Parecoxib (BioDeep_00000182086)
human metabolite blood metabolite
代谢物信息卡片
N-(((5-Methyl-3-phenylisoxazol-4-yl)-phenyl)sulfonyl)propanamine, sodium salt
化学式: C19H18N2O4S (370.0987)
中文名称: 帕瑞昔布
谱图信息:
最多检出来源 Homo sapiens(blood) 72.22%
分子结构信息
SMILES: CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C1=C(C)ON=C1C1=CC=CC=C1
InChI: InChI=1S/C19H18N2O4S/c1-3-17(22)21-26(23,24)16-11-9-14(10-12-16)18-13(2)25-20-19(18)15-7-5-4-6-8-15/h4-12H,3H2,1-2H3,(H,21,22)
描述信息
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AH - Coxibs
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
D004791 - Enzyme Inhibitors > D016861 - Cyclooxygenase Inhibitors > D052246 - Cyclooxygenase 2 Inhibitors
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
C471 - Enzyme Inhibitor > C1323 - Cyclooxygenase Inhibitor
D000893 - Anti-Inflammatory Agents
同义名列表
12 个代谢物同义名
N-(((5-Methyl-3-phenylisoxazol-4-yl)-phenyl)sulfonyl)propanamine, sodium salt; N-((p-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl)sulphonyl)propionamide; N-[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonyl]propanamide; N-((p-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl)sulfonyl)propionamide; N-(((5-Methyl-3-phenylisoxazol-4-yl)-phenyl)sulfonyl)propanamide; Parecoxib sodiuM; N-(((Me-P)-P)S)P; Parecoxibum; Parecoxib; SC-69124; Dynastat; SC 69124
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:73038
- PubChem: 119828
- HMDB: HMDB0256127
- DrugBank: DB08439
- ChEMBL: CHEMBL1206690
- Wikipedia: Parecoxib
- chemspider: 106990
- CAS: 198470-84-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Nan Xu, Ke Pang, Sihua Qi, Hongmei Wang. Correlation between perioperative parecoxib use and postoperative acute kidney injury in patients undergoing radical mastectomy: a retrospective cohort analysis.
BMC anesthesiology.
2022 05; 22(1):155. doi:
10.1186/s12871-022-01688-4. [PMID: 35596129] - Yuanyuan Guo, Bin Wu, Qibin Chen, Su Min. Parecoxib ameliorates renal toxicity and injury in sepsis-induced mouse model and LPS-induced HK-2 cells.
Drug development research.
2022 May; 83(3):659-668. doi:
10.1002/ddr.21897. [PMID: 34813666] - Mei Li, Zhi Zheng. Protective effect of parecoxib sodium against ischemia reperfusion‑induced intestinal injury.
Molecular medicine reports.
2021 Nov; 24(5):. doi:
10.3892/mmr.2021.12416. [PMID: 34498709] - Yong-Zhong Tang, Pingping Zeng, Yan Liao, Zheng Qin, Hao Zhang, Bo Li, Wen Ouyang, Dan Li. Correlation between perioperative parecoxib use and postoperative acute kidney injury in patients undergoing non-cardiac surgery: a retrospective cohort analysis.
BMJ open.
2021 08; 11(8):e047840. doi:
10.1136/bmjopen-2020-047840. [PMID: 34433595] - Hexin Yan, Hui Zhao, Yunxiao Kang, Xiaoming Ji, Tianyun Zhang, Yu Wang, Rui Cui, Guoliang Zhang, Geming Shi. Parecoxib alleviates the motor behavioral decline of aged rats by ameliorating mitochondrial dysfunction in the substantia nigra via COX-2/PGE2 pathway inhibition.
Neuropharmacology.
2021 08; 194(?):108627. doi:
10.1016/j.neuropharm.2021.108627. [PMID: 34089729] - Yu-Chen Wang, Wei-Zhong Yu. [Prospective study on the effect of parecoxib sodium analgesia on pain and stress response after surgery in elderly patients with hip fracture].
Zhongguo gu shang = China journal of orthopaedics and traumatology.
2021 Jul; 34(7):612-6. doi:
10.12200/j.issn.1003-0034.2021.07.005. [PMID: 34318635] - Yang Zhang, Haixia Gong, Biming Zhan, Shibiao Chen. Effects of bilateral Pecto-intercostal Fascial Block for perioperative pain management in patients undergoing open cardiac surgery: a prospective randomized study.
