N'-[(6-Oxo-5-prop-2-enyl-1-cyclohexa-2,4-dienylidene)methyl]-2-[4-(phenylmethyl)-1-piperazinyl]acetohydrazide (BioDeep_00000182040)

   

human metabolite blood metabolite


代谢物信息卡片


N-[(6-oxo-5-prop-2-enyl-1-cyclohexa-2,4-dienylidene)methyl]-2-[4-(phenylmethyl)-1-piperazinyl]acetohydrazide

化学式: C23H28N4O2 (392.2212148)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 14.29%

分子结构信息

SMILES: OC1=C(C=NNC(=O)CN2CCN(CC3=CC=CC=C3)CC2)C=CC=C1CC=C
InChI: InChI=1S/C23H28N4O2/c1-2-7-20-10-6-11-21(23(20)29)16-24-25-22(28)18-27-14-12-26(13-15-27)17-19-8-4-3-5-9-19/h2-6,8-11,16,29H,1,7,12-15,17-18H2,(H,25,28)



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Kurosh Parsi, David E Connor, Anne Pilotelle, Joyce Low, David D F Ma, Joanne E Joseph. Low concentration detergent sclerosants induce platelet activation but inhibit aggregation due to suppression of GPIIb/IIIa activation in vitro. Thrombosis research. 2012 Sep; 130(3):472-8. doi: 10.1016/j.thromres.2012.03.023. [PMID: 22531012]
  • Peter C Papageorgiou, Erik L Yeo, Peter H Backx, John S Floras. Activated plasma coagulation β-Factor XII-induced vasoconstriction in rats. Clinical science (London, England : 1979). 2012 Jun; 122(12):581-90. doi: 10.1042/cs20110517. [PMID: 22216926]
  • Matthew T Rondina, BreAnna Brewster, Colin K Grissom, Guy A Zimmerman, Diana H Kastendieck, Estelle S Harris, Andrew S Weyrich. In vivo platelet activation in critically ill patients with primary 2009 influenza A(H1N1). Chest. 2012 Jun; 141(6):1490-1495. doi: 10.1378/chest.11-2860. [PMID: 22383669]
  • Ying-Xue Li, Qiang Sun, Hui Zhang, Shu-Ting Ren, Yi-Ran Liao, Ya Wang, Xin-Liang Shen, Bing Wang. A novel anti-platelet peptide (Z4A5) potential for glycoprotein IIb/IIIa inhibits platelet aggregation. Thrombosis research. 2012 May; 129(5):e217-22. doi: 10.1016/j.thromres.2012.02.047. [PMID: 22445430]
  • Yan Yang, Zhenyin Shi, Adili Reheman, Joseph W Jin, Conglei Li, Yiming Wang, Marc C Andrews, Pingguo Chen, Guangheng Zhu, Wenhua Ling, Heyu Ni. Plant food delphinidin-3-glucoside significantly inhibits platelet activation and thrombosis: novel protective roles against cardiovascular diseases. PloS one. 2012; 7(5):e37323. doi: 10.1371/journal.pone.0037323. [PMID: 22624015]
  • Bryan N Kahner, Hisashi Kato, Asoka Banno, Mark H Ginsberg, Sanford J Shattil, Feng Ye. Kindlins, integrin activation and the regulation of talin recruitment to αIIbβ3. PloS one. 2012; 7(3):e34056. doi: 10.1371/journal.pone.0034056. [PMID: 22457811]
  • Kyu Kwang Kim, Ajay P Singh, Rakesh K Singh, Angelica Demartino, Laurent Brard, Nicholi Vorsa, Thilo S Lange, Richard G Moore. Anti-angiogenic activity of cranberry proanthocyanidins and cytotoxic properties in ovarian cancer cells. International journal of oncology. 2012 Jan; 40(1):227-35. doi: 10.3892/ijo.2011.1198. [PMID: 21922132]
  • Yue Liu, Hui-Jun Yin, Da-Zhuo Shi, Ke-Ji Chen. Chinese herb and formulas for promoting blood circulation and removing blood stasis and antiplatelet therapies. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):184503. doi: 10.1155/2012/184503. [PMID: 22454656]
