p-Iodoclonidine (BioDeep_00000182025)
human metabolite blood metabolite
代谢物信息卡片
化学式: C9H8Cl2IN3 (354.9140018)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 4.17%
分子结构信息
SMILES: C1CN=C(N1)NC2=C(C=C(C=C2Cl)I)Cl
InChI: InChI=1S/C9H8Cl2IN3/c10-6-3-5(12)4-7(11)8(6)15-9-13-1-2-14-9/h3-4H,1-2H2,(H2,13,14,15)
描述信息
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D000345 - Affinity Labels
同义名列表
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Angelos Halaris, He Zhu, Jeffery Ali, Amelia Nasrallah, C Lindsay De Vane, John E Piletz. Down-regulation of platelet imidazoline-1-binding sites after bupropion treatment.
The international journal of neuropsychopharmacology.
2002 Mar; 5(1):37-46. doi:
10.1017/s1461145701002759. [PMID: 12057030] - J E Piletz, U Halbreich. Imidazoline and alpha(2a)-adrenoceptor binding sites in postmenopausal women before and after estrogen replacement therapy.
Biological psychiatry.
2000 Nov; 48(9):932-9. doi:
10.1016/s0006-3223(00)00849-0. [PMID: 11074231] - J S Chan, T T Wang, S L Zhang, X Chen, S Carrière. Catecholamines and angiotensinogen gene expression in kidney proximal tubular cells.
Molecular and cellular biochemistry.
2000 Sep; 212(1-2):73-9. doi:
. [PMID: 11108138] - F M Heemskerk, M Dontenwill, H Greney, C Vonthron, P Bousquet. Evidence for the existence of imidazoline-specific binding sites in synaptosomal plasma membranes of the bovine brainstem.
Journal of neurochemistry.
1998 Nov; 71(5):2193-202. doi:
10.1046/j.1471-4159.1998.71052193.x. [PMID: 9798947] - J E Piletz, M Andrew, H Zhu, Y Z Feng, J Rains, A Halaris. Alpha 2-adrenoceptors and I1-imidazoline binding sites: relationship with catecholamines in women of reproductive age.
Journal of psychiatric research.
1998 Mar; 32(2):55-64. doi:
10.1016/s0022-3956(98)00048-x. [PMID: 9694001] - H Zhu, A Halaris, J E Piletz. Chronic imipramine treatment downregulates IR1-imidazoline receptors in rat brainstem.
Life sciences.
1997; 61(19):1973-83. doi:
10.1016/s0024-3205(97)00837-0. [PMID: 9364202] - T T Wang, S Lachance, A Delalandre, S Carrière, J S Chan. Alpha-adrenoceptors and angiotensinogen gene expression in opossum kidney cells.
Kidney international.
1995 Jul; 48(1):139-45. doi:
10.1038/ki.1995.277. [PMID: 7564070] - J E Piletz, K Sletten. Nonadrenergic imidazoline binding sites on human platelets.
The Journal of pharmacology and experimental therapeutics.
1993 Dec; 267(3):1493-502. doi:
. [PMID: 8263811] - P Ernsberger, T H Damon, L M Graff, S G Schäfer, M O Christen. Moxonidine, a centrally acting antihypertensive agent, is a selective ligand for I1-imidazoline sites.
The Journal of pharmacology and experimental therapeutics.
1993 Jan; 264(1):172-82. doi:
NULL. [PMID: 8380858] - M Van Dort, R Neubig, R E Counsell. Radioiodinated p-iodoclonidine: a high-affinity probe for the alpha 2-adrenergic receptor.
Journal of medicinal chemistry.
1987 Jul; 30(7):1241-4. doi:
10.1021/jm00390a021. [PMID: 3037080]