Nitroflurbiprofen (BioDeep_00000181711)

   

human metabolite blood metabolite


代谢物信息卡片


4-(Nitrooxy)butyl 2-fluoro-alpha-methyl-(1,1-biphenyl)-4-acetic acid

化学式: C19H20FNO5 (361.13254420000004)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C(=O)OCCCCO[N+]([O-])=O)C1=CC(F)=C(C=C1)C1=CC=CC=C1
InChI: InChI=1S/C19H20FNO5/c1-14(19(22)25-11-5-6-12-26-21(23)24)16-9-10-17(18(20)13-16)15-7-3-2-4-8-15/h2-4,7-10,13-14H,5-6,11-12H2,1H3

描述信息

C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
C471 - Enzyme Inhibitor > C1323 - Cyclooxygenase Inhibitor

同义名列表

10 个代谢物同义名

4-(Nitrooxy)butyl 2-fluoro-alpha-methyl-(1,1-biphenyl)-4-acetic acid; 4-(Nitrooxy)butyl 2-fluoro-a-methyl-(1,1-biphenyl)-4-acetic acid; 4-(Nitrooxy)butyl 2-fluoro-α-methyl-(1,1-biphenyl)-4-acetic acid; 4-(Nitrooxy)butyl 2-fluoro-alpha-methyl-(1,1-biphenyl)-4-acetate; 4-(Nitrooxy)butyl 2-fluoro-α-methyl-(1,1-biphenyl)-4-acetate; 4-(nitrooxy)butyl 2-{2-fluoro-[1,1-biphenyl]-4-yl}propanoate; 4-(Nitrooxy)butyl 2-fluoro-a-methyl-(1,1-biphenyl)-4-acetate; Nitroxybutyl flurbiprofen; Flurbinitroxybutylester; Nitroflurbiprofen



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Wim Laleman, Lien Van Landeghem, Ingrid Van der Elst, Marcel Zeegers, Johan Fevery, Frederik Nevens. Nitroflurbiprofen, a nitric oxide-releasing cyclooxygenase inhibitor, improves cirrhotic portal hypertension in rats. Gastroenterology. 2007 Feb; 132(2):709-19. doi: 10.1053/j.gastro.2006.12.041. [PMID: 17258737]
  • F Anuar, M Whiteman, M Bhatia, P K Moore. Flurbiprofen and its nitric oxide-releasing derivative protect against septic shock in rats. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2006 Nov; 55(11):498-503. doi: 10.1007/s00011-006-5150-y. [PMID: 17122968]
  • Mirco Govoni, Simona Casagrande, Raffaella Maucci, Valerio Chiroli, Paola Tocchetti. In vitro metabolism of (nitrooxy)butyl ester nitric oxide-releasing compounds: comparison with glyceryl trinitrate. The Journal of pharmacology and experimental therapeutics. 2006 May; 317(2):752-61. doi: 10.1124/jpet.105.097469. [PMID: 16424150]
  • Farhana Anuar, Matthew Whiteman, Jia Ling Siau, Shing Erl Kwong, Madhav Bhatia, Philip K Moore. Nitric oxide-releasing flurbiprofen reduces formation of proinflammatory hydrogen sulfide in lipopolysaccharide-treated rat. British journal of pharmacology. 2006 Apr; 147(8):966-74. doi: 10.1038/sj.bjp.0706696. [PMID: 16491094]
  • Paula Zacharowski, Kai Zacharowski, Clare Donnellan, Atholl Johnston, Ivana Vojnovic, Pablo Forte, Piero Del Soldato, Nigel Benjamin, Sharon O'Byrne. The effects and metabolic fate of nitroflurbiprofen in healthy volunteers. Clinical pharmacology and therapeutics. 2004 Oct; 76(4):350-8. doi: 10.1016/j.clpt.2004.05.008. [PMID: 15470334]
  • Anderson Ricardo Roman Gonçalves, Clarice Kazue Fujihara, Ana Lúcia Mattar, Denise Maria Avancini Costa Malheiros, Irene de Lourdes Noronha, Gilberto de Nucci, Roberto Zatz. Renal expression of COX-2, ANG II, and AT1 receptor in remnant kidney: strong renoprotection by therapy with losartan and a nonsteroidal anti-inflammatory. American journal of physiology. Renal physiology. 2004 May; 286(5):F945-54. doi: 10.1152/ajprenal.00238.2003. [PMID: 15075190]
  • Li Ma, Piero del Soldato, John L Wallace. Divergent effects of new cyclooxygenase inhibitors on gastric ulcer healing: Shifting the angiogenic balance. Proceedings of the National Academy of Sciences of the United States of America. 2002 Oct; 99(20):13243-7. doi: 10.1073/pnas.202392199. [PMID: 12232050]
  • Giancarlo Aldini, Marina Carini, Marica Orioli, Roberto Maffei Facino, Gary L Wenk. Metabolic profile of NO-flurbiprofen (HCT1026) in rat brain and plasma: a LC-MS study. Life sciences. 2002 Aug; 71(13):1487-500. doi: 10.1016/s0024-3205(02)01915-x. [PMID: 12127904]
  • Pasquale Maffia, Angela Ianaro, Raffella Sorrentino, Laura Lippolis, Francesco M Maiello, Piero del Soldato, Armando Ialenti, Giuseppe Cirino. Beneficial effects of NO-releasing derivative of flurbiprofen (HCT-1026) in rat model of vascular injury and restenosis. Arteriosclerosis, thrombosis, and vascular biology. 2002 Feb; 22(2):263-7. doi: 10.1161/hq0202.104064. [PMID: 11834526]
  • J Keeble, O A Al-Swayeh, P K Moore. Vasorelaxant effect of nitric oxide releasing steroidal and nonsteroidal anti-inflammatory drugs. British journal of pharmacology. 2001 Aug; 133(7):1023-8. doi: 10.1038/sj.bjp.0704161. [PMID: 11487511]
  • C K Fujihara, D M Malheiros, J L Donato, A Poli, G De Nucci, R Zatz. Nitroflurbiprofen, a new nonsteroidal anti-inflammatory, ameliorates structural injury in the remnant kidney. The American journal of physiology. 1998 03; 274(3):F573-9. doi: 10.1152/ajprenal.1998.274.3.f573. [PMID: 9530274]
  • G Cirino, C Cicala, F Mancuso, A R Baydoun, J L Wallace. Flurbinitroxybutylester: a novel anti-inflammatory drug has enhanced antithrombotic activity. Thrombosis research. 1995 Jul; 79(1):73-81. doi: 10.1016/0049-3848(95)00092-6. [PMID: 7495106]
  • J L Wallace, B Reuter, C Cicala, W McKnight, M B Grisham, G Cirino. Novel nonsteroidal anti-inflammatory drug derivatives with markedly reduced ulcerogenic properties in the rat. Gastroenterology. 1994 Jul; 107(1):173-9. doi: 10.1016/0016-5085(94)90074-4. [PMID: 8020659]