  • Jun Zhou, Changhong Zhang, Jinghan Liu, Lixia Fan, Liangui Yang. Loading solution prevents activation damage of human platelets before lyophilization. Cryobiology. 2011 Dec; 63(3):229-34. doi: 10.1016/j.cryobiol.2011.08.007. [PMID: 21945819]
  • Pamela W Lucas, Joanna M Schmit, Quinn P Peterson, Diana C West, Danny C Hsu, Chris J Novotny, Levent Dirikolu, Mona I Churchwell, Daniel R Doerge, Laura D Garrett, Paul J Hergenrother, Timothy M Fan. Pharmacokinetics and derivation of an anticancer dosing regimen for PAC-1, a preferential small molecule activator of procaspase-3, in healthy dogs. Investigational new drugs. 2011 Oct; 29(5):901-11. doi: 10.1007/s10637-010-9445-z. [PMID: 20499133]
  • Bing Wang, Yong-qiang Wang, Shu-hua Cao, Yong Liang. [Platelet parameters and platelet Toll-like receptor 4 (TLR4) expression in patients with sepsis, and the effect of a joint treatment-plan integrating traditional Chinese and western medicine: a clinical study]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue. 2011 Oct; 23(10):616-20. doi: NULL. [PMID: 22005564]
  • Raffaella Priora, Antonios Margaritis, Simona Frosali, Lucia Coppo, Domenico Summa, Danila Di Giuseppe, Carlo Aldinucci, Gianpaolo Pessina, Anna Di Stefano, Paolo Di Simplicio. In vitro inhibition of human and rat platelets by NO donors, nitrosoglutathione, sodium nitroprusside and SIN-1, through activation of cGMP-independent pathways. Pharmacological research. 2011 Sep; 64(3):289-97. doi: 10.1016/j.phrs.2011.03.014. [PMID: 21539916]
  • Y Zhang, H T Zong, C C Yang, X D Zhang. The clinical implication of inhibiting platelet activation on chronic renal allograft dysfunction: a prospective cohort study. Transplantation proceedings. 2011 Sep; 43(7):2596-600. doi: 10.1016/j.transproceed.2011.05.047. [PMID: 21911130]
  • Per Sandgren, Kharija Saeed. Storage of buffy-coat-derived platelets in additive solution: in vitro effects on platelets of the air bubbles and foam included in the final unit. Blood transfusion = Trasfusione del sangue. 2011 Apr; 9(2):182-8. doi: 10.2450/2010.0045-10. [PMID: 21084001]
  • Xin Zhang, Feng Tan, Chuan-zhi Duan. [Effect of electro-needling at acupoints of the yangming meridian on the expression of PAC-1 and lower limb functions in acute cerebral infarction patients]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2011 Apr; 31(4):483-6. doi: ". [PMID: 21608218]
  • Li-Na Fang, Xiao-Hui Chen, Qiu-Di Wang, Di Zhang, Juan-Juan Zhao, Zhi-Min Long, Ping Gong, Kai-Shun Bi. A liquid chromatography-tandem mass spectrometry method for the quantification of PAC-1 in rat plasma. Journal of pharmaceutical and biomedical analysis. 2011 Jan; 54(1):225-9. doi: 10.1016/j.jpba.2010.07.042. [PMID: 20828970]
  • Frank A J L Scheer, Alan D Michelson, Andrew L Frelinger, Heather Evoniuk, Erin E Kelly, Mary McCarthy, Lauren A Doamekpor, Marc R Barnard, Steven A Shea. The human endogenous circadian system causes greatest platelet activation during the biological morning independent of behaviors. PloS one. 2011; 6(9):e24549. doi: 10.1371/journal.pone.0024549. [PMID: 21931750]
  • Sarah A McGarrigle, Sarah O'Neill, Geraldine M Walsh, Niamh Moran, Ian M Graham, Marie-Therese Cooney, Ahmad Monavari, Philip Mayne, Patrick Collins. Integrin α(IIb)β₃ exists in an activated state in subjects with elevated plasma homocysteine levels. Platelets. 2011; 22(1):65-73. doi: 10.3109/09537104.2010.512646. [PMID: 21133649]
