Niludipine (BioDeep_00000181675)

   

human metabolite blood metabolite


代谢物信息卡片


3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, bis(2-propoxyethyl)ester

化学式: C25H34N2O8 (490.2315044)
中文名称: 尼鲁地平
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCOCCOC(=O)C1=C(NC(=C(C1C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OCCOCCC)C)C
InChI: InChI=1S/C25H34N2O8/c1-5-10-32-12-14-34-24(28)21-17(3)26-18(4)22(25(29)35-15-13-33-11-6-2)23(21)19-8-7-9-20(16-19)27(30)31/h7-9,16,23,26H,5-6,10-15H2,1-4H3

描述信息

C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker

同义名列表

7 个代谢物同义名

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, bis(2-propoxyethyl)ester; 3,5-bis(2-propoxyethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; Bis(2-propoxyethyl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate; Niludipin, (+-)-isomer; Bay a 7168; Niludipine; Niludipin



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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Plant Reactome(0)

INOH(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Janīna Briede, Māra Stivriņa, Dzintra Stoldere, Egīls Bisenieks, Jānis Uldriķis, Jānis Poikāns, Natālija Makarova, Gunārs Duburs. Effect of new and known 1,4-dihydropyridine derivatives on blood glucose levels in normal and streptozotocin-induced diabetic rats. Cell biochemistry and function. 2004 Jul; 22(4):219-24. doi: 10.1002/cbf.1091. [PMID: 15248181]
  • V Ceña, K W Brocklehurst, H B Pollard, E Rojas. Pertussis toxin stimulation of catecholamine release from adrenal medullary chromaffin cells: mechanism may be by direct activation of L-type and G-type calcium channels. The Journal of membrane biology. 1991 May; 122(1):23-31. doi: 10.1007/bf01872736. [PMID: 1714959]
  • E Kusano, Y Asano, K Takeda, N Terao, S Hosoda. Acute and chronic hypotensive effects of nifedipine and niludipine in hypertensive patients with chronic renal failure. Arzneimittel-Forschung. 1984; 34(5):624-9. doi: NULL. [PMID: 6432001]
  • A Ohneda, T Kobayashi, J Nihei. Effects of Ca antagonists, nifedipine, niludipine and verapamil, on endocrine function of the pancreas. The Tohoku journal of experimental medicine. 1983 Jun; 140(2):153-9. doi: 10.1620/tjem.140.153. [PMID: 6351351]
  • K Aoki, K Sato. Acute hypotensive, hemodynamic effects of long-term treatment with niludipine, a Ca2+-antagonist, in patients with essential hypertension. Niludipine monotherapy and combination with a beta-blocker and a diuretic). Arzneimittel-Forschung. 1982; 32(9):1141-5. doi: NULL. [PMID: 6756418]