Gliclazide (BioDeep_00000018167)
human metabolite blood metabolite
代谢物信息卡片
1-(4-methylbenzenesulfonyl)-3-{octahydrocyclopenta[c]pyrrol-2-yl}urea
化学式: C15H21N3O3S (323.13035560000003)
中文名称: 格列齐特
谱图信息:
最多检出来源 Homo sapiens(blood) 7.14%
分子结构信息
SMILES: CC1=CC=C(C=C1)S(=O)(=O)NC(=O)NN1CC2CCCC2C1
InChI: InChI=1S/C15H21N3O3S/c1-11-5-7-14(8-6-11)22(20,21)17-15(19)16-18-9-12-3-2-4-13(12)10-18/h5-8,12-13H,2-4,9-10H2,1H3,(H2,16,17,19)
描述信息
Gliclazide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic β cell receptor. Sulfonylureas also increase peripheral glucose utilization, decrease hepatic gluconeogenesis and may increase the number and sensitivity of insulin receptors. Sulfonylureas are associated with weight gain, though less so than insulin. Due to their mechanism of action, sulfonylureas may cause hypoglycemia and require consistent food intake to decrease this risk. The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals. Gliclazide has been shown to decrease fasting plasma glucose, postprandial blood glucose and glycosolated hemoglobin (HbA1c) levels (reflective of the last 8-10 weeks of glucose control). Gliclazide is extensively metabolized by the liver; its metabolites are excreted in both urine (60-70\\%) and feces (10-20\\%).
A - Alimentary tract and metabolism > A10 - Drugs used in diabetes > A10B - Blood glucose lowering drugs, excl. insulins > A10BB - Sulfonylureas
D007004 - Hypoglycemic Agents
同义名列表
26 个代谢物同义名
1-(4-methylbenzenesulfonyl)-3-{octahydrocyclopenta[c]pyrrol-2-yl}urea; 1-(Hexahydrocyclopenta(c)pyrrol-2(1H)-yl)-3-(p-tolylsulphonyl)urea; 1-(Hexahydrocyclopenta(c)pyrrol-2(1H)-yl)-3-(p-tolylsulfonyl)urea; N-(4-Methylbenzenesulfonyl)-n-(3-azabicyclo(3.3.0)oct-3-yl)urea; 1-(3-Azabicyclo(3.3.0)oct-3-yl)-3-(p-tolylsulphonyl)urea; 1-(3-Azabicyclo(3.3.0)oct-3-yl)-3-(p-tolylsulfonyl)urea; Alphapharm brand OF gliclazide; Novopharm brand OF gliclazide; Generics brand OF gliclazide; Genpharm brand OF gliclazide; Servier brand OF gliclazide; Helsinn brand OF gliclazide; Gliclazide servier brand; novo-Gliclazide; novo Gliclazide; Gen gliclazide; Gen-gliclazide; Diabrezide; Glyclazide; gliclazide; Glimicron; Gliklazid; Diamicron; Diaikron; Diaglyk; Glyade
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:31654
- PubChem: 3475
- HMDB: HMDB0015252
- DrugBank: DB01120
- ChEMBL: CHEMBL427216
- Wikipedia: Gliclazide
- MeSH: Gliclazide
- chemspider: 3356
- CAS: 21187-98-4
- PMhub: MS000003461
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Zahra Karami, Jalil Mehrzad, Mohammad Akrami, Saman Hosseinkhani. Anti-inflammation-based treatment of atherosclerosis using Gliclazide-loaded biomimetic nanoghosts.
Scientific reports.
2023 08; 13(1):13880. doi:
10.1038/s41598-023-41136-y. [PMID: 37620556] - Mohammad Parvez, Farrukh Hussain, Murad Khan. Crude extract from Euphorbia prostrata extended curative period of glibenclemide in alloxan-induced diabetic rats.
Journal of complementary & integrative medicine.
2023 Jan; ?(?):. doi:
10.1515/jcim-2022-0315. [PMID: 36662647] - Soebagijo Adi Soelistijo, Andi Makbul Aman, Hendra Zufry, Agung Pranoto, Achmad Rudijanto, Mohamed Hassanien. Indonesia DIA-RAMADAN Study: A Real-life, Prospective and Observational of Gliclazide MR in Type-2 Diabetes Patients During Ramadan Fasting.
Acta medica Indonesiana.
2022 Jan; 54(1):3-9. doi:
NULL. [PMID: 35398820] - Ewa Zurawska-Plaksej, Rafal Wiglusz, Agnieszka Piwowar, Katarzyna Wiglusz. In Vitro Investigation of Binding Interactions between Albumin-Gliclazide Model and Typical Hypotensive Drugs.
