14,15-Dihydroxyicosa-2,4,6-trienoic acid (BioDeep_00000181465)
human metabolite blood metabolite
代谢物信息卡片
14,15-Dihydroxyicosa-2,4,6-trienoic acid
化学式: C20H34O4 (338.24569640000004)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 99.18%
分子结构信息
SMILES: CCCCCC(O)C(O)CCCCCCC=CC=CC=CC(O)=O
InChI: InChI=1S/C20H34O4/c1-2-3-12-15-18(21)19(22)16-13-10-8-6-4-5-7-9-11-14-17-20(23)24/h5,7,9,11,14,17-19,21-22H,2-4,6,8,10,12-13,15-16H2,1H3,(H,23,24)
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
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PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Gang Zhao, Jianing Wang, Xizhen Xu, Yanyan Jing, Ling Tu, Xuguang Li, Chen Chen, Katherine Cianflone, Peihua Wang, Ryan T Dackor, Darryl C Zeldin, Dao Wen Wang. Epoxyeicosatrienoic acids protect rat hearts against tumor necrosis factor-α-induced injury.
Journal of lipid research.
2012 Mar; 53(3):456-466. doi:
10.1194/jlr.m017319. [PMID: 22223859] - Rose M Giordano, John W Newman, Theresa L Pedersen, Marisa I Ramos, Charles L Stebbins. Effects of dynamic exercise on plasma arachidonic acid epoxides and diols in human volunteers.
International journal of sport nutrition and exercise metabolism.
2011 Dec; 21(6):471-9. doi:
10.1123/ijsnem.21.6.471. [PMID: 22089302] - Kathryn M Gauthier, Lauren Olson, Adam Harder, Marilyn Isbell, John D Imig, David D Gutterman, J R Falck, William B Campbell. Soluble epoxide hydrolase contamination of specific catalase preparations inhibits epoxyeicosatrienoic acid vasodilation of rat renal arterioles.
American journal of physiology. Renal physiology.
2011 Oct; 301(4):F765-72. doi:
10.1152/ajprenal.00201.2011. [PMID: 21753077] - Penny Zhu, Brian Peck, Hermes Licea-Perez, James F Callahan, Catherine Booth-Genthe. Development of a semi-automated LC/MS/MS method for the simultaneous quantitation of 14,15-epoxyeicosatrienoic acid, 14,15-dihydroxyeicosatrienoic acid, leukotoxin and leukotoxin diol in human plasma as biomarkers of soluble epoxide hydrolase activity in vivo.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Sep; 879(25):2487-93. doi:
10.1016/j.jchromb.2011.06.042. [PMID: 21798825] - Changlong Zheng, Luyun Wang, Rui Li, Ben Ma, Ling Tu, Xizhen Xu, Ryan T Dackor, Darryl C Zeldin, Dao Wen Wang. Gene delivery of cytochrome p450 epoxygenase ameliorates monocrotaline-induced pulmonary artery hypertension in rats.
American journal of respiratory cell and molecular biology.
2010 Dec; 43(6):740-9. doi:
10.1165/rcmb.2009-0161oc. [PMID: 20118222] - Bin Xiao, Xuguang Li, Jiangtao Yan, Xuefeng Yu, Guangtian Yang, Xiao Xiao, James W Voltz, Darryl C Zeldin, Dao Wen Wang. Overexpression of cytochrome P450 epoxygenases prevents development of hypertension in spontaneously hypertensive rats by enhancing atrial natriuretic peptide.
The Journal of pharmacology and experimental therapeutics.
2010 Sep; 334(3):784-94. doi:
10.1124/jpet.110.167510. [PMID: 20501636] - Xizhen Xu, Chun Xia Zhao, Luyun Wang, Ling Tu, Xiaosai Fang, Changlong Zheng, Matthew L Edin, Darryl C Zeldin, Dao Wen Wang. Increased CYP2J3 expression reduces insulin resistance in fructose-treated rats and db/db mice.
Diabetes.
2010 Apr; 59(4):997-1005. doi:
10.2337/db09-1241. [PMID: 20068141] - Wenri Zhang, Jeffrey J Iliff, Caitlyn J Campbell, Ruikang K Wang, Patricia D Hurn, Nabil J Alkayed. Role of soluble epoxide hydrolase in the sex-specific vascular response to cerebral ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2009 Aug; 29(8):1475-81. doi:
10.1038/jcbfm.2009.65. [PMID: 19471280] - Beshay N M Zordoky, Mona E Aboutabl, Ayman O S El-Kadi. Modulation of cytochrome P450 gene expression and arachidonic acid metabolism during isoproterenol-induced cardiac hypertrophy in rats.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Nov; 36(11):2277-86. doi:
10.1124/dmd.108.023077. [PMID: 18725507] - Sarbani Ghosh, Po-Chang Chiang, Jan L Wahlstrom, Hideji Fujiwara, Jon G Selbo, Steven L Roberds. Oral delivery of 1,3-dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive rats.
Basic & clinical pharmacology & toxicology.
2008 May; 102(5):453-8. doi:
10.1111/j.1742-7843.2008.00213.x. [PMID: 18312493] - Xiang Fang, Shanming Hu, Bingkun Xu, Gary D Snyder, Shawn Harmon, Jianrong Yao, Yi Liu, Bhavani Sangras, J R Falck, Neal L Weintraub, Arthur A Spector. 14,15-Dihydroxyeicosatrienoic acid activates peroxisome proliferator-activated receptor-alpha.
American journal of physiology. Heart and circulatory physiology.
2006 Jan; 290(1):H55-63. doi:
10.1152/ajpheart.00427.2005. [PMID: 16113065] - Xiang Fang, Neal L Weintraub, Ryan B McCaw, Shanming Hu, Shawn D Harmon, James B Rice, Bruce D Hammock, Arthur A Spector. Effect of soluble epoxide hydrolase inhibition on epoxyeicosatrienoic acid metabolism in human blood vessels.
American journal of physiology. Heart and circulatory physiology.
2004 Dec; 287(6):H2412-20. doi:
10.1152/ajpheart.00527.2004. [PMID: 15284062] - Martin Spiecker, Harald Darius, Thomas Hankeln, Muhidien Soufi, Alexander M Sattler, Jürgen R Schaefer, Koichi Node, Jan Börgel, Andreas Mügge, Klaus Lindpaintner, Anika Huesing, Bernhard Maisch, Darryl C Zeldin, James K Liao. Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2.
Circulation.
2004 Oct; 110(15):2132-6. doi:
10.1161/01.cir.0000143832.91812.60. [PMID: 15466638]