2-Chloro-N-icosa-5,8,11,14-tetraenylacetamide (BioDeep_00000181492)
human metabolite blood metabolite
代谢物信息卡片
2-Chloro-N-(icosa-5,8,11,14-tetraen-1-yl)ethanimidate
化学式: C22H36ClNO (365.2485)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCC=CCC=CCC=CCC=CCCCCNC(=O)CCl
InChI: InChI=1S/C22H36ClNO/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-24-22(25)21-23/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,24,25)
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Marta Andres-Mach, Dorota Zolkowska, Beata Barcicka-Klosowska, Agnieszka Haratym-Maj, Magdalena Florek-Luszczki, Jarogniew J Luszczki. Effect of ACEA--a selective cannabinoid CB1 receptor agonist on the protective action of different antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model.
Progress in neuro-psychopharmacology & biological psychiatry.
2012 Dec; 39(2):301-9. doi:
10.1016/j.pnpbp.2012.07.001. [PMID: 22789660] - Hui-Chun Huang, Sun-Sang Wang, I-Fang Hsin, Ching-Chih Chang, Fa-Yauh Lee, Han-Chieh Lin, Chiao-Lin Chuang, Jing-Yi Lee, Hsian-Guey Hsieh, Shou-Dong Lee. Cannabinoid receptor 2 agonist ameliorates mesenteric angiogenesis and portosystemic collaterals in cirrhotic rats.
Hepatology (Baltimore, Md.).
2012 Jul; 56(1):248-58. doi:
10.1002/hep.25625. [PMID: 22290687] - Benjamin S Harvey, Katharina S Ohlsson, Jesper L V Mååg, Ian F Musgrave, Scott D Smid. Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro.
Neurotoxicology.
2012 Jan; 33(1):138-46. doi:
10.1016/j.neuro.2011.12.015. [PMID: 22233683] - Judit Hohmann, Dóra Rédei, Peter Forgo, Pál Szabó, Tamás F Freund, József Haller, Engin Bojnik, Sándor Benyhe. Alkamides and a neolignan from Echinacea purpurea roots and the interaction of alkamides with G-protein-coupled cannabinoid receptors.
Phytochemistry.
2011 Oct; 72(14-15):1848-53. doi:
10.1016/j.phytochem.2011.06.008. [PMID: 21764086] - Mako Toyoda, Akira Kitaoka, Kazuyuki Machida, Takuya Nishinakagawa, Ryoko Yada, Motoyuki Kohjima, Masaki Kato, Kazuhiro Kotoh, Naoya Sakamoto, Goshi Shiota, Makoto Nakamuta, Manabu Nakashima, Munechika Enjoji. Association between lipid accumulation and the cannabinoid system in Huh7 cells expressing HCV genes.
International journal of molecular medicine.
2011 May; 27(5):619-24. doi:
10.3892/ijmm.2011.622. [PMID: 21331443] - James D O'Hare, Elizabeth Zielinski, Bob Cheng, Thomas Scherer, Christoph Buettner. Central endocannabinoid signaling regulates hepatic glucose production and systemic lipolysis.
Diabetes.
2011 Apr; 60(4):1055-62. doi:
10.2337/db10-0962. [PMID: 21447652] - Silvia Zoppi, Beatriz G Pérez Nievas, José L M Madrigal, Jorge Manzanares, Juan C Leza, Borja García-Bueno. Regulatory role of cannabinoid receptor 1 in stress-induced excitotoxicity and neuroinflammation.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2011 Mar; 36(4):805-18. doi:
10.1038/npp.2010.214. [PMID: 21150911] - Andrea De Gottardi, Laurent Spahr, Florence Ravier-Dall'Antonia, Antoine Hadengue. Cannabinoid receptor 1 and 2 agonists increase lipid accumulation in hepatocytes.
Liver international : official journal of the International Association for the Study of the Liver.
