3-O-Methyl-a-methyldopamine (BioDeep_00000018174)

   

human metabolite Endogenous blood metabolite Chemicals and Drugs


代谢物信息卡片


3-O-Methyl-alpha-methyldopamine hydrochloride, (+-)-isomer

化学式: C10H15NO2 (181.110273)
中文名称:
谱图信息: 最多检出来源 Rattus norvegicus(blood) 1.41%

分子结构信息

SMILES: CC(CC1=CC(=C(C=C1)O)OC)N
InChI: InChI=1S/C10H15NO2/c1-7(11)5-8-3-4-9(12)10(6-8)13-2/h3-4,6-7,12H,5,11H2,1-2H3

描述信息

3-O-Methyl-a-methyldopamine is a metabolite of methyldopa. Methyldopa (-α-Methyl-3,4-dihydroxyphenylalanine; Aldomet, Aldoril, Dopamet, Dopegyt, etc. ) is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive drug used as a sympatholytic or antihypertensive. Its use is now mostly deprecated following the introduction of alternative safer classes of agents. However, it continues to have a role in otherwise difficult to treat hypertension and gestational hypertension (also known as pregnancy-induced hypertension). (Wikipedia)

同义名列表

7 个代谢物同义名

3-O-Methyl-alpha-methyldopamine hydrochloride, (+-)-isomer; 3-O-Methyl-alpha-methyldopamine hydrochloride; 3-O-Methyl-alpha-methyldopamine, (+-)-isomer; 4-(2-Aminopropyl)-2-methoxyphenol; 3-O-Methyl-alpha-methyldopamine; 4-Hydroxy-3-methoxyamphetamine; 3-O-Methyl-a-methyldopamine



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Michael A Darracq, Stephen L Thornton, Alicia B Minns, Roy R Gerona. A Case of 3,4-Dimethoxyamphetamine (3,4-DMA) and 3,4-Methylenedioxymethamphetamine (MDMA) Toxicity with Possible Metabolic Interaction. Journal of psychoactive drugs. 2016 Nov; 48(5):351-354. doi: 10.1080/02791072.2016.1225324. [PMID: 27636207]
  • Daniel Gomes da Silva, Paula Guedes de Pinho, Helena Pontes, Luísa Ferreira, Paula Branco, Fernando Remião, Félix Carvalho, M Lurdes Bastos, Helena Carmo. Gas chromatography-ion trap mass spectrometry method for the simultaneous measurement of MDMA (ecstasy) and its metabolites, MDA, HMA, and HMMA in plasma and urine. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Mar; 878(9-10):815-22. doi: 10.1016/j.jchromb.2010.01.042. [PMID: 20167546]
  • Erin A Kolbrich, Ross H Lowe, Marilyn A Huestis. Two-dimensional gas chromatography/electron-impact mass spectrometry with cryofocusing for simultaneous quantification of MDMA, MDA, HMMA, HMA, and MDEA in human plasma. Clinical chemistry. 2008 Feb; 54(2):379-87. doi: 10.1373/clinchem.2007.096800. [PMID: 18089653]
  • Sandra Valtier, Clyde F Phelix, John T Cody. Analysis of MDMA and its metabolites in urine and plasma following a neurotoxic dose of MDMA. Journal of analytical toxicology. 2007 Apr; 31(3):138-43. doi: 10.1093/jat/31.3.138. [PMID: 17579960]
  • Stephane O Pirnay, Tsadik T Abraham, Ross H Lowe, Marilyn A Huestis. Selection and optimization of hydrolysis conditions for the quantification of urinary metabolites of MDMA. Journal of analytical toxicology. 2006 Oct; 30(8):563-9. doi: 10.1093/jat/30.8.563. [PMID: 17132253]
  • Stephane O Pirnay, Tsadik T Abraham, Marilyn A Huestis. Sensitive gas chromatography-mass spectrometry method for simultaneous measurement of MDEA, MDMA, and metabolites HMA, MDA, and HMMA in human urine. Clinical chemistry. 2006 Sep; 52(9):1728-34. doi: 10.1373/clinchem.2006.069054. [PMID: 16858076]
  • Roland F Staack, Josef Fehn, Hans H Maurer. New designer drug p-methoxymethamphetamine: studies on its metabolism and toxicological detection in urine using gas chromatography-mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2003 Jun; 789(1):27-41. doi: 10.1016/s1570-0232(02)01018-8. [PMID: 12726841]
  • M Lanz, R Brenneisen, W Thormann. Enantioselective determination of 3,4-methylene-dioxymethamphetamine and two of its metabolites in human urine by cyclodextrin-modified capillary zone electrophoresis. Electrophoresis. 1997 Jun; 18(6):1035-43. doi: 10.1002/elps.1150180628. [PMID: 9221895]
  • H K Ensslin, K A Kovar, H H Maurer. Toxicological detection of the designer drug 3,4-methylenedioxyethylamphetamine (MDE, 'Eve') and its metabolites in urine by gas chromatography-mass spectrometry and fluorescence polarization immunoassay. Journal of chromatography. B, Biomedical applications. 1996 Aug; 683(2):189-97. doi: 10.1016/0378-4347(96)00129-6. [PMID: 8891915]
  • H K Lim, S Zeng, D M Chei, R L Foltz. Comparative investigation of disposition of 3,4-(methylenedioxy)methamphetamine (MDMA) in the rat and the mouse by a capillary gas chromatography-mass spectrometry assay based on perfluorotributylamine-enhanced ammonia positive ion chemical ionization. Journal of pharmaceutical and biomedical analysis. 1992 Sep; 10(9):657-65. doi: 10.1016/0731-7085(92)80094-4. [PMID: 1363061]
  • J W Hubbard, K Bailey, K K Midha, J K Cooper. 3-O-methyl-alpha-methyldopamine, a urinary metabolite of p-methoxyamphetamine in dog and monkey. Drug metabolism and disposition: the biological fate of chemicals. 1981 May; 9(3):250-4. doi: NULL. [PMID: 6113935]