Ac-(5H-Dibenzyl(a,d)cycloheptene-10,11-dihydroglycine-leu-asp-ile-ile-trp) (BioDeep_00000182130)
human metabolite blood metabolite
代谢物信息卡片
化学式: C52H67N7O10 (949.4949162)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(C)C(C(=O)NC(C(C)CC)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(C3C4=CC=CC=C4CCC5=CC=CC=C35)NC(=O)C
InChI: InChI=1S/C52H67N7O10/c1-8-29(5)44(49(65)57-41(52(68)69)25-34-27-53-38-21-15-14-18-35(34)38)59-50(66)45(30(6)9-2)58-48(64)40(26-42(61)62)55-47(63)39(24-28(3)4)56-51(67)46(54-31(7)60)43-36-19-12-10-16-32(36)22-23-33-17-11-13-20-37(33)43/h10-21,27-30,39-41,43-46,53H,8-9,22-26H2,1-7H3,(H,54,60)(H,55,63)(H,56,67)(H,57,65)(H,58,64)(H,59,66)(H,61,62)(H,68,69)
描述信息
同义名列表
4 个代谢物同义名
3-({1-[(1-{[1-carboxy-2-(1H-indol-3-yl)ethyl]-C-hydroxycarbonimidoyl}-2-methylbutyl)-C-hydroxycarbonimidoyl]-2-methylbutyl}-C-hydroxycarbonimidoyl)-3-{[1-hydroxy-2-({1-hydroxy-2-[(1-hydroxyethylidene)amino]-2-{tricyclo[9.4.0.0,]pentadeca-1(15),3,5,7,11,13-hexaen-2-yl}ethylidene}amino)-4-methylpentylidene]amino}propanoate; 3-({1-[(1-{[1-carboxy-2-(1H-indol-3-yl)ethyl]carbamoyl}-2-methylbutyl)carbamoyl]-2-methylbutyl}carbamoyl)-3-[2-(2-acetamido-2-{tricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3,5,7,11,13-hexaen-2-yl}acetamido)-4-methylpentanamido]propanoic acid; L-Tryptophan, N-[N-[N-[N-[N-[N-acetyl-D-2-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)glycyl]-L-leucyl]-L-alpha-aspartyl]-L-isoleucyl]-L-isoleucyl]-; Ac-(5H-Dibenzyl(a,d)cycloheptene-10,11-dihydroglycine-leu-asp-ile-ile-trp)
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Luca Bergamasco, Pier Paolo Sainaghi, Luigi Castello, Claudio Letizia, Ettore Bartoli. In vitro effect of cyclosporine-A on angiotensins secretion by glomerular cells.
Nephrology (Carlton, Vic.).
2008 Jun; 13(4):302-8. doi:
10.1111/j.1440-1797.2008.00917.x. [PMID: 18331442] - Ying Shi, Catherine Lau, William A Cupples. Interactive modulation of renal myogenic autoregulation by nitric oxide and endothelin acting through ET-B receptors.
American journal of physiology. Regulatory, integrative and comparative physiology.
2007 Jan; 292(1):R354-61. doi:
10.1152/ajpregu.00440.2006. [PMID: 16990488] - L Castello, P P Sainaghi, L Bergamasco, C Letizia, E Bartoli. Pathways of glomerular toxicity of cyclosporine-A: an 'in vitro' study.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2005 Dec; 56(4):649-60. doi:
NULL. [PMID: 16391421] - Eva Cediel, Beatriz Vázquez-Cruz, Josefa Navarro-Cid, Natalia de las Heras, David Sanz-Rosa, Victoria Cachofeiro, Vicente Lahera. Role of endothelin-1 and thromboxane A2 in renal vasoconstriction induced by angiotensin II in diabetes and hypertension.
Kidney international. Supplement.
2002 Dec; ?(82):S2-7. doi:
10.1046/j.1523-1755.62.s82.2.x. [PMID: 12410847] - M C Okafor, N A Delamere. The inhibitory influence of endothelin on active sodium-potassium transport in porcine lens.
Investigative ophthalmology & visual science.
2001 Apr; 42(5):1018-23. doi:
NULL. [PMID: 11274080] - R Sabra, N Zeinoun, L H Sharaf, R Ghali, G Beshara, H Serhal. Role of humoral mediators in, and influence of a liposomal formulation on, acute amphotericin B nephrotoxicity.
Pharmacology & toxicology.
2001 Apr; 88(4):168-75. doi:
10.1034/j.1600-0773.2001.d01-99.x. [PMID: 11322173] - N L Kanagy, B R Walker, L D Nelin. Role of endothelin in intermittent hypoxia-induced hypertension.
Hypertension (Dallas, Tex. : 1979).
