N-Pyridazin-3-yl-4-[[3-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]methylidene]piperidine-1-carboxamide (BioDeep_00000182291)

   

human metabolite blood metabolite


代谢物信息卡片


N-(pyridazin-3-yl)-4-[(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)methylidene]piperidine-1-carboxamide

化学式: C23H20F3N5O2 (455.1569016)
中文名称: N-哒嗪-3-基-4-(3-{[5-(三氟甲基)吡啶-2-基]醚}苯亚甲基丙酮)哌啶-1-羧酰胺
谱图信息: 最多检出来源 Homo sapiens(blood) 50%

分子结构信息

SMILES: C1CN(CCC1=CC2=CC(=CC=C2)OC3=NC=C(C=C3)C(F)(F)F)C(=O)NC4=NN=CC=C4
InChI: InChI=1S/C23H20F3N5O2/c24-23(25,26)18-6-7-21(27-15-18)33-19-4-1-3-17(14-19)13-16-8-11-31(12-9-16)22(32)29-20-5-2-10-28-30-20/h1-7,10,13-15H,8-9,11-12H2,(H,29,30,32)

描述信息

Redafamdastat (PF-04457845) is a highly efficacious and selective FAAH inhibitor with IC50 values is 7.2±0.63 nM and 7.4±0.62 nM for hFAAH and rFAAH, respectively.

同义名列表

5 个代谢物同义名

N-(pyridazin-3-yl)-4-[(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)methylidene]piperidine-1-carboxamide; N-Pyridazin-3-yl-4-[[3-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]methylidene]piperidine-1-carboxamide; N-Pyridazin-3-yl-4-(3-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzylidene)piperidine-1-carboxamide; PF-04457845; Redafamdastat



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Navatha Alugubelly, Afzaal N Mohammed, Russell L Carr. Persistent proteomic changes in glutamatergic and GABAergic signaling in the amygdala of adolescent rats exposed to chlorpyrifos as juveniles. Neurotoxicology. 2021 07; 85(?):234-244. doi: 10.1016/j.neuro.2021.05.012. [PMID: 34058248]
  • Deepak Cyril D'Souza, Jose Cortes-Briones, Gina Creatura, Grai Bluez, Halle Thurnauer, Emma Deaso, Kim Bielen, Toral Surti, Rajiv Radhakrishnan, Aarti Gupta, Swapnil Gupta, John Cahill, Mohamed A Sherif, Alexandros Makriyannis, Peter T Morgan, Mohini Ranganathan, Patrick D Skosnik. Efficacy and safety of a fatty acid amide hydrolase inhibitor (PF-04457845) in the treatment of cannabis withdrawal and dependence in men: a double-blind, placebo-controlled, parallel group, phase 2a single-site randomised controlled trial. The lancet. Psychiatry. 2019 01; 6(1):35-45. doi: 10.1016/s2215-0366(18)30427-9. [PMID: 30528676]
  • Robert W Buntyn, Navatha Alugubelly, Rachel L Hybart, Afzaal N Mohammed, Carole A Nail, Greta C Parker, Matthew K Ross, Russell L Carr. Inhibition of Endocannabinoid-Metabolizing Enzymes in Peripheral Tissues Following Developmental Chlorpyrifos Exposure in Rats. International journal of toxicology. 2017 Sep; 36(5):395-402. doi: 10.1177/1091581817725272. [PMID: 28820005]
  • Annelot C M van Esbroeck, Antonius P A Janssen, Armand B Cognetta, Daisuke Ogasawara, Guy Shpak, Mark van der Kroeg, Vasudev Kantae, Marc P Baggelaar, Femke M S de Vrij, Hui Deng, Marco Allarà, Filomena Fezza, Zhanmin Lin, Tom van der Wel, Marjolein Soethoudt, Elliot D Mock, Hans den Dulk, Ilse L Baak, Bogdan I Florea, Giel Hendriks, Luciano De Petrocellis, Herman S Overkleeft, Thomas Hankemeier, Chris I De Zeeuw, Vincenzo Di Marzo, Mauro Maccarrone, Benjamin F Cravatt, Steven A Kushner, Mario van der Stelt. Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474. Science (New York, N.Y.). 2017 06; 356(6342):1084-1087. doi: 10.1126/science.aaf7497. [PMID: 28596366]
  • Isabelle Boileau, Pablo M Rusjan, Belinda Williams, Esmaeil Mansouri, Romina Mizrahi, Vincenzo De Luca, Douglas S Johnson, Alan A Wilson, Sylvain Houle, Stephen J Kish, Junchao Tong. Blocking of fatty acid amide hydrolase activity with PF-04457845 in human brain: a positron emission tomography study with the novel radioligand [(11)C]CURB. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2015 Nov; 35(11):1827-35. doi: 10.1038/jcbfm.2015.133. [PMID: 26082009]
  • Gai Ling Li, Helen Winter, Rosalin Arends, Gary W Jay, Vu Le, Tim Young, John P Huggins. Assessment of the pharmacology and tolerability of PF-04457845, an irreversible inhibitor of fatty acid amide hydrolase-1, in healthy subjects. British journal of clinical pharmacology. 2012 May; 73(5):706-16. doi: 10.1111/j.1365-2125.2011.04137.x. [PMID: 22044402]
  • Oscar Sasso, Rosalia Bertorelli, Tiziano Bandiera, Rita Scarpelli, Giampiero Colombano, Andrea Armirotti, Guillermo Moreno-Sanz, Angelo Reggiani, Daniele Piomelli. Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions. Pharmacological research. 2012 May; 65(5):553-63. doi: 10.1016/j.phrs.2012.02.012. [PMID: 22420940]