Pentatreotide (BioDeep_00000182218)

   

human metabolite blood metabolite


代谢物信息卡片


2-({[10-(4-aminobutyl)-16-benzyl-19-({2-[11-carboxy-4,7,10-tris(carboxymethyl)-2-hydroxy-1,4,7,10-tetraazaundec-1-en-1-yl]-1-hydroxy-3-phenylpropylidene}amino)-6,9,12,15,18-pentahydroxy-7-(1-hydroxyethyl)-13-[(1H-indol-3-yl)methyl]-1,2-dithia-5,8,11,14,17-pentaazacycloicosa-5,8,11,14,17-pentaen-4-yl](hydroxy)methylidene}amino)-3-hydroxybutanoate

化学式: C63H85N13O20S2 (1407.547497)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C1C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCCN)CC2=CNC3=CC=CC=C32)CC4=CC=CC=C4)NC(=O)C(CC5=CC=CC=C5)NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)C(=O)NC(C(C)O)C(=O)O)O
InChI: InChI=1S/C63H85N13O20S2/c1-36(77)54-62(94)71-48(61(93)73-55(37(2)78)63(95)96)35-98-97-34-47(70-57(89)44(25-38-13-5-3-6-14-38)66-49(79)29-75(31-51(82)83)23-21-74(30-50(80)81)22-24-76(32-52(84)85)33-53(86)87)60(92)68-45(26-39-15-7-4-8-16-39)58(90)69-46(27-40-28-65-42-18-10-9-17-41(40)42)59(91)67-43(56(88)72-54)19-11-12-20-64/h3-10,13-18,28,36-37,43-48,54-55,65,77-78H,11-12,19-27,29-35,64H2,1-2H3,(H,66,79)(H,67,91)(H,68,92)(H,69,90)(H,70,89)(H,71,94)(H,72,88)(H,73,93)(H,80,81)(H,82,83)(H,84,85)(H,86,87)(H,95,96)



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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INOH(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Deni Hardiansyah, Nusrat Jihan Begum, Peter Kletting, Felix M Mottaghy, Gerhard Glatting. Sensitivity Analysis of a Physiologically Based Pharmacokinetic Model Used for Treatment Planning in Peptide Receptor Radionuclide Therapy. Cancer biotherapy & radiopharmaceuticals. 2016 Aug; 31(6):217-24. doi: 10.1089/cbr.2016.2012. [PMID: 27403777]
  • Peter Kletting, Berthold Muller, Bahar Erentok, Jorn Schmaljohann, Florian F Behrendt, Sven N Reske, Felix M Mottaghy, Gerhard Glatting. Differences in predicted and actually absorbed doses in peptide receptor radionuclide therapy. Medical physics. 2012 Sep; 39(9):5708-17. doi: 10.1118/1.4747266. [PMID: 22957636]
  • Stephan Walrand, Raffaella Barone, Stanislas Pauwels, François Jamar. Experimental facts supporting a red marrow uptake due to radiometal transchelation in 90Y-DOTATOC therapy and relationship to the decrease of platelet counts. European journal of nuclear medicine and molecular imaging. 2011 Jul; 38(7):1270-80. doi: 10.1007/s00259-011-1744-x. [PMID: 21318451]
  • Robert M Van Haren, Timothy L Fitzgerald. Intraoperative hand held gamma probe detection of a recurrent nonfunctional neuroendocrine tumor. JOP : Journal of the pancreas. 2008 Nov; 9(6):704-7. doi: NULL. [PMID: 18981551]
  • Flavio Forrer, Roelf Valkema, Dik J Kwekkeboom, Marion de Jong, Eric P Krenning. Neuroendocrine tumors. Peptide receptor radionuclide therapy. Best practice & research. Clinical endocrinology & metabolism. 2007 Mar; 21(1):111-29. doi: 10.1016/j.beem.2007.01.007. [PMID: 17382268]
  • Yung-Chang Lin, Guang-Uei Hung, Tsai-Yueh Luo, Chun-Hsiung Chen, Chien-Chung Hsia, Shu-Ling Hen, Yung-Jen Ho, Wan-Yu Lin. A comparison of biodistribution between 111In-DTPA octreotide and 111In-DOTATOC in rats bearing pancreatic tumors. The Journal of veterinary medical science. 2006 Apr; 68(4):367-71. doi: 10.1292/jvms.68.367. [PMID: 16679728]
