Perampanel (BioDeep_00000182238)
human metabolite blood metabolite
代谢物信息卡片
3-(2-Cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one
化学式: C23H15N3O (349.1215)
中文名称: 吡仑帕奈
谱图信息:
最多检出来源 Homo sapiens(not specific) 9.3%
分子结构信息
SMILES: C1=CC=C(C=C1)N2C=C(C=C(C2=O)C3=CC=CC=C3C#N)C4=CC=CC=N4
InChI: InChI=1S/C23H15N3O/c24-15-17-8-4-5-11-20(17)21-14-18(22-12-6-7-13-25-22)16-26(23(21)27)19-9-2-1-3-10-19/h1-14,16H
描述信息
N - Nervous system > N03 - Antiepileptics > N03A - Antiepileptics
C78272 - Agent Affecting Nervous System > C47795 - CNS Stimulant
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:71013
- PubChem: 9924495
- HMDB: HMDB0256305
- DrugBank: DB08883
- ChEMBL: CHEMBL1214124
- Wikipedia: Perampanel
- chemspider: 8100130
- CAS: 1174302-51-2
- CAS: 380917-97-5
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Ziad Hussein, Oneeb Majid, Peter Boyd, Jagadeesh Aluri, Leock Y Ngo, Larisa Reyderman. Intravenous Perampanel as an Interchangeable Alternative to Oral Perampanel: A Randomized, Crossover, Phase I Pharmacokinetic and Safety Study.
Clinical pharmacology in drug development.
2022 Jul; 11(7):878-888. doi:
10.1002/cpdd.1107. [PMID: 35596529] - Sara Meirinho, Márcio Rodrigues, Catarina L Ferreira, Rui Caetano Oliveira, Ana Fortuna, Adriana O Santos, Amílcar Falcão, Gilberto Alves. Intranasal delivery of lipid-based nanosystems as a promising approach for brain targeting of the new-generation antiepileptic drug perampanel.
International journal of pharmaceutics.
2022 Jun; 622(?):121853. doi:
10.1016/j.ijpharm.2022.121853. [PMID: 35623483] - Zifang Ding, Xu Wang, Ning Zhang, Chen Sun, Guode Zhao, Ying Peng, Jiang Zheng. Metabolic Activation of Perampanel Mediated by CYP1A2.
Chemical research in toxicology.
2022 03; 35(3):490-498. doi:
10.1021/acs.chemrestox.1c00396. [PMID: 35200000] - Paolo Bonanni, Antonio Gambardella, Paolo Tinuper, Benedetto Acone, Emilio Perucca, Giangennaro Coppola. Perampanel as first add-on antiseizure medication: Italian consensus clinical practice statements.
BMC neurology.
2021 Oct; 21(1):410. doi:
10.1186/s12883-021-02450-y. [PMID: 34702211] - Bruno Charlier, Albino Coglianese, Francesca Felicia Operto, Federica De Rosa, Francesca Mensitieri, Giangennaro Coppola, Amelia Filippelli, Fabrizio Dal Piaz, Viviana Izzo. Perampanel dosage in plasma samples: development and validation of a novel HPLC method with combined UV-Fluorescence detection.
Journal of pharmaceutical and biomedical analysis.
2021 Sep; 204(?):114252. doi:
10.1016/j.jpba.2021.114252. [PMID: 34265485] - Maya G Deshmukh, Joseph A Ippolito, Chun-Hui Zhang, Elizabeth A Stone, Raquel A Reilly, Scott J Miller, William L Jorgensen, Karen S Anderson. Structure-guided design of a perampanel-derived pharmacophore targeting the SARS-CoV-2 main protease.
Structure (London, England : 1993).
2021 08; 29(8):823-833.e5. doi:
10.1016/j.str.2021.06.002. [PMID: 34161756] - Gregory L Krauss, Elinor Ben-Menachem, Robert T Wechsler, Anna Patten, Betsy Williams, Antonio Laurenza, Manoj Malhotra. A multivariable prediction model of a major treatment response for focal-onset seizures: A post-hoc analysis of Phase III trials of perampanel.
