Donepezil (BioDeep_00000018172)

   

human metabolite Chemicals and Drugs


代谢物信息卡片


2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one

化学式: C24H29NO3 (379.2147324)
中文名称: 多萘哌齐碱, 多奈哌齐
谱图信息: 最多检出来源 () 0%

Reviewed

Last reviewed on 2024-09-14.

Cite this Page

Donepezil. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/donepezil (retrieved 2024-11-08) (BioDeep RN: BioDeep_00000018172). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC
InChI: InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3

描述信息

Donepezil, marketed under the trade name Aricept (Eisai), is a centrally acting reversible acetyl cholinesterase inhibitor. Its main therapeutic use is in the treatment of Alzheimers disease where it is used to increase cortical acetylcholine. It has an oral bioavailability of 100\\% and easily crosses the blood-brain barrier. Because it has a half life of about 70 hours, it can be taken once a day. Initial dose is 5 mg per day, which can be increased to 10 mg per day after an adjustment period of at least 4 weeks. Donepezil is a centrally acting reversible acetyl cholinesterase inhibitor. Its main therapeutic use is in the treatment of Alzheimers disease where it is used to increase cortical acetylcholine. It is well absorbed in the gut with an oral bioavailability of 100\\% and easily crosses the blood-brain barrier. Because it has a half life of about 70 hours, it can be taken once a day. Currently, there is no definitive proof that use of donepezil or other similar agents alters the course or progression of Alzheimers disease. However, 6-12 month controlled studies have shown modest benefits in cognition and/or behavior. Pilot studies have reported that donepezil therapy may potentially have effects on markers of disease progression, such as hippocampal volume. Therefore, many neurologists, psychiatrists, and primary care physicians use donepezil in patients with Alzheimers disease. In 2005, the UK National Institute for Clinical Excellence (NICE) withdrew its recommendation for use of the drug for mild-to-moderate AD, on the basis that there is no significant improvement in functional outcome; Currently, there is no definitive proof that use of donepezil or other similar agents alters the course or progression of Alzheimers disease. However, 6-12 month controlled studies have shown modest benefits in cognition and/or behavior. Pilot studies have reported that donepezil therapy may potentially have effects on markers of disease progression, such as hippocampal volume. Therefore, many neurologists, psychiatrists, and primary care physicians use donepezil in patients with Alzheimers disease. In 2005, the UK National Institute for Clinical Excellence (NICE) withdrew its recommendation for use of the drug for mild-to-moderate AD, on the basis that there is no significant improvement in functional outcome; of quality of life or of behavioral symptoms. However, NICE revised its guidelines to suggest that donepezil be used in moderate stage patients for whom the evidence is strongest. While the drug is currently indicated for mild to moderate Alzheimers, there is also evidence from 2 trials that it may be effective for moderate to severe disease. An example of this is a Karolinska Institute paper published in The Lancet in early 2006, which states that donepezil improves cognitive function even in patients with severe Alzheimers disease symptoms. of quality of life or of behavioral symptoms. However, NICE revised its guidelines to suggest that donepezil be used in moderate stage patients for whom the evidence is strongest. While the drug is currently indicated for mild to moderate Alzheimers, there is also evidence from 2 trials that it may be effective for moderate to severe disease. An example of this is a Karolinska Institute paper published in The Lancet in early 2006, which states that donepezil improves cognitive function even in patients with severe Alzheimers disease symptoms.
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors
N - Nervous system > N06 - Psychoanaleptics > N06D - Anti-dementia drugs > N06DA - Anticholinesterases
D002491 - Central Nervous System Agents > D018697 - Nootropic Agents
C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor
D004791 - Enzyme Inhibitors

同义名列表

11 个代谢物同义名

2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one; 1-Benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine hydrochloride; Donepezilium oxalate trihydrate; Donepezil Hydrochloride; Aricept odt; Donepezilum; Donepezilo; donepezil; Aricept; Donaz; Eranz



