2-[(3-Iodophenyl)methyl]-1-[[N'-[(3-iodophenyl)methyl]carbamimidoyl]amino]guanidine (BioDeep_00000181481)
human metabolite blood metabolite
代谢物信息卡片
化学式: C16H18I2N6 (547.9682408)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 66.67%
分子结构信息
SMILES: C1=CC(=CC(=C1)I)CN=C(N)NNC(=NCC2=CC(=CC=C2)I)N
InChI: InChI=1S/C16H18I2N6/c17-13-5-1-3-11(7-13)9-21-15(19)23-24-16(20)22-10-12-4-2-6-14(18)8-12/h1-8H,9-10H2,(H3,19,21,23)(H3,20,22,24)
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
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PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Judith G Villablanca, Wendy B London, Arlene Naranjo, Patrick McGrady, Matthew M Ames, Joel M Reid, Renee M McGovern, Sarah A Buhrow, Hollie Jackson, Enno Stranzinger, Brenda J Kitchen, Paul M Sondel, Marguerite T Parisi, Barry Shulkin, Gregory A Yanik, Susan L Cohn, C Patrick Reynolds. Phase II study of oral capsular 4-hydroxyphenylretinamide (4-HPR/fenretinide) in pediatric patients with refractory or recurrent neuroblastoma: a report from the Children's Oncology Group.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2011 Nov; 17(21):6858-66. doi:
10.1158/1078-0432.ccr-11-0995
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Clinical cancer research : an official journal of the American Association for Cancer Research.
2011 Apr; 17(8):2339-49. doi:
10.1158/1078-0432.ccr-10-2949
. [PMID: 21421857] - G Prabhakar, Anupam Mathur, G Shunmugam, Y D Teje, S S Sachdev, N Sivaprasad. Efficient production of therapeutic doses of [131I]-metaiodobenzylguanidine for clinical use.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.
2011 Jan; 69(1):63-7. doi:
10.1016/j.apradiso.2010.08.020
. [PMID: 20933432] - Shigehiko Katoh, Tetsuro Shishido, Daisuke Kutsuzawa, Takanori Arimoto, Shunsuke Netsu, Akira Funayama, Mitsunori Ishino, Takeshi Niizeki, Satoshi Nishiyama, Hiroki Takahashi, Takehiko Miyashita, Takuya Miyamoto, Joji Nitobe, Tetsu Watanabe, Isao Kubota. Iodine-123-metaiodobenzylguanidine imaging can predict future cardiac events in heart failure patients with preserved ejection fraction.
Annals of nuclear medicine.
2010 Nov; 24(9):679-86. doi:
10.1007/s12149-010-0409-3
. [PMID: 20824398] - Shaunak Navalkissoor, Dona M Alhashimi, Ann-Marie Quigley, Martyn E Caplin, John R Buscombe. Efficacy of using a standard activity of (131)I-MIBG therapy in patients with disseminated neuroendocrine tumours.
European journal of nuclear medicine and molecular imaging.
2010 May; 37(5):904-12. doi:
10.1007/s00259-009-1326-3
. [PMID: 20016892] - Sara Gonias, Robert Goldsby, Katherine K Matthay, Randall Hawkins, David Price, John Huberty, Lloyd Damon, Charles Linker, Aimee Sznewajs, Steve Shiboski, Paul Fitzgerald. Phase II study of high-dose [131I]metaiodobenzylguanidine therapy for patients with metastatic pheochromocytoma and paraganglioma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2009 Sep; 27(25):4162-8. doi:
10.1200/jco.2008.21.3496
. [PMID: 19636009] - Peter Brader, Kaitlyn J Kelly, Nanhai Chen, Yong A Yu, Qian Zhang, Pat Zanzonico, Eva M Burnazi, Rashid E Ghani, Inna Serganova, Hedvig Hricak, Aladar A Szalay, Yuman Fong, Ronald G Blasberg. Imaging a Genetically Engineered Oncolytic Vaccinia Virus (GLV-1h99) Using a Human Norepinephrine Transporter Reporter Gene.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2009 Jun; 15(11):3791-801. doi:
10.1158/1078-0432.ccr-08-3236
. [PMID: 19470726] - Elisabete Martins, Teresa Faria, J Silva-Cardoso, Ana Oliveira, Manuel Campelo, Sandra Amorim, Brenda Moura, F Rocha-Gonçalves, Jorge G Pereira, M Júlia Maciel. I-123-MIBG cardiac uptake imaging, in familial dilated cardiomyopathy.
Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology.
2009 Jan; 28(1):29-36. doi:
NULL
. [PMID: 19388491] - Amanda C Donovan, John F Valliant. A convenient solution-phase method for the preparation of meta-iodobenzylguanidine in high effective specific activity.
