Nitrosomethylnitroguanidine (BioDeep_00000181722)
human metabolite blood metabolite
代谢物信息卡片
N-Methyl-n-nitro-N-nitrosoguanidine
化学式: C2H5N5O3 (147.0392)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 5.37%
分子结构信息
SMILES: C(N=O)N(C(=N)N)[N+](=O)[O-]
InChI: InChI=1S/C2H5N5O3/c3-2(4)6(1-5-8)7(9)10/h1H2,(H3,3,4)
描述信息
D009676 - Noxae > D009153 - Mutagens > D009604 - Nitrosoguanidines
同义名列表
数据库引用编号
4 个数据库交叉引用编号
- PubChem: 20331539
- HMDB: HMDB0255663
- MeSH: Methylnitronitrosoguanidine
- chemspider: 15277857
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Fangyuan Zhu, Xiaoze Zhang, Junsong Wen, Yanqing Liu, Yaodong Zhu. Celastrus orbiculatus extract reverses precancerous lesions of gastric cancer by inhibiting autophagy via regulating the PDCD4-ATG5 signaling pathway.
The Journal of pharmacy and pharmacology.
2024 Mar; 76(3):257-268. doi:
10.1093/jpp/rgae006. [PMID: 38334432] - Yong He, Hong-Hong Liu, Xue-Lin Zhou, Ting-Ting He, Ao-Zhe Zhang, Xin Wang, Shi-Zhang Wei, Hao-Tian Li, Li-Sheng Chen, Lei Chang, Yan-Ling Zhao, Man-Yi Jing. Rutaecarpine Ameliorates Murine N-Methyl-N'-Nitro-N-Nitrosoguanidine-Induced Chronic Atrophic Gastritis by Sonic Hedgehog Pathway.
Molecules (Basel, Switzerland).
2023 Aug; 28(17):. doi:
10.3390/molecules28176294. [PMID: 37687125] - Dong Xie, Chao Wu, Dan Wang, Bahaji Azami Nisma Lena, Ningning Liu, Guan Ye, Mingyu Sun. Wei-fu-chun tablet halted gastric intestinal metaplasia and dysplasia associated with inflammation by regulating the NF-κB pathway.
Journal of ethnopharmacology.
2023 Aug; ?(?):117020. doi:
10.1016/j.jep.2023.117020. [PMID: 37567428] - Caicai Xi, Kang Feng, Xuan Chen, Hao Wu, Hongshan Chen, Hui Huang, Zeming Ren, Guanhai Dai, Xiaomin Xue, Huifang Zhou, Zhenmei Lu, Renzhao Wu. Granule Dendrobii suppresses chronic atrophic gastritis induced by N-methyl-N'-nitro-N-nitrosoguanidine by modulating the gastrointestinal bacteria in rats.
Cellular and molecular biology (Noisy-le-Grand, France).
2023 Jul; 69(7):205-211. doi:
10.14715/cmb/2023.69.7.33. [PMID: 37715378] - Yanning Zhu, Ruyun Ma, Wen Cheng, Mengyao Qin, Weiheng Guo, Ying Qi, Jianye Dai. Sijunzi decoction ameliorates gastric precancerous lesions via regulating oxidative phosphorylation based on proteomics and metabolomics.
Journal of ethnopharmacology.
2023 Jul; 318(Pt A):116925. doi:
10.1016/j.jep.2023.116925. [PMID: 37467821] - Huiqun Xie, Mengqing Hu, Jiao Yu, Xinyu Yang, Jinmiao Li, Nianjun Yu, Lan Han, Daiyin Peng. Mass spectrometry-based metabolomics reveal Dendrobium huoshanense polysaccharide effects and potential mechanism of N-methyl-N'-nitro-N-nitrosoguanidine -induced damage in GES-1 cells.
Journal of ethnopharmacology.
2023 Jun; 310(?):116342. doi:
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Journal of ethnopharmacology.
2023 Feb; 302(Pt A):115885. doi:
10.1016/j.jep.2022.115885. [PMID: 36328204] - Zhaofeng Liang, Jiajia Song, Yumeng Xu, Xinyi Zhang, Yue Zhang, Hui Qian. Hesperidin Reversed Long-Term N-methyl-N-nitro-N-Nitroguanidine Exposure Induced EMT and Cell Proliferation by Activating Autophagy in Gastric Tissues of Rats.
Nutrients.
2022 Dec; 14(24):. doi:
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Pharmaceutical biology.
2022 Dec; 60(1):87-95. doi:
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Biomedical chromatography : BMC.
2022 Sep; 36(9):e5414. doi:
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World journal of gastroenterology.