  • Quinn P Peterson, Danny C Hsu, Chris J Novotny, Diana C West, Dewey Kim, Joanna M Schmit, Levent Dirikolu, Paul J Hergenrother, Timothy M Fan. Discovery and canine preclinical assessment of a nontoxic procaspase-3-activating compound. Cancer research. 2010 Sep; 70(18):7232-41. doi: 10.1158/0008-5472.can-10-0766. [PMID: 20823163]
  • N S A Krushna, C Shiny, Pankaj Verma, D Nithya, P Basker, S Elango, Subash Babu, R B Narayanan. Wuchereria bancrofti: diminished platelet activation in filarial patients. Experimental parasitology. 2010 Jun; 125(2):114-23. doi: 10.1016/j.exppara.2010.01.003. [PMID: 20093116]
  • Paolo Gresele, Stefania Marzotti, Giuseppe Guglielmini, Stefania Momi, Silvia Giannini, Pietro Minuz, Paola Lucidi, Geremia B Bolli. Hyperglycemia-induced platelet activation in type 2 diabetes is resistant to aspirin but not to a nitric oxide-donating agent. Diabetes care. 2010 Jun; 33(6):1262-8. doi: 10.2337/dc09-2013. [PMID: 20299485]
  • Anne Fischer-Nielsen, Trine Stissing, Charlotte Maansson, Bent Gymoese Joergensen. Pressure-aided transfusion of platelets: does it affect the platelets?. Transfusion. 2010 Feb; 50(2):361-5. doi: 10.1111/j.1537-2995.2009.02396.x. [PMID: 19788509]
  • Hong-Xia Yao, Li Huang, Li-E Lin, Cong-Ming Wu, Hua Wang, Wen-Ting Chen, Xiang-Jun Fu, Yi-Peng Ding. [The study of relationship between platelet function and thrombus in patients with essential thrombocythaemia]. Zhonghua yi xue za zhi. 2010 Jan; 90(4):253-5. doi: . [PMID: 20356540]
  • Karen E Drahos, John D Welsh, Carla V Finkielstein, Daniel G S Capelluto. Sulfatides partition disabled-2 in response to platelet activation. PloS one. 2009 Nov; 4(11):e8007. doi: 10.1371/journal.pone.0008007. [PMID: 19956625]
  • Min Suk Kim, Fang Wang, Prasanth Puthanveetil, Girish Kewalramani, Sheila Innis, Lucy Marzban, Susan F Steinberg, Travis D Webber, Timothy J Kieffer, Ashraf Abrahani, Brian Rodrigues. Cleavage of protein kinase D after acute hypoinsulinemia prevents excessive lipoprotein lipase-mediated cardiac triglyceride accumulation. Diabetes. 2009 Nov; 58(11):2464-75. doi: 10.2337/db09-0681. [PMID: 19875622]
  • Anne-lie Ståhl, Lisa Sartz, Anders Nelsson, Zivile D Békássy, Diana Karpman. Shiga toxin and lipopolysaccharide induce platelet-leukocyte aggregates and tissue factor release, a thrombotic mechanism in hemolytic uremic syndrome. PloS one. 2009 Sep; 4(9):e6990. doi: 10.1371/journal.pone.0006990. [PMID: 19750223]
  • Ajay P Singh, Rakesh K Singh, Kyu Kwang Kim, K S Satyan, Roger Nussbaum, Monica Torres, Laurent Brard, Nicholi Vorsa. Cranberry proanthocyanidins are cytotoxic to human cancer cells and sensitize platinum-resistant ovarian cancer cells to paraplatin. Phytotherapy research : PTR. 2009 Aug; 23(8):1066-74. doi: 10.1002/ptr.2667. [PMID: 19172579]
  • Y Zhang, X D Zhang, L L Ma, D L Guan. Relationship between platelet activation and acute rejection after renal transplantation. Transplantation proceedings. 2009 Jun; 41(5):1547-51. doi: 10.1016/j.transproceed.2009.04.006. [PMID: 19545676]