Epilepsy research.
2021 08; 174(?):106649. doi:
10.1016/j.eplepsyres.2021.106649. [PMID: 34022524] - Ida Marie Bakke Lossius, Torleiv Svendsen, Hild F Sødal, Kari Kjeldstadli, Morten Ingvar Lossius, Karl Otto Nakken, Cecile Johannessen Landmark. Effect and tolerability of perampanel in patients with drug-resistant epilepsy.
Epilepsy & behavior : E&B.
2021 06; 119(?):107965. doi:
10.1016/j.yebeh.2021.107965. [PMID: 33940525] - John-Paul Nicolo, Zhibin Chen, Bradford Moffat, David K Wright, Benjamin Sinclair, Rebecca Glarin, Andrew Neal, Vincent Thijs, Udaya Seneviratne, Bernard Yan, Geoffrey Cloud, Terence J O'Brien, Patrick Kwan. Study protocol for a phase II randomised, double-blind, placebo-controlled trial of perampanel as an antiepileptogenic treatment following acute stroke.
BMJ open.
2021 05; 11(5):e043488. doi:
10.1136/bmjopen-2020-043488. [PMID: 33972334] - Cecilie Johannessen Landmark, Lene Rektorli, Margrete Larsen Burns, Eline Revdal, Svein I Johannessen, Eylert Brodtkorb. Pharmacokinetic data on brivaracetam, lacosamide and perampanel during pregnancy and lactation.
Epileptic disorders : international epilepsy journal with videotape.
2021 Apr; 23(2):426-431. doi:
10.1684/epd.2021.1273. [PMID: 33935028] - Seon-Jae Ahn, Tae-Joon Kim, Kwang Su Cha, Jin-Sun Jun, Jung-Ick Byun, Yong-Won Shin, Jun-Sang Sunwoo, SeungHwan Lee, Kyung-Sang Yu, In-Jin Jang, Kon Chu, Sang Kun Lee, Ki-Young Jung. Effects of perampanel on cognition and quantitative electroencephalography in patients with epilepsy.
Epilepsy & behavior : E&B.
2021 02; 115(?):107514. doi:
10.1016/j.yebeh.2020.107514. [PMID: 33328106] - Marko Blickhan, Tassanai Intravooth, Anke M Staack, Reinhold Kornmeier, Patricia Mahn, Matthias Schneider, Jakob Stockinger, Matthias Bacher, Christoph Kurth, Bernhard J Steinhoff. Clinical experience of abrupt discontinuation of perampanel: a case series.
Epileptic disorders : international epilepsy journal with videotape.
2021 Feb; 23(1):148-152. doi:
10.1684/epd.2021.1242. [PMID: 33602660] - Rosa Sabença, Joana Bicker, Rui Silva, Andreia Carona, Ana Silva, Isabel Santana, Francisco Sales, Amílcar Falcão, Ana Fortuna. Development and application of an HPLC-DAD technique for human plasma concentration monitoring of perampanel and lamotrigine in drug-resistant epileptic patients.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2021 Jan; 1162(?):122491. doi:
10.1016/j.jchromb.2020.122491. [PMID: 33360678] - Tao Chen, Wen-Bo Liu, Xiao Qian, Ke-Liang Xie, Yu-Hai Wang. The AMPAR antagonist perampanel protects the neurovascular unit against traumatic injury via regulating Sirt3.
CNS neuroscience & therapeutics.
2021 01; 27(1):134-144. doi:
10.1111/cns.13580. [PMID: 33421349] - Mohammad M Ghahremanpour, Julian Tirado-Rives, Maya Deshmukh, Joseph A Ippolito, Chun-Hui Zhang, Israel Cabeza de Vaca, Maria-Elena Liosi, Karen S Anderson, William L Jorgensen. Identification of 14 Known Drugs as Inhibitors of the Main Protease of SARS-CoV-2.
