n-methylthiotetrazole (BioDeep_00000181338)
human metabolite blood metabolite
代谢物信息卡片
1-(methylsulfanyl)-1H-1,2,3,4-tetrazole
化学式: C2H4N4S (116.0156664)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 33.33%
分子结构信息
SMILES: CSN1C=NN=N1
InChI: InChI=1S/C2H4N4S/c1-7-6-2-3-4-5-6/h2H,1H3
描述信息
同义名列表
11 个代谢物同义名
1-(methylsulfanyl)-1H-1,2,3,4-tetrazole; 1-(methylsulfanyl)-1,2,3,4-tetrazole; 1-N-Methyl-5-thiotetrazole sodium; 1-Methyl-5-mercaptotetrazole; 5-mercapto-N-Methyltetrazole; 1-N-Methyl-5-thiotetrazole; 1-Methyl-5-thio-tetrazole; 1-Methyltetrazole-5-thiol; N-Methyl-thio-tetrazole; N-Methyltetrazolethiol; N-Methylthiotetrazole
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Naoyuki Hirata, Noriaki Kanaya, Hitoshi Shimizu, Masanori Watanabe, Akiyoshi Namiki. [Suspicious case of epidural hematoma due to coagulopathy caused by vitamin K deficiency associated with antibiotics].
Masui. The Japanese journal of anesthesiology.
2007 Feb; 56(2):181-5. doi:
NULL. [PMID: 17315736] - N Kanazumi, S Takeda, S Inoue, K Ohshima, H Sugimoto, T Kaneko, K Watanabe, A Nakao. PIVKA-II during perioperative period in patients with hepato-biliary-pancreatic diseases.
Hepato-gastroenterology.
2000 Nov; 47(36):1695-9. doi:
NULL. [PMID: 11149034] - K Goto, M Oda, H Saitoh, M Nishida, M Takada. Effect of side chains including the N-methyl-tetrazole-thiol group of beta-lactam antibiotics on transport in cultured kidney epithelial cells LLC-PK1.
Biological & pharmaceutical bulletin.
1998 Oct; 21(10):1113-6. doi:
10.1248/bpb.21.1113. [PMID: 9821822] - A Yussim, J Sandbank, R Nakache, E Shaharabani, D Shmueli, S Lustig, N Bar-Nathan, E Geyer, V Sobolev, H Or. Detection of preservation-induced tubular damage by fine needle aspiration and tetrazolium-based quantitative cell viability assay.
Transplantation proceedings.
1994 Aug; 26(4):2379-81. doi:
NULL. [PMID: 8066780] - T F Goss, C A Walawander, T H Grasela, S Meisel, B Katona, K Jaynes. Prospective evaluation of risk factors for antibiotic-associated bleeding in critically ill patients.
Pharmacotherapy.
1992; 12(4):283-91. doi:
NULL. [PMID: 1518727] - L S Welage, M T Borin, J H Wilton, L G Hejmanowski, P B Wels, J J Schentag. Comparative evaluation of the pharmacokinetics of N-methylthiotetrazole following administration of cefoperazone, cefotetan, and cefmetazole.
Antimicrobial agents and chemotherapy.
1990 Dec; 34(12):2369-74. doi:
10.1128/aac.34.12.2369. [PMID: 2088192] - P A Bombardt, M Courtney, H Ko. Fast-LC determination of 1-methyl-1H-tetrazole-5-thiol in human plasma with column-switching sample clean-up.
Journal of pharmaceutical and biomedical analysis.
1990; 8(1):73-7. doi:
10.1016/0731-7085(90)80009-e. [PMID: 2102267] - H Schäfer, K Naber, D Adam. [Hemostasis disturbance caused by cephalosporins with an N-methylthiotetrazole side chain. A randomized pilot study].
Arzneimittel-Forschung.
1989 Sep; 39(9):1156-62. doi:
. [PMID: 2590268] - L S Welage, L G Hejmanowski, J H Wilton, C Walawander, D Rigan, J S Williams, J J Schentag. Comparison of N-methylthiotetrazole dispositions in healthy volunteers following single intravenous doses of moxalactam, cefoperazone, and cefotetan.
Antimicrobial agents and chemotherapy.
1989 Jun; 33(6):857-61. doi:
10.1128/aac.33.6.857. [PMID: 2764537] - J B Moe, R C Piper, H Tanase, K Sotani, J Manabe. Preclinical safety studies of cefmetazole.
The Journal of antimicrobial chemotherapy.
