Netobimin (BioDeep_00000181632)

   

human metabolite blood metabolite


代谢物信息卡片


2-({[(methoxycarbonyl)amino]({[2-nitro-5-(propylsulfanyl)phenyl]amino})methylidene}amino)ethane-1-sulfonic acid

化学式: C14H20N4O7S2 (420.077337)
中文名称: 奈韦拉平
谱图信息: 最多检出来源 Homo sapiens(blood) 80%

分子结构信息

SMILES: CCCSC1=CC(=C(C=C1)[N+](=O)[O-])NC(=NCCS(=O)(=O)O)NC(=O)OC
InChI: InChI=1S/C14H20N4O7S2/c1-3-7-26-10-4-5-12(18(20)21)11(9-10)16-13(17-14(19)25-2)15-6-8-27(22,23)24/h4-5,9H,3,6-8H2,1-2H3,(H,22,23,24)(H2,15,16,17,19)

描述信息

D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C250 - Antihelminthic Agent

同义名列表

5 个代谢物同义名

2-({[(methoxycarbonyl)amino]({[2-nitro-5-(propylsulfanyl)phenyl]amino})methylidene}amino)ethane-1-sulfonic acid; 2-({[(methoxycarbonyl)amino]({[2-nitro-5-(propylsulfanyl)phenyl]amino})methylidene}amino)ethanesulfonic acid; N-Methoxycarbonyl-n-(2-nitro-5-propylphenylthio)-n-(2-ethylsulfonic acid)guanidine; netobimin; Tobatin