ACS medicinal chemistry letters.
2020 Dec; 11(12):2526-2533. doi:
10.1021/acsmedchemlett.0c00521. [PMID: 33324471] - Sara Meirinho, Gonçalo Campos, Márcio Rodrigues, Ana Fortuna, Amílcar Falcão, Gilberto Alves. Salting-out assisted liquid-liquid extraction method optimized by design of experiments for the simultaneous high-performance liquid chromatography analysis of perampanel and stiripentol in mouse matrices.
Journal of separation science.
2020 Dec; 43(23):4289-4304. doi:
10.1002/jssc.202000656. [PMID: 32997431] - Sari Shiba, Hisakuni Sekino, Kaeko Ishiba, Sanae Yasuda, Syuhei Inoue, Ken Kotaka, Larisa Reyderman, Naoki Uchida. Bioequivalence of perampanel fine granules and tablets in healthy Japanese subjects.
International journal of clinical pharmacology and therapeutics.
2020 Dec; 58(12):757-764. doi:
10.5414/cp203781. [PMID: 32870153] - Manuela Contin, Federica Pondrelli, Lorenzo Muccioli, Susan Mohamed, Margherita Santucci, Lorenzo Ferri, Laura Licchetta, Paolo Tinuper, Francesca Bisulli. Relationship between plasma concentrations and clinical effects of perampanel: A prospective observational study.
Epilepsy & behavior : E&B.
2020 11; 112(?):107385. doi:
10.1016/j.yebeh.2020.107385. [PMID: 32858369] - Nobutsune Ishikawa, Yuichi Tateishi, Hiroo Tani, Yoshiyuki Kobayashi, Satoshi Okada. Effects of perampanel add-on therapy on immunoglobulin levels in pediatric patients with epilepsy.
Epilepsy research.
2020 11; 167(?):106447. doi:
10.1016/j.eplepsyres.2020.106447. [PMID: 32911259] - Sho Ohkubo, Yumiko Akamine, Tadashi Ohkubo, Yuka Kikuchi, Masatomo Miura. Quantification of the Plasma Concentrations of Perampanel Using High-Performance Liquid Chromatography and Effects of the CYP3A4*1G Polymorphism in Japanese Patients.
Journal of chromatographic science.
2020 Oct; 58(10):915-921. doi:
10.1093/chromsci/bmaa060. [PMID: 32888296] - Michel Bteich, Patrick Poulin, Sarah Piette, Sami Haddad. Impact of Extensive Plasma Protein Binding on the In Situ Hepatic Uptake and Clearance of Perampanel and Fluoxetine in Sprague Dawley Rats.
Journal of pharmaceutical sciences.
2020 10; 109(10):3190-3205. doi:
10.1016/j.xphs.2020.07.003. [PMID: 32649937] - Sumitha Murugesu, Kiminobu Okayama, Yoshiaki Yamamoto, Kiyohito Terada, Yukitoshi Takahashi. Changes in serum perampanel concentration profile after discontinuation of carbamazepine.
Epileptic disorders : international epilepsy journal with videotape.
2020 Aug; 22(4):455-461. doi:
10.1684/epd.2020.1182. [PMID: 32782230] - Nicole Trabs, Mathias Trabs, Stefan Stodieck, Patrick M House. Influence of stiripentol on perampanel serum levels.
Epilepsy research.
2020 08; 164(?):106367. doi:
10.1016/j.eplepsyres.2020.106367. [PMID: 32446162] - Edgar Schuck, Jim Ferry, Barry Gidal, Ziad Hussein. Changes in perampanel levels during de-induction: Simulations following carbamazepine discontinuation.
Acta neurologica Scandinavica.
2020 Aug; 142(2):131-138. doi:
10.1111/ane.13286. [PMID: 32430908] - Do-Yong Kim, Jangsup Moon, Yong-Won Shin, Soon-Tae Lee, Keun-Hwa Jung, Kyung-Il Park, Ki-Young Jung, Manho Kim, SeungHwan Lee, Kyung-Sang Yu, In-Jin Jang, KaHeon Song, Kon Chu, Sangkun Lee. Usefulness of saliva for perampanel therapeutic drug monitoring.