BMC anesthesiology.
2021 06; 21(1):175. doi:
10.1186/s12871-021-01391-w. [PMID: 34157970] - Chao Gong, Yu Qi, Yang Xu, Xiruo Tang, Feng Liang, Lianhua Chen. Parecoxib improves atherosclerotic plaque stability by suppressing inflammation and inhibiting matrix metalloproteinases production.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Jun; 138(?):111423. doi:
10.1016/j.biopha.2021.111423. [PMID: 33740522] - Abdullatif Al-Terki, Jaffar Hussain, Ahmed R El-Nahas, Abdullatif Aloumi, Monira Al-Asfoor, Abbas Amt Altamimi, Usama Abdelhamid, Majd Alkabbani, Tariq F Al-Shaiji. Parecoxib Vs Paracetamol for Treatment of Acute Renal Colic Due to Ureteric Calculi: A Randomized Controlled Trial.
Urology.
2021 03; 149(?):76-80. doi:
10.1016/j.urology.2020.12.017. [PMID: 33373701] - Fangyong Wu, Wei Wang, Yingying Duan, Jia Guo, Guanhua Li, Tao Ma. Effect of Parecoxib Sodium on Myocardial Ischemia-Reperfusion Injury Rats.
Medical science monitor : international medical journal of experimental and clinical research.
2021 Jan; 27(?):e928205. doi:
10.12659/msm.928205. [PMID: 33395402] - Ming Zhou, Ning Wang, Gang Wang, Zishan Jia, Xiaolei Qi. Parecoxib alleviates the inflammatory effect of leukocyte-rich platelet-rich plasma in normal rabbit tendons.
BMC musculoskeletal disorders.
2020 Dec; 21(1):831. doi:
10.1186/s12891-020-03793-2. [PMID: 33302906] - Xiaoxia Gu, Xiujuan Tan, Jinxian Chen, Jingjing Wang, Yue Lu, Liangqing Zhang. The clinical effect of dexmedetomidine combined with parecoxib sodium on sedation, antianxiety and prevention of intubation stress in patients undergoing functional endoscopic sinus surgery: a randomised controlled trial.
BMC anesthesiology.
2020 07; 20(1):166. doi:
10.1186/s12871-020-01080-0. [PMID: 32631301] - Chong Geng, Xiao Li, Yanni Li, Shuailing Song, Chunhui Wang. Nonsteroidal anti-inflammatory drugs alleviate severity of post-endoscopic retrograde cholangiopancreatography pancreatitis by inhibiting inflammation and reducing apoptosis.
Journal of gastroenterology and hepatology.
2020 May; 35(5):896-904. doi:
10.1111/jgh.15012. [PMID: 32064683] - Mengchun Chen, Wei Sun, Zhe Wang, Chengke Huang, Guoxin Hu, Yijie Chen, Ledan Wang. Determination of parecoxib and valdecoxib in rat plasma by UPLC-MS/MS and its application to pharmacokinetics studies.
BMC pharmacology & toxicology.
2020 04; 21(1):27. doi:
10.1186/s40360-020-00406-5. [PMID: 32264977] - Zhiyin Huang, Xiao Ma, Xintong Jia, Rui Wang, Ling Liu, Mingguang Zhang, Xiaoyan Wan, Chengwei Tang, Libin Huang. Prevention of Severe Acute Pancreatitis With Cyclooxygenase-2 Inhibitors: A Randomized Controlled Clinical Trial.
The American journal of gastroenterology.
2020 03; 115(3):473-480. doi:
10.14309/ajg.0000000000000529. [PMID: 32142484] - Shuang-Long Li, Yong-Liang Zhu, Chun-Yang Zhu, Shao-Bin Li, Zi-Heng Li, Xiang-Jun Qiu. Simultaneous Determination of Parecoxib and Its Metabolite Valdecoxib Concentrations in Beagle Plasma by UPLC-MS/MS and Application for Pharmacokinetics Study.
Drug design, development and therapy.