  • Marion de Jong, Raffaella Barone, Eric Krenning, Bert Bernard, Marleen Melis, Theo Visser, Michael Gekle, Thomas E Willnow, Stephan Walrand, François Jamar, Stanislas Pauwels. Megalin is essential for renal proximal tubule reabsorption of (111)In-DTPA-octreotide. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2005 Oct; 46(10):1696-700. doi: NULL. [PMID: 16204720]
  • Daniel Storch, Martin Béhé, Martin A Walter, Jianhua Chen, Pia Powell, Renata Mikolajczak, Helmut R Mäcke. Evaluation of [99mTc/EDDA/HYNIC0]octreotide derivatives compared with [111In-DOTA0,Tyr3, Thr8]octreotide and [111In-DTPA0]octreotide: does tumor or pancreas uptake correlate with the rate of internalization?. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2005 Sep; 46(9):1561-9. doi: . [PMID: 16157541]
  • Marion De Jong, Roelf Valkema, Arthur Van Gameren, Hester Van Boven, Axel Bex, Eric Pieter Van De Weyer, Jan Dirk Burggraaf, Meike Körner, Jean-Claude Reubi, Eric P Krenning. Inhomogeneous localization of radioactivity in the human kidney after injection of [(111)In-DTPA]octreotide. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2004 Jul; 45(7):1168-71. doi: NULL. [PMID: 15235063]
  • Edgar J Rolleman, Eric P Krenning, Arthur Van Gameren, Bert F Bernard, Marion De Jong. Uptake of [111In-DTPA0]octreotide in the rat kidney is inhibited by colchicine and not by fructose. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2004 Apr; 45(4):709-13. doi: . [PMID: 15073269]
  • Joris Robben, Jean Claude Reubi, Yvonne Pollak, George Voorhout. Biodistribution of [111In-DTPA-D-Phe1]-octreotide in dogs: uptake in the stomach and intestines but not in the spleen points towards interspecies differences. Nuclear medicine and biology. 2003 Apr; 30(3):225-32. doi: 10.1016/s0969-8051(02)00441-9. [PMID: 12745013]
  • Edgar J Rolleman, Roelf Valkema, Marion de Jong, Peter P M Kooij, Eric P Krenning. Safe and effective inhibition of renal uptake of radiolabelled octreotide by a combination of lysine and arginine. European journal of nuclear medicine and molecular imaging. 2003 Jan; 30(1):9-15. doi: 10.1007/s00259-002-0982-3. [PMID: 12483404]
  • Alain Rosière, Yves J Ernst, Véronique Roelants, Thierry Vander Borght, Luc Michel, Julian E Donckier. Intraoperative gamma probe detection of insulinoma in an elderly patient with pancreatic cystic lesions. Clinical endocrinology. 2002 Oct; 57(4):547-9. doi: 10.1046/j.1365-2265.2002.01646.x. [PMID: 12354138]
  • Marion De Jong, Roelf Valkema, Francois Jamar, Larry K Kvols, Dik J Kwekkeboom, Wout A P Breeman, Willem H Bakker, Chuck Smith, Stanislas Pauwels, Eric P Krenning. Somatostatin receptor-targeted radionuclide therapy of tumors: preclinical and clinical findings. Seminars in nuclear medicine. 2002 Apr; 32(2):133-40. doi: 10.1053/snuc.2002.31027. [PMID: 11965608]