Epilepsia.
2020 06; 61(6):1120-1128. doi:
10.1111/epi.16513. [PMID: 32378757] - Valentina Franco, Katia Baruffi, Roberto Marchiselli, Francesca Crema, Cinzia Fattore, Andrea Romigi, Valentina De Giorgis, Elena Tartara, Maurizio Elia, Antonio D'Avolio, Emilio Perucca. Determination of Perampanel in Dried Plasma Spots: Applicability to Therapeutic Drug Monitoring.
Therapeutic drug monitoring.
2020 04; 42(2):309-314. doi:
10.1097/ftd.0000000000000680. [PMID: 31365481] - Faleh Alqahtani, Mohammed A Assiri, Mohamed Mohany, Imran Imran, Sana Javaid, Muhammad Fawad Rasool, Waleed Shakeel, Farzane Sivandzade, Ahmed Z Alanazi, Salim S Al-Rejaie, Musaad A Alshammari, Fawaz Alasmari, Mohammed Mufadhe Alanazi, Faisal F Alamri. Coadministration of Ketamine and Perampanel Improves Behavioral Function and Reduces Inflammation in Acute Traumatic Brain Injury Mouse Model.
BioMed research international.
2020; 2020(?):3193725. doi:
10.1155/2020/3193725. [PMID: 33381547] - Satoru Ikemoto, Shin-Ichiro Hamano, Yuko Hirata, Ryuki Matsuura, Reiko Koichihara. Efficacy and serum concentrations of perampanel for treatment of drug-resistant epilepsy in children, adolescents, and young adults: comparison of patients younger and older than 12 years.
Seizure.
2019 Dec; 73(?):75-78. doi:
10.1016/j.seizure.2019.10.023. [PMID: 31759296] - Elizabeth Gaudio, Andrew J Gienapp, James Wheless. Perampanel Pharmacokinetics in Children: Correlation of Dose With Serum Concentrations.
Journal of child neurology.
2019 07; 34(8):427-431. doi:
10.1177/0883073819837465. [PMID: 30909831] - Hirotaka Iwaki, Kazutaka Jin, Norio Sugawara, Nobukazu Nakasato, Sunao Kaneko. Perampanel-induced weight gain depends on level of intellectual disability and its serum concentration.
Epilepsy research.
2019 05; 152(?):1-6. doi:
10.1016/j.eplepsyres.2019.02.011. [PMID: 30852339] - Nobutsune Ishikawa, Yuichi Tateishi, Hiroo Tani, Yoshiyuki Kobayashi, Masao Kobayashi. Clinical profiles associated with serum perampanel concentrations in children with refractory epilepsy.
Epilepsy & behavior : E&B.
2019 05; 94(?):82-86. doi:
10.1016/j.yebeh.2019.02.004. [PMID: 30897534] - Bernhard J Steinhoff, Elisabeth Hübers, Christoph Kurth, Uta Jürges Kehl-Kork. Plasma concentration and clinical effects of perampanel-The Kork experience.
Seizure.
2019 Apr; 67(?):18-22. doi:
10.1016/j.seizure.2019.02.022. [PMID: 30852267] - Stefano de Biase, Gian Luigi Gigli, Annacarmen Nilo, Giorgia Romano, Mariarosaria Valente. Pharmacokinetic and pharmacodynamic considerations for the clinical efficacy of perampanel in focal onset seizures.
Expert opinion on drug metabolism & toxicology.
2019 Feb; 15(2):93-102. doi:
10.1080/17425255.2019.1560420. [PMID: 30577702] - Barry E Gidal, Jim Ferry, Antonio Laurenza, Takashi Ueno. Potential protein-binding displacement interactions with perampanel: An in vitro analysis.
Epilepsy research.
