Nimesulide (BioDeep_00000181678)

   

human metabolite blood metabolite


代谢物信息卡片


N-(4-nitro-2-phenoxyphenyl)methanesulfonamide

化学式: C13H12N2O5S (308.0466902)
中文名称: 尼美舒利
谱图信息: 最多检出来源 Homo sapiens(blood) 95.83%

分子结构信息

SMILES: CS(=O)(=O)NC1=C(C=C(C=C1)[N+](=O)[O-])OC2=CC=CC=C2
InChI: InChI=1S/C13H12N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h2-9,14H,1H3

描述信息

M - Musculo-skeletal system > M02 - Topical products for joint and muscular pain > M02A - Topical products for joint and muscular pain > M02AA - Antiinflammatory preparations, non-steroids for topical use
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
C471 - Enzyme Inhibitor > C1323 - Cyclooxygenase Inhibitor
D000893 - Anti-Inflammatory Agents
D004791 - Enzyme Inhibitors

同义名列表

15 个代谢物同义名

N-(4-nitro-2-phenoxyphenyl)methanesulfonamide; 4-NITRO-2-phenoxymethanesulphonanilide; 4-Nitro-2-phenoxymethanesulphonanilide; 4-NITRO-2-phenoxymethanesulfonanilide; 4-Nitro-2-phenoxymethanesulfonanilide; Antifloxil; nimesulide; Redaflam; Eskaflam; Nimesil; Lizepat; Mesulid; Guaxan; Aulin; Nexen