  • Roelf Valkema, Marion De Jong, Willem H Bakker, Wout A p Breeman, Peter P m Kooij, Pieternella J Lugtenburg, Frank H De Jong, Arjan Christiansen, Boen L r Kam, Wouter W De Herder, Mats Stridsberg, Jan Lindemans, Geert Ensing, Eric P Krenning. Phase I study of peptide receptor radionuclide therapy with [In-DTPA]octreotide: the Rotterdam experience. Seminars in nuclear medicine. 2002 Apr; 32(2):110-22. doi: 10.1053/snuc/2002.31025. [PMID: 11965606]
  • Alice Laznickova, M Laznicek, F Trejtnar, L Melicharova, Kazuko Horiuchi Suzuki, Hiromichi Akizawa, Yasushi Arano, Akira Yokoyama. Distribution and elimination characteristics of 111In-DTPA-D-phe1-octreotide and 111In-DTPA-L-phe1-octreotide in rats. European journal of drug metabolism and pharmacokinetics. 2002 Jan; 27(1):37-43. doi: 10.1007/bf03190403. [PMID: 11996325]
  • A Colao, M Dorato, M Pulcrano, F W Rossi, R S Auriemma, G Lombardi, S Lastoria. [Somatostatin analogs in the clinical management of pituitary neoplasms]. Minerva endocrinologica. 2001 Sep; 26(3):181-91. doi: NULL. [PMID: 11753242]
  • C J Anderson, F Dehdashti, P D Cutler, S W Schwarz, R Laforest, L A Bass, J S Lewis, D W McCarthy. 64Cu-TETA-octreotide as a PET imaging agent for patients with neuroendocrine tumors. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2001 Feb; 42(2):213-21. doi: . [PMID: 11216519]
  • F Gibril, J C Reynolds, I A Lubensky, P K Roy, P L Peghini, J L Doppman, R T Jensen. Ability of somatostatin receptor scintigraphy to identify patients with gastric carcinoids: a prospective study. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2000 Oct; 41(10):1646-56. doi: NULL. [PMID: 11037994]
  • E T Janson, J E Westlin, U Ohrvall, K Oberg, A Lukinius. Nuclear localization of 111In after intravenous injection of [111In-DTPA-D-Phe1]-octreotide in patients with neuroendocrine tumors. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2000 Sep; 41(9):1514-8. doi: NULL. [PMID: 10994731]
  • H Akizawa, Y Arano, T Uezono, M Ono, Y Fujioka, T Uehara, A Yokoyama, K Akaji, Y Kiso, M Koizumi, H Saji. Renal metabolism of 111In-DTPA-D-Phe1-octreotide in vivo. Bioconjugate chemistry. 1998 Nov; 9(6):662-70. doi: 10.1021/bc9702258. [PMID: 9815158]
  • S Angeletti, V D Corleto, O Schillaci, M Marignani, B Annibale, A Moretti, G Silecchia, F Scopinaro, N Basso, C Bordi, G Delle Fave. Use of the somatostatin analogue octreotide to localise and manage somatostatin-producing tumours. Gut. 1998 Jun; 42(6):792-4. doi: 10.1136/gut.42.6.792. [PMID: 9691916]
  • L A Bass, M V Lanahan, J R Duncan, J L Erion, A Srinivasan, M A Schmidt, C J Anderson. Identification of the soluble in vivo metabolites of indium-111-diethylenetriaminepentaacetic acid-D-Phe1-octreotide. Bioconjugate chemistry. 1998 Mar; 9(2):192-200. doi: 10.1021/bc970158h. [PMID: 9548534]
  • W A Breeman, P M van Hagen, D J Kwekkeboom, T J Visser, E P Krenning. Somatostatin receptor scintigraphy using [111In-DTPA0]RC-160 in humans: a comparison with [111In-DTPA0]octreotide. European journal of nuclear medicine. 1998 Feb; 25(2):182-6. doi: 10.1007/s002590050213. [PMID: 9473268]
  • M G Stabin, P P Kooij, W H Bakker, T Inoue, K Endo, J Coveney, R de Jong, A Minegishi. Radiation dosimetry for indium-111-pentetreotide. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1997 Dec; 38(12):1919-22. doi: NULL. [PMID: 9430470]
