Nimesulide (BioDeep_00000181678)
human metabolite blood metabolite
代谢物信息卡片
化学式: C13H12N2O5S (308.0466902)
中文名称: 尼美舒利
谱图信息:
最多检出来源 Homo sapiens(blood) 95.83%
分子结构信息
SMILES: CS(=O)(=O)NC1=C(C=C(C=C1)[N+](=O)[O-])OC2=CC=CC=C2
InChI: InChI=1S/C13H12N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h2-9,14H,1H3
描述信息
M - Musculo-skeletal system > M02 - Topical products for joint and muscular pain > M02A - Topical products for joint and muscular pain > M02AA - Antiinflammatory preparations, non-steroids for topical use
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
C471 - Enzyme Inhibitor > C1323 - Cyclooxygenase Inhibitor
D000893 - Anti-Inflammatory Agents
D004791 - Enzyme Inhibitors
同义名列表
15 个代谢物同义名
N-(4-nitro-2-phenoxyphenyl)methanesulfonamide; 4-NITRO-2-phenoxymethanesulphonanilide; 4-Nitro-2-phenoxymethanesulphonanilide; 4-NITRO-2-phenoxymethanesulfonanilide; 4-Nitro-2-phenoxymethanesulfonanilide; Antifloxil; nimesulide; Redaflam; Eskaflam; Nimesil; Lizepat; Mesulid; Guaxan; Aulin; Nexen
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:44445
- PubChem: 4495
- HMDB: HMDB0255611
- DrugBank: DB04743
- ChEMBL: CHEMBL56367
- Wikipedia: Nimesulide
- CAS: 1364966-82-4
- CAS: 51803-78-2
- RefMet: Nimesulide
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Xuanliang Liu, Xinfang Liao, Zhongquan Yang, Jingli Chen, Fanghao Zheng, Mingfeng He. Efficacy and safety of Lingnan surgery for the treatment of multi-quadrant acute incarcerated hemorrhoids: A retrospective study.
Asian journal of surgery.
2023 Sep; 46(9):3555-3559. doi:
10.1016/j.asjsur.2023.06.066
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Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040
. [PMID: 33910017] - Mariafrancesca Scalise, Cesare Indiveri. Repurposing Nimesulide, a Potent Inhibitor of the B0AT1 Subunit of the SARS-CoV-2 Receptor, as a Therapeutic Adjuvant of COVID-19.
SLAS discovery : advancing life sciences R & D.
2020 12; 25(10):1171-1173. doi:
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Archives of toxicology.
2020 12; 94(12):4037-4041. doi:
10.1007/s00204-020-02869-1
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Molecular pharmacology.
2019 11; 96(5):629-640. doi:
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Brain, behavior, and immunity.
2019 10; 81(?):317-328. doi:
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. [PMID: 31228610] - Dhiman Halder, Shubhasis Dan, Pradipta Sarkar, Dibya Das, Umesh Chandra Halder, Tapan Kumar Pal. LC-MS/MS determination of 4-hydroxynimesulide, an active metabolite of nimesulide and application to bioequivalence study in Indian subjects.
European journal of mass spectrometry (Chichester, England).
2019 Oct; 25(5):399-411. doi:
10.1177/1469066718822621
. [PMID: 30696255] - Joana R Campos, Ana R Fernandes, Raquel Sousa, Joana F Fangueiro, Prapaporn Boonme, Maria Luisa Garcia, Amelia M Silva, Beatriz C Naveros, Eliana B Souto. Optimization of nimesulide-loaded solid lipid nanoparticles (SLN) by factorial design, release profile and cytotoxicity in human Colon adenocarcinoma cell line.
Pharmaceutical development and technology.
2019 Jun; 24(5):616-622. doi:
10.1080/10837450.2018.1549075
. [PMID: 30477410] - M Afzal, D P Bhardwaj, R Khan, Imran Kazmi, S Saleem, F A Al-Abbasi, Firoz Anwar. Antineoplastic influence of nimesulide in chemically induced hepatocellular carcinoma by inhibition of DNA synthesis.
Inflammopharmacology.
2019 Feb; 27(1):89-98. doi:
10.1007/s10787-018-0481-1
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Theranostics.
2019; 9(3):708-720. doi:
10.7150/thno.30418
. [PMID: 30809303] - Li-Fang Feng, Xiao-Hong Chen, Dong-Xiao Li, Xi-Yuan Li, Jin-Qing Song, Ying Jin, Yan-Ling Yang. [Reye syndrome and sudden death symptoms after oral administration of nimesulide due to upper respiratory tract infection in a boy].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics.
2018 Nov; 20(11):944-949. doi:
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Inflammopharmacology.
2018 Jun; 26(3):755-768. doi:
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Journal of Ayub Medical College, Abbottabad : JAMC.
2018 Apr; 30(2):184-186. doi:
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Journal of chromatographic science.
2018 Mar; 56(3):233-241. doi:
10.1093/chromsci/bmx105
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Journal of pharmaceutical and biomedical analysis.
2018 Feb; 149(?):278-289. doi:
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Ecotoxicology and environmental safety.
2018 Feb; 148(?):160-168. doi:
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PloS one.
2018; 13(8):e0203123. doi:
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Archives of oral biology.