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Haifei Lu, Aihua Tan, Yini Zhang, Yumeng Chen, Simiao Ran, Ping Wang. Neuroprotective effects of Shenghui decoction via inhibition of the JNK/p38 MAPK signaling pathway in an AlCl3-induced zebrafish (Danio rerio) model of Alzheimer's disease. Journal of ethnopharmacology. 2024 Jun; 328(?):117993. doi: 10.1016/j.jep.2024.117993. [PMID: 38423408]
  • Eshani Mahajan, Anupam Raja, Amit Raj Sharma, Ashish Jain, Praisy K Prabha, Ajay Prakash, Bikash Medhi. To evaluate the effect of endothelin receptor agonist IRL-1620 alone and in combination with donepezil in modulating neurodegeneration elicited by amyloid-β in rats. Experimental neurology. 2024 May; 375(?):114720. doi: 10.1016/j.expneurol.2024.114720. [PMID: 38342181]
  • Tushar Agarwal, Suman Manandhar, Harish Kumar B, Ademola C Famurewa, Prasada Chowdari Gurram, Ramya Shri Suggala, Runali Sankhe, Jayesh Mudgal, K Sreedhara Ranganath Pai. Oxyresveratrol-β-cyclodextrin mitigates streptozotocin-induced Alzheimer's model cognitive impairment, histone deacetylase activity in rats: in silico & in vivo studies. Scientific reports. 2024 04; 14(1):9897. doi: 10.1038/s41598-024-57188-7. [PMID: 38688962]
  • Rei Funahashi, Fumiaki Matsuura, Masayuki Ninomiya, Sayo Okabe, Shigeo Takashima, Kaori Tanaka, Atsuyoshi Nishina, Mamoru Koketsu. Hybrid pharmacophore design and synthesis of donepezil-inspired aurone derivative salts as multifunctional acetylcholinesterase inhibitors. Bioorganic chemistry. 2024 Apr; 145(?):107229. doi: 10.1016/j.bioorg.2024.107229. [PMID: 38401360]
  • Sun Linjuan, L I Chengfu, Liu Jiangang, L I Nannan, Han Fuhua, Qiao Dandan, Tao Zhuang, Zhan Min, Chen Wenjie, Zhang Xiaohui, Tong Chenguang, Chen Dong, Qi Jiangxia, Liu Yang, Liang Xiao, Zheng Xiaoying, Zhang Yunling. Efficacy of Sailuotong on neurovascular unit in amyloid precursor protein/presenilin-1 transgenic mice with Alzheimer's disease. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2024 Apr; 44(2):289-302. doi: 10.19852/j.cnki.jtcm.20240203.007. [PMID: 38504535]
  • Doha M Beltagy, Nagat F Nawar, Tarek M Mohamed, Ehab Tousson, Mai M El-Keey. The synergistic effect of nanocurcumin and donepezil on Alzheimer's via PI3K/AKT/GSK-3β pathway modulating. Prostaglandins & other lipid mediators. 2024 Feb; 170(?):106791. doi: 10.1016/j.prostaglandins.2023.106791. [PMID: 37918555]
  • Mohan Gupta, Swati Pant, Preeti Rana, Avinash Kumar, Chakrawarti Prasun, Maya S Nair, Sarvesh Paliwal, Sumitra Nain. Investigation, scaffold hopping of novel donepezil-based compounds as anti-Alzhiemer's agents: synthesis, in-silico and pharmacological evaluations. Scientific reports. 2024 01; 14(1):1687. doi: 10.1038/s41598-024-51713-4. [PMID: 38242995]
  • Ismaheel Akinwale Adeniyi, Peace Oluwafolakemi Oregbesan, Adegboyega Adesanya, Mujeedat Adebukola Olubori, Gbenga Stanley Olayinka, Abayomi Mayowa Ajayi, Samuel Adetunji Onasanwo. Olax subscorpioidea prevented scopolamine-induced memory impairment through the prevention of oxido-inflammatory damage and modulation of cholinergic transmission. Journal of ethnopharmacology. 2024 Jan; 318(Pt B):116995. doi: 10.1016/j.jep.2023.116995. [PMID: 37541399]