2020; 14(?):1117-1125. doi:
10.2147/dddt.s226349. [PMID: 32214797] - Jie Hu, Bing-Feng Lv, Wen-Jing Guo, Bo-Wen Wang, Di Miao, Xiang-Jun Qiu, Xing-Peng Chen. Effects of Dexmedetomidine on the Pharmacokinetics of Parecoxib and Its Metabolite Valdecoxib in Beagles by UPLC-MS/MS.
BioMed research international.
2020; 2020(?):1563874. doi:
10.1155/2020/1563874. [PMID: 32832543] - Tiago Ferreira, Sandra Campos, Mónica G Silva, Rita Ribeiro, Susana Santos, José Almeida, Maria João Pires, Rui Miguel Gil da Costa, Cláudia Córdova, António Nogueira, Maria João Neuparth, Rui Medeiros, Margarida Maria da Silva Monteiro Bastos, Isabel Gaivão, Francisco Peixoto, Maria Manuel Oliveira, Paula Alexandra Oliveira. The Cyclooxigenase-2 Inhibitor Parecoxib Prevents Epidermal Dysplasia in HPV16-Transgenic Mice: Efficacy and Safety Observations.
International journal of molecular sciences.
2019 Aug; 20(16):. doi:
10.3390/ijms20163902. [PMID: 31405112] - Zhifang Luo, Huarong Wang, Dinggui Huang. The Impact of Parecoxib on Pain Management for Laparoscopic Cholecystectomy: A Meta-analysis of Randomized Controlled Trials.
Surgical laparoscopy, endoscopy & percutaneous techniques.
2019 Apr; 29(2):69-74. doi:
10.1097/sle.0000000000000626. [PMID: 30817695] - Jiansong Fang, Chuipu Cai, Yanting Chai, Jingwei Zhou, Yujie Huang, Li Gao, Qi Wang, Feixiong Cheng. Quantitative and systems pharmacology 4. Network-based analysis of drug pleiotropy on coronary artery disease.
European journal of medicinal chemistry.
2019 Jan; 161(?):192-204. doi:
10.1016/j.ejmech.2018.10.020. [PMID: 30359818] - Xiaoliang Jin, Fang Zhou, Yan Liu, Chen Cheng, Lan Yao, Yuanwei Jia, Guangji Wang, Jingwei Zhang. Simultaneous determination of parecoxib and its main metabolites valdecoxib and hydroxylated valdecoxib in mouse plasma with a sensitive LC-MS/MS method to elucidate the decreased drug metabolism of tumor bearing mice.
Journal of pharmaceutical and biomedical analysis.
2018 Sep; 158(?):1-7. doi:
10.1016/j.jpba.2018.05.034. [PMID: 29843006] - Xi Luo, Feng Lv, Mingqing Peng. Analgesic effect of different dosage of Flurbiprofen axetil in laparoscopic cholecystectomy in comparison with other analgesic drugs.
Pakistan journal of pharmaceutical sciences.
2017 Sep; 30(5(Special)):1895-1898. doi:
". [PMID: 29084663] - Fan-You Meng, Wei Gao, Ying-Nan Ju. Parecoxib reduced ventilation induced lung injury in acute respiratory distress syndrome.
BMC pharmacology & toxicology.
2017 03; 18(1):25. doi:
10.1186/s40360-017-0131-z. [PMID: 28356130] - Timin Yang, Haibo Si, Yuangang Wu, Yi Zeng, Fuxing Pei, Xisheng Weng, Bin Shen. [EFFICACY OF SEQUENTIAL TREATMENT WITH ADDUCTOR CANAL NERVE BLOCK AND CYCLOOXYGENASE 2 SELECTIVE INHIBITOR AFTER TOTAL KNEE ARTHROPLASTY].
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery.
2016 Sep; 30(9):1065-1071. doi:
10.7507/1002-1892.20160217. [PMID: 29786356] - Yang-Zi Zhu, Rui Yao, Zhe Zhang, Hui Xu, Li-Wei Wang. Parecoxib prevents early postoperative cognitive dysfunction in elderly patients undergoing total knee arthroplasty: A double-blind, randomized clinical consort study.
Medicine.