Nuclear medicine and biology.
2008 Oct; 35(7):741-6. doi:
10.1016/j.nucmedbio.2008.07.006
. [PMID: 18848658] - Marie Boyd, Annette Sorensen, Anthony G McCluskey, Robert J Mairs. Radiation quality-dependent bystander effects elicited by targeted radionuclides.
The Journal of pharmacy and pharmacology.
2008 Aug; 60(8):951-8. doi:
10.1211/jpp.60.8.0002
. [PMID: 18644188] - Takanori Arimoto, Hiroyasu Sukekawa, Mutsuo Harada, Shin Takayama, Eiichiro Ikeno, Kouichi Nisugi, Yasuchika Takeishi, Isao Kubota. Short cardiac iodine-123-metaiodobenzylguanidine imaging protocol in heart failure.
Circulation journal : official journal of the Japanese Circulation Society.
2008 Jul; 72(7):1106-11. doi:
10.1253/circj.72.1106
. [PMID: 18577819] - Shakeel Modak, Neeta Pandit-Taskar, Brian H Kushner, Kim Kramer, Peter Smith-Jones, Steven Larson, Nai-Kong V Cheung. Transient sialoadenitis: a complication of 131I-metaiodobenzylguanidine therapy.
Pediatric blood & cancer.
2008 Jun; 50(6):1271-3. doi:
10.1002/pbc.21391
. [PMID: 17973318] - Maxim A Moroz, Inna Serganova, Pat Zanzonico, Ludmila Ageyeva, Tatiana Beresten, Ekaterina Dyomina, Eva Burnazi, Ronald D Finn, Michael Doubrovin, Ronald G Blasberg. Imaging hNET reporter gene expression with 124I-MIBG.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2007 May; 48(5):827-36. doi:
10.2967/jnumed.106.037812
. [PMID: 17475971] - C Ramos Font, E Martínez Gimeno, A Allende Riera, M De Sequera Rahola, C Cárdenas Negro, L E Rodríguez Delgado. [Unexpected renal uptake in a 123I-MIBG study].
Revista espanola de medicina nuclear.
2006 Sep; 25(5):325-6. doi:
10.1157/13092701
. [PMID: 17173780] - Reisuke Yuyama, Fumio Yuasa, Makoto Hikosaka, Jun Mimura, Akihiro Kawamura, Kengo Hatada, Masayuki Motohiro, Masayoshi Iwasaki, Tetsuro Sugiura, Toshiji Iwasaka. Iodine 123-metaiodobenzylguanidine imaging reflect generalized sympathetic activation in patients with left ventricular dysfunction.
Clinical physiology and functional imaging.
2005 Jan; 25(1):34-9. doi:
10.1111/j.1475-097x.2004.00571.x
. [PMID: 15659078] - Michael Höpfner, Andreas P Sutter, Alexander Huether, Gudrun Ahnert-Hilger, Hans Scherübl. A novel approach in the treatment of neuroendocrine gastrointestinal tumors: additive antiproliferative effects of interferon-gamma and meta-iodobenzylguanidine.
BMC cancer.
2004 May; 4(?):23. doi:
10.1186/1471-2407-4-23
. [PMID: 15154969] - Samuel Samnick, Claudia Scheuer, Sven Münks, Amr M El-Gibaly, Michael D Menger, Carl-Martin Kirsch. Technetium-99m labeled 1-(4-fluorobenzyl)-4-(2-mercapto-2-methyl-4-azapentyl)-4-(2-mercapto-2-methylpropylamino)-piperidine and iodine-123 metaiodobenzylguanidine for studying cardiac adrenergic function: a comparison of the uptake characteristics in vascular smooth muscle cells and neonatal cardiac myocytes, and an investigation in rats.
Nuclear medicine and biology.
2004 May; 31(4):511-22. doi:
10.1016/j.nucmedbio.2003.12.007
. [PMID: 15093822] - Myron C Gerson, Nancy McGuire, Lynne E Wagoner. Sympathetic nervous system function as measured by I-123 metaiodobenzylguanidine predicts transplant-free survival in heart failure patients with idiopathic dilated cardiomyopathy.
Journal of cardiac failure.
2003 Oct; 9(5):384-91. doi:
10.1054/s1071-9164(03)00134-9
. [PMID: 14583900] - Annette Altmann, Maria Kissel, Sabine Zitzmann, Wolfgang Kübler, Miriam Mahmut, Peter Peschke, Uwe Haberkorn. Increased MIBG uptake after transfer of the human norepinephrine transporter gene in rat hepatoma.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2003 Jun; 44(6):973-80. doi:
. [PMID: 12791828]
- Paul A R de Milliano, Andre C de Groot, Jan G P Tijssen, Berthe L F van Eck-Smit, Pieter A Van Zwieten, Kong I Lie. Beneficial effects of metoprolol on myocardial sympathetic function: Evidence from a randomized, placebo-controlled study in patients with congestive heart failure.