  • Osamu Ayukawa, Kazuo Nakamura, Hiroko Kariyazono, Ryuji Ikeda, Junko Arima, Terutoshi Shinkawa, Harunobu Iwase, Ryuzo Sakata, Katsushi Yamada. Enhanced platelet responsiveness due to chilling and its relation to CD40 ligand level and platelet-leukocyte aggregate formation. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. 2009 Apr; 20(3):176-84. doi: 10.1097/mbc.0b013e328322ffd5. [PMID: 19300046]
  • Konstantinos Stellos, Boris Bigalke, Harald Langer, Tobias Geisler, Annika Schad, Andreas Kögel, Florian Pfaff, Dimitrios Stakos, Peter Seizer, Iris Müller, Patrick Htun, Stephan Lindemann, Meinrad Gawaz. Expression of stromal-cell-derived factor-1 on circulating platelets is increased in patients with acute coronary syndrome and correlates with the number of CD34+ progenitor cells. European heart journal. 2009 Mar; 30(5):584-93. doi: 10.1093/eurheartj/ehn566. [PMID: 19109356]
  • Li-Na Fang, Xiao-Hui Chen, Zhen Song, Gang Wang, Xu Zhao, Lei Ren, Ping Gong, Kai-Shun Bi. Development of a high performance liquid chromatography method for quantification of PAC-1 in rat plasma. Journal of pharmaceutical and biomedical analysis. 2009 Feb; 49(2):447-50. doi: 10.1016/j.jpba.2008.11.024. [PMID: 19135329]
  • Dimitris Papapanagiotou, Elena A Nicu, Sergio Bizzarro, Victor E A Gerdes, Joost C Meijers, Rienk Nieuwland, Ubele van der Velden, Bruno G Loos. Periodontitis is associated with platelet activation. Atherosclerosis. 2009 Feb; 202(2):605-11. doi: 10.1016/j.atherosclerosis.2008.05.035. [PMID: 18617175]
  • Ishtiaq Qadri, Ling-Jia Hu, Mieko Iwahashi, Subhi Al-Zuabi, Linda C Quattrochi, Francis R Simon. Interaction of hepatocyte nuclear factors in transcriptional regulation of tissue specific hormonal expression of human multidrug resistance-associated protein 2 (abcc2). Toxicology and applied pharmacology. 2009 Feb; 234(3):281-92. doi: 10.1016/j.taap.2008.10.005. [PMID: 19010343]
  • Lei Ren, Kaishun Bi, Ping Gong, Weiming Cheng, Zhen Song, Lina Fang, Xiaohui Chen. Characterization of the in vivo and in vitro metabolic profile of PAC-1 using liquid chromatography-mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2008 Dec; 876(1):47-53. doi: 10.1016/j.jchromb.2008.10.006. [PMID: 18996064]
  • Vassiliki Koloka, Elena D Christofidou, Spyros Vaxevanelis, Andromaxi A Dimitriou, Vassilios Tsikaris, Alexandros D Tselepis, Eugenia Panou-Pomonis, Maria Sakarellos-Daitsiotis, Demokritos C Tsoukatos. A palmitoylated peptide, derived from the acidic carboxyl-terminal segment of the integrin alphaIIb cytoplasmic domain, inhibits platelet activation. Platelets. 2008 Nov; 19(7):502-11. doi: 10.1080/09537100802266875. [PMID: 18979362]
  • A Thijs, P W B Nanayakkara, P M Ter Wee, P C Huijgens, C van Guldener, C D A Stehouwer. Mild-to-moderate renal impairment is associated with platelet activation: a cross-sectional study. Clinical nephrology. 2008 Oct; 70(4):325-31. doi: NULL. [PMID: 18826858]
  • Ronit Mor-Cohen, Nurit Rosenberg, Meytal Landau, Judith Lahav, Uri Seligsohn. Specific cysteines in beta3 are involved in disulfide bond exchange-dependent and -independent activation of alphaIIbbeta3. The Journal of biological chemistry. 2008 Jul; 283(28):19235-44. doi: 10.1074/jbc.m802399200. [PMID: 18458089]