  • B F Bernard, E P Krenning, W A Breeman, E J Rolleman, W H Bakker, T J Visser, H Mäcke, M de Jong. D-lysine reduction of indium-111 octreotide and yttrium-90 octreotide renal uptake. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1997 Dec; 38(12):1929-33. doi: NULL. [PMID: 9430472]
  • A Otte, E Jermann, M Behe, M Goetze, H C Bucher, H W Roser, A Heppeler, J Mueller-Brand, H R Maecke. DOTATOC: a powerful new tool for receptor-mediated radionuclide therapy. European journal of nuclear medicine. 1997 Jul; 24(7):792-5. doi: 10.1007/bf00879669. [PMID: 9211767]
  • J H Robben, H A Visser-Wisselaar, G R Rutteman, P P van Rijk, A J van Dongen, G Voorhout, T S van den Ingh, L J Hofland, S W Lamberts. In vitro and in vivo detection of functional somatostatin receptors in canine insulinomas. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1997 Jul; 38(7):1036-42. doi: NULL. [PMID: 9225787]
  • O Schillaci, B Annibale, F Scopinaro, G delle Fave, A C Colella. Somatostatin receptor scintigraphy of malignant somatostatinoma with indium-111-pentetreotide. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1997 Jun; 38(6):886-7. doi: NULL. [PMID: 9189135]
  • L E Tisell, H Ahlman, B Wängberg, G Hansson, J Mölne, O Nilsson, G Lindstedt, M Fjälling, E Forssell-Aronsson. Somatostatin receptor scintigraphy in medullary thyroid carcinoma. The British journal of surgery. 1997 Apr; 84(4):543-7. doi: NULL. [PMID: 9112914]
  • F Gibril, L T Curtis, B Termanini, M K Fritsch, I A Lubensky, J L Doppman, R T Jensen. Primary cardiac gastrinoma causing Zollinger-Ellison syndrome. Gastroenterology. 1997 Feb; 112(2):567-74. doi: 10.1053/gast.1997.v112.pm9024311. [PMID: 9024311]
  • B Termanini, F Gibril, J L Doppman, J C Reynolds, C A Stewart, V E Sutliff, D J Venzon, R T Jensen. Distinguishing small hepatic hemangiomas from vascular liver metastases in gastrinoma: use of a somatostatin-receptor scintigraphic agent. Radiology. 1997 Jan; 202(1):151-8. doi: 10.1148/radiology.202.1.8988205. [PMID: 8988205]
  • B Wängberg, G Westberg, U Tylén, L Tisell, S Jansson, O Nilsson, V Johansson, T Scherstén, H Ahlman. Survival of patients with disseminated midgut carcinoid tumors after aggressive tumor reduction. World journal of surgery. 1996 Sep; 20(7):892-9; discussion 899. doi: 10.1007/s002689900136. [PMID: 8678968]
  • M Fjälling, P Andersson, E Forssell-Aronsson, J Grétarsdóttir, V Johansson, L E Tisell, B Wängberg, O Nilsson, G Berg, A Michanek, G Lindstedt, H Ahlman. Systemic radionuclide therapy using indium-111-DTPA-D-Phe1-octreotide in midgut carcinoid syndrome. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1996 Sep; 37(9):1519-21. doi: NULL. [PMID: 8790206]
  • M de Jong, E J Rolleman, B F Bernard, T J Visser, W H Bakker, W A Breeman, E P Krenning. Inhibition of renal uptake of indium-111-DTPA-octreotide in vivo. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1996 Aug; 37(8):1388-92. doi: NULL. [PMID: 8708781]
  • A Kurtaran, M Leimer, K Kaserer, Q Yang, P Angelberger, B Niederle, I Virgolini. Combined use of 111In-DTPA-D-Phe-1-octreotide (OCT) and 123I-vasoactive intestinal peptide (VIP) in the localization diagnosis of medullary thyroid carcinoma (MTC). Nuclear medicine and biology. 1996 May; 23(4):503-7. doi: 10.1016/0969-8051(96)00031-5. [PMID: 8832707]