2022 Aug; 28(32):4668-4680. doi:
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BMC complementary medicine and therapies.
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Environmental toxicology.
2022 May; 37(5):1222-1230. doi:
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Phytomedicine : international journal of phytotherapy and phytopharmacology.
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Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2021 Aug; 46(16):4089-4095. doi:
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2021 May; 271(?):113893. doi:
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Molecular and cellular biochemistry.
2021 Mar; 476(3):1541-1554. doi:
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Dec; 120(?):109427. doi:
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Molecules (Basel, Switzerland).
2019 Jul; 24(14):. doi:
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Aug; 104(?):291-299. doi:
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Toxins.
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Medicine and science in sports and exercise.
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Archives of Iranian medicine.
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Biochemistry and cell biology = Biochimie et biologie cellulaire.
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Carbohydrate polymers.
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Mutation research.
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Gut microbes.
2011 Nov; 2(6):319-25. doi:
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Anaerobe.
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Prikladnaia biokhimiia i mikrobiologiia.
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Journal of digestive diseases.
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The Journal of reproduction and development.
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Singapore medical journal.
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Anti-cancer drugs.
2008 Oct; 19(9):885-90. doi:
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Clinical and experimental pharmacology & physiology.
2008 Oct; 35(10):1190-6. doi:
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Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine.
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Journal of virological methods.
2008 Jul; 151(1):101-6. doi:
10.1016/j.jviromet.2008.03.015. [PMID: 18462813] - Wenije Yang, Jing Chen, Weidong Li, Xiaobin Chen. [Preventive effects of 4 Se-enriched plants on rat stomach cancer induced by MNNG--3. Se accumulation and distribution in rats of different selenium resources for prevention of stomach cancer].
Wei sheng yan jiu = Journal of hygiene research.
2008 Jul; 37(4):435-7. doi:
NULL. [PMID: 18839527] - Pankaj Trivedi, Tongmin Sa. Pseudomonas corrugata (NRRL B-30409) Mutants Increased Phosphate Solubilization, Organic Acid Production, and Plant Growth at Lower Temperatures.
Current microbiology.
2008 Feb; 56(2):140-4. doi:
10.1007/s00284-007-9058-8. [PMID: 18026795] - Ganapathy Ekambaram, Peramaiyan Rajendran, Venkataraman Magesh, Dhanapal Sakthisekaran. Naringenin reduces tumor size and weight lost in N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in rats.
Nutrition research (New York, N.Y.).
2008 Feb; 28(2):106-12. doi:
10.1016/j.nutres.2007.12.002. [PMID: 19083396] - Wenjie Yang, Jing Chen, Weidong Li, Xiaobin Chen. [Preventive effects of 4 Se-enriched plants on rat stomach cancer induced by MNNG 2. Safety of different selenium resources for prevention of stomach cancer].
Wei sheng yan jiu = Journal of hygiene research.
2008 Jan; 37(1):90-2. doi:
. [PMID: 18421875] - P Manikandan, P Vidjaya Letchoumy, D Prathiba, S Nagini. Proliferation, angiogenesis and apoptosis-associated proteins are molecular targets for chemoprevention of MNNG-induced gastric carcinogenesis by ethanolic Ocimum sanctum leaf extract.
Singapore medical journal.
2007 Jul; 48(7):645-51. doi:
. [PMID: 17609827] - V Skourou, T Keramitsoglou, D Koussoulakou, V Mitashov, S Koussoulakos. Immunostimulation exacerbates the biological effects of chemical carcinogens.
Izvestiia Akademii nauk. Seriia biologicheskaia.
2007 Jul; ?(4):406-12. doi:
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Journal of ethnopharmacology.
2007 May; 112(1):199-202. doi:
10.1016/j.jep.2007.01.027. [PMID: 17324542] - Ramalingam Senthil Murugan, Kurapathy Venkata Poorna Chandra Mohan, Koji Uchida, Yukihiko Hara, Duvuru Prathiba, Siddavaram Nagini. Modulatory effects of black tea polyphenols on oxidant-antioxidant profile and expression of proliferation, apoptosis, and angiogenesis-associated proteins in the rat forestomach carcinogenesis model.
Journal of gastroenterology.
2007 May; 42(5):352-61. doi:
10.1007/s00535-007-2018-z. [PMID: 17530359] - Mihi Yang, Soo-Young Kim, Seong-Sil Chang, In-Seon Lee, Toshihiro Kawamoto. Urinary concentrations of bisphenol A in relation to biomarkers of sensitivity and effect and endocrine-related health effects.
Environmental and molecular mutagenesis.