  • S Giannini, A M Mezzasoma, G Guglielmini, R Rossi, E Falcinelli, P Gresele. A new case of acquired Glanzmann's thrombasthenia: diagnostic value of flow cytometry. Cytometry. Part B, Clinical cytometry. 2008 May; 74(3):194-9. doi: 10.1002/cyto.b.20396. [PMID: 18200593]
  • Won Kyung Jeon, Yeong Eun Kim, Sun Ok Park, Dae Young Kwon, Sang Woo Ahn, Jeong Hwa Lee, Myoung Soon Ji, Byoung Seob Ko. The modified Je-Ho-Tang, Korean herbal medicine, inhibits whole-blood aggregation and platelet adhesion to collagen under flow. Thrombosis research. 2008; 122(6):804-9. doi: 10.1016/j.thromres.2008.03.002. [PMID: 18448152]
  • Andreas Link, Matthias Girndt, Simina Selejan, Ranja Rbah, Michael Böhm. Tirofiban preserves platelet loss during continuous renal replacement therapy in a randomised prospective open-blinded pilot study. Critical care (London, England). 2008; 12(4):R111. doi: 10.1186/cc6998. [PMID: 18759963]
  • Silverio Sbrana, Francesca Della Pina, Antonio Rizza, Manuela Buffa, Rossella De Filippis, Jacopo Gianetti, Aldo Clerico. Relationships between optical aggregometry (type born) and flow cytometry in evaluating ADP-induced platelet activation. Cytometry. Part B, Clinical cytometry. 2008 Jan; 74(1):30-9. doi: 10.1002/cyto.b.20360. [PMID: 17630652]
  • Jun Zhou, Jin-Han Liu, Yu Jin, Xi-Lin Ouyang, Lian-Gui Yang. [Protective effects of DMSO on function of lyophilized human platelets]. Zhongguo shi yan xue ye xue za zhi. 2007 Dec; 15(6):1284-8. doi: . [PMID: 18088485]
  • Ronit Mor-Cohen, Nurit Rosenberg, Hava Peretz, Meytal Landau, Barry S Coller, Abdalla Awidi, Uri Seligsohn. Disulfide bond disruption by a beta 3-Cys549Arg mutation in six Jordanian families with Glanzmann thrombasthenia causes diminished production of constitutively active alpha IIb beta 3. Thrombosis and haemostasis. 2007 Dec; 98(6):1257-65. doi: 10.1160/th07-04-0248. [PMID: 18064323]
  • Jing-Han Liu, Jun Zhou, Dong-Mei Wang, Xi-Lin Ouyang, Yan-Chao Xing, Fa-Qiang Lu. [Experimental study on lyophilization of platelets]. Zhongguo shi yan xue ye xue za zhi. 2007 Oct; 15(5):1098-101. doi: . [PMID: 17956699]
  • T Chung, D Connor, J Joseph, L Emmett, R Mansberg, M Peters, D Ma, L Kritharides. Platelet activation in acute pulmonary embolism. Journal of thrombosis and haemostasis : JTH. 2007 May; 5(5):918-24. doi: 10.1111/j.1538-7836.2007.02461.x. [PMID: 17371486]
  • Yuan-Tao Liu, Lifang Song, Douglas M Templeton. Heparin suppresses lipid raft-mediated signaling and ligand-independent EGF receptor activation. Journal of cellular physiology. 2007 Apr; 211(1):205-12. doi: 10.1002/jcp.20924. [PMID: 17226785]
  • D E Barre. Arginyl-glycyl-aspartyl (RGD) epitope of human apolipoprotein (a) inhibits platelet aggregation by antagonizing the IIb subunit of the fibrinogen (GPIIb/IIIa) receptor. Thrombosis research. 2007; 119(5):601-7. doi: 10.1016/j.thromres.2006.04.013. [PMID: 16860375]
  • Won Kyung Jeon, Ju Hyun Lee, Ho Kyoung Kim, A Yeong Lee, Sung Ok Lee, Young Sup Kim, Shi Yong Ryu, Soo Young Kim, Yong Jin Lee, Byoung Seob Ko. Anti-platelet effects of bioactive compounds isolated from the bark of Rhus verniciflua Stokes. Journal of ethnopharmacology. 2006 Jun; 106(1):62-9. doi: 10.1016/j.jep.2005.12.015. [PMID: 16431050]