2016 Jul; 95(28):e4082. doi:
10.1097/md.0000000000004082. [PMID: 27428192] - Meina Liu, Qiuyang Yu, Ping Li, Meng Zhu, Mingming Fang, Bingjun Sun, Mengchi Sun, Yinghua Sun, Peng Zhang, Zhonggui He, Jin Sun, Yongjun Wang, Xiaohong Liu. Simultaneous determination of parecoxib sodium and its active metabolite valdecoxib in rat plasma by UPLC-MS/MS and its application to a pharmacokinetic study after intravenous and intramuscular administration.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Jun; 1022(?):220-229. doi:
10.1016/j.jchromb.2016.04.009. [PMID: 27107851] - Tao Zhang, Yi Ma, Kang-Qing Xu, Wen-Qi Huang. Pretreatment of parecoxib attenuates hepatic ischemia/reperfusion injury in rats.
BMC anesthesiology.
2015 Nov; 15(?):165. doi:
10.1186/s12871-015-0147-0. [PMID: 26577339] - José Pedro Calistro Neto, Rômulo da Costa Torres, Giovanna Maria Gonçalves, Leopoldo Muniz da Silva, Maria Aparecida Custódio Domingues, Norma Sueli Pinheiro Módolo, Guilherme Antonio Moreira de Barros. Parecoxib reduces renal injury in an ischemia/reperfusion model in rats.
Acta cirurgica brasileira.
2015 Apr; 30(4):270-6. doi:
10.1590/s0102-865020150040000006. [PMID: 25923260] - Lian-Dong Wang, Xia Gao, Jun-Ying Li, Hong-Yan Yu, Hai-Wen Su, Lian-Zhong Liu, Jun Qi. Effects of preemptive analgesia with parecoxib sodium on haemodynamics and plasma stress hormones in surgical patients with thyroid carcinoma.
Asian Pacific journal of cancer prevention : APJCP.
2015; 16(9):3977-80. doi:
10.7314/apjcp.2015.16.9.3977. [PMID: 25987072] - Shujun Shang, Qingling Liu, Jiandong Gao, Yulin Zhu, Jingying Liu, Kaiyan Wang, Wei Shao, Shudong Zhang. Insights into in vitro binding of parecoxib to human serum albumin by spectroscopic methods.
Journal of biochemical and molecular toxicology.
2014 Oct; 28(10):433-41. doi:
10.1002/jbt.21582. [PMID: 24939449] - T W Kim, C Vercelli, A Briganti, G Re, M Giorgi. The pharmacokinetics and in vitro/ex vivo cyclooxygenase selectivity of parecoxib and its active metabolite valdecoxib in cats.
Veterinary journal (London, England : 1997).
2014 Oct; 202(1):37-42. doi:
10.1016/j.tvjl.2014.07.025. [PMID: 25135338] - Xiuze Li, Mengjun Zhou, Qing Xia, Wei Li, Yonghong Zhang. Effect of parecoxib sodium on postoperative shivering: a randomised, double-blind clinical trial.
European journal of anaesthesiology.
2014 Apr; 31(4):225-30. doi:
10.1097/01.eja.0000436684.94403.1e. [PMID: 24270900] - Willy Arung, François Jehaes, Jean-Paul Cheramy, Jean-Olivier Defraigne, Michel Meurisse, Pierre Honoré, Pierre Drion, Olivier Detry. Effects of parecoxib on the prevention of postoperative peritoneal adhesions in rats.
Journal of investigative surgery : the official journal of the Academy of Surgical Research.
2013 Dec; 26(6):340-6. doi:
10.3109/08941939.2013.810316. [PMID: 23927529] - Jing-zhu Li, Xiao-zheng Li, Xiao-min Wang, Ming-shan Wang, Hai-fang Yu, Fei Shi, Dan Miao, Yan-lin Bi. [Effects of parecoxib sodium analgesia on serum concentrations of neuron-specific enolase and S-100β and postoperative cognitive function of elderly patients undergoing acute replacement of femoral head].
Zhonghua yi xue za zhi.
2013 Jul; 93(27):2152-4. doi:
NULL. [PMID: 24284249] - Qingping Wu, Gunsham Purusram, Huiqing Wang, Ruixia Yuan, Wanli Xie, Ping Gui, Nianguo Dong, Shanglong Yao. The efficacy of parecoxib on systemic inflammatory response associated with cardiopulmonary bypass during cardiac surgery.
British journal of clinical pharmacology.
