Sulpiride (BioDeep_00000018135)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


5-(Aminosulphonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxybenzamide

化学式: C15H23N3O4S (341.1409198)
中文名称: (±)-舒必利, 舒必利
谱图信息: 最多检出来源 Homo sapiens(urine) 22.22%

Reviewed

Last reviewed on 2024-09-14.

Cite this Page

Sulpiride. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/sulpiride (retrieved 2024-11-05) (BioDeep RN: BioDeep_00000018135). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CCN1CCCC1CNC(=O)C1=C(OC)C=CC(=C1)S(N)(=O)=O
InChI: InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)

描述信息

Sulpiride is only found in individuals that have used or taken this drug. It is a dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid. (From Merck Index, 11th ed)In contrast to most other neuroleptics which block both dopamine D1 and D2 receptors, Sulpiride is more selective and acts primarily as a dopamine D2 antagonist. Sulpiride appears to lack effects on norepinephrine, acetylcholine, serotonin, histamine, or gamma-aminobutyric acid (GABA) receptors.
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AL - Benzamides
C78272 - Agent Affecting Nervous System > C66883 - Dopamine Antagonist
Sulpiride is an orally active dopamine D2/D3 receptor antagonist. Sulpiride is an atypical antipsychotic agent of the benzamide family. Sulpiride can be used in research into anxiety, depression and breast cancer[1][2][3].

同义名列表

61 个代谢物同义名

5-(Aminosulphonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxybenzamide; 5-(Aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxybenzamide; N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulphamoylbenzamide; N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide; N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoylbenzamide; N-((1-Ethyl-2-pyrrolidinyl)methyl)-5-sulphamoyl-O-anisamide; N-((1-Ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-O-anisamide; Sanofi synthelabo brand OF sulpiride; Sanofi-synthelabo brand OF sulpiride; Erempharma brand OF sulpiride; Psicofarma brand OF sulpiride; Dolorgiet brand OF sulpiride; Pharmacia brand OF sulpiride; Rosemont brand OF sulpiride; Fumouzer brand OF sulpiride; Hormosan brand OF sulpiride; Spyfarma brand OF sulpiride; Almirall brand OF sulpiride; Desitin brand OF sulpiride; Centrum brand OF sulpiride; Hoechst brand OF sulpiride; Allphar brand OF sulpiride; Uriach brand OF sulpiride; Krewel brand OF sulpiride; Hennig brand OF sulpiride; Hexal brand OF sulpiride; Areu brand OF sulpiride; vertigo Neogama; vertigo-Neogama; vertigo Meresa; vertigo-Meresa; (+-)-Sulpiride; Levosulpiride; Deponerton; Sulpiridum; Desisulpid; Sulpirida; Pontiride; Lebopride; sulpiride; Sulpivert; Sulperide; Sulpirid; Psicocen; Sulpyrid; Dogmatyl; Sulpitil; Dolmatil; Dogmatil; Aiglonyl; Neogama; Arminol; Tepavil; Synédil; Guastil; Eglonyl; Digton; Meresa; Ekilid; Sulpor; Sulp



