Navitoclax (BioDeep_00000181574)

   

human metabolite blood metabolite


代谢物信息卡片


4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-(4-{[4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-trifluoromethanesulfonylbenzenesulfonyl)benzamide

化学式: C47H55ClF3N5O6S3 (973.2954915999998)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 50%

分子结构信息

SMILES: CC1(C)CCC(=C(CN2CCN(CC2)C2=CC=C(C=C2)C(=O)NS(=O)(=O)C2=CC(=C(NC(CCN3CCOCC3)CSC3=CC=CC=C3)C=C2)S(=O)(=O)C(F)(F)F)C1)C1=CC=C(Cl)C=C1
InChI: InChI=1S/C47H55ClF3N5O6S3/c1-46(2)20-18-42(34-8-12-37(48)13-9-34)36(31-46)32-55-22-24-56(25-23-55)39-14-10-35(11-15-39)45(57)53-65(60,61)41-16-17-43(44(30-41)64(58,59)47(49,50)51)52-38(19-21-54-26-28-62-29-27-54)33-63-40-6-4-3-5-7-40/h3-17,30,38,52H,18-29,31-33H2,1-2H3,(H,53,57)

描述信息

同义名列表

3 个代谢物同义名

4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-(4-{[4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-trifluoromethanesulfonylbenzenesulfonyl)benzamide; 4-[4-[[2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohexenyl]methyl]-1-piperazinyl]-N-[4-[[4-(4-morpholinyl)-1-(phenylthio)butan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamide; Navitoclax



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mohammad Badran, Clementine Puech, Abdelnaby Khalyfa, Rene Cortese, Kylie Cataldo, Zhuanhong Qiao, David Gozal. Senolytic-facilitated Reversal of End-Organ Dysfunction in a Murine Model of Obstructive Sleep Apnea. American journal of respiratory and critical care medicine. 2024 Apr; 209(8):1001-1012. doi: 10.1164/rccm.202306-1101oc. [PMID: 38113165]
  • Syahru Agung Setiawan, Winston Zhenhao Liu, Pei-Wei Weng, Chia-Hwa Lee, Vijesh Kumar Yadav, Mardiah Suci Hardianti, Chi-Tai Yeh, Tsu-Yi Chao. Synergistic disruption of BTK and BCL-2 causes apoptosis while inducing ferroptosis in double-hit lymphoma. European journal of pharmacology. 2023 Mar; 943(?):175526. doi: 10.1016/j.ejphar.2023.175526. [PMID: 36693553]
  • Akira Koyanagi, Hitoshi Kotani, Yuichi Iida, Ryosuke Tanino, Irna D Kartika, Koji Kishimoto, Mamoru Harada. Protective roles of cytoplasmic p21Cip1 /Waf1 in senolysis and ferroptosis of lung cancer cells. Cell proliferation. 2022 Dec; 55(12):e13326. doi: 10.1111/cpr.13326. [PMID: 36054146]
  • Yingjie Qing, Hui Li, Yunzi Zhao, Po Hu, Xiangyuan Wang, Xiaoxuan Yu, Mengyuan Zhu, Hongzheng Wang, Zhanyu Wang, Qinglong Guo, Hui Hui. One-Two Punch Therapy for the Treatment of T-Cell Malignancies Involving p53-Dependent Cellular Senescence. Oxidative medicine and cellular longevity. 2021; 2021(?):5529518. doi: 10.1155/2021/5529518. [PMID: 34603598]
  • Xiaohui Wang, Zhimin Gu, Gongquan Li, Shufeng Zhang, Zhenjie Cao, Zhanfeng Yang, Guangzhi Liu. Norcantharidin enhances ABT-263-mediated anticancer activity in neuroblastoma cells by upregulation of Noxa. Oncology reports. 2014 Aug; 32(2):716-22. doi: 10.3892/or.2014.3228. [PMID: 24891300]
  • Huanjie Shao, Kai Jing, Esraa Mahmoud, Haihong Huang, Xianjun Fang, Chunrong Yu. Apigenin sensitizes colon cancer cells to antitumor activity of ABT-263. Molecular cancer therapeutics. 2013 Dec; 12(12):2640-50. doi: 10.1158/1535-7163.mct-13-0066. [PMID: 24126433]