  • Marie-Theres Kasimir, Erwin Rieder, Gernot Seebacher, Anneliese Nigisch, Barbara Dekan, Ernst Wolner, Guenter Weigel, Paul Simon. Decellularization does not eliminate thrombogenicity and inflammatory stimulation in tissue-engineered porcine heart valves. The Journal of heart valve disease. 2006 Mar; 15(2):278-86; discussion 286. doi: NULL. [PMID: 16607912]
  • Y Zhang, D L Guan, C Q Xia, Z Y Han, J J Xu, J Z Gao, K R Wu. Clinical study of Lipo PGE1-inhibiting platelet activation in acute rejection after kidney transplantation. Transplantation proceedings. 2005 Dec; 37(10):4208-10. doi: 10.1016/j.transproceed.2005.10.122. [PMID: 16387079]
  • Marie-Theres Kasimir, Guenter Weigel, Jyotindra Sharma, Erwin Rieder, Gernot Seebacher, Ernst Wolner, Paul Simon. The decellularized porcine heart valve matrix in tissue engineering: platelet adhesion and activation. Thrombosis and haemostasis. 2005 Sep; 94(3):562-7. doi: 10.1160/th05-01-0025. [PMID: 16268473]
  • Annette Vetlesen, Mohammad Reza Mirlashari, Inger Anne Torsheim, Jens Kjeldsen-Kragh. Platelet activation and residual activation potential during storage of hyperconcentrated platelet products in two different platelet additive solutions. Transfusion. 2005 Aug; 45(8):1349-55. doi: 10.1111/j.1537-2995.2005.00218.x. [PMID: 16078925]
  • Jie Meng, Li Song, Haiyan Xu, Hua Kong, Chaoying Wang, Xiaotian Guo, Sishen Xie. Effects of single-walled carbon nanotubes on the functions of plasma proteins and potentials in vascular prostheses. Nanomedicine : nanotechnology, biology, and medicine. 2005 Jun; 1(2):136-42. doi: 10.1016/j.nano.2005.03.003. [PMID: 17292070]
  • Eva Birgitte Leinoe, Marianne Hutchings Hoffmann, Erik Kjaersgaard, Joern Dalsgaard Nielsen, Olav Jonas Bergmann, Tobias Wirenfeldt Klausen, Hans Erik Johnsen. Prediction of haemorrhage in the early stage of acute myeloid leukaemia by flow cytometric analysis of platelet function. British journal of haematology. 2005 Feb; 128(4):526-32. doi: 10.1111/j.1365-2141.2004.05335.x. [PMID: 15686463]
  • Shinobu Wakamoto, Mitsuhiro Fujihara, Hideki Abe, Miki Yamaguchi, Hiroshi Azuma, Hisami Ikeda, Shinji Takeoka, Eishun Tsuchida. Effects of hemoglobin vesicles on resting and agonist-stimulated human platelets in vitro. Artificial cells, blood substitutes, and immobilization biotechnology. 2005; 33(2):101-11. doi: 10.1081/bio-200055856. [PMID: 15960075]
  • Xue-yuan Tang, Zai-fu Jian, Guo-ping Wang, Hong-hui Yang, Wei Liu. Effects of integrin alpha IIb(R995A) mutation on receptor affinity and pp125 (FAK) phosphorylation. Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih. 2004 Dec; 19(4):276-81. doi: NULL. [PMID: 15669186]
  • Xi-Lin Ouyang, Jing-Han Liu, Ji-Chun Pan, Xi-Jin Li, Shu-Xuan Ma, Hai-Bao Wang, Feng-Lei Lai, Da-Yong Gao. [Qualitative analysis of batch preparing cryopreserved fresh platelet rich plasma]. Zhongguo shi yan xue ye xue za zhi. 2004 Dec; 12(6):841-4. doi: NULL. [PMID: 15631674]
  • E B Leinoe, M H Hoffmann, E Kjaersgaard, H E Johnsen. Multiple platelet defects identified by flow cytometry at diagnosis in acute myeloid leukaemia. British journal of haematology. 2004 Oct; 127(1):76-84. doi: 10.1111/j.1365-2141.2004.05156.x. [PMID: 15384980]