2006 Oct; 47(8):571-8. doi:
10.1002/em.20230. [PMID: 16795089] - Hui-Zhen Li, Hong Wang, Guan-Qun Wang, Jie Liu, Shuang-Mei Zhao, Jie Chen, Qing-Wu Song, Wang Gao, Xiang-Zheng Qi, Qiang Gao. Treatment of gastric precancerous lesions with Weiansan.
World journal of gastroenterology.
2006 Sep; 12(33):5389-92. doi:
10.3748/wjg.v12.i33.5389. [PMID: 16981274] - K Regi Raphael, Mc Sabu, Kb Hari Kumar, Ramadasan Kuttan. Inhibition of N-Methyl N'-nitro-N-nitrosoguanidine (MNNG) induced gastric carcinogenesis by Phyllanthus amarus extract.
Asian Pacific journal of cancer prevention : APJCP.
2006 Apr; 7(2):299-302. doi:
. [PMID: 16839226] - Masanori Mazaki, Keiko Kataoka, Takemi Kinouchi, Usanee Vinitketkumnuen, Masami Yamada, Takehiko Nohmi, Tomomi Kuwahara, Shigeru Akimoto, Yoshinari Ohnishi. Inhibitory effects of caraway (Carum carvi L. ) and its component on N-methyl-N'-nitro-N-nitrosoguanidine-induced mutagenicity.
The journal of medical investigation : JMI.
2006 Feb; 53(1-2):123-33. doi:
10.2152/jmi.53.123. [PMID: 16538005] - Marcel Schmitt, Petra Schwanewilm, Jost Ludwig, Hella Lichtenberg-Fraté. Use of PMA1 as a housekeeping biomarker for assessment of toxicant-induced stress in Saccharomyces cerevisiae.
Applied and environmental microbiology.
2006 Feb; 72(2):1515-22. doi:
10.1128/aem.72.2.1515-1522.2006. [PMID: 16461706] - Su Juan Fei, Shu Dong Xiao, Yan Shen Peng, Xiao Yu Chen, Yao Shi. Chemopreventive effects of rofecoxib and folic acid on gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats.
Chinese journal of digestive diseases.
2006; 7(3):134-40. doi:
10.1111/j.1443-9573.2006.00258.x. [PMID: 16808793] - Sheng-Bing Wang, Feng Chen, Milton Sommerfeld, Qiang Hu. Isolation and proteomic analysis [corrected] of cell wall-deficient Haematococcus pluvialis mutants.
Proteomics.
2005 Dec; 5(18):4839-51. doi:
10.1002/pmic.200400092. [PMID: 16281177] - Samar Kumar Pal, Tapan Kumar Das. Biochemical characterization of N-methyl N'-nitro-N-nitrosoguanidine-induced cadmium resistant mutants of Aspergillus niger.
Journal of biosciences.
2005 Dec; 30(5):639-46. doi:
10.1007/bf02703564. [PMID: 16388138] - Ta Ajith, J P Subin, J Jacob, P S Sanjay, N V Babitha. Antimutagenic and anti-oxidant activities of the non-steroidal anti-inflammatory drug celecoxib.
Clinical and experimental pharmacology & physiology.
2005 Oct; 32(10):888-93. doi:
10.1111/j.1440-1681.2010.04280.x. [PMID: 16173952] - Yun Huang, Jing Shen, Ting Wang, Yan-Ke Yu, Fanqing F Chen, Jun Yang. A lipidomic study of the effects of N-methyl-N'-nitro-N-nitrosoguanidine on sphingomyelin metabolism.
Acta biochimica et biophysica Sinica.
2005 Aug; 37(8):515-24. doi:
10.1111/j.1745-7270.2005.00073.x. [PMID: 16077898] - Jun-Xiang Li, Zhi-Bin Wang, Ling-Qun Zhu, Fuling Zhu, Wei Cui. [Cell proliferation inhibitive and apoptosis promoting effects of sanchi extract on GES-1 cell after being transformed by MNNG].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2005 Aug; 25(8):719-22. doi:
NULL. [PMID: 16152831] - Tsung-Yin J Yeh, Juan I Sbodio, M T Audrey Nguyen, Tobias N Meyer, Ray M Lee, Nai-Wen Chi. Tankyrase-1 overexpression reduces genotoxin-induced cell death by inhibiting PARP1.
Molecular and cellular biochemistry.
2005 Aug; 276(1-2):183-92. doi:
10.1007/s11010-005-4059-z. [PMID: 16132700] - Yun Huang, Jun Yang, Jing Shen, Fanqing F Chen, Yingnian Yu. Sphingolipids are involved in N-methyl-N'-nitro-N-nitrosoguanidine-induced epidermal growth factor receptor clustering.
