Nitrosomethane (BioDeep_00000181721)
human metabolite blood metabolite Volatile Flavor Compounds
代谢物信息卡片
Nitrosomethane
化学式: CH3NO (45.0214628)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN=O
InChI: InChI=1S/CH3NO/c1-2-3/h1H3
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
INOH(0)
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Carmen Arce, Sabela Diaz-Castroverde, María J Canales, José Marco-Contelles, Abdelouahid Samadi, María J Oset-Gasque, María P González. Drugs for stroke: action of nitrone (Z)-N-(2-bromo-5-hydroxy-4-methoxybenzylidene)-2-methylpropan-2-amine oxide on rat cortical neurons in culture subjected to oxygen-glucose-deprivation.
European journal of medicinal chemistry.
2012 Sep; 55(?):475-9. doi:
10.1016/j.ejmech.2012.07.032. [PMID: 22858224] - Serdar Dogan, Gulsum Ozlem Elpek, Esma Kirimlioglu Konuk, Nejdet Demir, Mutay Aslan. Measurement of intracellular biomolecular oxidation in liver ischemia-reperfusion injury via immuno-spin trapping.
Free radical biology & medicine.
2012 Aug; 53(3):406-14. doi:
10.1016/j.freeradbiomed.2012.05.028. [PMID: 22634144] - Ramón Soto-Otero, Estefanía Méndez-Álvarez, Sofía Sánchez-Iglesias, José Luís Labandeira-García, Jannette Rodríguez-Pallares, Fedor I Zubkov, Vladimir P Zaytsev, Leonid G Voskressensky, Alexey V Varlamov, Modesto de Candia, Filomena Fiorella, Cosimo Altomare. 2-Benzazepine nitrones protect dopaminergic neurons against 6-hydroxydopamine-induced oxidative toxicity.
Archiv der Pharmazie.
2012 Aug; 345(8):598-609. doi:
10.1002/ardp.201200007. [PMID: 22532340] - Yewei Sun, Gaoxiao Zhang, Zaijun Zhang, Pei Yu, Haijing Zhong, Jing Du, Yuqiang Wang. Novel multi-functional nitrones for treatment of ischemic stroke.
Bioorganic & medicinal chemistry.
2012 Jun; 20(12):3939-45. doi:
10.1016/j.bmc.2012.04.016. [PMID: 22579617] - Cesar N Tsumbu, Ginette Deby-Dupont, Monique Tits, Luc Angenot, Thierry Franck, Didier Serteyn, Ange Mouithys-Mickalad. Antioxidant and antiradical activities of Manihot esculenta Crantz (Euphorbiaceae) leaves and other selected tropical green vegetables investigated on lipoperoxidation and phorbol-12-myristate-13-acetate (PMA) activated monocytes.
Nutrients.
2011 09; 3(9):818-38. doi:
10.3390/nu3090818. [PMID: 22254126] - Carine Chevrier, Didier Le Nouën, Albert Defoin, Céline Tarnus. Synthesis of 4-amino-4,5-dideoxy-L-lyxofuranose derivatives and their evaluation as fucosidase inhibitors.
Carbohydrate research.
2011 Jul; 346(10):1202-11. doi:
10.1016/j.carres.2011.03.030. [PMID: 21550024] - Ting He, Sabrina Doblas, Debra Saunders, Rebba Casteel, Megan Lerner, Jerry W Ritchey, Tim Snider, Robert A Floyd, Rheal A Towner. Effects of PBN and OKN007 in rodent glioma models assessed by 1H MR spectroscopy.
Free radical biology & medicine.
2011 Jul; 51(2):490-502. doi:
10.1016/j.freeradbiomed.2011.04.037. [PMID: 21600283] - Angelike Triantafyllou, Alfiya Bikineyeva, Anna Dikalova, Rafal Nazarewicz, Stamatios Lerakis, Sergey Dikalov. Anti-inflammatory activity of Chios mastic gum is associated with inhibition of TNF-alpha induced oxidative stress.
Nutrition journal.
