n-methyl-2-(4'-methylaminophenyl)-6-hydroxybenzothiazole (BioDeep_00000181319)
human metabolite blood metabolite
代谢物信息卡片
3-methyl-2-[4-(methylamino)phenyl]-2,3-dihydro-1,3-benzothiazol-6-ol
化学式: C15H16N2OS (272.0983286)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CNC1=CC=C(C=C1)C1SC2=C(C=CC(O)=C2)N1C
InChI: InChI=1S/C15H16N2OS/c1-16-11-5-3-10(4-6-11)15-17(2)13-8-7-12(18)9-14(13)19-15/h3-9,15-16,18H,1-2H3
描述信息
同义名列表
11 个代谢物同义名
3-methyl-2-[4-(methylamino)phenyl]-2,3-dihydro-1,3-benzothiazol-6-ol; N-Methyl-(11C)2-(4-(methylamino)phenyl)-6-hydroxybenzothiazole; 3-methyl-2-[4-(methylamino)phenyl]-2H-1,3-benzothiazol-6-ol; N-Methyl-2-(4-methylaminophenyl)-6-hydroxybenzothiazole; 2-(4-(Methylamino)phenyl)-6-hydroxybenzothiazole; Pittsburgh compound b; PIB benzothiazole; (11C)6-OH-BTA-1; 6-OH-BTA-1; ((11)C)PIB; 11C-PIB
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yasuhiro Aso, Noriyuki Kimura, Etsuro Matsubara. Novel Serum Biomarkers of Neurovascular Unit Associated with Cortical Amyloid Deposition.
Journal of Alzheimer's disease : JAD.
2021; 84(2):905-914. doi:
10.3233/jad-215135. [PMID: 34602488] - Zheng Niu, Riddhiman Sarkar, Michaela Aichler, Hans-Jürgen Wester, Behrooz Hooshyar Yousefi, Bernd Reif. Mapping the Binding Interface of PET Tracer Molecules and Alzheimer Disease Aβ Fibrils by Using MAS Solid-State NMR Spectroscopy.
Chembiochem : a European journal of chemical biology.
2020 09; 21(17):2495-2502. doi:
10.1002/cbic.202000143. [PMID: 32291951] - Breton M Asken, Fanny M Elahi, Renaud La Joie, Amelia Strom, Adam M Staffaroni, Cutter A Lindbergh, Alexandra C Apple, Michelle You, Sophia Weiner-Light, Nivetha Brathaban, Nicole Fernandes, Anna Karydas, Paul Wang, Julio C Rojas, Adam L Boxer, Bruce L Miller, Gil D Rabinovici, Joel H Kramer, Kaitlin B Casaletto. Plasma Glial Fibrillary Acidic Protein Levels Differ Along the Spectra of Amyloid Burden and Clinical Disease Stage.
Journal of Alzheimer's disease : JAD.
2020; 78(1):265-276. doi:
10.3233/jad-200755. [PMID: 32986672] - Koji Abe, Jingwei Shang, Xiaowen Shi, Toru Yamashita, Nozomi Hishikawa, Mami Takemoto, Ryuta Morihara, Yumiko Nakano, Yasuyuki Ohta, Kentaro Deguchi, Masaki Ikeda, Yoshio Ikeda, Koichi Okamoto, Mikio Shoji, Masamitsu Takatama, Motohisa Kojo, Takeshi Kuroda, Kenjiro Ono, Noriyuki Kimura, Etsuro Matsubara, Yosuke Osakada, Yosuke Wakutani, Yoshiki Takao, Yasuto Higashi, Kyoichi Asada, Takehito Senga, Lyang-Ja Lee, Kenji Tanaka. A New Serum Biomarker Set to Detect Mild Cognitive Impairment and Alzheimer's Disease by Peptidome Technology.
Journal of Alzheimer's disease : JAD.