2019 01; 149(?):102-106. doi:
10.1016/j.eplepsyres.2018.12.003. [PMID: 30580179] - Yoshiaki Yamamoto, Yukitoshi Takahashi, Asako Horino, Naotaka Usui, Takuji Nishida, Katsumi Imai, Yoshiyuki Kagawa, Yushi Inoue. Influence of Inflammation on the Pharmacokinetics of Perampanel.
Therapeutic drug monitoring.
2018 12; 40(6):725-729. doi:
10.1097/ftd.0000000000000556. [PMID: 30086086] - Naotaka Usui, Naoki Akamatsu, Nobukazu Nakasato, Akihiro Ohnishi, Sunao Kaneko, Hidetaka Hiramatsu, Kazunori Saeki, Hideaki Miyagishi, Yushi Inoue. Long-term tolerability, safety and efficacy of adjunctive perampanel in the open-label, dose-ascending Study 231 and extension Study 233 in Japanese patients with epilepsy.
Seizure.
2018 Nov; 62(?):26-32. doi:
10.1016/j.seizure.2018.09.012. [PMID: 30267941] - Petr Tůma, Miroslava Bursová, Blanka Sommerová, Rachel Horsley, Radomír Čabala, Tomáš Hložek. Novel electrophoretic acetonitrile-based stacking for sensitive monitoring of the antiepileptic drug perampanel in human serum.
Journal of pharmaceutical and biomedical analysis.
2018 Oct; 160(?):368-373. doi:
10.1016/j.jpba.2018.08.006. [PMID: 30121554] - Ugo de Grazia, Annachiara DʼUrso, Federica Ranzato, Valentina De Riva, Giorgia Contarato, Giuseppe Billo, Francesco Perini, Elisabetta Galloni. A Liquid Chromatography-Mass Spectrometry Assay for Determination of Perampanel and Concomitant Antiepileptic Drugs in the Plasma of Patients With Epilepsy Compared With a Fluorescent HPLC Assay.
Therapeutic drug monitoring.
2018 08; 40(4):477-485. doi:
10.1097/ftd.0000000000000531. [PMID: 29746395] - Hiroko Tabuchi, Sari Shiba, Sanae Yasuda, Akihiro Ohnishi, Jae-Gook Shin. Pharmacokinetics of Perampanel in Healthy Korean, White, and Japanese Adult Subjects.
Clinical pharmacology in drug development.
2018 08; 7(6):613-620. doi:
10.1002/cpdd.581. [PMID: 29870595] - Manuela Contin, Francesca Bisulli, Margherita Santucci, Roberto Riva, Francesca Tonon, Susan Mohamed, Lorenzo Ferri, Carlotta Stipa, Paolo Tinuper. Effect of valproic acid on perampanel pharmacokinetics in patients with epilepsy.
Epilepsia.
2018 07; 59(7):e103-e108. doi:
10.1111/epi.14446. [PMID: 29897632] - Shuichi Izumoto, Masaharu Miyauchi, Takayuki Tasaki, Takeshi Okuda, Nobuhiro Nakagawa, Naoki Nakano, Amami Kato, Mitsugu Fujita. Seizures and Tumor Progression in Glioma Patients with Uncontrollable Epilepsy Treated with Perampanel.
Anticancer research.
2018 Jul; 38(7):4361-4366. doi:
10.21873/anticanres.12737. [PMID: 29970574] - David Paul, Lingesh Allakonda, Amit Sahu, Shruti Surendran, Nanjappan Satheeshkumar. Pharmacokinetics and brain uptake study of novel AMPA receptor antagonist perampanel in SD rats using a validated UHPLC-QTOF-MS method.
Journal of pharmaceutical and biomedical analysis.
2018 Feb; 149(?):234-241. doi:
10.1016/j.jpba.2017.11.008. [PMID: 29127904] - Yoshiaki Yamamoto, Naotaka Usui, Takuji Nishida, Miho Mori, Yukitoshi Takahashi, Katsumi Imai, Yoshiyuki Kagawa, Yushi Inoue. Influence of Renal Function on Pharmacokinetics of Antiepileptic Drugs Metabolized by CYP3A4 in a Patient With Renal Impairment.