2013 Mar; 75(3):769-78. doi:
10.1111/j.1365-2125.2012.04393.x. [PMID: 22835079] - Sofia Eberstål, Wiaam Badn, Sara Fritzell, Magnus Esbjörnsson, Anna Darabi, Edward Visse, Peter Siesjö. Inhibition of cyclooxygenase-2 enhances immunotherapy against experimental brain tumors.
Cancer immunology, immunotherapy : CII.
2012 Aug; 61(8):1191-9. doi:
10.1007/s00262-011-1196-y. [PMID: 22213142] - M Giorgi, G Saccomanni, S Del Carlo, C Manera, E Lavy. Pharmacokinetics of intravenous and intramuscular parecoxib in healthy Beagles.
Veterinary journal (London, England : 1997).
2012 Jul; 193(1):246-50. doi:
10.1016/j.tvjl.2011.11.005. [PMID: 22130459] - Line Nilsson, Kirsten Madsen, Sukru Oguzkan Topcu, Boye L Jensen, Jørgen Frøkiær, Rikke Nørregaard. Disruption of cyclooxygenase-2 prevents downregulation of cortical AQP2 and AQP3 in response to bilateral ureteral obstruction in the mouse.
American journal of physiology. Renal physiology.
2012 Jun; 302(11):F1430-9. doi:
10.1152/ajprenal.00682.2011. [PMID: 22397925] - Bruce Hullett, Sam Salman, Sean J O'Halloran, Deborah Peirce, Kylie Davies, Kenneth F Ilett. Development of a population pharmacokinetic model for parecoxib and its active metabolite valdecoxib after parenteral parecoxib administration in children.
Anesthesiology.
2012 May; 116(5):1124-33. doi:
10.1097/aln.0b013e31825154ef. [PMID: 22450476] - Michael J Paech, Sam Salman, Kenneth F Ilett, Sean J O'Halloran, Neil A Muchatuta. Transfer of parecoxib and its primary active metabolite valdecoxib via transitional breastmilk following intravenous parecoxib use after cesarean delivery: a comparison of naive pooled data analysis and nonlinear mixed-effects modeling.
Anesthesia and analgesia.
2012 Apr; 114(4):837-44. doi:
10.1213/ane.0b013e3182468fa7. [PMID: 22344242] - Andy J Liedtke, Brenda C Crews, Cristina M Daniel, Anna L Blobaum, Philip J Kingsley, Kebreab Ghebreselasie, Lawrence J Marnett. Cyclooxygenase-1-selective inhibitors based on the (E)-2'-des-methyl-sulindac sulfide scaffold.
Journal of medicinal chemistry.
2012 Mar; 55(5):2287-300. doi:
10.1021/jm201528b. [PMID: 22263894] - Y Bao, J Fang, L Peng, Y Yi, K Liu, W Li, H Luo. Comparison of preincisional and postincisional parecoxib administration on postoperative pain control and cytokine response after total hip replacement.
The Journal of international medical research.
2012; 40(5):1804-11. doi:
10.1177/030006051204000518. [PMID: 23206461] - G Saccomanni, M Giorgi, S Del Carlo, C Manera, A Saba, M Macchia. Simultaneous detection and quantification of parecoxib and valdecoxib in canine plasma by HPLC with spectrofluorimetric detection: development and validation of a new methodology.
Analytical and bioanalytical chemistry.
2011 Sep; 401(5):1677-84. doi:
10.1007/s00216-011-5244-4. [PMID: 21769548] - Antonio Valero, Jaime Sánchez-López, Joan Bartra, Carlos Serrano, Rosa Muñoz-Cano, Jordi Roca, Cesar Picado. Safety of parecoxib in asthmatic patients with aspirin-exacerbated respiratory disease.
International archives of allergy and immunology.
2011; 156(2):221-3. doi:
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The open cardiovascular medicine journal.
2010 Oct; 4(?):198-205. doi:
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Interactive cardiovascular and thoracic surgery.
2010 Oct; 11(4):461-7. doi:
10.1510/icvts.2010.239053. [PMID: 20639308] - Włodzimierz Matysiak, Barbara Jodłowska-Jedrych. Does administration of non-steroidal anti-inflammatory drug determine morphological changes in adrenal cortex: ultrastructural studies.
