O-Demethylencainide (BioDeep_00000181869)
human metabolite blood metabolite
代谢物信息卡片
化学式: C21H26N2O2 (338.1994176)
中文名称:
谱图信息:
最多检出来源 Mus musculus(blood) 86.96%
分子结构信息
SMILES: CN1CCCCC1CCC1=CC=CC=C1NC(=O)C1=CC=C(O)C=C1
InChI: InChI=1S/C21H26N2O2/c1-23-15-5-4-7-18(23)12-9-16-6-2-3-8-20(16)22-21(25)17-10-13-19(24)14-11-17/h2-3,6,8,10-11,13-14,18,24H,4-5,7,9,12,15H2,1H3,(H,22,25)
描述信息
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
同义名列表
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- J Turgeon, T A Wisialowski, W Wong, W A Altemeier, J P Wikswo, D M Roden. Suppression of longitudinal versus transverse conduction by sodium channel block. Effects of sodium bolus.
Circulation.
1992 Jun; 85(6):2221-6. doi:
10.1161/01.cir.85.6.2221. [PMID: 1317273] - J S Fleming, J O Buchanan, F D Yocca, L G Iben, M J Antonaccio. Effect of encainide, ODE, MODE, and flecainide on ADP/5-HT induced platelet aggregation and in the anesthetized dog coronary artery stenosis-occlusion model of intravascular thrombosis.
Cardiovascular drugs and therapy.
1991 Aug; 5(4):763-8. doi:
10.1007/bf03029752. [PMID: 1909560] - M B Halvorsen, J T Whitmer, C E Halstenson. Hemodialysis clearance of encainide and metabolites.
Therapeutic drug monitoring.
1991 Jul; 13(4):375-8. doi:
10.1097/00007691-199107000-00016. [PMID: 1780973] - J M Poirier, M Lebot, G Cheymol. Analysis of encainide and its three major metabolites in plasma by column liquid chromatography.
Journal of chromatography.
1990 Dec; 534(?):223-7. doi:
10.1016/s0378-4347(00)82166-0. [PMID: 2128839] - A K Bajaj, R L Woosley, D M Roden. Acute electrophysiologic effects of sodium administration in dogs treated with O-desmethyl encainide.
Circulation.
1989 Oct; 80(4):994-1002. doi:
10.1161/01.cir.80.4.994. [PMID: 2551538] - J T Barbey, K A Thompson, D S Echt, R L Woosley, D M Roden. Antiarrhythmic activity, electrocardiographic effects and pharmacokinetics of the encainide metabolites O-desmethyl encainide and 3-methoxy-O-desmethyl encainide in man.
Circulation.
1988 Feb; 77(2):380-91. doi:
10.1161/01.cir.77.2.380. [PMID: 3123092] - D M Roden, A J Wood, G R Wilkinson, R L Woosley. Disposition kinetics of encainide and metabolites.
The American journal of cardiology.
1986 Aug; 58(5):4C-9C. doi:
10.1016/0002-9149(86)90097-4. [PMID: 3092618] - D C Harrison, R E Kates, B D Quart. Relation of blood level and metabolites to the antiarrhythmic effectiveness of encainide.
The American journal of cardiology.
1986 Aug; 58(5):66C-73C. doi:
10.1016/0002-9149(86)90107-4. [PMID: 3092622] - A W Gomoll, J E Byrne, R F Mayol. Comparative antiarrhythmic actions of encainide and its major metabolites.
Archives internationales de pharmacodynamie et de therapie.
1986 Jun; 281(2):277-97. doi:
. [PMID: 3092755] - R L Woosley, D M Roden, G H Dai, T Wang, D Altenbern, J Oates, G R Wilkinson. Co-inheritance of the polymorphic metabolism of encainide and debrisoquin.
Clinical pharmacology and therapeutics.
1986 Mar; 39(3):282-7. doi:
10.1038/clpt.1986.40. [PMID: 3081292] - P Dumoulin, P Jaillon, A Kher, J M Poirier, G Cheymol, J Valty, D Flammang, P Coumel, J L Medvedowsky, C Barnay. Long-term efficacy and safety of oral encainide in the treatment of chronic ventricular ectopic activity: relationship to plasma concentrations--a French multicenter trial.
American heart journal.
1985 Sep; 110(3):575-81. doi:
10.1016/0002-8703(85)90077-8. [PMID: 2412428] - A K Dawson, D M Roden, H J Duff, R L Woosley, R F Smith. Differential effects of O-demethyl encainide on induced and spontaneous arrhythmias in the conscious dog.
The American journal of cardiology.
1984 Sep; 54(6):654-8. doi:
10.1016/0002-9149(84)90267-4. [PMID: 6475789] - D M Roden, A K Dawson, H J Duff, R L Woosley, R F Smith. Electrophysiology of O-demethyl encainide in a canine model of sustained ventricular tachycardia.
Journal of cardiovascular pharmacology.
1984 Jul; 6(4):588-95. doi:
10.1097/00005344-198407000-00006. [PMID: 6206311] - R Latini, A M Gillis, R E Kates. Myocardial uptake of encainide and its two major metabolites, O-demethyl encainide and 3-methoxy-O-demethyl encainide, in the dog.
Journal of cardiovascular pharmacology.
1984 Jul; 6(4):663-7. doi:
10.1097/00005344-198407000-00017. [PMID: 6206322] - E L Carey, H J Duff, D M Roden, R K Primm, G R Wilkinson, T Wang, J A Oates, R L Woosley. Encainide and its metabolites. Comparative effects in man on ventricular arrhythmia and electrocardiographic intervals.
The Journal of clinical investigation.
1984 Feb; 73(2):539-47. doi:
10.1172/jci111241. [PMID: 6421879] - H J Duff, A K Dawson, D M Roden, J A Oates, R F Smith, R L Woosley. Electrophysiologic actions of O-demethyl encainide: an active metabolite.
Circulation.
1983 Aug; 68(2):385-91. doi:
10.1161/01.cir.68.2.385. [PMID: 6861313] - D M Roden, H J Duff, D Altenbern, R L Woosley. Antiarrhythmic activity of the O-demethyl metabolite of encainide.
The Journal of pharmacology and experimental therapeutics.
1982 Jun; 221(3):552-7. doi:
. [PMID: 6806461]