  • Yi Zhou, Ying He, Xue Teng, Jing Mi, Jing Yang, Rongrui Wei, Wenmin Liu, Qinge Ma, Zhenghuai Tan, Zhipei Sang. Development of novel salicylic acid-donepezil-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease. Journal of enzyme inhibition and medicinal chemistry. 2023 Dec; 38(1):2231661. doi: 10.1080/14756366.2023.2231661. [PMID: 37414563]
  • Sung Bae Kim, Hyun Yeoul Ryu, Woo Nam, So Min Lee, Mi Ran Jang, Youn Gil Kwak, Gyoo Il Kang, Kyung Seok Song, Jae Won Lee. The Neuroprotective Effects of Dendropanax morbifera Water Extract on Scopolamine-Induced Memory Impairment in Mice. International journal of molecular sciences. 2023 Nov; 24(22):. doi: 10.3390/ijms242216444. [PMID: 38003650]
  • Avinash R Tekade, Mayuri R Suryavanshi, Ashutosh B Shewale, Vilas S Patil. Design and development of donepezil hydrochloride loaded nanostructured lipid carriers for efficient management of Alzheimer's disease. Drug development and industrial pharmacy. 2023 Sep; 49(9):590-600. doi: 10.1080/03639045.2023.2262035. [PMID: 37733474]
  • Manfei Xu, Yuebing Yue, Jie Huang. Efficacy evaluation and metabolomics analysis of Huanglian Jiedu decoction in combination with donepezil for Alzheimer's disease treatment. Journal of pharmaceutical and biomedical analysis. 2023 Jul; 235(?):115610. doi: 10.1016/j.jpba.2023.115610. [PMID: 37542831]
  • Shenwei Li, Dongyan Wang, Yiyin Zhang, Hong Huo, Yue Liu, Yiyan Wang, Dongxue Zhao, Xu Dong, Hongyan Zhang. The efficacy of acupuncture combined with other therapies in post stroke cognitive impairment: A network meta-analysis. Medicine. 2023 Jul; 102(29):e34086. doi: 10.1097/md.0000000000034086. [PMID: 37478264]
  • Aliasgar F Shahiwala, Samar Salam Qawoogha, Nuruzzaman Faruqui. Designing Optimum Drug Delivery Systems Using Machine Learning Approaches: a Prototype Study of Niosomes. AAPS PharmSciTech. 2023 Apr; 24(4):94. doi: 10.1208/s12249-023-02547-2. [PMID: 37012582]
  • Yongbo Xue, Andrei I Savchenko, Kylie A Agnew-Francis, Jared A Miles, Tina Holt, Hieng Lu, Sharon Chow, Paul I Forster, Glen M Boyle, Benjamin P Ross, Katja Fischer, Andrei G Kutateladze, Craig M Williams. seco-Pregnane Glycosides from Australian Caustic Vine (Cynanchum viminale subsp. australe). Journal of natural products. 2023 Feb; ?(?):. doi: 10.1021/acs.jnatprod.2c01037. [PMID: 36795946]
  • Eman M Elbaz, Reham M Essam, Kawkab A Ahmed, Maheera H Safwat. Donepezil halts acetic acid-induced experimental colitis in rats and its associated cognitive impairment through regulating inflammatory/oxidative/apoptotic cascades: An add-on to its anti-dementia activity. International immunopharmacology. 2023 Feb; 116(?):109841. doi: 10.1016/j.intimp.2023.109841. [PMID: 36764270]
  • Yogesh Chand Yadav, Satyanarayan Pattnaik. Hesperetin-loaded polymeric nanofibers: assessment of bioavailability and neuroprotective effect. Drug development and industrial pharmacy. 2023 Feb; 49(2):240-247. doi: 10.1080/03639045.2023.2201625. [PMID: 37032647]
