N(4)-Acetylsulfadimethoxine (BioDeep_00000181408)

   

human metabolite blood metabolite


代谢物信息卡片


N-{4-[(4,6-dimethoxypyrimidin-2-yl)sulphamoyl]phenyl}ethanimidic acid

化学式: C14H16N4O5S (352.0841366)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 50%

分子结构信息

SMILES: CC(=O)NC1=CC=C(C=C1)S(=O)(=O)NC2=NC(=CC(=N2)OC)OC
InChI: InChI=1S/C14H16N4O5S/c1-9(19)15-10-4-6-11(7-5-10)24(20,21)18-14-16-12(22-2)8-13(17-14)23-3/h4-8H,1-3H3,(H,15,19)(H,16,17,18)

描述信息

D000890 - Anti-Infective Agents > D013424 - Sulfanilamides

同义名列表

9 个代谢物同义名

N-{4-[(4,6-dimethoxypyrimidin-2-yl)sulphamoyl]phenyl}ethanimidic acid; N-{4-[(4,6-dimethoxypyrimidin-2-yl)sulfamoyl]phenyl}ethanimidic acid; 4-Acetylamino-N-(4,6-dimethoxy-pyrimidin-2-yl)-benzenesulphonamide; N-{4-[(4,6-dimethoxypyrimidin-2-yl)sulphamoyl]phenyl}ethanimidate; 4-Acetylamino-N-(4,6-dimethoxy-pyrimidin-2-yl)-benzenesulfonamide; N-{4-[(4,6-dimethoxypyrimidin-2-yl)sulfamoyl]phenyl}ethanimidate; N(4)-Acetylsulphadimethoxine; N(4)-Acetylsulfadimethoxine; N(4)-AcSDM



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hui Li, Michelle L Smith, O Alberto Chiesa, Philip J Kijak. Determination of sulfadimethoxine and 4N-acetylsulfadimethoxine in bovine plasma, urine, oral fluid, and kidney and liver biopsy samples obtained surgically from standing animals by LC/MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2009 Jan; 877(3):237-46. doi: 10.1016/j.jchromb.2008.12.015. [PMID: 19124282]
  • N Furusawa. Elimination half-lives of sulphadimethoxine and its N4-acetyl metabolite in tissues of laying hens. Zentralblatt fur Veterinarmedizin. Reihe A. 1999 Feb; 46(1):59-64. doi: 10.1046/j.1439-0442.1999.00190.x. [PMID: 10085768]
  • C C Walker, R L Thune, S A Barker. Plasma/muscle ratios of sulfadimethoxine residues in channel catfish (Ictalurus punctatus). Journal of veterinary pharmacology and therapeutics. 1995 Aug; 18(4):306-10. doi: 10.1111/j.1365-2885.1995.tb00595.x. [PMID: 8583544]
  • T Nagata, Y Fukuda. Distribution and elimination of sulphadimethoxine and its metabolites in treated chicken. The Journal of pharmacy and pharmacology. 1994 Dec; 46(12):1004-12. doi: 10.1111/j.2042-7158.1994.tb03257.x. [PMID: 7714711]
  • C C Walker, S A Barker. Extraction and liquid chromatographic analysis of sulfadimethoxine and 4-N-acetylsulfadimethoxine residues in channel catfish (Ictalurus punctatus) muscle and plasma. Journal of AOAC International. 1994 Nov; 77(6):1460-6. doi: NULL. [PMID: 7819754]
  • S P Boom, A C Wouterse, T B Vree, C A Van Ginneken, F G Russel. Renal tubular excretion of the N4-acetyl metabolites of sulphasomidine and sulphadimethoxine in the dog. The Journal of pharmacy and pharmacology. 1993 Jul; 45(7):614-7. doi: 10.1111/j.2042-7158.1993.tb05663.x. [PMID: 8105055]
  • M Shimoda, T B Vree, E W Beneken Kolmer, T H Arts. The role of plasma protein binding on the metabolism and renal excretion of sulphadimethoxine and its metabolite N4-acetylsulphadimethoxine in pigs. The veterinary quarterly. 1990 Apr; 12(2):87-97. doi: 10.1080/01652176.1990.9694250. [PMID: 2363242]
  • Y Imamura, H Nakamura, M Otagiri. Effect of phenylbutazone on serum protein binding and pharmacokinetic behavior of sulfadimethoxine in rabbits, dogs and rats. Journal of pharmacobio-dynamics. 1989 Apr; 12(4):208-15. doi: 10.1248/bpb1978.12.208. [PMID: 2795429]
  • M Otagiri, H Nakamura, T Maruyama, Y Imamura, A Takadate. Characterization of binding sites for sulfadimethoxine and its major metabolite, N4-acetylsulfadimethoxine, on human and rabbit serum albumin. Chemical & pharmaceutical bulletin. 1989 Feb; 37(2):498-501. doi: 10.1248/cpb.37.498. [PMID: 2743500]
  • Y Imamura, H Agemura, M Otagiri. [Displacing effect of serum protein binding on intestinal absorption of sulfadimethoxine]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 1989 Jan; 109(1):65-70. doi: 10.1248/yakushi1947.109.1_65. [PMID: 2732906]
  • Y Imamura, H Mori, M Otagiri. Sulfadimethoxine-bucolome interaction in rabbits: role of N4-acetylsulfadimethoxine, a major metabolite of sulfadimethoxine. European journal of drug metabolism and pharmacokinetics. 1987 Jul; 12(3):169-73. doi: 10.1007/bf03189893. [PMID: 2893735]
  • Y Imamura, H Mori, H Ichibagase. Effect of simultaneous administration of drugs on absorption and excretion. XV. Effect of probenecid on plasma protein binding of sulfadimethoxine in rabbits: the role of N4-acetylsulfadimethoxine, the major metabolite of sulfadimethoxine. Chemical & pharmaceutical bulletin. 1983 Jan; 31(1):274-8. doi: 10.1248/cpb.31.274. [PMID: 6850942]