2011 Jun; 10(?):64. doi:
10.1186/1475-2891-10-64. [PMID: 21645369] - Sha Li, Hainan Chen, Xingli Wang, Jianfeng Wu, Jie Jiang, Yuqiang Wang. Pharmacokinetic study of a novel stroke therapeutic, 2-[[(1,1-dimethylethyl)oxidoimino]methyl]-3,5,6-trimethylpyrazine, by a simple HPLC-UV method in rats.
European journal of drug metabolism and pharmacokinetics.
2011 Jun; 36(2):95-101. doi:
10.1007/s13318-011-0032-2. [PMID: 21424683] - A Heather Eliassen, Donna Spiegelman, Bruce W Hollis, Ronald L Horst, Walter C Willett, Susan E Hankinson. Plasma 25-hydroxyvitamin D and risk of breast cancer in the Nurses' Health Study II.
Breast cancer research : BCR.
2011 May; 13(3):R50. doi:
10.1186/bcr2880. [PMID: 21569367] - Mei Jing Piao, Eun Sook Yoo, Young Sang Koh, Hee Kyoung Kang, Junoh Kim, Yong Jin Kim, Hak Hee Kang, Jin Won Hyun. Antioxidant effects of the ethanol extract from flower of Camellia japonica via scavenging of reactive oxygen species and induction of antioxidant enzymes.
International journal of molecular sciences.
2011; 12(4):2618-30. doi:
10.3390/ijms12042618. [PMID: 21731461] - Mei Jing Piao, Weon Jong Yoon, Hee Kyoung Kang, Eun Sook Yoo, Young Sang Koh, Dong Sam Kim, Nam Ho Lee, Jin Won Hyun. Protective effect of the ethyl acetate fraction of Sargassum muticum against ultraviolet B-irradiated damage in human keratinocytes.
International journal of molecular sciences.
2011; 12(11):8146-60. doi:
10.3390/ijms12118146. [PMID: 22174656] - Kiran S Panickar, Richard A Anderson. Effect of polyphenols on oxidative stress and mitochondrial dysfunction in neuronal death and brain edema in cerebral ischemia.
International journal of molecular sciences.
2011; 12(11):8181-207. doi:
10.3390/ijms12118181. [PMID: 22174658] - Tatiana Barichello, Ana Lucia B Santos, Cintia Silvestre, Jaqueline S Generoso, Andreza L Cipriano, Fabricia Petronilho, Felipe Dal-Pizzol, Clarissa M Comim, João Quevedo. Dexamethasone treatment reverses cognitive impairment but increases brain oxidative stress in rats submitted to pneumococcal meningitis.
Oxidative medicine and cellular longevity.
2011; 2011(?):173035. doi:
10.1155/2011/173035. [PMID: 22191010] - Zeen Tong, Appavu Chandrasekaran, William DeMaio, Robert Espina, Wei Lu, Ronald Jordan, JoAnn Scatina. Metabolism of vabicaserin in mice, rats, dogs, monkeys, and humans.
Drug metabolism and disposition: the biological fate of chemicals.
2010 Dec; 38(12):2266-77. doi:
10.1124/dmd.110.033670. [PMID: 20739639] - Huan Du, Xu Zhao, Jeong-Soon You, Ji-Yeon Park, Sung-Hoon Kim, Kyung-Ja Chang. Antioxidant and hepatic protective effects of lotus root hot water extract with taurine supplementation in rats fed a high fat diet.
Journal of biomedical science.
2010 Aug; 17 Suppl 1(?):S39. doi:
10.1186/1423-0127-17-s1-s39. [PMID: 20804615] - Kalina Ranguelova, Marcelo G Bonini, Ronald P Mason. (Bi)sulfite oxidation by copper, zinc-superoxide dismutase: Sulfite-derived, radical-initiated protein radical formation.
Environmental health perspectives.
2010 Jul; 118(7):970-5. doi:
10.1289/ehp.0901533. [PMID: 20348042] - Natarajan Arumugam, Raghavachary Raghunathan, Vellaisamy Shanmugaiah, Narayanasamy Mathivanan. Synthesis of novel beta-lactam fused spiroisoxazolidine chromanones and tetralones as potent antimicrobial agent for human and plant pathogens.
Bioorganic & medicinal chemistry letters.
