M8-Nelfinavir (BioDeep_00000181603)
human metabolite blood metabolite
代谢物信息卡片
化学式: C32H45N3O5S (583.307976)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 66.67%
分子结构信息
SMILES: CC1=C(C=CC=C1O)C(=O)NC(CSC1=CC=CC=C1)C(O)CN1CC2CCCCC2CC1C(=O)NC(C)(C)CO
InChI: InChI=1S/C32H45N3O5S/c1-21-25(14-9-15-28(21)37)30(39)33-26(19-41-24-12-5-4-6-13-24)29(38)18-35-17-23-11-8-7-10-22(23)16-27(35)31(40)34-32(2,3)20-36/h4-6,9,12-15,22-23,26-27,29,36-38H,7-8,10-11,16-20H2,1-3H3,(H,33,39)(H,34,40)
描述信息
同义名列表
3 个代谢物同义名
N-(1-hydroxy-2-methylpropan-2-yl)-2-{2-hydroxy-3-[(3-hydroxy-2-methylphenyl)formamido]-4-(phenylsulfanyl)butyl}-octahydro-1H-isoquinoline-3-carboxamide; N-(1-hydroxy-2-methylpropan-2-yl)-2-{2-hydroxy-3-[(3-hydroxy-2-methylphenyl)formamido]-4-(phenylsulfanyl)butyl}-decahydroisoquinoline-3-carboxamide; M8-Nelfinavir
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ahizechukwu C Eke, Shelley A McCormack, Brookie M Best, Alice M Stek, Jiajia Wang, Regis Kreitchmann, David Shapiro, Elizabeth Smith, Lynne M Mofenson, Edmund V Capparelli, Mark Mirochnick. Pharmacokinetics of Increased Nelfinavir Plasma Concentrations in Women During Pregnancy and Postpartum.
Journal of clinical pharmacology.
2019 03; 59(3):386-393. doi:
10.1002/jcph.1331. [PMID: 30358179] - Nancy L Sheehan, Rolf P G van Heeswijk, Brian C Foster, Humayoun Akhtar, Neera Singhal, Isabelle Seguin, Lina DelBalso, Marc Bourbeau, Bobby M Chauhan, Mohammed-Rachid Boulassel, David M Burger, Richard G Lalonde, Donald William Cameron. The effect of β-carotene supplementation on the pharmacokinetics of nelfinavir and its active metabolite M8 in HIV-1-infected patients.
Molecules (Basel, Switzerland).
2012 Jan; 17(1):688-702. doi:
10.3390/molecules17010688. [PMID: 22241465] - Bharat D Damle, Howard Uderman, Pinaki Biswas, Penelope Crownover, Chang Lin, Paul Glue. Influence of CYP2C19 polymorphism on the pharmacokinetics of nelfinavir and its active metabolite.
British journal of clinical pharmacology.
2009 Nov; 68(5):682-9. doi:
10.1111/j.1365-2125.2009.03499.x. [PMID: 19916992] - Alessia Uglietti, Giovanni Ravasi, Valeria Meroni, Pasquale Narciso, Nicoletta Ladisa, Salvatore Martini, Paolo Perini, Lucia Testa, Alessandro Masala, Lisa Malicarne, Cecilia Occhino, Elena Donadel, Francesca Genco, Guido Chichino, Renato Maserati. Nelfinavir+M8 plasma levels determined with an ELISA test in HIV infected patients with or without HCV and/or HBV coinfection: the VIRAKINETICS II study.
Current HIV research.
2009 May; 7(3):293-301. doi:
10.2174/157016209788347967. [PMID: 19442125] - Alessia Uglietti, Francesca Genco, Elena Donadel, Serena Rinaldi, Erica Bastiani, Renato Maserati, Valeria Meroni. Evaluation of Elisa test for therapeutic monitoring of Nelfinavir in HIV-positive patients.
The new microbiologica.
2007 Jul; 30(3):318-20. doi:
NULL. [PMID: 17802918] - R Verbesselt, E Van Wijngaerden, J de Hoon. Simultaneous determination of 8 HIV protease inhibitors in human plasma by isocratic high-performance liquid chromatography with combined use of UV and fluorescence detection: amprenavir, indinavir, atazanavir, ritonavir, lopinavir, saquinavir, nelfinavir and M8-nelfinavir metabolite.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Jan; 845(1):51-60. doi:
10.1016/j.jchromb.2006.07.068. [PMID: 16997640]