Protoplasma.
2010 Oct; 246(1-4):109-18. doi:
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Journal of investigative surgery : the official journal of the Academy of Surgical Research.
2010 Oct; 23(5):257-61. doi:
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Journal of clinical biochemistry and nutrition.
2010 Sep; 47(2):138-47. doi:
10.3164/jcbn.10-33. [PMID: 20838569] - Swagata Tripathy, Suresh Chandra Dash. Etoricoxib-induced life-threatening hyperkalemia and acute kidney dysfunction against the background of telmisartan and a low sodium diet.
International journal of emergency medicine.
2010 Aug; 3(4):443-6. doi:
10.1007/s12245-010-0208-6. [PMID: 21373319] - Li-li Xu, Jian-jun Shen, Hai-yan Zhou. [Effects of parecoxib sodium preemptive analgesia on perioperative cytokine responses and stress responses in patients undergoing ophthalmology surgery].
Zhonghua yi xue za zhi.
2010 Jul; 90(27):1893-6. doi:
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American journal of physiology. Renal physiology.
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American journal of physiology. Regulatory, integrative and comparative physiology.
2010 Apr; 298(4):R1017-25. doi:
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PloS one.
2010 Feb; 5(2):e9340. doi:
10.1371/journal.pone.0009340. [PMID: 20174466] - Aree Tanavalee, Satit Thiengwittayaporn. Multimodal pain management following minimally invasive total knee arthroplasty: an experience in 3-dose parecoxib.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet.
2009 Dec; 92 Suppl 6(?):S11-8. doi:
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Prostaglandins & other lipid mediators.
2009 Nov; 90(1-2):7-12. doi:
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American journal of physiology. Renal physiology.
2009 Apr; 296(4):F790-4. doi:
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Nutrition journal.
2009 Feb; 8(?):7. doi:
10.1186/1475-2891-8-7. [PMID: 19187557] - Klaus Höcherl, Christoph Schmidt, Michael Bucher. COX-2 inhibition attenuates endotoxin-induced downregulation of organic anion transporters in the rat renal cortex.
Kidney international.
2009 Feb; 75(4):373-80. doi:
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Veterinary anaesthesia and analgesia.
2009 Jan; 36(1):86-94. doi:
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Renal failure.
2009; 31(4):284-9. doi:
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Rheumatology international.
2008 Aug; 28(10):1017-22. doi:
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British journal of pharmacology.
2008 Jul; 154(6):1297-307. doi:
10.1038/bjp.2008.193. [PMID: 18500363] - I Moodley. Review of the cardiovascular safety of COXIBs compared to NSAIDS.
Cardiovascular journal of Africa.
2008 Mar; 19(2):102-7. doi:
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Clinical pharmacology and therapeutics.
2008 Mar; 83(3):430-5. doi:
10.1038/sj.clpt.6100304. [PMID: 17687276] - Joy L Frestedt, Melanie Walsh, Michael A Kuskowski, John L Zenk. A natural mineral supplement provides relief from knee osteoarthritis symptoms: a randomized controlled pilot trial.
Nutrition journal.
2008 Feb; 7(?):9. doi:
10.1186/1475-2891-7-9. [PMID: 18279523] - Dingzhi Wang, Raymond N Dubois. Peroxisome proliferator-activated receptors and progression of colorectal cancer.
PPAR research.
2008; 2008(?):931074. doi:
10.1155/2008/931074. [PMID: 18551185] - Jane Stubbe, Kirsten Madsen, Finn T Nielsen, Rasmus K Bonde, Ole Skøtt, Boye L Jensen. Postnatal adrenalectomy impairs urinary concentrating ability by increased COX-2 and leads to renal medullary injury.
American journal of physiology. Renal physiology.
2007 Sep; 293(3):F780-9. doi:
10.1152/ajprenal.00193.2007. [PMID: 17581922] - Nimesh S A Patel, Salvatore Cuzzocrea, Massimo Collino, Prabal K Chaterjee, Emanuela Mazzon, Domenico Britti, Muhammad M Yaqoob, Christoph Thiemermann. The role of cycloxygenase-2 in the rodent kidney following ischaemia/reperfusion injury in vivo.
European journal of pharmacology.