2010 Jun; 20(12):3698-702. doi:
10.1016/j.bmcl.2010.04.084. [PMID: 20483609] - Mohamed D Morsy, Waleed N Hassan, Sherif I Zalat. Improvement of renal oxidative stress markers after ozone administration in diabetic nephropathy in rats.
Diabetology & metabolic syndrome.
2010 May; 2(1):29. doi:
10.1186/1758-5996-2-29. [PMID: 20465785] - Ana Navarro, Alberto Boveris. Brain mitochondrial dysfunction in aging, neurodegeneration, and Parkinson's disease.
Frontiers in aging neuroscience.
2010; 2(?):. doi:
10.3389/fnagi.2010.00034. [PMID: 20890446] - Mizanur Rahman, Ganesh V Halade, Arunabh Bhattacharya, Gabriel Fernandes. The fat-1 transgene in mice increases antioxidant potential, reduces pro-inflammatory cytokine levels, and enhances PPAR-gamma and SIRT-1 expression on a calorie restricted diet.
Oxidative medicine and cellular longevity.
2009 Nov; 2(5):307-16. doi:
10.4161/oxim.2.5.9579. [PMID: 20716918] - Beata Janowska, Marek Komisarski, Paulina Prorok, Beata Sokołowska, Jarosław Kuśmierek, Celina Janion, Barbara Tudek. Nucleotide excision repair and recombination are engaged in repair of trans-4-hydroxy-2-nonenal adducts to DNA bases in Escherichia coli.
International journal of biological sciences.
2009 Sep; 5(6):611-20. doi:
10.7150/ijbs.5.611. [PMID: 19834545] - Nobuyuki Endo, Shigeru Oowada, Yoshimi Sueishi, Masashi Shimmei, Keisuke Makino, Hirotada Fujii, Yashige Kotake. Serum hydroxyl radical scavenging capacity as quantified with iron-free hydroxyl radical source.
Journal of clinical biochemistry and nutrition.
2009 Sep; 45(2):193-201. doi:
10.3164/jcbn.08-265. [PMID: 19794928] - O Pinarbasli, Y Aktas, T Dalkara, K Andrieux, M J Alonso, E Fernandez-Megia, R Novoa-Carballal, R Riguera, P Couvreur, Y Capan. Preparation and evaluation of alpha-phenyl-n-tert-butyl nitrone (PBN)-encapsulated chitosan and PEGylated chitosan nanoparticles.
Die Pharmazie.
2009 Jul; 64(7):436-9. doi:
NULL. [PMID: 19694179] - Ramón Soto-Otero, Estefanía Méndez-Alvarez, Sofía Sánchez-Iglesias, Fedor I Zubkov, Leonid G Voskressensky, Alexey V Varlamov, Modesto de Candia, Cosimo Altomare. Inhibition of 6-hydroxydopamine-induced oxidative damage by 4,5-dihydro-3H-2-benzazepine N-oxides.
Biochemical pharmacology.
2008 Apr; 75(7):1526-37. doi:
10.1016/j.bcp.2007.12.010. [PMID: 18275937] - Yue-Hu Wang, Suo Gao, Fu-Mei Yang, Qian-Yun Sun, Jun-Song Wang, Hai-Yang Liu, Chun-Shun Li, Ying-Tong Di, Shun-Lin Li, Hong-Ping He, Xiao-Jiang Hao. Structure elucidation and biomimetic synthesis of hostasinine A, a new benzylphenethylamine alkaloid from Hosta plantaginea.
Organic letters.
2007 Dec; 9(25):5279-81. doi:
10.1021/ol702438h. [PMID: 17994756] - Victor L Serebruany. Hypokalemia, cardiac failure, and reporting NXY-059 safety for acute stroke.
Journal of cardiovascular pharmacology and therapeutics.
2006 Dec; 11(4):229-31. doi:
10.1177/1074248406297311. [PMID: 17220468] - Irfan Rahman. Antioxidant therapies in COPD.
International journal of chronic obstructive pulmonary disease.
2006; 1(1):15-29. doi:
10.2147/copd.2006.1.1.15. [PMID: 18046899] - György T Balogh, Zoltán Szántó, Erika Forrai, Werner Gyorffy, Antal Lopata. Use of reversed-phase liquid chromatography for determining the lipophilicity of alpha-aryl-N-cyclopropylnitrones.
