Nylidrin (BioDeep_00000181851)
human metabolite blood metabolite
代谢物信息卡片
化学式: C19H25NO2 (299.188519)
中文名称: 脑清
谱图信息:
最多检出来源 Homo sapiens(blood) 98.6%
分子结构信息
SMILES: CC(CCC1=CC=CC=C1)NC(C)C(C2=CC=C(C=C2)O)O
InChI: InChI=1S/C19H25NO2/c1-14(8-9-16-6-4-3-5-7-16)20-15(2)19(22)17-10-12-18(21)13-11-17/h3-7,10-15,19-22H,8-9H2,1-2H3
描述信息
G - Genito urinary system and sex hormones > G02 - Other gynecologicals > G02C - Other gynecologicals > G02CA - Sympathomimetics, labour repressants
C - Cardiovascular system > C04 - Peripheral vasodilators > C04A - Peripheral vasodilators > C04AA - 2-amino-1-phenylethanol derivatives
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013566 - Sympathomimetics
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
D012102 - Reproductive Control Agents > D015149 - Tocolytic Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:91656
- PubChem: 4567
- HMDB: HMDB0255826
- DrugBank: DB06152
- ChEMBL: CHEMBL114655
- Wikipedia: Buphenine
- MeSH: Nylidrin
- chemspider: 4407
- CAS: 447-41-6
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
Journal of medicinal chemistry.
2011 Jul; 54(13):4548-58. doi:
10.1021/jm2001629. [PMID: 21599003] - T Kurki, L Viinikka, O Ylikorkala. Urinary excretion of prostacyclin and thromboxane metabolites in threatened preterm labor: effect of indomethacin and nylidrin.
American journal of obstetrics and gynecology.
1992 Jan; 166(1 Pt 1):150-4. doi:
10.1016/0002-9378(92)91851-z. [PMID: 1733190] - T Kurki, T Laatikainen, K Salminen-Lappalainen, O Ylikorkala. Maternal plasma corticotrophin-releasing hormone--elevated in preterm labour but unaffected by indomethacin or nylidrin.
British journal of obstetrics and gynaecology.
1991 Jul; 98(7):685-91. doi:
10.1111/j.1471-0528.1991.tb13456.x. [PMID: 1883793] - A Hashem, B Lubczyk. Determination of isoxsuprine in equine plasma by high-performance liquid chromatography with electrochemical detection.
Journal of chromatography.
1991 Jan; 563(1):216-23. doi:
10.1016/0378-4347(91)80299-r. [PMID: 2061392] - M Santala, S Saarikoski, O Castrén. Decreased numbers of lymphocyte beta 2-adrenoceptors in pregnant women receiving beta 2-adrenergic agonist therapy.
Acta obstetricia et gynecologica Scandinavica.
1990; 69(1):17-21. doi:
10.3109/00016349009021033. [PMID: 1971738] - D Neubüser. [The influence of partusisten and dilatol on the amino-acid metabolism (author's transl)].
Archiv fur Gynakologie.
1976 Sep; 221(2):175-8. doi:
10.1007/bf00667147. [PMID: 10875] - H Li, P Cervoni. GLC determination of nylidrin in human urine samples.
Journal of pharmaceutical sciences.
1976 Sep; 65(9):1352-6. doi:
10.1002/jps.2600650923. [PMID: 966153] - A Wasilewski. [Clinical pharmacology of Opino-gel--the demonstration of its effectiveness (author's transl)].
Wiener klinische Wochenschrift.
1975 May; 87(9):306-8. doi:
". [PMID: 1094748] - H Halle, R Bollmann, G Ittrich. [Placental function in dilatol therapy].
Zentralblatt fur Gynakologie.
1973 Feb; 95(8):267-70. doi:
NULL. [PMID: 4697130] - E Marmo, R K Saini, A P Caputi. Effects of various beta-adrenergic stimulant drugs on the serum cholinesterase levels of rats.
Research communications in chemical pathology and pharmacology.
1973 Jan; 5(1):219-22. doi:
NULL. [PMID: 4405563] - G HERTTING, M LOUDON. [Effect of phenoxy-isopropyl-nor-suprifen (duvadilan) and phenyl-isobutyl-nor suprifen (dilatol) on renal blood flow and glomerular filtrate in non-anesthetized dogs].
Wiener klinische Wochenschrift.
1956 Jul; 68(30):604-7. doi:
NULL. [PMID: 13392857]