2007 May; 562(1-2):148-54. doi:
10.1016/j.ejphar.2007.01.079. [PMID: 17343844] - Rikke Nørregaard, Boye L Jensen, Sukru Oguzkan Topcu, Maria Diget, Horst Schweer, Mark A Knepper, Søren Nielsen, Jørgen Frøkiaer. COX-2 activity transiently contributes to increased water and NaCl excretion in the polyuric phase after release of ureteral obstruction.
American journal of physiology. Renal physiology.
2007 May; 292(5):F1322-33. doi:
10.1152/ajprenal.00394.2006. [PMID: 17229676] - Jochen Graff, Mohammed Arabmotlagh, Raymond Cheung, Gerd Geisslinger, Sebastian Harder. Effects of parecoxib and dipyrone on platelet aggregation in patients undergoing meniscectomy: a double-blind, randomized, parallel-group study.
Clinical therapeutics.
2007 Mar; 29(3):438-47. doi:
10.1016/s0149-2918(07)80082-8. [PMID: 17577465] - Wolfgang Koppert, Katrin Frötsch, Nilofar Huzurudin, Wolfgang Böswald, Norbert Griessinger, Volker Weisbach, Roland E Schmieder, Jürgen Schüttler. The effects of paracetamol and parecoxib on kidney function in elderly patients undergoing orthopedic surgery.
Anesthesia and analgesia.
2006 Nov; 103(5):1170-6. doi:
10.1213/01.ane.0000244324.87947.29. [PMID: 17056950] - Gabriella Iohom, Hamza Abdalla, James O'Brien, Szilvia Szarvas, Vivienne Larney, Elisabeth Buckley, Mark Butler, George Declan Shorten. The associations between severity of early postoperative pain, chronic postsurgical pain and plasma concentration of stable nitric oxide products after breast surgery.
Anesthesia and analgesia.
2006 Oct; 103(4):995-1000. doi:
10.1213/01.ane.0000240415.49180.4a. [PMID: 17000819] - R Nørregaard, B L Jensen, S O Topcu, S S Nielsen, S Walter, J C Djurhuus, J Frøkiaer. Cyclooxygenase type 2 is increased in obstructed rat and human ureter and contributes to pelvic pressure increase after obstruction.
Kidney international.
2006 Sep; 70(5):872-81. doi:
10.1038/sj.ki.5001616. [PMID: 16820795] - U Werner, C Lamprecht, D Werner, S Schaefer, H Wuttke, B Hinz, M F Fromm, K Brune. Valdecoxib does not interfere with the CYP2D6 substrate metoprolol.
International journal of clinical pharmacology and therapeutics.
2006 Sep; 44(9):397-400. doi:
10.5414/cpp44397. [PMID: 16995327] - Piet Borgdorff, Geert Jan Tangelder, Walter J Paulus. Cyclooxygenase-2 inhibitors enhance shear stress-induced platelet aggregation.
Journal of the American College of Cardiology.
2006 Aug; 48(4):817-23. doi:
10.1016/j.jacc.2006.03.053. [PMID: 16904555] - Mirjana Jerkic, Juan V Rivas-Elena, Juan F Santibanez, Marta Prieto, Alicia Rodríguez-Barbero, Fernando Perez-Barriocanal, Miguel Pericacho, Miguel Arévalo, Calvin P H Vary, Michelle Letarte, Carmelo Bernabeu, Jose M López-Novoa. Endoglin regulates cyclooxygenase-2 expression and activity.
Circulation research.
2006 Aug; 99(3):248-56. doi:
10.1161/01.res.0000236755.98627.69. [PMID: 16840721] - José Luiz Jesus de Almeida, José Jukemura, Ana Maria Mendonça Coelho, Rosely Antunes Patzina, Marcel Cerqueira César Machado, José Eduardo Monteiro da Cunha. Inhibition of cyclooxygenase-2 in experimental severe acute pancreatitis.
Clinics (Sao Paulo, Brazil).
2006 Aug; 61(4):301-6. doi:
10.1590/s1807-59322006000400005. [PMID: 16924320] - E Munsterhjelm, T T Niemi, O Ylikorkala, P J Neuvonen, P H Rosenberg. Influence on platelet aggregation of i.v. parecoxib and acetaminophen in healthy volunteers.