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Xuanliang Liu, Xinfang Liao, Zhongquan Yang, Jingli Chen, Fanghao Zheng, Mingfeng He. Efficacy and safety of Lingnan surgery for the treatment of multi-quadrant acute incarcerated hemorrhoids: A retrospective study. Asian journal of surgery. 2023 Sep; 46(9):3555-3559. doi: 10.1016/j.asjsur.2023.06.066. [PMID: 37419805]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Mariafrancesca Scalise, Cesare Indiveri. Repurposing Nimesulide, a Potent Inhibitor of the B0AT1 Subunit of the SARS-CoV-2 Receptor, as a Therapeutic Adjuvant of COVID-19. SLAS discovery : advancing life sciences R & D. 2020 12; 25(10):1171-1173. doi: 10.1177/2472555220934421. [PMID: 32500793]
  • Narjes Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Bushra Mdkhana, Saba Al Heialy, Elaref Ratemi, Malak Alghamdi, Salah Abusnana, Tarek Kashour, Qutayba Hamid, Rabih Halwani. Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue. Archives of toxicology. 2020 12; 94(12):4037-4041. doi: 10.1007/s00204-020-02869-1. [PMID: 32808185]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Amanda L Blaker, Eric A Rodriguez, Bryan K Yamamoto. Neurotoxicity to dopamine neurons after the serial exposure to alcohol and methamphetamine: Protection by COX-2 antagonism. Brain, behavior, and immunity. 2019 10; 81(?):317-328. doi: 10.1016/j.bbi.2019.06.028. [PMID: 31228610]
  • Dhiman Halder, Shubhasis Dan, Pradipta Sarkar, Dibya Das, Umesh Chandra Halder, Tapan Kumar Pal. LC-MS/MS determination of 4-hydroxynimesulide, an active metabolite of nimesulide and application to bioequivalence study in Indian subjects. European journal of mass spectrometry (Chichester, England). 2019 Oct; 25(5):399-411. doi: 10.1177/1469066718822621. [PMID: 30696255]
  • Joana R Campos, Ana R Fernandes, Raquel Sousa, Joana F Fangueiro, Prapaporn Boonme, Maria Luisa Garcia, Amelia M Silva, Beatriz C Naveros, Eliana B Souto. Optimization of nimesulide-loaded solid lipid nanoparticles (SLN) by factorial design, release profile and cytotoxicity in human Colon adenocarcinoma cell line. Pharmaceutical development and technology. 2019 Jun; 24(5):616-622. doi: 10.1080/10837450.2018.1549075. [PMID: 30477410]
  • M Afzal, D P Bhardwaj, R Khan, Imran Kazmi, S Saleem, F A Al-Abbasi, Firoz Anwar. Antineoplastic influence of nimesulide in chemically induced hepatocellular carcinoma by inhibition of DNA synthesis. Inflammopharmacology. 2019 Feb; 27(1):89-98. doi: 10.1007/s10787-018-0481-1. [PMID: 29728874]
  • Yunlong Wang, Zhongbing Liu, Ting Li, Lin Chen, Jiayao Lyu, Chunhong Li, Yan Lin, Na Hao, Meiling Zhou, Zhirong Zhong. Enhanced Therapeutic Effect of RGD-Modified Polymeric Micelles Loaded With Low-Dose Methotrexate and Nimesulide on Rheumatoid Arthritis. Theranostics. 2019; 9(3):708-720. doi: 10.7150/thno.30418. [PMID: 30809303]
  • Li-Fang Feng, Xiao-Hong Chen, Dong-Xiao Li, Xi-Yuan Li, Jin-Qing Song, Ying Jin, Yan-Ling Yang. [Reye syndrome and sudden death symptoms after oral administration of nimesulide due to upper respiratory tract infection in a boy]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. 2018 Nov; 20(11):944-949. doi: . [PMID: 30477628]
  • Ruchika Mittal, Anil Kumar, Dhirendra Pratap Singh, Mahendra Bishnoi, Tapas Chandra Nag. Ameliorative potential of rutin in combination with nimesulide in STZ model of diabetic neuropathy: targeting Nrf2/HO-1/NF-kB and COX signalling pathway. Inflammopharmacology. 2018 Jun; 26(3):755-768. doi: 10.1007/s10787-017-0413-5. [PMID: 29094308]