  • Yuqiu Yang, Yufeng Gao, Chelimoge Wang. [Mongolian medicine Heisuga-25 promotes the expression of neuroskeletal protein, increases the content of neurotransmitter and improves the symptoms of Alzheimer's disease in mice]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 2023 Feb; 39(2):153-158. doi: . [PMID: 36872434]
  • Mustafa K Shehata, Assem A Ismail, Maher A Kamel. Combined Donepezil with Astaxanthin via Nanostructured Lipid Carriers Effective Delivery to Brain for Alzheimer's Disease in Rat Model. International journal of nanomedicine. 2023; 18(?):4193-4227. doi: 10.2147/ijn.s417928. [PMID: 37534058]
  • Yuanyuan Wang, Baichen Xiong, Hongzhi Lin, Qi Li, Hongyu Yang, Yuting Qiao, Qihang Li, Ziwei Xu, Weiping Lyu, Wei Qu, Wenyuan Liu, Yao Chen, Feng Feng, Haopeng Sun. Design, synthesis and evaluation of fused hybrids with acetylcholinesterase inhibiting and Nrf2 activating functions for Alzheimer's disease. European journal of medicinal chemistry. 2022 Dec; 244(?):114806. doi: 10.1016/j.ejmech.2022.114806. [PMID: 36223681]
  • Bingliang Lian, Jingwen Gu, Chen Zhang, Zhicong Zou, Meng Yu, Fanghong Li, Xiaoli Wu, Allan Zijian Zhao. Protective effects of isofraxidin against scopolamine-induced cognitive and memory impairments in mice involve modulation of the BDNF-CREB-ERK signaling pathway. Metabolic brain disease. 2022 12; 37(8):2751-2762. doi: 10.1007/s11011-022-00980-z. [PMID: 35921056]
  • De-Feng Liu, Ming Bai, Ning-Ning Du, Shuai Shen, Zhi-Yuan Li, Xin Zhang, Rui Guo, Guo-Dong Yao, Shao-Jiang Song, Xiao-Xiao Huang. Insight into Isolation and Characterization of Phenolic Compounds from Hawthorn (Crataegus pinnatifida Bge.) with Antioxidant, Anti-Acetylcholinesterase, and Neuroprotective Activities. Plant foods for human nutrition (Dordrecht, Netherlands). 2022 Dec; 77(4):538-544. doi: 10.1007/s11130-022-01004-y. [PMID: 35986175]
  • Xin-Chen Wang, Chen-Liang Chu, Kuan Lu, Xi Chen, Xiao-Qian Jin, Shi-Jian Quan. The role of tonifying kidney decoction and acupuncture in the treatment of Alzheimer's disease: A network meta-analysis. Medicine. 2022 Nov; 101(46):e31243. doi: 10.1097/md.0000000000031243. [PMID: 36401402]
  • Opeyemi B Ogunsuyi, Folorunsho B Omage, Omamuyovwi M Ijomone, Ganiyu Oboh, João B T Rocha. Effect of chlorogenic acid plus donepezil on critical neurocortical enzyme activities, inflammatory markers, and synaptophysin immunoreactivity in scopolamine-assaulted rats, supported by multiple ligand simultaneous docking. Journal of food biochemistry. 2022 11; 46(11):e14312. doi: 10.1111/jfbc.14312. [PMID: 35791518]
  • Yibin Hu, Lijuan Zhang, Xiuju Guan, Hanru Hou, Shuyue Bi, Changning Liu, Mingxiang Li, Kangfeng Wang. Gunao-Yizhi decoction combined with donepezil for vascular dementia: A systematic review and meta-analysis. Medicine. 2022 Oct; 101(40):e30971. doi: 10.1097/md.0000000000030971. [PMID: 36221397]
  • Zhipei Sang, Ping Bai, Yujuan Ban, Keren Wang, Anguo Wu, Jing Mi, Jiaqi Hu, Rui Xu, Gaofeng Zhu, Jianta Wang, Jiquan Zhang, Changning Wang, Zhenghuai Tan, Lei Tang. Novel donepezil-chalcone-rivastigmine hybrids as potential multifunctional anti-Alzheimer's agents: Design, synthesis, in vitro biological evaluation, in vivo and in silico studies. Bioorganic chemistry. 2022 10; 127(?):106007. doi: 10.1016/j.bioorg.2022.106007. [PMID: 35849893]