British journal of anaesthesia.
2006 Aug; 97(2):226-31. doi:
10.1093/bja/ael108. [PMID: 16698862] - R M Langford, V Mehta. Selective cyclooxygenase inhibition: its role in pain and anaesthesia.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2006 Aug; 60(7):323-8. doi:
10.1016/j.biopha.2006.06.017. [PMID: 16837162] - Michael Bucher, Frieder K Kees, Barbara Messmann, Dirk Lunz, Stephan Rath, Marek Zelenka, Hans J Schlitt, Jonny Hobbhahn. Prostaglandin I2 release following mesenteric traction during abdominal surgery is mediated by cyclooxygenase-1.
European journal of pharmacology.
2006 May; 536(3):296-300. doi:
10.1016/j.ejphar.2006.03.009. [PMID: 16581062] - Marika Collin, Oliver Murch, Christoph Thiemermann. Peroxisome proliferator-activated receptor-gamma antagonists GW9662 and T0070907 reduce the protective effects of lipopolysaccharide preconditioning against organ failure caused by endotoxemia.
Critical care medicine.
2006 Apr; 34(4):1131-8. doi:
10.1097/01.ccm.0000206472.63040.6d. [PMID: 16484917] - M W Khalil, A Chaterjee, G Macbryde, P K Sarkar, R R D Marks. Single dose parecoxib significantly improves ventilatory function in early extubation coronary artery bypass surgery: a prospective randomized double blind placebo controlled trial.
British journal of anaesthesia.
2006 Feb; 96(2):171-8. doi:
10.1093/bja/aei298. [PMID: 16361300] - Sigrid Schuh-Hofer, Mandana Tayefeh, Uwe Reuter, Ulrich Dirnagl, Guy Arnold. Effects of parecoxib on plasma protein extravasation and c-fos expression in the rat.
Headache.
2006 Feb; 46(2):276-85. doi:
10.1111/j.1526-4610.2006.00332.x. [PMID: 16492237] - Neelam Seedher, Sonu Bhatia. Interaction of non-steroidal anti-inflammatory drugs, etoricoxib and parecoxib sodium, with human serum albumin studied by fluorescence spectroscopy.
Drug metabolism and drug interactions.
2006; 22(1):25-45. doi:
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Shock (Augusta, Ga.).
2005 Nov; 24(5):476-81. doi:
10.1097/01.shk.0000183433.24716.83. [PMID: 16247335] - Rikke Nørregaard, Boye L Jensen, Chunling Li, Weidong Wang, Mark A Knepper, Søren Nielsen, Jørgen Frøkiaer. COX-2 inhibition prevents downregulation of key renal water and sodium transport proteins in response to bilateral ureteral obstruction.
American journal of physiology. Renal physiology.
2005 Aug; 289(2):F322-33. doi:
10.1152/ajprenal.00061.2005. [PMID: 15840770] - Elliot V Hersh, Edward T Lally, Paul A Moore. Update on cyclooxygenase inhibitors: has a third COX isoform entered the fray?.
Current medical research and opinion.
2005 Aug; 21(8):1217-26. doi:
10.1185/030079905x56367. [PMID: 16083531] - Jean-Yves Jouzeau, Mikaël Daouphars, Alexandre Benani, Patrick Netter. [Pharmacology and classification of cyclooxygenase inhibitors].
Gastroenterologie clinique et biologique.
2004 Apr; 28 Spec No 3(?):C7-17. doi:
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American journal of physiology. Regulatory, integrative and comparative physiology.
2003 May; 284(5):R1179-89. doi:
10.1152/ajpregu.00340.2002. [PMID: 12560203] - Andra E Ibrahim, Jennifer Feldman, Aziz Karim, Evan D Kharasch. Simultaneous assessment of drug interactions with low- and high-extraction opioids: application to parecoxib effects on the pharmacokinetics and pharmacodynamics of fentanyl and alfentanil.
Anesthesiology.
2003 Apr; 98(4):853-61. doi:
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Anesthesia and analgesia.
2002 Sep; 95(3):667-73, table of contents. doi:
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Anesthesiology.
2002 Jan; 96(1):88-95. doi:
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Journal of clinical pharmacology.
2001 Oct; 41(10):1111-9. doi:
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