1989 Apr; 23 Suppl D(?):125-9. doi:
10.1093/jac/23.suppl_d.125. [PMID: 2722719] - T Matsubara, S Otsubo, A Ogawa, K Kawamoto, J Okamoto, K Sugeno, Y Tochino, T Yoshida, E Hirai. Effects of beta-lactam antibiotics and N-methyltetrazolethiol on the alcohol-metabolizing system in rats.
Japanese journal of pharmacology.
1987 Nov; 45(3):303-15. doi:
10.1254/jjp.45.303. [PMID: 2893854] - P M Allison, L L Mummah-Schendel, C G Kindberg, C S Harms, N U Bang, J W Suttie. Effects of a vitamin K-deficient diet and antibiotics in normal human volunteers.
The Journal of laboratory and clinical medicine.
1987 Aug; 110(2):180-8. doi:
. [PMID: 3598347] - K Mizojiri, R Norikura, A Takashima, H Tanaka, T Yoshimori, K Inazawa, T Yukawa, H Okabe, K Sugeno. Disposition of moxalactam and N-methyltetrazolethiol in rats and monkeys.
Antimicrobial agents and chemotherapy.
1987 Aug; 31(8):1169-76. doi:
10.1128/aac.31.8.1169. [PMID: 3631941] - H Nakahata, Y Hirai, Y Kumasaka, T Miyazawa, T Nakamura, K Imamura, I Makino, K Takebe, H Kudo. [Free methyltetrazolethiol concentrations in men subjected to intravenous administration of cephems with methyltetrazolethiol].
The Japanese journal of antibiotics.
1987 Jul; 40(7):1294-8. doi:
NULL. [PMID: 3479623] - U Ganzinger, F Schatz, H Haberl, A Haslberger, H Schiel, G Hitzenberger. Comparative pharmacokinetic analysis of latamoxef and CPW 86-363, a novel carboxy-pyrazol-cephalosporin and formation of N-methyl-thiotetrazole.
International journal of clinical pharmacology, therapy, and toxicology.
1987 Mar; 25(3):152-6. doi:
NULL. [PMID: 3557743] - K Uchida, M Nakamura, M Konishi, T Ishigami, T Komeno. Effect of latamoxef on platelet function and prothrombin time in partially nephrectomized rats.
Japanese journal of pharmacology.
1987 Jan; 43(1):9-16. doi:
10.1254/jjp.43.9. [PMID: 3573419] - F R Sattler, M R Weitekamp, J O Ballard. Potential for bleeding with the new beta-lactam antibiotics.
Annals of internal medicine.
1986 Dec; 105(6):924-31. doi:
10.7326/0003-4819-105-6-924. [PMID: 3535606] - G R Aronoff, R L Wolen, B D Obermeyer, H R Black. Pharmacokinetics and protein binding of cefamandole and its 1-methyl-1 H-tetrazole-5-thiol side chain in subjects with normal and impaired renal function.
The Journal of infectious diseases.
1986 Jun; 153(6):1069-74. doi:
10.1093/infdis/153.6.1069. [PMID: 3701118] - A L Kerremans, J J Lipsky, J Van Loon, M O Gallego, R M Weinshilboum. Cephalosporin-induced hypoprothrombinemia: possible role for thiol methylation of 1-methyltetrazole-5-thiol and 2-methyl-1,3,4-thiadiazole-5-thiol.
The Journal of pharmacology and experimental therapeutics.
1985 Nov; 235(2):382-8. doi:
NULL. [PMID: 2865352] - K Uchida, T Shike, H Kakushi, H Takase, Y Nomura, T Harauchi, T Yoshizaki. Effect of sex hormones on hypoprothrombinemia induced by N-methyltetrazolethiol in rats.
Thrombosis research.
1985 Sep; 39(6):741-50. doi:
10.1016/0049-3848(85)90258-0. [PMID: 4082108] - J Shimada, Y Hayashi, K Nakamura. Cefmetazole: clinical evaluation of efficacy and safety in Japan.
Drugs under experimental and clinical research.
1985; 11(3):181-94. doi:
. [PMID: 3869805] - K Andrassy, E Ritz. Antimicrobial therapy in dialysis patients. I. Penicillins and cephalosporins.
Blood purification.
1985; 3(1-3):94-103. doi:
10.1159/000169402. [PMID: 3854281] - K Nakamura, A Nakagawa, M Tanaka, H Masuda, Y Hayashi, K Saionji. [Effects of cephem antibiotics on ethanol metabolism].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
1984 Feb; 83(2):183-91. doi:
10.1254/fpj.83.183. [PMID: 6745808]