International journal of molecular sciences.
2021 Dec; 23(1):. doi:
10.3390/ijms23010286. [PMID: 35008711] - Syed Abbas Raza, Javed Akram, Azizul Hasan Aamir, Yakoob Ahmedani, Mohammad Imtiaz Hassan. Evaluation of the effectiveness and tolerability of gliclazide modified release 60 mg in patients with type 2 diabetes observing fasting during Ramadan in Pakistan: An analysis from the global DIA-RAMADAN study.
Diabetes research and clinical practice.
2021 Nov; 181(?):109086. doi:
10.1016/j.diabres.2021.109086. [PMID: 34634390] - Jeffry Adiwidjaja, Lucy Sasongko. Effect of Nigella sativa oil on pharmacokinetics and pharmacodynamics of gliclazide in rats.
Biopharmaceutics & drug disposition.
2021 Sep; 42(8):359-371. doi:
10.1002/bdd.2300. [PMID: 34327715] - M L Morieri, N Vitturi, A Avogaro, G Targher, G P Fadini. Prevalence of hepatic steatosis in patients with type 2 diabetes and response to glucose-lowering treatments. A multicenter retrospective study in Italian specialist care.
Journal of endocrinological investigation.
2021 Sep; 44(9):1879-1889. doi:
10.1007/s40618-021-01501-y. [PMID: 33432553] - Ruth L M Cordiner, Andrea Mari, Andrea Tura, Ewan R Pearson. The Impact of Low-dose Gliclazide on the Incretin Effect and Indices of Beta-cell Function.
The Journal of clinical endocrinology and metabolism.
2021 06; 106(7):2036-2046. doi:
10.1210/clinem/dgab151. [PMID: 33693776] - Fatemeh Taghizadeh, Seyed Jalal Hosseinimehr, Mehryar Zargari, Abbasali Karimpour Malekshah, Mansoureh Mirzaei, Fereshteh Talebpour Amiri. Alleviation of cisplatin-induced hepatotoxicity by gliclazide: Involvement of oxidative stress and caspase-3 activity.
Pharmacology research & perspectives.
2021 05; 9(3):e00788. doi:
10.1002/prp2.788. [PMID: 34003600] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
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Endocrinology, diabetes & metabolism.
2021 04; 4(2):e00209. doi:
10.1002/edm2.209. [PMID: 33855212] - Lucy Sasongko, Gladdis K Pratiwi, Margaretha Leo, Jeffry Adiwidjaja. Simultaneous HPLC Assay of Gliclazide and Ciprofloxacin in Plasma and its Implementation for Pharmacokinetic Study in Rats.
Journal of chromatographic science.
2021 Mar; 59(4):338-346. doi:
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Journal of chromatography. A.
2021 Feb; 1638(?):461683. doi:
10.1016/j.chroma.2020.461683. [PMID: 33223150] - Sayed M M Mizar, Magy R Kozman, Ali A Abo-Saif, Basim A S Messiha. Combination of Captopril with Gliclazide Decreases Vascular and Renal Complications and Improves Glycemic Control in Rats with Streptozotocin- Induced Diabetes Mellitus.
Endocrine, metabolic & immune disorders drug targets.
2021; 21(6):1096-1106. doi:
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Journal of diabetes research.
2021; 2021(?):9973862. doi:
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Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering.
2021; 56(3):310-323. doi:
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Clinical science (London, England : 1979).
2020 12; 134(23):3107-3118. doi:
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Materials science & engineering. C, Materials for biological applications.
2020 Nov; 116(?):111191. doi:
10.1016/j.msec.2020.111191. [PMID: 32806298] - Prabhat Pratap Singh Tomar, Isaiah T Arkin. SARS-CoV-2 E protein is a potential ion channel that can be inhibited by Gliclazide and Memantine.
Biochemical and biophysical research communications.
2020 09; 530(1):10-14. doi:
10.1016/j.bbrc.2020.05.206. [PMID: 32828269] - Wen-Qiang Pan, Shu-Fan Wang, Bo-Ping Ding, Zhen-Gui Huang. [Protective effects of gliclazide on myocardium of diabetic rats and its mechanism].
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.
2020 Sep; 36(5):402-407. doi:
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IUBMB life.
2020 09; 72(9):2024-2033. doi:
10.1002/iub.2342. [PMID: 32687680] - Erik J M van Bommel, Mark M Smits, Danique Ruiter, Marcel H A Muskiet, Mark H H Kramer, Max Nieuwdorp, Daan J Touw, Hiddo J L Heerspink, Jaap A Joles, Daniël H van Raalte. Effects of dapagliflozin and gliclazide on the cardiorenal axis in people with type 2 diabetes.