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ravi Kant, Ajaypal Singh, Rohit Raina, Vandana Dhingra, Mukesh Bairwa, Varsha Kanwar. Real-world safety and effectiveness of Pistacia lentiscus (mastic gum) in patients with diabetic gastroparesis: 24-week interim analysis postintervention. Indian journal of pharmacology. 2024 Jan; 56(1):4-9. doi: 10.4103/ijp.ijp_555_23. [PMID: 38454582]
  • Olusegun Adebayo Adeoluwa, Anthony Taghogho Eduviere, Gladys Onyinye Adeoluwa, Lily Oghenevovwero Otomewo, Funmilayo Racheal Adeniyi. The monoaminergic pathways are involved in the antidepressant-like effect of quercetin. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Oct; ?(?):. doi: 10.1007/s00210-023-02789-8. [PMID: 37851059]
  • Erin L Oberhaus, Kaitlyn M Wilson, Caroline M Camp, Jenny L Sones. Sucrose Acetate Isobutyrate (SAIB) as a Delivery Vehicle for Estradiol and Sulpiride: Evaluation of Endocrine Responses in Geldings and Ovarian Response in Seasonally Anovulatory Mares. Journal of equine veterinary science. 2022 05; 112(?):103896. doi: 10.1016/j.jevs.2022.103896. [PMID: 35150853]
  • Yingliang Xie, Peizhen Wang, Xiaoyan Cui, Lei Liu, Pengcheng Wang, Shimei Jing, Qi Liu, Yuting Wang, Shiqiang Wang. Dopaminergic neurons project to the nucleus accumbens regulates anxiety-like behaviors through dopamine D1 signaling. Behavioural brain research. 2022 01; 416(?):113540. doi: 10.1016/j.bbr.2021.113540. [PMID: 34419513]
  • Viktor Román, Rita Kedves, Kristóf Kelemen, Zsolt Némethy, Beáta Sperlágh, Balázs Lendvai, E Sylvester Vizi. Contribution of analog signaling to neurotransmitter interactions and behavior: Role of transporter-mediated nonquantal dopamine release. Physiological reports. 2021 11; 9(21):e15088. doi: 10.14814/phy2.15088. [PMID: 34762352]
  • Salma M Mohyeldin, Wael M Samy, Doaa Ragab, Doaa A Abdelmonsif, Rania G Aly, Nazik A Elgindy. Hybrid lipid core chitosan-TPGS shell nanocomposites as a promising integrated nanoplatform for enhanced oral delivery of sulpiride in depressive disorder therapy. International journal of biological macromolecules. 2021 Oct; 188(?):432-449. doi: 10.1016/j.ijbiomac.2021.08.035. [PMID: 34375663]
  • Erwin Chiquete, Liz Toapanta-Yanchapaxi, José Jesús Aceves-Buendía, Eduardo Ruiz-Ruiz, Elizabeth Rodríguez-Perea, Salvador Durán-Coyote, Carlos Cantú-Brito. Levosulpiride Relieved Persistent Hiccups in a Patient With COVID-19 and Vascular Cognitive Impairment. Clinical neuropharmacology. 2021 Sep; 44(5):186-188. doi: 10.1097/wnf.0000000000000459. [PMID: 34238784]
  • Fengli Sun, Fang Yu, Zhihan Gao, Zhibin Ren, Weidong Jin. Study on the relationship among dose, concentration and clinical response in Chinese schizophrenic patients treated with Amisulpride. Asian journal of psychiatry. 2021 Aug; 62(?):102694. doi: 10.1016/j.ajp.2021.102694. [PMID: 34052710]
  • Nasrin Mehranfard, Alireza Halabian, Hojatallah Alaei, Maryam Radahmadi, Zahra Bahari, Maedeh Ghasemi. Possible involvement of the dopamine D2 receptors of ventromedial hypothalamus in the control of free- and scheduled-feeding and plasma ghrelin level in rat. Journal of complementary & integrative medicine. 2021 May; 18(4):711-717. doi: 10.1515/jcim-2020-0250. [PMID: 33979902]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Salma M Mohyeldin, Wael M Samy, Doaa Ragab, Doaa A Abdelmonsif, Rania G Aly, Nazik A Elgindy. Precisely Fabricated Sulpiride-Loaded Nanolipospheres with Ameliorated Oral Bioavailability and Antidepressant Activity. International journal of nanomedicine. 2021; 16(?):2013-2044. doi: 10.2147/ijn.s296726. [PMID: 33727812]