  • Afsheen Siddiqi, Zainab Nazneen, Saadia Shahzad Alam, Sumbal Tariq. Mechanism Of Nephroprotection By Picrorhiza Kurroa. Journal of Ayub Medical College, Abbottabad : JAMC. 2018 Apr; 30(2):184-186. doi: NULL. [PMID: 29938416]
  • Fathalla Belal, Mahmoud A Omar, Sayed Derayea, Mohamed A Hammad, Sahar Zayed, Safaa F Saleh. Simultaneous Determination of Tizanidine, Nimesulide, Aceclofenac and Paracetamol in Tablets and Biological Fluids Using Micellar Liquid Chromatography. Journal of chromatographic science. 2018 Mar; 56(3):233-241. doi: 10.1093/chromsci/bmx105. [PMID: 29236980]
  • Arthur T Kopylov, Alexander A Novikov, Anna L Kaysheva, Igor T Vykhodets, Dmitry E Karateev, Victor G Zgoda, Andrey V Lisitsa. Quantitative assessment of betamethasone dual-acting formulation in urine of patients with rheumatoid arthritis and ankylosing spondylitis after single-dose intramuscular administration and its application to long-term pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 2018 Feb; 149(?):278-289. doi: 10.1016/j.jpba.2017.11.021. [PMID: 29128828]
  • Nektarios Politakis, Alexia Belavgeni, Ioanna Efthimiou, Nikolina Charalampous, Chara Kourkouta, Stefanos Dailianis. The impact of expired commercial drugs on non-target marine species: A case study with the use of a battery of biomarkers in hemocytes of mussels. Ecotoxicology and environmental safety. 2018 Feb; 148(?):160-168. doi: 10.1016/j.ecoenv.2017.10.021. [PMID: 29045922]
  • Muhammad Hanif, Muhammad Harris Shoaib, Rabia Ismail Yousuf, Farya Zafar. Development of in vitro - in vivo correlations for newly optimized Nimesulide formulations. PloS one. 2018; 13(8):e0203123. doi: 10.1371/journal.pone.0203123. [PMID: 30169547]
  • Camila Carvalho de Oliveira, Paulo Goberlânio de Barros Silva, Antonio Ernando Carlos Ferreira, Romélia Pinheiro Gonçalves, Fabrício Bitu de Sousa, Mário Rogério Lima Mota, Ana Paula Negreiros Nunes Alves. Effects of dexamethasone and nimesulide on bisphosphonate-related osteonecrosis of the jaw: An experimental study. Archives of oral biology. 2017 Nov; 83(?):317-326. doi: 10.1016/j.archoralbio.2017.08.016. [PMID: 28869827]
  • Juliana B M Lima, Clarice C Veloso, Fabiana C Vilela, Alexandre Giusti-Paiva. Prostaglandins mediate zymosan-induced sickness behavior in mice. The journal of physiological sciences : JPS. 2017 Nov; 67(6):673-679. doi: 10.1007/s12576-016-0494-8. [PMID: 27699583]
  • Heran Li, Jianxin Wang, Jialiang Cong, Chen Wei, Jing Li, Hongzhuo Liu, Sanming Li, Mingshi Yang. Biomimetic synthesis of proline-derivative templated mesoporous silica for increasing the brain distribution of diazepam and improving the pharmacodynamics of nimesulide. Drug delivery. 2017 Nov; 24(1):1086-1098. doi: 10.1080/10717544.2017.1359863. [PMID: 28762846]
  • Seyedeh Marziyeh Mahdavi Moghddam, Abdul Ahad, Mohd Aqil, Syed Sarim Imam, Yasmin Sultana. Optimization of nanostructured lipid carriers for topical delivery of nimesulide using Box-Behnken design approach. Artificial cells, nanomedicine, and biotechnology. 2017 May; 45(3):617-624. doi: 10.3109/21691401.2016.1167699. [PMID: 27050533]
  • Lei Zhou, Xiaoyan Pang, Jingfang Jiang, Dafang Zhong, Xiaoyan Chen. Nimesulide and 4'-Hydroxynimesulide as Bile Acid Transporters Inhibitors Are Contributory Factors for Drug-Induced Cholestasis. Drug metabolism and disposition: the biological fate of chemicals. 2017 05; 45(5):441-448. doi: 10.1124/dmd.116.074104. [PMID: 28202577]
  • Santanu Patra, Ekta Roy, Raksha Choudhary, Ashutosh Tiwari, Rashmi Madhuri, Prashant K Sharma. RETRACTED: Graphene quantum dots decorated CdS doped graphene oxide sheets in dual action mode: As initiator and platform for designing of nimesulide imprinted polymer. Biosensors & bioelectronics. 2017 03; 89(Pt 1):627-635. doi: 10.1016/j.bios.2015.12.053. [PMID: 26718547]