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • María Sol Arias, José Luis Suárez, G V Hillyer, Iván Francisco, Enrique Calvo, Rita Sánchez-Andrade, Pablo Díaz, Rubén Francisco, Pablo Díez-Baños, Patrocinio Morrondo, Adolfo Paz-Silva. A recombinant-based ELISA evaluating the efficacy of netobimin and albendazole in ruminants with naturally acquired fascioliasis. Veterinary journal (London, England : 1997). 2009 Oct; 182(1):73-8. doi: 10.1016/j.tvjl.2008.05.015. [PMID: 19524206]
  • C Gokbulut, V Y Cirak, B Senlik, F Yildirim, Q A McKellar. Pharmacological assessment of netobimin as a potential anthelmintic for use in horses: plasma disposition, faecal excretion and efficacy. Research in veterinary science. 2009 Jun; 86(3):514-20. doi: 10.1016/j.rvsc.2008.10.001. [PMID: 19022462]
  • G Cringoli, V Veneziano, F Jackson, J Vercruysse, A W Greer, V Fedele, L Mezzino, L Rinaldi. Effects of strategic anthelmintic treatments on the milk production of dairy sheep naturally infected by gastrointestinal strongyles. Veterinary parasitology. 2008 Oct; 156(3-4):340-5. doi: 10.1016/j.vetpar.2008.06.015. [PMID: 18644674]
  • C Gokbulut, V Y Cirak, B Senlik. Plasma disposition and faecal excretion of netobimin metabolites and enantiospecific disposition of albendazole sulphoxide produced in ewes. Veterinary research communications. 2006 Oct; 30(7):791-805. doi: 10.1007/s11259-006-3336-y. [PMID: 17004041]
  • J L García-Llamazares, G Merino-Pelaez, O Larrode-Pellicer, P A Redondo-Cardeña, J G Prieto-Fernández, A I Alvarez-de-Felipe. Pharmacokinetics of netobimin and microsomal metabolism of albendazole in infected gerbils with Echinococcus granulosus. Parasitology research. 2001 Feb; 87(2):107-11. doi: 10.1007/s004360000309. [PMID: 11206105]
  • H Oge, E Ayaz, T Ide, S Dalgiç. The effect of doramectin, moxidectin and netobimin against natural infections of Syphacia muris in rats. Veterinary parasitology. 2000 Mar; 88(3-4):299-303. doi: 10.1016/s0304-4017(99)00218-6. [PMID: 10714468]
  • C Cristòfol, M Navarro, C Franquelo, J E Valladares, M Arboix. Sex differences in the disposition of albendazole metabolites in sheep. Veterinary parasitology. 1998 Aug; 78(3):223-31. doi: 10.1016/s0304-4017(98)00141-1. [PMID: 9760064]
  • M Navarro, C Cristofol, A Carretero, M Arboix, J Ruberte. Anthelmintic induced congenital malformations in sheep embryos using netobimin. The Veterinary record. 1998 Jan; 142(4):86-90. doi: 10.1136/vr.142.4.86. [PMID: 9491529]
  • C Cristòfol, M Navarro, C Franquelo, J E Valladares, A Carretero, J Ruberte, M Arboix. Disposition of netobimin, albendazole, and its metabolites in the pregnant rat: developmental toxicity. Toxicology and applied pharmacology. 1997 May; 144(1):56-61. doi: 10.1006/taap.1997.8114. [PMID: 9169069]
  • C Cristòfol, C Franquelo, M Navarro, A Carretero, J Ruberte, M Arboix. Comparative pharmacokinetics of netobimin metabolites in pregnant ewes. Research in veterinary science. 1997 Mar; 62(2):117-20. doi: 10.1016/s0034-5288(97)90131-4. [PMID: 9243708]
  • J L García-Llamazares, A I Alvarez-de-Felipe, P Redondo-Cardeña, J A Voces-Alonso, J G Prieto-Fernández. In vivo inhibition of the regenerative capacity of hydatid material after treatment with netobimin. Parasitology research. 1997; 83(2):105-8. doi: 10.1007/s004360050219. [PMID: 9039691]
  • A Meana, M Luzón-Peña, J Santiago-Moreno, A De Bulnes, M Gómez-Bautista. Natural infection by gastrointestinal and bronchopulmonary nematodes in mouflons (Ovis musimon) and their response to netobimin treatment. Journal of wildlife diseases. 1996 Jan; 32(1):39-43. doi: 10.7589/0090-3558-32.1.39. [PMID: 8627934]
  • Q A McKellar, R L Coop, F Jackson. The pharmacokinetics of albendazole metabolites following administration of albendazole, albendazole sulfoxide and netobimin to one-month- and eight-month-old sheep. International journal for parasitology. 1995 Oct; 25(10):1207-12. doi: 10.1016/0020-7519(95)00053-5. [PMID: 8557468]
  • C Cristofol, A Carretero, M Fernandez, M Navarro, J Sautet, J Ruberte, M Arboix. Transplacental transport of netobimin metabolites in ewes. European journal of drug metabolism and pharmacokinetics. 1995 Jul; 20(3):167-71. doi: 10.1007/bf03189665. [PMID: 8751036]
  • C E Lanusse, L H Gascon, R K Prichard. Gastrointestinal distribution of albendazole metabolites following netobimin administration to cattle: relationship with plasma disposition kinetics. Journal of veterinary pharmacology and therapeutics. 1993 Mar; 16(1):38-47. doi: 10.1111/j.1365-2885.1993.tb00287.x. [PMID: 8478999]
  • Q A McKellar, F Jackson, R L Coop, J D Baggot. Plasma profiles of albendazole metabolites after administration of netobimin and albendazole in sheep: effects of parasitism and age. The British veterinary journal. 1993 Jan; 149(1):101-13. doi: 10.1016/s0007-1935(05)80213-1. [PMID: 8439796]
  • L S Vieira, M E Berne, A C Cavalcante, C A Costa. Haemonchus contortus resistance to ivermectin and netobimin in Brazilian sheep. Veterinary parasitology. 1992 Dec; 45(1-2):111-6. doi: 10.1016/0304-4017(92)90032-5. [PMID: 1485411]
  • C E Lanusse, L Gascon, R K Prichard. Methimazole-mediated modulation of netobimin biotransformation in sheep: a pharmacokinetic assessment. Journal of veterinary pharmacology and therapeutics. 1992 Sep; 15(3):267-74. doi: 10.1111/j.1365-2885.1992.tb01016.x. [PMID: 1433490]
  • C E Lanusse, R K Prichard. Methimazole increases the plasma concentrations of the albendazole metabolites of netobimin in sheep. Biopharmaceutics & drug disposition. 1992 Mar; 13(2):95-103. doi: 10.1002/bdd.2510130204. [PMID: 1550912]
  • C E Lanusse, R K Prichard. Effects of methimazole on the kinetics of netobimin metabolites in cattle. Xenobiotica; the fate of foreign compounds in biological systems. 1992 Jan; 22(1):115-23. doi: 10.3109/00498259209053108. [PMID: 1615702]
  • C E Lanusse, R K Prichard. Enhancement of the plasma concentration of albendazole sulphoxide in sheep following coadministration of parenteral netobimin and liver oxidase inhibitors. Research in veterinary science. 1991 Nov; 51(3):306-12. doi: 10.1016/0034-5288(91)90082-y. [PMID: 1780586]
  • J Cabaret. Efficacy of netobimin against Muellerius capillaris and resistant strain of digestive tract strongyles in dairy goats. American journal of veterinary research. 1991 Aug; 52(8):1313-5. doi: NULL. [PMID: 1928914]
  • Q A McKellar, F Jackson, R L Coop, E Jackson, E Scott. Effect of parasitism with Nematodirus battus on the pharmacokinetics of levamisole, ivermectin and netobimin. Veterinary parasitology. 1991 Jul; 39(1-2):123-36. doi: 10.1016/0304-4017(91)90068-7. [PMID: 1897114]
  • C E Lanusse, C Trudeau, S Ranjan, R K Prichard. Pharmacokinetic profiles of netobimin metabolites after oral administration of zwitterion and trisamine formulations of netobimin to cattle. Journal of veterinary pharmacology and therapeutics. 1991 Mar; 14(1):101-8. doi: 10.1111/j.1365-2885.1991.tb00810.x. [PMID: 2038091]
  • F H Borgsteede, A P Stallinga. The efficacy of netobimin against a benzimidazole susceptible and a resistant strain of Haemonchus contortus in sheep in The Netherlands. The veterinary quarterly. 1990 Oct; 12(4):241-6. doi: 10.1080/01652176.1990.9694272. [PMID: 2270650]
  • C E Lanusse, S Ranjan, R K Prichard. Comparison of pharmacokinetic variables for two injectable formulations of netobimin administered to calves. American journal of veterinary research. 1990 Sep; 51(9):1459-63. doi: . [PMID: 2396793]
  • C E Lanusse, R K Prichard. Pharmacokinetic behaviour of netobimin and its metabolites in sheep. Journal of veterinary pharmacology and therapeutics. 1990 Jun; 13(2):170-8. doi: 10.1111/j.1365-2885.1990.tb00765.x. [PMID: 2384908]
  • P Delatour, A Ouhsine, E Benoit. Comparative pharmacokinetics of netobimin and albendazole in the one-humped camel (Camelus dromedarius). The British veterinary journal. 1989 Sep; 145(5):478-82. doi: 10.1016/0007-1935(89)90058-4. [PMID: 2790441]