  • Opeyemi Babatunde Ogunsuyi, Olayemi Philemon Aro, Ganiyu Oboh, Olawande Chinedu Olagoke. Curcumin improves the ability of donepezil to ameliorate memory impairment in Drosophila melanogaster: involvement of cholinergic and cnc/Nrf2-redox systems. Drug and chemical toxicology. 2022 Sep; ?(?):1-9. doi: 10.1080/01480545.2022.2119995. [PMID: 36069210]
  • Qin-Hui Fu, Jian Pei, Hou-Guang Zhou, Tao Wang, Yi-Jun Zhan, Lin Tao, Jia Xu, Qian Zhou, Liao-Yao Wang. Effect of acupuncture with donepezil based on syndrome differentiation on cognitive function in patients with mild-to-moderate Alzheimer's disease: a study protocol for a multicenter randomized controlled trial. Trials. 2022 Aug; 23(1):695. doi: 10.1186/s13063-022-06532-1. [PMID: 35986297]
  • Qiang Yang, Jia Liu, Kai-Lin Huang, Guang-Yao Wang, Mi-Yuan Wang, Ai-Hua Tan, Si-Miao Ran. A systematic review of the efficacy of donepezil hydrochloride combined with nimodipine on treating vascular dementia. Medicine. 2022 Aug; 101(31):e29307. doi: 10.1097/md.0000000000029307. [PMID: 35945739]
  • Meihua Li, Can Zheng, Toru Kawada, Kazunori Uemura, Masashi Inagaki, Keita Saku, Masaru Sugimachi. Early donepezil monotherapy or combination with metoprolol significantly prevents subsequent chronic heart failure in rats with reperfused myocardial infarction. The journal of physiological sciences : JPS. 2022 Jun; 72(1):12. doi: 10.1186/s12576-022-00836-2. [PMID: 35725377]
  • Hien Thu Nguyen, Xoan Thi Le, Tai Van Nguyen, Hoa Nhu Phung, Hang Thi Nguyet Pham, Khoi Minh Nguyen, Kinzo Matsumoto. Ursolic acid and its isomer oleanolic acid are responsible for the anti-dementia effects of Ocimum sanctum in olfactory bulbectomized mice. Journal of natural medicines. 2022 Jun; 76(3):621-633. doi: 10.1007/s11418-022-01609-2. [PMID: 35218459]
  • Ayokunle O Ademosun, Adeniyi A Adebayo, Temitope V Popoola, Ganiyu Oboh. Shaddock (Citrus maxima) peels extract restores cognitive function, cholinergic and purinergic enzyme systems in scopolamine-induced amnesic rats. Drug and chemical toxicology. 2022 May; 45(3):1073-1080. doi: 10.1080/01480545.2020.1808668. [PMID: 32847424]
  • Yan-Wen Huang, Li Ding, YuanMing Chen, Weichen Lin, Fei Lin, Yunsheng Hsieh. 2-μm fused-core column ultra-high-performance liquid chromatography/tandem mass spectrometric determination of donepezil in human plasma: Application to a bioequivalence study. Journal of pharmaceutical and biomedical analysis. 2022 Mar; 211(?):114596. doi: 10.1016/j.jpba.2022.114596. [PMID: 35104737]
  • Yichun Shi, Heng Zhang, Qing Song, Guangjun Yu, Zhuoling Liu, Feng Zhong, Zhenghuai Tan, Xiuxiu Liu, Yong Deng. Development of novel 2-aminoalkyl-6-(2-hydroxyphenyl)pyridazin-3(2H)-one derivatives as balanced multifunctional agents against Alzheimer's disease. European journal of medicinal chemistry. 2022 Feb; 230(?):114098. doi: 10.1016/j.ejmech.2021.114098. [PMID: 35026532]