Therapeutic drug monitoring.
2018 02; 40(1):144-147. doi:
10.1097/ftd.0000000000000461. [PMID: 29095797] - Nina Dupuis, Julie Enderlin, Jeremy Thomas, Béatrice Desnous, Pascal Dournaud, Delphine Allorge, Stéphane Auvin. Anti-ictogenic and antiepileptogenic properties of perampanel in mature and immature rats.
Epilepsia.
2017 11; 58(11):1985-1992. doi:
10.1111/epi.13894. [PMID: 28850671] - Barry E Gidal, Rama Maganti, Antonio Laurenza, Haichen Yang, David A Verbel, Edgar Schuck, Jim Ferry. Effect of enzyme inhibition on perampanel pharmacokinetics: Why study design matters.
Epilepsy research.
2017 08; 134(?):41-48. doi:
10.1016/j.eplepsyres.2017.04.018. [PMID: 28535410] - Yoshiaki Yamamoto, Naotaka Usui, Takuji Nishida, Yukitoshi Takahashi, Katsumi Imai, Yoshiyuki Kagawa, Yushi Inoue. Therapeutic Drug Monitoring for Perampanel in Japanese Epilepsy Patients: Influence of Concomitant Antiepileptic Drugs.
Therapeutic drug monitoring.
2017 08; 39(4):446-449. doi:
10.1097/ftd.0000000000000416. [PMID: 28703720] - Tao Chen, Shu-Hui Dai, Zhi-Quan Jiang, Peng Luo, Xiao-Fan Jiang, Zhou Fei, Song-Bai Gui, Yi-Long Qi. The AMPAR Antagonist Perampanel Attenuates Traumatic Brain Injury Through Anti-Oxidative and Anti-Inflammatory Activity.
Cellular and molecular neurobiology.
2017 Jan; 37(1):43-52. doi:
10.1007/s10571-016-0341-8. [PMID: 26883519] - Valentina Franco, Roberto Marchiselli, Cinzia Fattore, Elena Tartara, Giovambattista De Sarro, Emilio Russo, Emilio Perucca. Development and Validation of an HPLC-UV Assay for the Therapeutic Monitoring of the New Antiepileptic Drug Perampanel in Human Plasma.
Therapeutic drug monitoring.
2016 12; 38(6):744-750. doi:
10.1097/ftd.0000000000000350. [PMID: 27753779] - Yuji Mano. An inter-laboratory cross-validation study for the determination of perampanel in human plasma by liquid chromatography assays.
Biomedical chromatography : BMC.
2016 Dec; 30(12):2067-2069. doi:
10.1002/bmc.3764. [PMID: 27217163] - Vicente Villanueva, Oneeb Majid, Charcrin Nabangchang, Haichen Yang, Antonio Laurenza, Jim Ferry, Ziad Hussein. Pharmacokinetics, exposure-cognition, and exposure-efficacy relationships of perampanel in adolescents with inadequately controlled partial-onset seizures.
Epilepsy research.
2016 Nov; 127(?):126-134. doi:
10.1016/j.eplepsyres.2016.08.025. [PMID: 27595590] - Alexandra Rohracher, Francesco Brigo, Julia Höfler, Gudrun Kalss, Caroline Neuray, Judith Dobesberger, Giorgi Kuchukhidze, Markus Leitinger, Eugen Trinka. Perampanel for the treatment of primary generalized tonic-clonic seizures in idiopathic generalized epilepsy.
Expert opinion on pharmacotherapy.
2016 Jul; 17(10):1403-11. doi:
10.1080/14656566.2016.1195810. [PMID: 27267634] - Philip N Patsalos, Marilia Gougoulaki, Josemir W Sander. Perampanel Serum Concentrations in Adults With Epilepsy: Effect of Dose, Age, Sex, and Concomitant Anti-Epileptic Drugs.
