2-(20-Hydroxyicosa-5,14-dienoylamino)acetic acid (BioDeep_00000181472)
human metabolite blood metabolite
代谢物信息卡片
化学式: C22H39NO4 (381.28789340000003)
中文名称:
谱图信息:
最多检出来源 Mus musculus(blood) 79.17%
分子结构信息
SMILES: OCCCCCC=CCCCCCCCC=CCCCC(=O)NCC(O)=O
InChI: InChI=1S/C22H39NO4/c24-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-21(25)23-20-22(26)27/h7,9-10,12,24H,1-6,8,11,13-20H2,(H,23,25)(H,26,27)
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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BioCyc(0)
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Plant Reactome(0)
INOH(0)
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Bahar Tunctan, Belma Korkmaz, Ayse Nihal Sari, Meltem Kacan, Demet Unsal, Mehmet Sami Serin, C Kemal Buharalioglu, Seyhan Sahan-Firat, Wolf-Hagen Schunck, John R Falck, Kafait U Malik. A novel treatment strategy for sepsis and septic shock based on the interactions between prostanoids, nitric oxide, and 20-hydroxyeicosatetraenoic acid.
Anti-inflammatory & anti-allergy agents in medicinal chemistry.
2012; 11(2):121-50. doi:
10.2174/187152312803305759. [PMID: 23013331] - Tuba Cuez, Belma Korkmaz, C Kemal Buharalioglu, Seyhan Sahan-Firat, John Falck, Kafait U Malik, Bahar Tunctan. A synthetic analogue of 20-HETE, 5,14-HEDGE, reverses endotoxin-induced hypotension via increased 20-HETE levels associated with decreased iNOS protein expression and vasodilator prostanoid production in rats.
Basic & clinical pharmacology & toxicology.
2010 May; 106(5):378-88. doi:
10.1111/j.1742-7843.2009.00501.x. [PMID: 20002062] - Talha Akbulut, Kevin R Regner, Richard J Roman, Ellis D Avner, John R Falck, Frank Park. 20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.
American journal of physiology. Renal physiology.
2009 Sep; 297(3):F662-70. doi:
10.1152/ajprenal.00146.2009. [PMID: 19570883] - Bahar Tunctan, Belma Korkmaz, C Kemal Buharalioglu, Seyhan Sahan Firat, Siddam Anjaiah, John Falck, Richard J Roman, Kafait U Malik. A 20-hydroxyeicosatetraenoic acid agonist, N-[20-hydroxyeicosa-5(Z),14(Z)-dienoyl]glycine, opposes the fall in blood pressure and vascular reactivity in endotoxin-treated rats.
Shock (Augusta, Ga.).
2008 Sep; 30(3):329-35. doi:
10.1097/shk.0b013e31816471c6. [PMID: 18323740]