  • Hiroko Ikeda, Naomi Yonemochi, Risa Mikami, Manabu Abe, Meiko Kawamura, Rie Natsume, Kenji Sakimura, John L Waddington, Junzo Kamei. Central dopamine D2 receptors regulate plasma glucose levels in mice through autonomic nerves. Scientific reports. 2020 12; 10(1):22347. doi: 10.1038/s41598-020-79292-0. [PMID: 33339892]
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  • Nan Zhang, Mu Luo, Lei He, Lei Yao. Chemical Composition of Essential Oil from Flower of 'Shanzhizi' (Gardenia jasminoides Ellis) and Involvement of Serotonergic System in Its Anxiolytic Effect. Molecules (Basel, Switzerland). 2020 Oct; 25(20):. doi: 10.3390/molecules25204702. [PMID: 33066512]
  • Carlos D Nuñez-Amaro, Aura Ileana Moreno-Vega, Elva Adan-Castro, Magdalena Zamora, Renata Garcia-Franco, Paulina Ramirez-Neria, Marlon Garcia-Roa, Yolanda Villalpando, Juan Pablo Robles, Gabriela Ramirez-Hernandez, Mariana Lopez, Jorge Sanchez, Ellery Lopez-Star, Thomas Bertsch, Gonzalo Martinez de la Escalera, Ma Ludivina Robles-Osorio, Jakob Triebel, Carmen Clapp. Levosulpiride Increases the Levels of Prolactin and Antiangiogenic Vasoinhibin in the Vitreous of Patients with Proliferative Diabetic Retinopathy. Translational vision science & technology. 2020 08; 9(9):27. doi: 10.1167/tvst.9.9.27. [PMID: 32879783]
  • Amany T Mohammed, Samah R Khalil, Fagr A Mahmoud, Gamal A Elmowalid, Haytham A Ali, Hamed A El-Serehy, Mohamed M Abdel-Daim. The role of sulpiride in attenuating the cardiac, renal, and immune disruptions in rats receiving clozapine: mRNA expression pattern of the genes encoding Kim-1, TIMP-1, and CYP isoforms. Environmental science and pollution research international. 2020 Jul; 27(20):25404-25414. doi: 10.1007/s11356-020-08914-x. [PMID: 32350838]
  • Siew Cheng Foong, May Loong Tan, Wai Cheng Foong, Lisa A Marasco, Jacqueline J Ho, Joo Howe Ong. Oral galactagogues (natural therapies or drugs) for increasing breast milk production in mothers of non-hospitalised term infants. The Cochrane database of systematic reviews. 2020 05; 5(?):CD011505. doi: 10.1002/14651858.cd011505.pub2. [PMID: 32421208]
  • Lin Li, Lu Li, De-Wei Shang, Yu-Guan Wen, Yu-Ping Ning. A systematic review and combined meta-analysis of concentration of oral amisulpride. British journal of clinical pharmacology. 2020 04; 86(4):668-678. doi: 10.1111/bcp.14246. [PMID: 32090363]
  • Nadra Khaleeq, Fakhar-Ud Din, Anam Sajjad Khan, Samreen Rabia, Junaid Dar, Gul Majid Khan. Development of levosulpiride-loaded solid lipid nanoparticles and their in vitro and in vivo comparison with commercial product. Journal of microencapsulation. 2020 Mar; 37(2):160-169. doi: 10.1080/02652048.2020.1713242. [PMID: 31916886]
  • Wei Yang, Adam C Munhall, Steven W Johnson. Dopamine Evokes a Trace Amine Receptor-dependent Inward Current that is Regulated by AMP Kinase in Substantia Nigra Dopamine Neurons. Neuroscience. 2020 02; 427(?):77-91. doi: 10.1016/j.neuroscience.2019.11.044. [PMID: 31883822]
  • I S Tsvetkov, A M Kosyreva, V A Mkhitarov, E A Postovalova, D N Khochanskiy, O V Makarova, O Y Bredova, V F Ostrov. Morphological and Biochemical Characteristics of Prostate Hyperplasia during Sulpiride Treatment. Bulletin of experimental biology and medicine. 2020 Feb; 168(4):533-537. doi: 10.1007/s10517-020-04748-2. [PMID: 32152847]