2001 Feb; 37(2 Pt 2):511-5. doi:
10.1161/01.hyp.37.2.511. [PMID: 11230327] - J E Tanus-Santos, W M Gordo, A Udelsmann, M H Cittadino, H Moreno. Nonselective endothelin-receptor antagonism attenuates hemodynamic changes after massive pulmonary air embolism in dogs.
Chest.
2000 Jul; 118(1):175-9. doi:
10.1378/chest.118.1.175. [PMID: 10893375] - L J Rosolowsky, C J Hanke, W B Campbell. Adrenal capillary endothelial cells stimulate aldosterone release through a protein that is distinct from endothelin.
Endocrinology.
1999 Oct; 140(10):4411-8. doi:
10.1210/endo.140.10.7060. [PMID: 10499493] - J Gao, X Wu, Z Yang. [The dynamic changes and significances of endothelins in early burned rats].
Zhonghua zheng xing shao shang wai ke za zhi = Zhonghua zheng xing shao shang waikf [i.e. waike] zazhi = Chinese journal of plastic surgery and burns.
1998 May; 14(3):207-10. doi:
NULL. [PMID: 10452068] - H K Han, B H Stewart, A M Doherty, W L Cody, G L Amidon. In vitro stability and intestinal absorption characteristics of hexapeptide endothelin receptor antagonists.
Life sciences.
1998; 63(18):1599-609. doi:
10.1016/s0024-3205(98)00429-9. [PMID: 9806213] - K E Todd, M P Lewis, B Gloor, J S Lane, S W Ashley, H A Reber. An ETa/ETb endothelin antagonist ameliorates systemic inflammation in a murine model of acute hemorrhagic pancreatitis.
Surgery.
1997 Aug; 122(2):443-9; discussion 449. doi:
10.1016/s0039-6060(97)90038-6. [PMID: 9288152] - V M Reddy, K D Hendricks-Munoz, H A Rajasinghe, E Petrossian, F L Hanley, J R Fineman. Post-cardiopulmonary bypass pulmonary hypertension in lambs with increased pulmonary blood flow. A role for endothelin 1.
Circulation.
1997 Feb; 95(4):1054-61. doi:
10.1161/01.cir.95.4.1054. [PMID: 9054770] - J Gao, X Wu, Z Yang. [Role of endogenous endothelins in renal injury in burnt rats].
Zhonghua zheng xing shao shang wai ke za zhi = Zhonghua zheng xing shao shang waikf [i.e. waike] zazhi = Chinese journal of plastic surgery and burns.
1997 Jan; 13(1):21-4. doi:
NULL. [PMID: 9812443] - L Dobrowolski, K Endlich, J Sadowski, M Steinhausen. Cardiovascular and renal effects of endothelin receptor blockade with PD 145065 and interaction with urodilatin.
Acta physiologica Scandinavica.
1997 Jan; 159(1):7-13. doi:
10.1046/j.1365-201x.1997.583331000.x. [PMID: 9124073] - T Kato, S Kassab, F C Wilkins, K A Kirchner, J Keiser, J P Granger. Endothelin antagonists improve renal function in spontaneously hypertensive rats.
Hypertension (Dallas, Tex. : 1979).
1995 Apr; 25(4 Pt 2):883-7. doi:
10.1161/01.hyp.25.4.883. [PMID: 7721448] - T D Warner, G H Allcock, J R Vane. Reversal of established responses to endothelin-1 in vivo and in vitro by the endothelin receptor antagonists, BQ-123 and PD 145065.
British journal of pharmacology.
1994 May; 112(1):207-13. doi:
10.1111/j.1476-5381.1994.tb13053.x. [PMID: 8032643] - R P Wellings, R Corder, A M Doherty, J R Vane. Antagonism of renal and systemic responses to endothelin-1 infusion with PD 145065.
European journal of pharmacology.
1994 Apr; 256(2):201-4. doi:
10.1016/0014-2999(94)90246-1. [PMID: 8050471] - R P Wellings, R Corder, T D Warner, J P Cristol, C Thiemermann, J R Vane. Evidence from receptor antagonists of an important role for ETB receptor-mediated vasoconstrictor effects of endothelin-1 in the rat kidney.
British journal of pharmacology.
1994 Feb; 111(2):515-20. doi:
10.1111/j.1476-5381.1994.tb14767.x. [PMID: 8004396] - T D Warner, B Battistini, G H Allcock, J R Vane. Endothelin ETA and ETB receptors mediate vasoconstriction and prostanoid release in the isolated kidney of the rat.
European journal of pharmacology.
1993 Dec; 250(3):447-53. doi:
10.1016/0014-2999(93)90032-d. [PMID: 8112405] - R P Wellings, T D Warner, C Thiemermann, J P Cristol, R Corder, J R Vane. Vasoconstriction in the rat kidney induced by endothelin-1 is blocked by PD 145065.
Journal of cardiovascular pharmacology.
1993; 22 Suppl 8(?):S103-6. doi:
10.1097/00005344-199322008-00028. [PMID: 7509915]