Journal of pharmaceutical and biomedical analysis.
2005 Oct; 39(5):1057-62. doi:
10.1016/j.jpba.2005.05.019. [PMID: 16019180] - Rüdiger Hardeland, S R Pandi-Perumal. Melatonin, a potent agent in antioxidative defense: actions as a natural food constituent, gastrointestinal factor, drug and prodrug.
Nutrition & metabolism.
2005 Sep; 2(?):22. doi:
10.1186/1743-7075-2-22. [PMID: 16153306] - Dario C Ramirez, Sandra E Gomez Mejiba, Ronald P Mason. Copper-catalyzed protein oxidation and its modulation by carbon dioxide: enhancement of protein radicals in cells.
The Journal of biological chemistry.
2005 Jul; 280(29):27402-11. doi:
10.1074/jbc.m504241200. [PMID: 15905164] - György T Balogh, Krisztina Vukics, Arpád Könczöl, Agnes Kis-Varga, Anikó Gere, János Fischer. Nitrone derivatives of trolox as neuroprotective agents.
Bioorganic & medicinal chemistry letters.
2005 Jun; 15(12):3012-5. doi:
10.1016/j.bmcl.2005.04.043. [PMID: 15896960] - James J Ley, Alexey Vigdorchik, Ludmila Belayev, Weizhao Zhao, Raul Busto, Larissa Khoutorova, David A Becker, Myron D Ginsberg. Stilbazulenyl nitrone, a second-generation azulenyl nitrone antioxidant, confers enduring neuroprotection in experimental focal cerebral ischemia in the rat: neurobehavior, histopathology, and pharmacokinetics.
The Journal of pharmacology and experimental therapeutics.
2005 Jun; 313(3):1090-100. doi:
10.1124/jpet.105.083386. [PMID: 15716383] - Alison Hay, Mark J Burkitt, Clare M Jones, Richard C Hartley. Development of a new EPR spin trap, DOD-8C (N-[4-dodecyloxy-2-(7'-carboxyhept-1'-yloxy)benzylidene]-N-tert-butylamine N-oxide), for the trapping of lipid radicals at a predetermined depth within biological membranes.
Archives of biochemistry and biophysics.
2005 Mar; 435(2):336-46. doi:
10.1016/j.abb.2004.12.030. [PMID: 15708377] - Lichuan Yang, Noel Y Calingasan, Junyu Chen, James J Ley, David A Becker, M Flint Beal. A novel azulenyl nitrone antioxidant protects against MPTP and 3-nitropropionic acid neurotoxicities.
Experimental neurology.
2005 Jan; 191(1):86-93. doi:
10.1016/j.expneurol.2004.07.012. [PMID: 15589515] - Siv Jönsson, Yi-Fang Cheng, Charlotte Edenius, Kennedy R Lees, Tomas Odergren, Mats O Karlsson. Population pharmacokinetic modelling and estimation of dosing strategy for NXY-059, a nitrone being developed for stroke.
Clinical pharmacokinetics.
2005; 44(8):863-78. doi:
10.2165/00003088-200544080-00007. [PMID: 16029070] - Chang Won Choi, Jong Hee Hwang, Yun Sil Chang, Son Moon Shin, Won Soon Park, Munhyang Lee. Effects of alpha-phenyl-N-tert-butyl nitrone (PBN)on brain cell membrane function and energy metabolism during transient global cerebral hypoxia-ischemia and reoxygenation-reperfusion in newborn piglets.
Journal of Korean medical science.
2004 Jun; 19(3):413-8. doi:
10.3346/jkms.2004.19.3.413. [PMID: 15201509] - Kirk R Maples, A Richard Green, Robert A Floyd. Nitrone-related therapeutics: potential of NXY-059 for the treatment of acute ischaemic stroke.
CNS drugs.
2004; 18(15):1071-84. doi:
10.2165/00023210-200418150-00003. [PMID: 15581379] - A Richard Green, Tim Ashwood, Tomas Odergren, David M Jackson. Nitrones as neuroprotective agents in cerebral ischemia, with particular reference to NXY-059.
Pharmacology & therapeutics.