American heart journal.
2002 Aug; 144(2):E3. doi:
10.1067/mhj.2002.121807
. [PMID: 12177661] - Yang-Yi Ong, Deborah Cohn, Johan Wijaya, Paul Roach. The importance of renal localization with MIBG scintigraphy.
Clinical nuclear medicine.
2002 Jul; 27(7):479-82. doi:
10.1097/00003072-200207000-00002
. [PMID: 12072772] - P A R de Milliano, J G P Tijssen, B L F van Eck-Smit, K I Lie. Cardiac 123 I-MIBG imaging and clinical variables in risk stratification in patients with heart failure treated with beta blockers.
Nuclear medicine communications.
2002 Jun; 23(6):513-9. doi:
10.1097/00006231-200206000-00002
. [PMID: 12029205] - Joost F Swart, Jan de Kraker, Nico van der Lely. Metaiodobenzylguanidine total-body scintigraphy required for revealing occult neuroblastoma in opsoclonus-myoclonus syndrome.
European journal of pediatrics.
2002 May; 161(5):255-8. doi:
10.1007/s00431-002-0934-8
. [PMID: 12012219] - Margit Pissarek, Johannes Ermert, Guido Oesterreich, Dirk Bier, Heinz H Coenen. Relative uptake, metabolism, and beta-receptor binding of (1R,2S)-4-(18)F-fluorometaraminol and (123)I-MIBG in normotensive and spontaneously hypertensive rats.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2002 Mar; 43(3):366-73. doi:
NULL
. [PMID: 11884497] - Shigeki Nagamachi, Seishi Jinnouchi, Takeshi Kurose, Ryuichi Nishii, Keiichi Kawai, Shigemi Futami, Shozo Tamura, Shigeru Matsukura. Serial change in 123I-MIBG myocardial scintigraphy in non-insulin-dependent diabetes mellitus.
Annals of nuclear medicine.
2002 Feb; 16(1):33-8. doi:
10.1007/bf02995289
. [PMID: 11922206] - M S Eigelberger, Q Y Duh. Pheochromocytoma.
Current treatment options in oncology.
2001 Aug; 2(4):321-9. doi:
10.1007/s11864-001-0025-5
. [PMID: 12057112] - D W Gao, P O Talke, M W Dae. Effects of reduced sympathetic activity on myocardial metaiodobenzylguanidine (MIBG) washout.
Journal of autonomic pharmacology.
2001 Jun; 21(3):159-64. doi:
10.1046/j.1365-2680.2001.00221.x
. [PMID: 11844024] - M Owa, K Aizawa, N Urasawa, H Ichinose, K Yamamoto, K Karasawa, M Kagoshima, J Koyama, S Ikeda. Emotional stress-induced 'ampulla cardiomyopathy': discrepancy between the metabolic and sympathetic innervation imaging performed during the recovery course.
Japanese circulation journal.
2001 Apr; 65(4):349-52. doi:
10.1253/jcj.65.349
. [PMID: 11316138] - Y Imamura, T Fukuyama, T Mochizuki, M Miyagawa, K Watanabe. Prognostic value of iodine-123-metaiodobenzylguanidine imaging and cardiac natriuretic peptide levels in patients with left ventricular dysfunction resulting from cardiomyopathy.
Japanese circulation journal.
2001 Mar; 65(3):155-60. doi:
10.1253/jcj.65.155
. [PMID: 11266187] - C A Hoefnagel, M Rutgers, C K Buitenhuis, L A Smets, J de Kraker, M Meli, F Carrel, H Amstutz, P A Schubiger, I Novak-Hofer. A comparison of targeting of neuroblastoma with mIBG and anti L1-CAM antibody mAb chCE7: therapeutic efficacy in a neuroblastoma xenograft model and imaging of neuroblastoma patients.
European journal of nuclear medicine.
2001 Mar; 28(3):359-68. doi:
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. [PMID: 11315605] - E van der Harst, W W de Herder , H A Bruining, H J Bonjer, R R de Krijger , S W Lamberts, A H van de Meiracker , F Boomsma, T Stijnen, E P Krenning, F T Bosman, D J Kwekkeboom. [(123)I]metaiodobenzylguanidine and [(111)In]octreotide uptake in begnign and malignant pheochromocytomas.
The Journal of clinical endocrinology and metabolism.
2001 Feb; 86(2):685-93. doi:
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. [PMID: 11158032]