Biochemical and biophysical research communications.
2005 May; 330(2):430-8. doi:
10.1016/j.bbrc.2005.03.002. [PMID: 15796901] - R Kumaraguruparan, K V P Chandra Mohan, S K Abraham, S Nagini. Attenuation of N-methyl-N'-nitro-N-nitrosoguanidine induced genotoxicity and oxidative stress by tomato and garlic combination.
Life sciences.
2005 Mar; 76(19):2247-55. doi:
10.1016/j.lfs.2004.11.006. [PMID: 15733939] - Jun-Xiang Li, Zhi-Bin Wang, Ling-Qun Zhu, Fu-Ling Niu, Wei Cui. [Apoptosis-promoting effect of Panax notoginseng extracts on MNNG-transformed GES-1 cells].
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine.
2005 Mar; 3(2):123-7. doi:
10.3736/jcim20050212. [PMID: 15763060] - Nupur Raychaudhuri, Subrata K Das, Pran K Chakrabartty. Symbiotic effectiveness of a siderophore overproducing mutant of Mesorhizobium ciceri.
Polish journal of microbiology.
2005; 54(1):37-41. doi:
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Journal of medicinal food.
2005; 8(4):494-501. doi:
10.1089/jmf.2005.8.494. [PMID: 16379561] - G Rani, K Kaur, R Wadhwa, S C Kaul, A Nagpal. Evaluation of the anti-genotoxicity of leaf extract of Ashwagandha.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2005 Jan; 43(1):95-8. doi:
10.1016/j.fct.2004.07.021. [PMID: 15582200] - Zhi-Bin Wang, Jun-Xiang Li, Ling-Qun Zhu, Fu-Ling Niu, Wei Cui. [Inhibiting effects of Panax notoginseng extracts on proliferation of GES-1 cells and MNNG-transformed GES-1 cells].
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine.
2004 Nov; 2(6):445-9. doi:
10.3736/jcim20040613. [PMID: 15539025] - Sang Soo Kim, Liu Cao, Cuiling Li, Xiaoling Xu, L Julie Huber, Lewis A Chodosh, Chu-Xia Deng. Uterus hyperplasia and increased carcinogen-induced tumorigenesis in mice carrying a targeted mutation of the Chk2 phosphorylation site in Brca1.
Molecular and cellular biology.
2004 Nov; 24(21):9498-507. doi:
10.1128/mcb.24.21.9498-9507.2004. [PMID: 15485917] - Julie Beauséjour, Carole Beaulieu. Characterization of Streptomyces scabies mutants deficient in melanin biosynthesis.
Canadian journal of microbiology.
2004 Sep; 50(9):705-9. doi:
10.1139/w04-043. [PMID: 15644924] - Balaiya Velmurugan, Vaidhyanathan Bhuvaneswari, Suresh K Abraham, Siddavaram Nagini. Protective effect of tomato against N-methyl-N'-nitro-N-nitrosoguanidine-induced in vivo clastogenicity and oxidative stress.
Nutrition (Burbank, Los Angeles County, Calif.).
2004 Sep; 20(9):812-6. doi:
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Drug and chemical toxicology.
2004 Feb; 27(1):15-26. doi:
10.1081/dct-120027894. [PMID: 15038245] - Kazuaki Ninomiya, Motomu Nishioka, Masahiro Kino-oka, Masahito Taya. Differences in responses of plant hairy roots to chemical toxicity compared between primary and ramified roots.
Environmental sciences : an international journal of environmental physiology and toxicology.
2004; 11(5):283-91. doi:
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Journal of medicinal food.
2004; 7(3):334-9. doi:
10.1089/jmf.2004.7.334. [PMID: 15383228] - In-Seon Lee, Akiyoshi Nishikawa. Polyozellus multiplex, a Korean wild mushroom, as a potent chemopreventive agent against stomach cancer.
Life sciences.
2003 Nov; 73(25):3225-34. doi:
10.1016/j.lfs.2003.06.006. [PMID: 14561527] - S Arivazhagan, S Nagini, S T Santhiya, A Ramesh. N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced in vivo clastogenicity: protective effects of aqueous neem leaf extract.
Die Pharmazie.
2003 Oct; 58(10):750-2. doi:
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Die Pharmazie.
2003 Jul; 58(7):512-7. doi:
. [PMID: 12889539] - R Subapriya, S Nagini. Ethanolic neem leaf extract protects against N-methyl -N'-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in Wistar rats.
Asian Pacific journal of cancer prevention : APJCP.
2003 Jul; 4(3):215-23. doi:
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The EMBO journal.
2003 May; 22(9):2245-54. doi:
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