2020; 73(1):217-227. doi:
10.3233/jad-191016. [PMID: 31771070] - Jong-Chan Park, Sun-Ho Han, Hangyeore Lee, Hyobin Jeong, Min Soo Byun, Jingi Bae, Hokeun Kim, Dong Young Lee, Dahyun Yi, Seong A Shin, Yu Kyeong Kim, Daehee Hwang, Sang-Won Lee, Inhee Mook-Jung. Prognostic plasma protein panel for Aβ deposition in the brain in Alzheimer's disease.
Progress in neurobiology.
2019 12; 183(?):101690. doi:
10.1016/j.pneurobio.2019.101690. [PMID: 31605717] - Julia Shirvan, Nathan Clement, Rong Ye, Samantha Katz, Aaron Schultz, Keith A Johnson, Teresa Gomez-Isla, Matthew Frosch, John H Growdon, Stephen N Gomperts. Neuropathologic correlates of amyloid and dopamine transporter imaging in Lewy body disease.
Neurology.
2019 07; 93(5):e476-e484. doi:
10.1212/wnl.0000000000007855. [PMID: 31243072] - Michelle M Mielke, Jeremy A Syrjanen, Kaj Blennow, Henrik Zetterberg, Prashanthi Vemuri, Ingmar Skoog, Mary M Machulda, Walter K Kremers, David S Knopman, Clifford Jack, Ronald C Petersen, Silke Kern. Plasma and CSF neurofilament light: Relation to longitudinal neuroimaging and cognitive measures.
Neurology.
2019 07; 93(3):e252-e260. doi:
10.1212/wnl.0000000000007767. [PMID: 31182505] - V Pérez-Grijalba, J Romero, P Pesini, L Sarasa, I Monleón, I San-José, J Arbizu, P Martínez-Lage, J Munuera, A Ruiz, L Tárraga, M Boada, M Sarasa. Plasma Aβ42/40 Ratio Detects Early Stages of Alzheimer's Disease and Correlates with CSF and Neuroimaging Biomarkers in the AB255 Study.
The journal of prevention of Alzheimer's disease.
2019; 6(1):34-41. doi:
10.14283/jpad.2018.41. [PMID: 30569084] - Sun-Ho Han, Jong-Chan Park, Min Soo Byun, Dahyun Yi, Jun Ho Lee, Dong Young Lee, Inhee Mook-Jung. Blood acetylcholinesterase level is a potential biomarker for the early detection of cerebral amyloid deposition in cognitively normal individuals.
Neurobiology of aging.
2019 01; 73(?):21-29. doi:
10.1016/j.neurobiolaging.2018.09.001. [PMID: 30316049] - Zhong-Bao Gao, Wei Wang, Xing-Li Zhao, Tong Chen, Li-Ping Fu, Bai-Xuan Xu, Zhen-Fu Wang. Multi-modality molecular imaging characteristics of dementia with Lewy bodies.
The Journal of international medical research.
2018 Jun; 46(6):2317-2326. doi:
10.1177/0300060518764749. [PMID: 29619853] - Jiaqi Zeng, Jiaqi Wu, Minghua Li, Peijun Wang. A Novel Magnetic Nanoparticle for Early Detection of Amyloid Plaques in Alzheimer's Disease.
Archives of medical research.
2018 05; 49(4):282-285. doi:
10.1016/j.arcmed.2018.09.005. [PMID: 30266531] - Naoki Ezawa, Nagaaki Katoh, Kazuhiro Oguchi, Tsuneaki Yoshinaga, Masahide Yazaki, Yoshiki Sekijima. Visualization of multiple organ amyloid involvement in systemic amyloidosis using 11C-PiB PET imaging.
European journal of nuclear medicine and molecular imaging.
2018 03; 45(3):452-461. doi:
10.1007/s00259-017-3814-1. [PMID: 28891012] - Min Jeong Wang, SangHak Yi, Jee-Young Han, So Young Park, Jae-Won Jang, In Kook Chun, Sang Eun Kim, Byoung Sub Lee, Gwang Je Kim, Ji Sun Yu, Kuntaek Lim, Sung Min Kang, Young Ho Park, Young Chul Youn, Seong Soo A An, SangYun Kim. Oligomeric forms of amyloid-β protein in plasma as a potential blood-based biomarker for Alzheimer's disease.