  • Muhammad Hanif, Akhtar Rasul, Muhammad Harris Shoaib, Ghulam Abbas, Huma Ali, Sajid Mahmood Khan. PHARMACOKINETICS AND BIOEQUIVALENCE STUDIES OF TWO NIMESULIDE 100 mg TABLETS: UNIT DOSE, RANDOMIZED-SEQUENCE, TWO-WAY CROSSOVER STUDY IN HEALTHY VOLUNTEERS OF PAKISTANI POPULATION. Acta poloniae pharmaceutica. 2017 Mar; 74(2):489-495. doi: NULL. [PMID: 29624254]
  • You-Sin Jian, Ching-Wen Chen, Chih-An Lin, Hsiu-Ping Yu, Hua-Yang Lin, Ming-Yuan Liao, Shu-Huan Wu, Yan-Fu Lin, Ping-Shan Lai. Hyaluronic acid-nimesulide conjugates as anticancer drugs against CD44-overexpressing HT-29 colorectal cancer in vitro and in vivo. International journal of nanomedicine. 2017; 12(?):2315-2333. doi: 10.2147/ijn.s120847. [PMID: 28392690]
  • Theresa R Ramalho, Luciano R Filgueiras, Maria Talita Pacheco de Oliveira, Ana Luisa de Araujo Lima, Claudio Roberto Bezerra-Santos, Sonia Jancar, Marcia Regina Piuvezam. Gamma-Terpinene Modulation of LPS-Stimulated Macrophages is Dependent on the PGE2/IL-10 Axis. Planta medica. 2016 Oct; 82(15):1341-1345. doi: 10.1055/s-0042-107799. [PMID: 27224271]
  • Shunsuke Tsujimoto, Manabu Kishina, Masahiko Koda, Yasutaka Yamamoto, Kohei Tanaka, Yusuke Harada, Akio Yoshida, Ichiro Hisatome. Nimesulide, a cyclooxygenase-2 selective inhibitor, suppresses obesity-related non-alcoholic fatty liver disease and hepatic insulin resistance through the regulation of peroxisome proliferator-activated receptor γ. International journal of molecular medicine. 2016 Sep; 38(3):721-8. doi: 10.3892/ijmm.2016.2674. [PMID: 27431935]
  • Xiao Sun, Kai-Lu Xue, Xin-Yue Jiao, Qian Chen, Li Xu, Heng Zheng, Yu-Feng Ding. Simultaneous determination of nimesulide and its four possible metabolites in human plasma by LC-MS/MS and its application in a study of pharmacokinetics. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Aug; 1027(?):139-48. doi: 10.1016/j.jchromb.2016.05.008. [PMID: 27284972]
  • Elisabetta Caiazzo, Francesco Maione, Silvana Morello, Andrea Lapucci, Sara Paccosi, Bodo Steckel, Antonio Lavecchia, Astrid Parenti, Teresa Iuvone, Jürgen Schrader, Armando Ialenti, Carla Cicala. Adenosine signalling mediates the anti-inflammatory effects of the COX-2 inhibitor nimesulide. Biochemical pharmacology. 2016 07; 112(?):72-81. doi: 10.1016/j.bcp.2016.05.006. [PMID: 27188793]
  • R K Shikhkerimov. [The use of nimesulide in the treatment of acute low back pain]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2016; 116(5):28-32. doi: 10.17116/jnevro20161165128-32. [PMID: 27240177]
  • Sachin Manocha, Dushyant Lal, Subramanian Venkataraman. ADMINISTRATION OF H2 BLOCKERS IN NSAID INDUCED GASTROPATHY IN RATS: effect on histopathological changes in gastric, hepatic and renal tissues. Arquivos de gastroenterologia. 2016 Jan; 53(1):36-43. doi: 10.1590/s0004-28032016000100008. [PMID: 27281503]
  • Anil Kumar, Barinder Singh, Jitendriya Mishra, Sangeeta Pilkhwal Sah, Raghavender Pottabathini. Neuroprotective mechanism of losartan and its interaction with nimesulide against chronic fatigue stress. Inflammopharmacology. 2015 Dec; 23(6):291-305. doi: 10.1007/s10787-015-0238-z. [PMID: 26122818]
  • Li Li, Xing Zhang, Lei Wang, Zhenhai Chai, Xiuping Shen, Zongpeng Zhang, Changxiao Liu. A toxicology study to evaluate the embryotoxicity of metformin compared with the hypoglycemic drugs, the anticancer drug, the anti-epileptic drug, the antibiotic, and the cyclo-oxygenase (COX)-2 inhibitor. Journal of diabetes. 2015 Nov; 7(6):839-49. doi: 10.1111/1753-0407.12251. [PMID: 25492223]