Therapeutic drug monitoring.
2016 06; 38(3):358-64. doi:
10.1097/ftd.0000000000000274. [PMID: 26727625] - Vera Russmann, Josephine D Salvamoser, Maruja L Rettenbeck, Takafumi Komori, Heidrun Potschka. Synergism of perampanel and zonisamide in the rat amygdala kindling model of temporal lobe epilepsy.
Epilepsia.
2016 Apr; 57(4):638-47. doi:
10.1111/epi.13328. [PMID: 26854031] - Patrick Kwan, Martin J Brodie, Antonio Laurenza, Hannah FitzGibbon, Barry E Gidal. Analysis of pooled phase III trials of adjunctive perampanel for epilepsy: Impact of mechanism of action and pharmacokinetics on clinical outcomes.
Epilepsy research.
2015 Nov; 117(?):117-24. doi:
10.1016/j.eplepsyres.2015.09.002. [PMID: 26448264] - Yuji Mano, Osamu Takenaka, Kazutomi Kusano. HPLC with fluorescence detection assay of perampanel, a novel AMPA receptor antagonist, in human plasma for clinical pharmacokinetic studies.
Biomedical chromatography : BMC.
2015 Oct; 29(10):1589-93. doi:
10.1002/bmc.3463. [PMID: 25828925] - Haichen Yang, Antonio Laurenza, Betsy Williams, Anna Patten, Ziad Hussein, Jim Ferry. Lack of effect of perampanel on QT interval duration: Results from a thorough QT analysis and pooled partial seizure Phase III clinical trials.
Epilepsy research.
2015 Aug; 114(?):122-30. doi:
10.1016/j.eplepsyres.2015.04.010. [PMID: 26088895] - Yuji Mano, Osamu Takenaka, Kazutomi Kusano. High-performance liquid chromatography-tandem mass spectrometry method for the determination of perampanel, a novel α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist in human plasma.
Journal of pharmaceutical and biomedical analysis.
2015 Mar; 107(?):56-62. doi:
10.1016/j.jpba.2014.12.018. [PMID: 25569285] - Andreas Schulze-Bonhage. Perampanel for epilepsy with partial-onset seizures: a pharmacokinetic and pharmacodynamic evaluation.
Expert opinion on drug metabolism & toxicology.
2015; 11(8):1329-37. doi:
10.1517/17425255.2015.1061504. [PMID: 26111428] - Philip N Patsalos. The clinical pharmacology profile of the new antiepileptic drug perampanel: A novel noncompetitive AMPA receptor antagonist.
Epilepsia.
2015 Jan; 56(1):12-27. doi:
10.1111/epi.12865. [PMID: 25495693] - Ting Wu, Yoko Nagaya, Takahisa Hanada. Pharmacodynamic and pharmacokinetic interactions of perampanel and other antiepileptic drugs in a rat amygdala kindling model.
Seizure.
2014 Oct; 23(9):732-9. doi:
10.1016/j.seizure.2014.06.001. [PMID: 24997072] - Barry E Gidal, Oneeb Majid, Jim Ferry, Ziad Hussein, Haichen Yang, Jin Zhu, Randi Fain, Antonio Laurenza. The practical impact of altered dosing on perampanel plasma concentrations: pharmacokinetic modeling from clinical studies.
Epilepsy & behavior : E&B.
2014 Jun; 35(?):6-12. doi:
10.1016/j.yebeh.2014.03.013. [PMID: 24785428] - Takahisa Hanada. The discovery and development of perampanel for the treatment of epilepsy.
Expert opinion on drug discovery.
2014 Apr; 9(4):449-58. doi:
10.1517/17460441.2014.891580. [PMID: 24559052] - Michele A Faulkner. Perampanel: a new agent for adjunctive treatment of partial seizures.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2014 Feb; 71(3):191-8. doi:
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Epilepsia.
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