  • L B Anthony, W Martin, D Delbeke, M Sandler. Somatostatin receptor imaging: predictive and prognostic considerations. Digestion. 1996; 57 Suppl 1(?):50-3. doi: 10.1159/000201396. [PMID: 8813470]
  • A D'addabbo, G Simeone, G Rubini, L Nitti. Description of a multicompartmental model of the biodistribution of 111In-DTPA-D-Phe-1-octreotide in human. The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR). 1995 Dec; 39(4 Suppl 1):86-9. doi: NULL. [PMID: 9002758]
  • M de Jong, W A Breeman, B F Bernard, E J Rolleman, L J Hofland, T J Visser, B Setyono-Han, W H Bakker, M E van der Pluijm, E P Krenning. Evaluation in vitro and in rats of 161Tb-DTPA-octreotide, a somatostatin analogue with potential for intraoperative scanning and radiotherapy. European journal of nuclear medicine. 1995 Jul; 22(7):608-16. doi: 10.1007/bf01254561. [PMID: 7498221]
  • T Inoue, H Ootake, T Hirano, K Tomiyoshi, K Endo, K Tanaka, N Shimizu, T Saito. [Clinical evaluation of safety, pharmacokinetics and dosimetry of the somatostatin analog 111In-DTPA-D-Phe-octreotide--report of the phase 1 study]. Kaku igaku. The Japanese journal of nuclear medicine. 1995 May; 32(5):511-21. doi: NULL. [PMID: 7596072]
  • F Lauriero, G Rubini, F D'Addabbo, D Rubini, F Schettini, A D'Addabbo. I-131 MIBG scintigraphy of neuroectodermal tumors. Comparison between I-131 MIBG and In-111 DTPA-octreotide. Clinical nuclear medicine. 1995 Mar; 20(3):243-9. doi: 10.1097/00003072-199503000-00011. [PMID: 7750219]
  • L Berná, R Cabezas, J Mora, G Torres, M Estorch, I Carrió. 111In-octreotide and 99mTc(V)-dimercaptosuccinic acid studies in the imaging of recurrent medullary thyroid carcinoma. The Journal of endocrinology. 1995 Feb; 144(2):339-45. doi: 10.1677/joe.0.1440339. [PMID: 7706986]
  • P Flamen, A Bossuyt, J De Greve, M Pipeleers-Marichal, F Keuppens, G Somers. Imaging of renal cell cancer with radiolabelled octreotide. Nuclear medicine communications. 1993 Oct; 14(10):873-7. doi: 10.1097/00006231-199310000-00007. [PMID: 8233231]
  • H Arnberg, J E Westlin, S Husin, S Nilsson. Distribution and elimination of the somatostatin analogue (111In-DTPA-D-Phe1)-Octreotide (OctreoScan111). Acta oncologica (Stockholm, Sweden). 1993; 32(2):177-82. doi: 10.3109/02841869309083909. [PMID: 8391831]
  • H J Adrian, U Dörr, D Bach, H Bihl. Biodistribution of 111In-pentetreotide and dosimetric considerations with respect to somatostatin receptor expressing tumor burden. Hormone and metabolic research. Supplement series. 1993; 27(?):18-23. doi: NULL. [PMID: 8330868]
  • U Dörr, K Wurm, E Höring, G Guzman, U Räth, H Bihl. Diagnostic reliability of somatostatin receptor scintigraphy during continuous treatment with different somatostatin analogs. Hormone and metabolic research. Supplement series. 1993; 27(?):36-43. doi: NULL. [PMID: 8330870]
  • E P Krenning, D J Kwekkeboom, J C Reubi, P M van Hagen, C H van Eijck, H Y Oei, S W Lamberts. 111In-octreotide scintigraphy in oncology. Digestion. 1993; 54 Suppl 1(?):84-7. doi: 10.1159/000201083. [PMID: 8359573]