  • Qing-Yu Yao, Jian Li, Rong Chen, Ye Yao, Jun-Sheng Xue, Wen-Jun Chen, Wei Lu, Tian-Yan Zhou. Preclinical PK/PD model for the combinatorial use of dexamethasone and sulpiride in the treatment of breast cancer. Acta pharmacologica Sinica. 2019 Dec; 40(12):1596-1602. doi: 10.1038/s41401-019-0251-7. [PMID: 31165782]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • S A Nizomov, I V Sorokina, N A Zhukova, T G Tolstikova, D E Semenov, A E Prosenko. Morphological Assessment of Prostatotropic Activity of (3,5-Dimethyl-4-Hydroxy)Benzyl Thiododecane on a Model of Benign Prostatic Hyperplasia in Rats. Bulletin of experimental biology and medicine. 2019 Oct; 167(6):809-812. doi: 10.1007/s10517-019-04628-4. [PMID: 31656010]
  • Beata Łebkowska-Wieruszewska, Giovanni Barsotti, Francesco Camillo, Alessandra Rota, Duccio Panzani, Amnart Poapolathep, Andrzej Lisowski, Mario Giorgi. Pharmacokinetics of levosulpiride after single-dose administration in goats (Capra hircus) by different routes of administration. Journal of veterinary pharmacology and therapeutics. 2019 Jul; 42(4):440-446. doi: 10.1111/jvp.12786. [PMID: 31206720]
  • Olanrewaju A Salako, Abidemi J Akindele, Aishat O Balogun, Olufunmilayo O Adeyemi. Investigation of Antidepressant, Anxiolytic and Sedative Activities of the Aqueous Leaf Extract of Musa sapientum Linn. (Banana; Musaceae). Drug research. 2019 Feb; 69(3):136-143. doi: 10.1055/a-0651-7978. [PMID: 30075482]
  • Fakhar-Ud-Din, Gul Majid Khan. Development and characterisation of levosulpiride-loaded suppositories with improved bioavailability in vivo. Pharmaceutical development and technology. 2019 Jan; 24(1):63-69. doi: 10.1080/10837450.2017.1419256. [PMID: 29251521]
  • Danijela Radojkovic, Milica Pesic, Milan Radojkovic, Dragan Dimic, Marija Vukelic Nikolic, Tatjana Jevtovic Stoimenov, Sasa Radenkovic, Milena Velojic Golubovic, Tatjana Radjenovic Petkovic, Slobodan Antic. Expression of prolactin receptors in the duodenum, kidneys and skeletal system during physiological and sulpiride-induced hyperprolactinaemia. Endocrine. 2018 12; 62(3):681-691. doi: 10.1007/s12020-018-1730-1. [PMID: 30143940]
  • Marwa H Shukr, Omar A Ahmed Farid. Amisulpride-CD-Loaded Liposomes: Optimization and In Vivo Evaluation. AAPS PharmSciTech. 2018 Aug; 19(6):2658-2671. doi: 10.1208/s12249-018-1079-z. [PMID: 29943282]
  • Xia Zhou, Liying Ren, Zhiling Yu, Xiaoqian Huang, Yuhao Li, Chunxia Wang. The antipsychotics sulpiride induces fatty liver in rats via phosphorylation of insulin receptor substrate-1 at Serine 307-mediated adipose tissue insulin resistance. Toxicology and applied pharmacology. 2018 04; 345(?):66-74. doi: 10.1016/j.taap.2018.02.023. [PMID: 29551354]
  • M Ciechanowska, M Apot, E Paruszewska, W Radawiec, F Przekop. The influence of dopaminergic system inhibition on biosynthesis of gonadotrophin-releasing hormone (GnRH) and GnRH receptor in anoestrous sheep; hierarchical role of kisspeptin and RFamide-related peptide-3 (RFRP-3). Reproduction, fertility, and development. 2018 Mar; 30(4):672-680. doi: 10.1071/rd16309. [PMID: 29019791]
  • Liping Li, Yayun Weng, Wei Wang, Mengru Bai, Hongmei Lei, Hui Zhou, Huidi Jiang. Multiple organic cation transporters contribute to the renal transport of sulpiride. Biopharmaceutics & drug disposition. 2017 Dec; 38(9):526-534. doi: 10.1002/bdd.2104. [PMID: 28926871]