2003 Dec; 100(3):195-214. doi:
10.1016/j.pharmthera.2003.07.003. [PMID: 14652110] - Chris Gray, Hitoshi Nukada, David M Jackson, P Denise McMorran, A Wu, F Ma. Neuroprotective effects of nitrone radical scavenger S-PBN on reperfusion nerve injury in rats.
Brain research.
2003 Aug; 982(2):179-85. doi:
10.1016/s0006-8993(03)03006-3. [PMID: 12915253] - K W Colston, G Pirianov, E Bramm, K J Hamberg, L Binderup. Effects of Seocalcitol (EB1089) on nitrosomethyl urea-induced rat mammary tumors.
Breast cancer research and treatment.
2003 Aug; 80(3):303-11. doi:
10.1023/a:1024962316691. [PMID: 14503802] - Yunhui Wu, James T Farrell, Kari Lynn, Danielle Euler, Gloria Kwei, Tsang-Lin Hwang, Xue-Zhi Qin. The importance of chromatographic separation in LC/MS/MS quantitation of drugs in biological fluids: detection, characterization, and synthesis of a previously unknown low-level nitrone metabolite of a substance P antagonist.
Analytical chemistry.
2003 Feb; 75(3):426-34. doi:
10.1021/ac020572x. [PMID: 12585467] - Niklas Marklund, Sven Sihver, Bengt Långström, Mats Bergström, Lars Hillered. Effect of traumatic brain injury and nitrone radical scavengers on relative changes in regional cerebral blood flow and glucose uptake in rats.
Journal of neurotrauma.
2002 Oct; 19(10):1139-53. doi:
10.1089/08977150260337958. [PMID: 12427324] - Klaus Stolze, Natascha Udilova, Hans Nohl. Spin adducts of superoxide, alkoxyl, and lipid-derived radicals with EMPO and its derivatives.
Biological chemistry.
2002 May; 383(5):813-20. doi:
10.1515/bc.2002.085. [PMID: 12108546] - Klaus Stolze, Natascha Udilova, Hans Nohl. ESR analysis of spin adducts of alkoxyl and lipid-derived radicals with the spin trap Trazon.
Biochemical pharmacology.
2002 Apr; 63(8):1465-70. doi:
10.1016/s0006-2952(02)00887-0. [PMID: 11996887] - Egidija Sakiniene, L Vincent Collins. Combined antibiotic and free radical trap treatment is effective at combating Staphylococcus-aureus-induced septic arthritis.
Arthritis research.
2002; 4(3):196-200. doi:
10.1186/ar406. [PMID: 12010570] - N Marklund, T Lewander, F Clausen, L Hillered. Effects of the nitrone radical scavengers PBN and S-PBN on in vivo trapping of reactive oxygen species after traumatic brain injury in rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2001 Nov; 21(11):1259-67. doi:
10.1097/00004647-200111000-00002. [PMID: 11702041] - C P Novakov, D Feierman, A I Cederbaum, D A Stoyanovsky. An ESR and HPLC-EC assay for the detection of alkyl radicals.
Chemical research in toxicology.
2001 Sep; 14(9):1239-46. doi:
10.1021/tx015507h. [PMID: 11559038] - Z Zhao, M Cheng, K R Maples, J Y Ma, A M Buchan. NXY-059, a novel free radical trapping compound, reduces cortical infarction after permanent focal cerebral ischemia in the rat.
Brain research.
2001 Aug; 909(1-2):46-50. doi:
10.1016/s0006-8993(01)02618-x. [PMID: 11478919] - S Kotamraju, N Hogg, J Joseph, L K Keefer, B Kalyanaraman. Inhibition of oxidized low-density lipoprotein-induced apoptosis in endothelial cells by nitric oxide. Peroxyl radical scavenging as an antiapoptotic mechanism.
The Journal of biological chemistry.
2001 May; 276(20):17316-23. doi:
10.1074/jbc.m011731200. [PMID: 11278975] - A Heeres, H A van Doren, K F Gotlieb, I P Bleeker, J Bergsma, R M Kellogg. Synthesis, analysis and reduction of 2-nitropropyl starch.
Carbohydrate research.
2001 Jan; 330(2):191-204. doi:
10.1016/s0008-6215(00)00288-3. [PMID: 11217972]