Journal of hypertension.
2020 09; 38(9):1811-1819. doi:
10.1097/hjh.0000000000002480. [PMID: 32516291] - Vidhushini Sekar, Sugumar Mani, R Malarvizhi, R Barathidasan, Hannah R Vasanthi. Positive interaction of mangiferin with selected oral hypoglycemic drugs: a therapeutic strategy to alleviate diabetic nephropathy in experimental rats.
Molecular biology reports.
2020 Jun; 47(6):4465-4475. doi:
10.1007/s11033-020-05517-0. [PMID: 32451927] - Mohamed Hassanein, Saud Al Sifri, Shehla Shaikh, Syed Abbas Raza, Javed Akram, Agung Pranoto, Achmad Rudijanto, Inass Shaltout, Md Fariduddin, Wan Mohd Izani Wan Mohamed, Fatheya Al Awadi, Thamer Alessa. A real-world study in patients with type 2 diabetes mellitus treated with gliclazide modified-release during fasting: DIA-RAMADAN.
Diabetes research and clinical practice.
2020 May; 163(?):108154. doi:
10.1016/j.diabres.2020.108154. [PMID: 32330510] - Noha F Abdelkader, Hebatollah E Eitah, Yousreya A Maklad, Amina A Gamaleldin, Manal A Badawi, Sanaa A Kenawy. New combination therapy of gliclazide and quercetin for protection against STZ-induced diabetic rats.
Life sciences.
2020 Apr; 247(?):117458. doi:
10.1016/j.lfs.2020.117458. [PMID: 32092333] - E J M van Bommel, H Herrema, M Davids, M H H Kramer, M Nieuwdorp, D H van Raalte. Effects of 12-week treatment with dapagliflozin and gliclazide on faecal microbiome: Results of a double-blind randomized trial in patients with type 2 diabetes.
Diabetes & metabolism.
2020 04; 46(2):164-168. doi:
10.1016/j.diabet.2019.11.005. [PMID: 31816432] - Alaa Mohamed Nazief, Passainte Saber Hassaan, Hoda Mahmoud Khalifa, Magda Samir Sokar, Amal Hassan El-Kamel. Lipid-Based Gliclazide Nanoparticles for Treatment of Diabetes: Formulation, Pharmacokinetics, Pharmacodynamics and Subacute Toxicity Study.
International journal of nanomedicine.
2020; 15(?):1129-1148. doi:
10.2147/ijn.s235290. [PMID: 32110012] - Meisam Saberi, Zahra Ramazani, Homeira Rashidi, Alihossein Saberi. The Effect of CYP2C9 Genotype Variants in Type 2 Diabetes on the Pharmacological Effectiveness of Sulfonylureas, Diabetic Retinopathy, and Nephropathy.
Vascular health and risk management.
2020; 16(?):241-248. doi:
10.2147/vhrm.s230639. [PMID: 32606720] - Erik J M van Bommel, Marcel H A Muskiet, Michaël J B van Baar, Lennart Tonneijck, Mark M Smits, Anna L Emanuel, Andrea Bozovic, A H Jan Danser, Frank Geurts, Ewout J Hoorn, Daan J Touw, Emil L Larsen, Henrik E Poulsen, Mark H H Kramer, Max Nieuwdorp, Jaap A Joles, Daniël H van Raalte. The renal hemodynamic effects of the SGLT2 inhibitor dapagliflozin are caused by post-glomerular vasodilatation rather than pre-glomerular vasoconstriction in metformin-treated patients with type 2 diabetes in the randomized, double-blind RED trial.
Kidney international.
2020 01; 97(1):202-212. doi:
10.1016/j.kint.2019.09.013. [PMID: 31791665] - Simon Mifsud, Emma Louise Schembri, Stephen Fava. A case of severe relapsing sulphonylurea-induced hypoglycaemia.
BMJ case reports.
2019 Dec; 12(12):. doi:
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Pharmacological research.
2019 12; 150(?):104522. doi:
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Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - P-Y Yang, P-C Li, B Feng. Protective effects of gliclazide on high glucose and AGEs-induced damage of glomerular mesangial cells and renal tubular epithelial cells via inhibiting RAGE-p22phox-NF-kB pathway.
European review for medical and pharmacological sciences.