  • Etsuko Kasuya, Madoka Sutoh, Ken-Ichi Yayou. The effects of l-DOPA and sulpiride on growth hormone secretion at different injection times in Holstein steers. Animal science journal = Nihon chikusan Gakkaiho. 2017 Nov; 88(11):1842-1848. doi: 10.1111/asj.12850. [PMID: 28585780]
  • Adriana S F S J Ayres, Wilton B Santos, Décio D Junqueira-Ayres, Geison M Costa, Freddy A Ramos, Leonardo Castellanos, Jovelina S F Alves, Laila Asth, Iris U de Medeiros, Silvana M Zucolotto, Elaine C Gavioli. Monoaminergic neurotransmission is mediating the antidepressant-like effects of Passiflora edulis Sims fo. edulis. Neuroscience letters. 2017 Nov; 660(?):79-85. doi: 10.1016/j.neulet.2017.09.010. [PMID: 28893593]
  • Si-Si Cao, Yan-Xia Ma, Ping-Fei Fang, Hua-Lin Cai, Yang Deng, Zhen-Yan Hou, Ying Chen, Miao Yan, Bi-Kui Zhang. Pharmacokinetics and relative bioavailability of a generic amisulpride tablet in healthy Chinese volunteers
. International journal of clinical pharmacology and therapeutics. 2017 Oct; 55(10):825-831. doi: 10.5414/cp203000. [PMID: 28793958]
  • Harumasa Takano, Sumito Ito, Xuan Zhang, Hiroshi Ito, Ming-Rong Zhang, Hiroshi Suzuki, Kazuya Maeda, Hiroyuki Kusuhara, Tetsuya Suhara, Yuichi Sugiyama. Possible Role of Organic Cation Transporters in the Distribution of [11C]Sulpiride, a Dopamine D2 Receptor Antagonist. Journal of pharmaceutical sciences. 2017 09; 106(9):2558-2565. doi: 10.1016/j.xphs.2017.05.006. [PMID: 28499878]
  • Anna Migdał, Łukasz Migdał, Agata Zagrajczuk, Joanna Kochan, Agnieszka Nowak, Adam Okólski. Influence of sulpiride treatment on the level of prolactin and immunoglobulins in the peripheral blood of mares during the postpartum period. Acta veterinaria Hungarica. 2017 09; 65(3):417-428. doi: 10.1556/004.2017.039. [PMID: 28956481]
  • Kevin M Gray, Susan C Sonne, Erin A McClure, Udi E Ghitza, Abigail G Matthews, Aimee L McRae-Clark, Kathleen M Carroll, Jennifer S Potter, Katharina Wiest, Larissa J Mooney, Albert Hasson, Sharon L Walsh, Michelle R Lofwall, Shanna Babalonis, Robert W Lindblad, Steven Sparenborg, Aimee Wahle, Jacqueline S King, Nathaniel L Baker, Rachel L Tomko, Louise F Haynes, Ryan G Vandrey, Frances R Levin. A randomized placebo-controlled trial of N-acetylcysteine for cannabis use disorder in adults. Drug and alcohol dependence. 2017 08; 177(?):249-257. doi: 10.1016/j.drugalcdep.2017.04.020. [PMID: 28623823]
  • Piotr Skrobecki, Anna Chmielińska, Piotr Bonarek, Piotr Stepien, Anna Wisniewska-Becker, Marta Dziedzicka-Wasylewska, Agnieszka Polit. Sulpiride, Amisulpride, Thioridazine, and Olanzapine: Interaction with Model Membranes. Thermodynamic and Structural Aspects. ACS chemical neuroscience. 2017 07; 8(7):1543-1553. doi: 10.1021/acschemneuro.7b00057. [PMID: 28375612]
  • Fawzia A Ibrahim, Amira F El-Yazbi, Mira M Wagih, Magda A Barary. Chromatographic determination of zonisamide, topiramate and sulpiride in plasma by a fluorescent 'turn-on' chemosensor. Bioanalysis. 2017 Jul; 9(14):1049-1064. doi: 10.4155/bio-2017-0090. [PMID: 28737428]
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  • Simona De Gregori, Laura Cipollina, Annalisa De Silvestri, Marianna Ventura, Roberta Michelini, Monica Morosini, Michela Montagna, Carmine Tinelli, Mario Regazzi, Mariadelfina Molinaro, Roberto Imberti. Bioequivalence of a New Oral Levosulpiride Formulation Compared With a Standard One in Healthy Volunteers. Therapeutic drug monitoring. 2017 04; 39(2):118-123. doi: 10.1097/ftd.0000000000000380. [PMID: 28196046]
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