  • L Sun, P Tan, C Yap, W Hwang, L P Koh, C K Lim, S E Aw. In vitro biological characteristics of human cord blood-derived megakaryocytes. Annals of the Academy of Medicine, Singapore. 2004 Sep; 33(5):570-5. doi: NULL. [PMID: 15531951]
  • Shosaku Nomura, Norihito Inami, Toshiji Iwasaka, Yongge Liu. Platelet activation markers, microparticles and soluble adhesion molecules are elevated in patients with arteriosclerosis obliterans: therapeutic effects by cilostazol and potentiation by dipyridamole. Platelets. 2004 May; 15(3):167-72. doi: 10.1080/09537100410001682779. [PMID: 15203718]
  • Shinji Takeoka, Yosuke Okamura, Yuji Teramura, Naohide Watanabe, Hidenori Suzuki, Eishun Tsuchida, Makoto Handa, Yasuo Ikeda. Function of fibrinogen gamma-chain dodecapeptide-conjugated latex beads under flow. Biochemical and biophysical research communications. 2003 Dec; 312(3):773-9. doi: 10.1016/j.bbrc.2003.10.184. [PMID: 14680832]
  • Yong Zhang, De-lin Guan, Cheng-qing Xia, Zhi-you Han, Jian-jun Xu, Ju-zhong Gao, Ke-rang Wu. [The relationship between the peripheral blood of CD61, CD63, PAC-1 and the transplant kidney function]. Zhonghua wai ke za zhi [Chinese journal of surgery]. 2003 Dec; 41(12):881-4. doi: NULL. [PMID: 14728824]
  • Victor L Serebruany, Alex I Malinin, Scott D Jerome, David R Lowry, Athol W Morgan, David C Sane, Jean-François Tanguay, Steven R Steinhubl, Christopher M O'connor. Effects of clopidogrel and aspirin combination versus aspirin alone on platelet aggregation and major receptor expression in patients with heart failure: the Plavix Use for Treatment Of Congestive Heart Failure (PLUTO-CHF) trial. American heart journal. 2003 Oct; 146(4):713-20. doi: 10.1016/s0002-8703(03)00260-6. [PMID: 14564328]
  • Nikolaos Biris, Morfis Abatzis, John V Mitsios, Maria Sakarellos-Daitsiotis, Constantinos Sakarellos, Demokritos Tsoukatos, Alexandros D Tselepis, Lambros Michalis, Dimitrios Sideris, Georgia Konidou, Ketty Soteriadou, Vassilios Tsikaris. Mapping the binding domains of the alpha(IIb) subunit. A study performed on the activated form of the platelet integrin alpha(IIb)beta(3). European journal of biochemistry. 2003 Sep; 270(18):3760-7. doi: 10.1046/j.1432-1033.2003.03762.x. [PMID: 12950259]
  • V L Serebruany, A H Glassman, A I Malinin, D Atar, D C Sane, B R Oshrine, J J Ferguson, C M O'Connor. Selective serotonin reuptake inhibitors yield additional antiplatelet protection in patients with congestive heart failure treated with antecedent aspirin. European journal of heart failure. 2003 Aug; 5(4):517-21. doi: 10.1016/s1388-9842(03)00005-9. [PMID: 12921813]
  • Barry Wilbourn, Paul Harrison, Ian J Mackie, Ri Liesner, Samuel J Machin. Activation of platelets in whole blood by recombinant factor VIIa by a thrombin-dependent mechanism. British journal of haematology. 2003 Aug; 122(4):651-61. doi: 10.1046/j.1365-2141.2003.04461.x. [PMID: 12899721]
  • Y Zhang, D L Guan, C Q Xia, Z Y Han, J J Xu, J Z Gao, K R Wu, Y G Zhang, D Guan. Relationship between the expression levels of CD61, CD63, and PAC-1 on platelet surface in peripheral blood and the transplanted kidney function. Transplantation proceedings. 2003 Jun; 35(4):1360-3. doi: 10.1016/s0041-1345(03)00469-x. [PMID: 12826159]