2010 Nov; 30(10):1482-9. doi:
10.1111/j.1478-3231.2010.02298.x. [PMID: 20602678] - Ying-Ying Yang, Han-Chieh Lin. Cross-regulation of cannabinoid CB₁ and CB₂ receptors governs hepatic steatosis.
Liver international : official journal of the International Association for the Study of the Liver.
2010 Nov; 30(10):1397-9. doi:
10.1111/j.1478-3231.2010.02352.x. [PMID: 20860563] - Takahiro Shimizu, Lianyi Lu, Kunihiko Yokotani. Possible inhibitory roles of endogenous 2-arachidonoylglycerol during corticotropin-releasing factor-induced activation of central sympatho-adrenomedullary outflow in anesthetized rats.
European journal of pharmacology.
2010 Sep; 641(1):54-60. doi:
10.1016/j.ejphar.2010.05.007. [PMID: 20519139] - Jarogniew J Luszczki, Piotr Czuczwar, Anna Cioczek-Czuczwar, Monika Dudra-Jastrzebska, Marta Andres-Mach, Stanislaw J Czuczwar. Effect of arachidonyl-2'-chloroethylamide, a selective cannabinoid CB1 receptor agonist, on the protective action of the various antiepileptic drugs in the mouse maximal electroshock-induced seizure model.
Progress in neuro-psychopharmacology & biological psychiatry.
2010 Feb; 34(1):18-25. doi:
10.1016/j.pnpbp.2009.09.005. [PMID: 19751793] - M Rutkowska, H Gliniak. The influence of ACEA--a selective cannabinoid CB1 receptor agonist on whole blood and platelet-poor plasma serotonin concentrations.
Die Pharmazie.
2009 Sep; 64(9):598-601. doi:
NULL. [PMID: 19827303] - Moisés García-Arencibia, Sara González, Eva de Lago, José A Ramos, Raphael Mechoulam, Javier Fernández-Ruiz. Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: importance of antioxidant and cannabinoid receptor-independent properties.
Brain research.
2007 Feb; 1134(1):162-70. doi:
10.1016/j.brainres.2006.11.063. [PMID: 17196181] - Mila Kessiova, Albena Alexandrova, Almira Georgieva, Margarita Kirkova, Simeon Todorov. In vitro effects of CB1 receptor ligands on lipid peroxidation and antioxidant defense systems in the rat brain.
Pharmacological reports : PR.
2006 Nov; 58(6):870-5. doi:
". [PMID: 17220544] - Elina Tsvetanova, Mila Kessiova, Albena Alexandrova, Lubomir Petrov, Margarita Kirkova, Simeon Todorov. In vivo effects of CB1 receptor ligands on lipid peroxidation and antioxidant defense systems in the rat brain of healthy and ethanol-treated rats.
Pharmacological reports : PR.
2006 Nov; 58(6):876-83. doi:
". [PMID: 17220545] - Jarogniew J Luszczki, Piotr Czuczwar, Anna Cioczek-Czuczwar, Stanislaw J Czuczwar. Arachidonyl-2'-chloroethylamide, a highly selective cannabinoid CB1 receptor agonist, enhances the anticonvulsant action of valproate in the mouse maximal electroshock-induced seizure model.
European journal of pharmacology.
2006 Oct; 547(1-3):65-74. doi:
10.1016/j.ejphar.2006.07.037. [PMID: 16930590] - Edward S Kimball, Craig R Schneider, Nathaniel H Wallace, Pamela J Hornby. Agonists of cannabinoid receptor 1 and 2 inhibit experimental colitis induced by oil of mustard and by dextran sulfate sodium.
American journal of physiology. Gastrointestinal and liver physiology.
2006 Aug; 291(2):G364-71. doi:
10.1152/ajpgi.00407.2005. [PMID: 16574988] - Aaron M D'Antona, Kwang H Ahn, Debra A Kendall. Mutations of CB1 T210 produce active and inactive receptor forms: correlations with ligand affinity, receptor stability, and cellular localization.
Biochemistry.
2006 May; 45(17):5606-17. doi:
10.1021/bi060067k. [PMID: 16634642]