2017 Nov; 83(?):317-326. doi:
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The journal of physiological sciences : JPS.
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Drug delivery.
2017 Nov; 24(1):1086-1098. doi:
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. [PMID: 28762846] - Seyedeh Marziyeh Mahdavi Moghddam, Abdul Ahad, Mohd Aqil, Syed Sarim Imam, Yasmin Sultana. Optimization of nanostructured lipid carriers for topical delivery of nimesulide using Box-Behnken design approach.
Artificial cells, nanomedicine, and biotechnology.
2017 May; 45(3):617-624. doi:
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. [PMID: 27050533] - Lei Zhou, Xiaoyan Pang, Jingfang Jiang, Dafang Zhong, Xiaoyan Chen. Nimesulide and 4'-Hydroxynimesulide as Bile Acid Transporters Inhibitors Are Contributory Factors for Drug-Induced Cholestasis.
Drug metabolism and disposition: the biological fate of chemicals.
2017 05; 45(5):441-448. doi:
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Biosensors & bioelectronics.
2017 03; 89(Pt 1):627-635. doi:
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. [PMID: 26718547] - Muhammad Hanif, Akhtar Rasul, Muhammad Harris Shoaib, Ghulam Abbas, Huma Ali, Sajid Mahmood Khan. PHARMACOKINETICS AND BIOEQUIVALENCE STUDIES OF TWO NIMESULIDE 100 mg TABLETS: UNIT DOSE, RANDOMIZED-SEQUENCE, TWO-WAY CROSSOVER STUDY IN HEALTHY VOLUNTEERS OF PAKISTANI POPULATION.
Acta poloniae pharmaceutica.
2017 Mar; 74(2):489-495. doi:
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International journal of nanomedicine.
2017; 12(?):2315-2333. doi:
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Planta medica.
2016 Oct; 82(15):1341-1345. doi:
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International journal of molecular medicine.
2016 Sep; 38(3):721-8. doi:
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. [PMID: 27431935] - Xiao Sun, Kai-Lu Xue, Xin-Yue Jiao, Qian Chen, Li Xu, Heng Zheng, Yu-Feng Ding. Simultaneous determination of nimesulide and its four possible metabolites in human plasma by LC-MS/MS and its application in a study of pharmacokinetics.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Aug; 1027(?):139-48. doi:
10.1016/j.jchromb.2016.05.008
. [PMID: 27284972] - Elisabetta Caiazzo, Francesco Maione, Silvana Morello, Andrea Lapucci, Sara Paccosi, Bodo Steckel, Antonio Lavecchia, Astrid Parenti, Teresa Iuvone, Jürgen Schrader, Armando Ialenti, Carla Cicala. Adenosine signalling mediates the anti-inflammatory effects of the COX-2 inhibitor nimesulide.
Biochemical pharmacology.
2016 07; 112(?):72-81. doi:
10.1016/j.bcp.2016.05.006
. [PMID: 27188793] - R K Shikhkerimov. [The use of nimesulide in the treatment of acute low back pain].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova.
2016; 116(5):28-32. doi:
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Arquivos de gastroenterologia.
2016 Jan; 53(1):36-43. doi:
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Inflammopharmacology.
2015 Dec; 23(6):291-305. doi:
10.1007/s10787-015-0238-z
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Journal of diabetes.
2015 Nov; 7(6):839-49. doi:
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Journal of ethnopharmacology.
2015 Aug; 172(?):273-80. doi:
10.1016/j.jep.2015.06.048
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Peptides.
2015 Jul; 69(?):1-8. doi:
10.1016/j.peptides.2015.03.022
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Chemico-biological interactions.
2015 Jun; 234(?):105-13. doi:
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Journal of Ayub Medical College, Abbottabad : JAMC.
2015 Apr; 27(2):312-3. doi:
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. [PMID: 26411104] - Zeynep Suleyman, Ebru Sener, Nezahat Kurt, Mehmet Comez, Turgut Yapanoglu. The effect of nimesulide on oxidative damage inflicted by ischemia-reperfusion on the rat renal tissue.
Renal failure.
2015 Mar; 37(2):323-31. doi:
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Blood.
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Terapevticheskii arkhiv.
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Turkish journal of medical sciences.
2015; 45(2):277-83. doi:
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Pharmacological reports : PR.
2014 Aug; 66(4):647-52. doi:
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Current drug discovery technologies.
2014 Jun; 11(2):162-7. doi:
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Biochemical pharmacology.
2014 Jun; 89(3):422-30. doi:
10.1016/j.bcp.2014.03.014
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Bosnian journal of basic medical sciences.
2014 May; 14(2):63-9. doi:
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Ukrainian biochemical journal.
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"
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Journal of medicinal chemistry.
2014 Mar; 57(6):2568-81. doi:
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European journal of medicinal chemistry.
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PloS one.
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Toxicological sciences : an official journal of the Society of Toxicology.
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Acta cirurgica brasileira.
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Toxicological sciences : an official journal of the Society of Toxicology.
2013 Dec; 136(2):581-94. doi:
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American journal of physiology. Heart and circulatory physiology.
2013 Nov; 305(10):H1462-70. doi:
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Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
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Blood.
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