  • Vanphuc Nguyen, Jianchun Huang, Vanminh Doan, Xing Lin, Xiuneng Tang, Yuanheng Huang, Aicun Tang, Xin Yang, Renbin Huang. Hepatoprotective effects of Yulangsan polysaccharide against nimesulide-induced liver injury in mice. Journal of ethnopharmacology. 2015 Aug; 172(?):273-80. doi: 10.1016/j.jep.2015.06.048. [PMID: 26144697]
  • Byung Mun Park, Shan Gao, Seung Ah Cha, Suhn Hee Kim. Attenuation of renovascular hypertension by cyclooxygenase-2 inhibitor partly through ANP release. Peptides. 2015 Jul; 69(?):1-8. doi: 10.1016/j.peptides.2015.03.022. [PMID: 25846103]
  • Julio Mesa, Cristina Alsina, Udo Oppermann, Xavier Parés, Jaume Farrés, Sergio Porté. Human prostaglandin reductase 1 (PGR1): Substrate specificity, inhibitor analysis and site-directed mutagenesis. Chemico-biological interactions. 2015 Jun; 234(?):105-13. doi: 10.1016/j.cbi.2015.01.021. [PMID: 25619643]
  • Afsheen Siddiqi, Saadia S Alam, Sajada Begum, Zainab Nazneen, Bushra Aaqil, Muhammad Adeel Alam. EVALUATION OF THERAPEUTIC POTENTIAL OF PICRURHIZA KURROA GLYCOSIDAL EXTRACT AGAINST NIMESULIDE NEPHROTOXICITY: A PILOT STUDY. Journal of Ayub Medical College, Abbottabad : JAMC. 2015 Apr; 27(2):312-3. doi: NULL. [PMID: 26411104]
  • Zeynep Suleyman, Ebru Sener, Nezahat Kurt, Mehmet Comez, Turgut Yapanoglu. The effect of nimesulide on oxidative damage inflicted by ischemia-reperfusion on the rat renal tissue. Renal failure. 2015 Mar; 37(2):323-31. doi: 10.3109/0886022x.2014.985996. [PMID: 25418059]
  • Evi X Stavrou, Chao Fang, Alona Merkulova, Omar Alhalabi, Nadja Grobe, Silvio Antoniak, Nigel Mackman, Alvin H Schmaier. Reduced thrombosis in Klkb1-/- mice is mediated by increased Mas receptor, prostacyclin, Sirt1, and KLF4 and decreased tissue factor. Blood. 2015 Jan; 125(4):710-9. doi: 10.1182/blood-2014-01-550285. [PMID: 25339356]
  • I A Zolotovskaya, I L Davydkin. [Effect of nonsteroidal anti-inflammatory drugs on the indicators of cardiovascular risk in patients with acute nonspecific back pain]. Terapevticheskii arkhiv. 2015; 87(12):18-25. doi: 10.17116/terarkh2015871218-25. [PMID: 26978413]
  • Sagheer Ahmed, Saima Gul, Muhammad Zia-ul-Haq, Muhammad Riaz. Hypolipidemic effects of nimesulide and celecoxib in experimentally induced hypercholesterolemia in rabbits. Turkish journal of medical sciences. 2015; 45(2):277-83. doi: 10.3906/sag-1312-106. [PMID: 26084115]
  • Ismail Demiryilmaz, Mehmet Ibrahim Turan, Abdullah Kisaoglu, Mine Gulapoglu, Ismayil Yilmaz, Halis Suleyman. Protective effect of nimesulide against hepatic ischemia/reperfusion injury in rats: effects on oxidant/antioxidants, DNA mutation and COX-1/COX-2 levels. Pharmacological reports : PR. 2014 Aug; 66(4):647-52. doi: 10.1016/j.pharep.2014.02.015. [PMID: 24948067]
  • K R Vandana, Prasanna R Yalavarthi, C R Sundaresan, Raghava N Sriramaneni, Harini C Vadlamudi. In-vitro assessment and pharmacodynamics of nimesulide incorporated Aloe vera transemulgel. Current drug discovery technologies. 2014 Jun; 11(2):162-7. doi: 10.2174/1570163810666131202233721. [PMID: 24295369]
  • Lorena Pochini, Angela Seidita, Cristina Sensi, Mariafrancesca Scalise, Ivano Eberini, Cesare Indiveri. Nimesulide binding site in the B0AT1 (SLC6A19) amino acid transporter. Mechanism of inhibition revealed by proteoliposome transport assay and molecular modelling. Biochemical pharmacology. 2014 Jun; 89(3):422-30. doi: 10.1016/j.bcp.2014.03.014. [PMID: 24704252]
  • Sagheer Ahmed, Saima Gul, Humera Gul, Muhammad Zia-Ul-Haq, Sezai Ercisli. Cyclooxygenase-2 inhibition improves antioxidative defense during experimental hypercholesterolemia. Bosnian journal of basic medical sciences. 2014 May; 14(2):63-9. doi: 10.17305/bjbms.2014.2264. [PMID: 24856376]