2019 Oct; 23(20):9099-9107. doi:
10.26355/eurrev_201910_19313. [PMID: 31696501] - Chunmei Zhang, Piyong Ma, Zhongyan Zhao, Nan Jiang, Dede Lian, Pengfei Huo, Hailing Yang. miRNA‑mRNA regulatory network analysis of mesenchymal stem cell treatment in cisplatin‑induced acute kidney injury identifies roles for miR‑210/Serpine1 and miR‑378/Fos in regulating inflammation.
Molecular medicine reports.
2019 Aug; 20(2):1509-1522. doi:
10.3892/mmr.2019.10383. [PMID: 31257474] - Vidhushini Sekar, Sugumar Mani, R Malarvizhi, P Nithya, Hannah R Vasanthi. Antidiabetic effect of mangiferin in combination with oral hypoglycemic agents metformin and gliclazide.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2019 Jun; 59(?):152901. doi:
10.1016/j.phymed.2019.152901. [PMID: 30981189] - Pei Liang, Yong-Feng Zhou, Bi-Jie Xu, Yan Xuan, Jing Xia, Dan Wang, De Zhang, Jia-Ming Ye, Zhi Yu, Shang-Zhong Jin. SERS-based vibration model and trace detection of drug molecules: Theoretical and experimental aspects.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2019 May; 215(?):168-175. doi:
10.1016/j.saa.2019.02.102. [PMID: 30836305] - Weiheng Wen, Jinru Gong, Peili Wu, Min Zhao, Ming Wang, Hong Chen, Jia Sun. Mutations in gliclazide-associated genes may predict poor bladder cancer prognosis.
FEBS open bio.
2019 03; 9(3):457-467. doi:
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Journal of diabetes investigation.
2019 Mar; 10(2):399-407. doi:
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AAPS PharmSciTech.
2019 Jan; 20(2):45. doi:
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Clinical pharmacology in drug development.
2019 01; 8(1):16-21. doi:
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Molecules (Basel, Switzerland).
2018 Dec; 24(1):. doi:
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Diabetes research and clinical practice.
2018 Dec; 146(?):41-47. doi:
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Oct; 106(?):1267-1270. doi:
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Molecular medicine (Cambridge, Mass.).
2018 09; 24(1):47. doi:
10.1186/s10020-018-0042-5. [PMID: 30180807] - Yang Zhou, Cheng Hu, Xinjie Zhao, Ping Luo, Jingyi Lu, Qing Li, Miao Chen, Dandan Yan, Xin Lu, Hongwei Kong, Weiping Jia, Guowang Xu. Serum Metabolomics Study of Gliclazide-Modified-Release-Treated Type 2 Diabetes Mellitus Patients Using a Gas Chromatography-Mass Spectrometry Method.
Journal of proteome research.
2018 04; 17(4):1575-1585. doi:
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Diabetologia.
2018 04; 61(4):780-789. doi:
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Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2018 Jan; 189(?):625-633. doi:
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Journal of diabetes research.
2018; 2018(?):2791584. doi:
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PloS one.
2018; 13(5):e0197634. doi:
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European journal of drug metabolism and pharmacokinetics.
2017 Dec; 42(6):1005-1011. doi:
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Pharmaceutical biology.
2017 Dec; 55(1):1442-1449. doi:
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Luminescence : the journal of biological and chemical luminescence.
2017 Nov; 32(7):1203-1211. doi:
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Chemico-biological interactions.
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JAMA internal medicine.
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Clinical and experimental pharmacology & physiology.
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Terapevticheskii arkhiv.
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Current drug delivery.
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Diabetes care.
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Drug delivery.
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Endocrine, metabolic & immune disorders drug targets.
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Hormone research in paediatrics.
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Diabetes/metabolism research and reviews.
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Pakistan journal of pharmaceutical sciences.
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Analytical and quantitative cytopathology and histopathology.
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AAPS PharmSciTech.
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Diabetes & metabolism.
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Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.
2014 May; 122(5):295-302. doi:
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Toxicological sciences : an official journal of the Society of Toxicology.
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Journal of ethnopharmacology.
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Endocrine.
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Journal of postgraduate medicine.
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Pakistan journal of pharmaceutical sciences.
2013 Sep; 26(5):973-6. doi:
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European journal of drug metabolism and pharmacokinetics.
2013 Jun; 38(2):123-30. doi:
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Drug development and industrial pharmacy.
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Drug metabolism and disposition: the biological fate of chemicals.
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Forensic science international.
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European journal of pharmacology.
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Current drug delivery.
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Zhonghua nei ke za zhi.
2012 Aug; 51(8):638-41. doi:
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Journal of diabetes and its complications.
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
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Nutrition research (New York, N.Y.).
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European journal of pharmacology.
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European journal of pharmacology.
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Drug delivery.
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