  • Alex I Malinin, Dan Atar, Kevin P Callahan, Marcus E McKenzie, Victor L Serebruany. Effect of a single dose aspirin on platelets in humans with multiple risk factors for coronary artery disease. European journal of pharmacology. 2003 Feb; 462(1-3):139-43. doi: 10.1016/s0014-2999(02)02956-4. [PMID: 12591106]
  • Ellinor I B Peerschke, Tara K Murphy, Berhane Ghebrehiwet. Activation-dependent surface expression of gC1qR/p33 on human blood platelets. Thrombosis and haemostasis. 2003 Feb; 89(2):331-9. doi: 10.1055/s-0037-1613450. [PMID: 12574814]
  • Demetrios Simos, Frans Boomsma, Daniel H Osmond. Human coagulation factor XII-related 'new pressor protein': role of PACAP in its cardiovascular and sympathoadrenal effects. The Canadian journal of cardiology. 2002 Oct; 18(10):1093-103. doi: NULL. [PMID: 12420044]
  • Jean-Max Pasquet, Malia Noury, Alan T Nurden. Evidence that the platelet integrin alphaIIb beta3 is regulated by the integrin-linked kinase, ILK, in a PI3-kinase dependent pathway. Thrombosis and haemostasis. 2002 Jul; 88(1):115-22. doi: 10.1055/s-0037-1613163. [PMID: 12152651]
  • Debra A Pearson, Teresa G Paglieroni, Dietrich Rein, Ted Wun, Derek D Schramm, Janice F Wang, Roberta R Holt, Robert Gosselin, Harold H Schmitz, Carl L Keen. The effects of flavanol-rich cocoa and aspirin on ex vivo platelet function. Thrombosis research. 2002 May; 106(4-5):191-7. doi: 10.1016/s0049-3848(02)00128-7. [PMID: 12297125]
  • S-Y Woo, J-H Kie, K-H Ryu, H-S Moon, W-S Chung, D-H Hwang, S-K Kim, T-H Han, M-J Hahn, Y-H Chong, H-K Park, J-Y Seoh. Megakaryothrombopoiesis during ex vivo expansion of human cord blood CD34+ cells using thrombopoietin. Scandinavian journal of immunology. 2002 Jan; 55(1):88-95. doi: 10.1046/j.1365-3083.2002.01031.x. [PMID: 11841696]
  • F Ahmed, P Alexandridis, H Shankaran, S Neelamegham. The ability of poloxamers to inhibit platelet aggregation depends on their physicochemical properties. Thrombosis and haemostasis. 2001 Dec; 86(6):1532-9. doi: 10.1055/s-0037-1616759. [PMID: 11776324]
  • C Ruiz, C Y Liu, Q H Sun, M Sigaud-Fiks, E Fressinaud, J Y Muller, P Nurden, A T Nurden, P J Newman, N Valentin. A point mutation in the cysteine-rich domain of glycoprotein (GP) IIIa results in the expression of a GPIIb-IIIa (alphaIIbbeta3) integrin receptor locked in a high-affinity state and a Glanzmann thrombasthenia-like phenotype. Blood. 2001 Oct; 98(8):2432-41. doi: 10.1182/blood.v98.8.2432. [PMID: 11588040]
  • W Bu, J L Sun, X C Yang. [Cloning, sequence analysis and high-level expression in Escherichia coli and activity assay of pac-1 gene from Schizosaccharmyces pombe]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. 2001 Mar; 17(2):203-6. doi: . [PMID: 11411232]
  • T H Mondoro, B B Ryan, B W Hrinczenko, A N Schechter, J G Vostal, A I Alayash. Biological action of nitric oxide donor compounds on platelets from patients with sickle cell disease. British journal of haematology. 2001 Mar; 112(4):1048-54. doi: 10.1046/j.1365-2141.2001.02623.x. [PMID: 11298605]