  • Iu I Hubs'kyĭ, T A Bukhtiarova, H H Horiushko, N V Litvinova, H I Paramonova, T M Kurapova, O M Velychko, L P Babenko. [Biophysical parameters of erythrocyte membranes and mechanisms of interaction with non-opioid analgesics under acute pain syndrome]. Ukrainian biochemical journal. 2014 May; 86(3):98-106. doi: ". [PMID: 25033559]
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  • Jean-François Renard, Frédéric Lecomte, Philippe Hubert, Xavier de Leval, Bernard Pirotte. N-(3-Arylaminopyridin-4-yl)alkanesulfonamides as pyridine analogs of nimesulide: cyclooxygenases inhibition, anti-inflammatory studies and insight on metabolism. European journal of medicinal chemistry. 2014 Mar; 74(?):12-22. doi: 10.1016/j.ejmech.2013.12.033. [PMID: 24440378]
  • Ylenia Ingrasciotta, Janet Sultana, Francesco Giorgianni, Achille Patrizio Caputi, Vincenzo Arcoraci, Daniele Ugo Tari, Claudio Linguiti, Margherita Perrotta, Andrea Nucita, Fabio Pellegrini, Andrea Fontana, Lorenzo Cavagna, Domenico Santoro, Gianluca Trifirò. The burden of nephrotoxic drug prescriptions in patients with chronic kidney disease: a retrospective population-based study in Southern Italy. PloS one. 2014; 9(2):e89072. doi: 10.1371/journal.pone.0089072. [PMID: 24558471]
  • Daphna Laifenfeld, Luping Qiu, Rachel Swiss, Jennifer Park, Michael Macoritto, Yvonne Will, Husam S Younis, Michael Lawton. Utilization of causal reasoning of hepatic gene expression in rats to identify molecular pathways of idiosyncratic drug-induced liver injury. Toxicological sciences : an official journal of the Society of Toxicology. 2014 Jan; 137(1):234-48. doi: 10.1093/toxsci/kft232. [PMID: 24136188]
  • Marina Borges, Rivaldo Marini Filho, Cecília Braga Laposy, Priscylla Tatiana Chalfun Guimarães-Okamoto, Marina Platzeck Chaves, André Nanny Le Sueur Vieira, Alessandra Melchert. Nonsteroidal anti-inflammatory therapy: changes on renal function of healthy dogs. Acta cirurgica brasileira. 2013 Dec; 28(12):842-7. doi: 10.1590/s0102-86502013001200006. [PMID: 24316857]
  • Liang Guo, Luke Coyle, Rory M C Abrams, Raymond Kemper, Eric T Chiao, Kyle L Kolaja. Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model. Toxicological sciences : an official journal of the Society of Toxicology. 2013 Dec; 136(2):581-94. doi: 10.1093/toxsci/kft205. [PMID: 24052561]
  • Ninitha Asirvatham-Jeyaraj, Andrew J King, Carrie A Northcott, Shivanshu Madan, Gregory D Fink. Cyclooxygenase-1 inhibition attenuates angiotensin II-salt hypertension and neurogenic pressor activity in the rat. American journal of physiology. Heart and circulatory physiology. 2013 Nov; 305(10):H1462-70. doi: 10.1152/ajpheart.00245.2013. [PMID: 24014677]
  • João P Monteiro, Ana M Silva, Amália S Jurado, Paulo J Oliveira. Rapeseed oil-rich diet alters in vitro menadione and nimesulide hepatic mitochondrial toxicity. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2013 Oct; 60(?):479-87. doi: 10.1016/j.fct.2013.07.073. [PMID: 23933359]
  • Chao Fang, Evi Stavrou, Alec A Schmaier, Nadja Grobe, Mariana Morris, Andrew Chen, Marvin T Nieman, Gregory N Adams, Gretchen LaRusch, Yihua Zhou, Matthew L Bilodeau, Fakhri Mahdi, Mark Warnock, Alvin H Schmaier. Angiotensin 1-7 and Mas decrease thrombosis in Bdkrb2-/- mice by increasing NO and prostacyclin to reduce platelet spreading and glycoprotein VI activation. Blood. 2013 Apr; 121(15):3023-32. doi: 10.1182/blood-2012-09-459156. [PMID: 23386129]
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