher, Phillip D Yates, Albert M Kim, Amit S Kalgutkar, Leonard Buckbinder. Myeloperoxidase inhibition in mice alters atherosclerotic lesion composition. PloS one. 2019; 14(3):e0214150. doi: 10.1371/journal.pone.0214150. [PMID: 30889221]
  • Jamie E Moscovitz, Zhiwu Lin, Nathaniel Johnson, Meihua Tu, Theunis C Goosen, Yan Weng, Amit S Kalgutkar. Induction of human cytochrome P450 3A4 by the irreversible myeloperoxidase inactivator PF-06282999 is mediated by the pregnane X receptor. Xenobiotica; the fate of foreign compounds in biological systems. 2018 Jul; 48(7):647-655. doi: 10.1080/00498254.2017.1353163. [PMID: 28685622]
  • Jennifer Q Dong, James R Gosset, Odette A Fahmi, Zhiwu Lin, Jeffrey R Chabot, Steven G Terra, Vu Le, Kristin Chidsey, Parya Nouri, Albert Kim, Leonard Buckbinder, Amit S Kalgutkar. Examination of the Human Cytochrome P4503A4 Induction Potential of PF-06282999, an Irreversible Myeloperoxidase Inactivator: Integration of Preclinical, In Silico, and Biomarker Methodologies in the Prediction of the Clinical Outcome. Drug metabolism and disposition: the biological fate of chemicals. 2017 05; 45(5):501-511. doi: 10.1124/dmd.116.074476. [PMID: 28254951]
  • Jennifer Q Dong, Manthena V Varma, Angela Wolford, Tim Ryder, Li Di, Bo Feng, Steven G Terra, Kazuko Sagawa, Amit S Kalgutkar. Pharmacokinetics and Disposition of the Thiouracil Derivative PF-06282999, an Orally Bioavailable, Irreversible Inactivator of Myeloperoxidase Enzyme, Across Animals and Humans. Drug metabolism and disposition: the biological fate of chemicals. 2016 Feb; 44(2):209-19. doi: 10.1124/dmd.115.067868. [PMID: 26608081]
  • Roger B Ruggeri, Leonard Buckbinder, Scott W Bagley, Philip A Carpino, Edward L Conn, Matthew S Dowling, Dilinie P Fernando, Wenhua Jiao, Daniel W Kung, Suvi T M Orr, Yingmei Qi, Benjamin N Rocke, Aaron Smith, Joseph S Warmus, Yan Zhang, Daniel Bowles, Daniel W Widlicka, Heather Eng, Tim Ryder, Raman Sharma, Angela Wolford, Carlin Okerberg, Karen Walters, Tristan S Maurer, Yanwei Zhang, Paul D Bonin, Samantha N Spath, Gang Xing, David Hepworth, Kay Ahn, Amit S Kalgutkar. Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases. Journal of medicinal chemistry. 2015 Nov; 58(21):8513-28. doi: 10.1021/acs.jmedchem.5b00963. [PMID: 26509551]