N-(4-Methoxy-3-phenethoxyphenethyl)-N-propylpropan-1-amine (BioDeep_00000181592)

   

human metabolite blood metabolite


代谢物信息卡片


N,N-Dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride

化学式: C23H33NO2 (355.25111580000004)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCN(CCC)CCC1=CC(=C(C=C1)OC)OCCC2=CC=CC=C2
InChI: InChI=1S/C23H33NO2/c1-4-15-24(16-5-2)17-13-21-11-12-22(25-3)23(19-21)26-18-14-20-9-7-6-8-10-20/h6-12,19H,4-5,13-18H2,1-3H3

描述信息

同义名列表

3 个代谢物同义名

N,N-Dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride; N-(4-Methoxy-3-phenethoxyphenethyl)-N-propylpropan-1-amine; {2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethyl}dipropylamine



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Rebecca L Brindley, Mary Beth Bauer, Nolan D Hartley, Kyle J Horning, Kevin P M Currie. Sigma-1 receptor ligands inhibit catecholamine secretion from adrenal chromaffin cells due to block of nicotinic acetylcholine receptors. Journal of neurochemistry. 2017 10; 143(2):171-182. doi: 10.1111/jnc.14149. [PMID: 28815595]
  • J Hong, S Sha, L Zhou, C Wang, J Yin, L Chen. Sigma-1 receptor deficiency reduces MPTP-induced parkinsonism and death of dopaminergic neurons. Cell death & disease. 2015 Jul; 6(?):e1832. doi: 10.1038/cddis.2015.194. [PMID: 26203861]
  • Tamaki Ishima, Yuko Fujita, Kenji Hashimoto. Interaction of new antidepressants with sigma-1 receptor chaperones and their potentiation of neurite outgrowth in PC12 cells. European journal of pharmacology. 2014 Mar; 727(?):167-73. doi: 10.1016/j.ejphar.2014.01.064. [PMID: 24508523]
  • Takato Hiranita, Paul L Soto, Stephen J Kohut, Theresa Kopajtic, Jianjing Cao, Amy H Newman, Gianluigi Tanda, Jonathan L Katz. Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors. The Journal of pharmacology and experimental therapeutics. 2011 Nov; 339(2):662-77. doi: 10.1124/jpet.111.185025. [PMID: 21859929]
  • Stéphane Bastianetto, Marc Danik, Françoise Mennicken, Sylvain Williams, Rémi Quirion. Prototypical antipsychotic drugs protect hippocampal neuronal cultures against cell death induced by growth medium deprivation. BMC neuroscience. 2006 Mar; 7(?):28. doi: 10.1186/1471-2202-7-28. [PMID: 16573831]
  • T Yamamoto, H Itoga, Y Kohno, K Nagata, Y Yamazoe. Prediction of oral clearance from in vitro metabolic data using recombinant CYPs: comparison among well-stirred, parallel-tube, distributed and dispersion models. Xenobiotica; the fate of foreign compounds in biological systems. 2005 Jun; 35(6):627-46. doi: 10.1080/00498250500159371. [PMID: 16192112]
  • Takahito Yamamoto, Naoko Hagima, Misako Fukasawa, Jun-ichi Yamaguchi, Masato Nakamura, Yoshiro Kohno, Kiyoshi Nagata, Yasushi Yamazoe. Metabolism of N,N-dipropyl-2-[4-methoxy-3-(2-phenyl-ethoxy)-phenyl]-ethyl-amine-monohydrochloride (NE-100), a novel sigma ligand: contribution of cytochrome P450 forms involved in the formation of individual metabolites in human liver and small intestine. Drug metabolism and pharmacokinetics. 2003; 18(3):173-85. doi: 10.2133/dmpk.18.173. [PMID: 15618733]
  • M Perfumi, I Panocka, R Ciccocioppo, D Vitali, R Froldi, M Massi. Effects of a methanolic extract and a hyperforin-enriched CO2 extract of Hypericum perforatum on alcohol intake in rats. Alcohol and alcoholism (Oxford, Oxfordshire). 2001 May; 36(3):199-206. doi: 10.1093/alcalc/36.3.199. [PMID: 11373255]
  • J Yamaguchi, Y Watanabe, M Ohmichi, S Jingu, N Ogawa, J Kokatsu, K Fukushima, J Goto. Ultrasensitive determination of NE-100, a novel sigma ligand, in human plasma by liquid chromatography and electrospray ionization tandem mass spectrometry combined with a column-switching technique. Journal of chromatography. B, Biomedical sciences and applications. 1999 Jun; 730(1):61-70. doi: 10.1016/s0378-4347(99)00183-8. [PMID: 10437673]