  • Xiaokang Li, Jinwen Li, Yunyuan Huang, Qi Gong, Yan Fu, Yixiang Xu, Junyang Huang, Haolan You, Dong Zhang, Dan Zhang, Fei Mao, Jin Zhu, Huan Wang, Haiyan Zhang, Jian Li. The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression. European journal of medicinal chemistry. 2022 Feb; 229(?):114045. doi: 10.1016/j.ejmech.2021.114045. [PMID: 34922191]
  • Shatw Khalid Ali, Rojgar H Ali. Effects of antidiabetic agents on Alzheimer's disease biomarkers in experimentally induced hyperglycemic rat model by streptozocin. PloS one. 2022; 17(7):e0271138. doi: 10.1371/journal.pone.0271138. [PMID: 35802659]
  • Fangcheng Fan, Hua Liu, Xiaojie Shi, Yangwen Ai, Qingshan Liu, Yong Cheng. The Efficacy and Safety of Alzheimer's Disease Therapies: An Updated Umbrella Review. Journal of Alzheimer's disease : JAD. 2022; 85(3):1195-1204. doi: 10.3233/jad-215423. [PMID: 34924395]
  • Mahdieh Anoush, Nasrin Tayebi, Soroush Bijani, Mina Ebrahimi, Ali Reza Yazdinezhad, Mir-Jamal Hosseini. Thymus daenensis extract prevents scopolamine‑induced memory impairment through declining oxidative stress in rats. Acta neurobiologiae experimentalis. 2022; 82(3):380-388. doi: 10.55782/ane-2022-036. [PMID: 36214720]
  • Ping-Song Chou, Ling-Chun Huang, Tzyh-Chyuan Hour, Chen-Wen Yen, Yuan-Han Yang. Impact of the CYP2D6 single nucleotide polymorphism on the concentration of and therapeutic response to donepezil in mild-to-moderate Alzheimer's disease. Journal of the Formosan Medical Association = Taiwan yi zhi. 2022 Jan; 121(1 Pt 2):409-415. doi: 10.1016/j.jfma.2021.05.026. [PMID: 34120801]
  • Shuai-Nan Zheng, Long Pan, Ai-Mei Liao, Yin-Chen Hou, Guang-Hai Yu, Xiao-Xiao Li, Yong-Jian Yuan, Yu-Qi Dong, Zi-Shan Zhang, Cui-Zhu Tian, Zeng-Liang Liu, Wen-Jin Lin, Ming Hui, Jian Cao, Ji-Hong Huang. Wheat embryo globulin nutrients ameliorate d-galactose and aluminum chloride-induced cognitive impairment in rats. Brain research. 2021 12; 1773(?):147672. doi: 10.1016/j.brainres.2021.147672. [PMID: 34606748]
  • Tajudeen O Obafemi, Olutumise V Owolabi, Benjamin O Omiyale, Blessing A Afolabi, Oluwafemi A Ojo, Amos Onasanya, Isaac A I Adu, Damilare Rotimi. Combination of donepezil and gallic acid improves antioxidant status and cholinesterases activity in aluminum chloride-induced neurotoxicity in Wistar rats. Metabolic brain disease. 2021 12; 36(8):2511-2519. doi: 10.1007/s11011-021-00749-w. [PMID: 33978901]
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  • Hsin-Miao Wang, Li-Min Liou, Chung-Yao Hsu, Hsiu-Fen Lin. Letter to the editor: Donepezil-induced parkinsonism in end-stage renal disease. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2021 Nov; 42(11):4809-4812. doi: 10.1007/s10072-021-05522-6. [PMID: 34346013]
  • Mingcui Zheng, Zhenhong Liu, Lulu Mana, Gaofeng Qin, Shuaiyang Huang, Zhuoyan Gong, Meijing Tian, Yannan He, Pengwen Wang. Shenzhiling oral liquid protects the myelin sheath against Alzheimer's disease through the PI3K/Akt-mTOR pathway. Journal of ethnopharmacology. 2021 Oct; 278(?):114264. doi: 10.1016/j.jep.2021.114264. [PMID: 34082015]
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