Alzheimer's research & therapy.
2017 Dec; 9(1):98. doi:
10.1186/s13195-017-0324-0. [PMID: 29246249] - J Q Zeng, J Q Wu, M H Li, P J Wang. [In vitro early detection of amyloid plaques in Alzheimer's disease by Pittsburgh compound B-modified magnetic nanoparticles].
Zhonghua yi xue za zhi.
2017 Nov; 97(41):3258-3262. doi:
10.3760/cma.j.issn.0376-2491.2017.41.013. [PMID: 29141366] - Hyo Jung Choi, Min Soo Byun, Dahyun Yi, Bo Kyung Sohn, Jun Ho Lee, Jun-Young Lee, Yu Kyung Kim, Dong Young Lee. Associations of thyroid hormone serum levels with in-vivo Alzheimer's disease pathologies.
Alzheimer's research & therapy.
2017 Aug; 9(1):64. doi:
10.1186/s13195-017-0291-5. [PMID: 28818092] - Jong-Chan Park, Sun-Ho Han, Hyun Jin Cho, Min Soo Byun, Dahyun Yi, Young Min Choe, Seokjo Kang, Eun Sun Jung, Su Jin Won, Eun Hye Kim, Yu Kyeong Kim, Dong Young Lee, Inhee Mook-Jung. Chemically treated plasma Aβ is a potential blood-based biomarker for screening cerebral amyloid deposition.
Alzheimer's research & therapy.
2017 Mar; 9(1):20. doi:
10.1186/s13195-017-0248-8. [PMID: 28330509] - Nan Zhang, Liling Zhang, Yan Li, Marc L Gordon, Li Cai, Ying Wang, Mengya Xing, Yan Cheng. Urine AD7c-NTP Predicts Amyloid Deposition and Symptom of Agitation in Patients with Alzheimer's Disease and Mild Cognitive Impairment.
Journal of Alzheimer's disease : JAD.
2017; 60(1):87-95. doi:
10.3233/jad-170383. [PMID: 28777752] - Keisuke Matsubara, Masanobu Ibaraki, Hitoshi Shimada, Yoko Ikoma, Tetsuya Suhara, Toshibumi Kinoshita, Hiroshi Ito. Impact of spillover from white matter by partial volume effect on quantification of amyloid deposition with [11C]PiB PET.
NeuroImage.
2016 12; 143(?):316-324. doi:
10.1016/j.neuroimage.2016.09.028. [PMID: 27639351] - Hussein N Yassine, Qingru Feng, Ida Azizkhanian, Varun Rawat, Katherine Castor, Alfred N Fonteh, Michael G Harrington, Ling Zheng, Bruce R Reed, Charles DeCarli, William J Jagust, Helena C Chui. Association of Serum Docosahexaenoic Acid With Cerebral Amyloidosis.
JAMA neurology.
2016 Oct; 73(10):1208-1216. doi:
10.1001/jamaneurol.2016.1924. [PMID: 27532692] - Seokjo Kang, Hyobin Jeong, Je-Hyun Baek, Seung-Jin Lee, Sun-Ho Han, Hyun Jin Cho, Hee Kim, Hyun Seok Hong, Young Ho Kim, Eugene C Yi, Sang Won Seo, Duk L Na, Daehee Hwang, Inhee Mook-Jung. PiB-PET Imaging-Based Serum Proteome Profiles Predict Mild Cognitive Impairment and Alzheimer's Disease.
Journal of Alzheimer's disease : JAD.
2016 07; 53(4):1563-76. doi:
10.3233/jad-160025. [PMID: 27392853] - Alexandra M V Wennberg, Deborah Gustafson, Clinton E Hagen, Rosebud O Roberts, David Knopman, Clifford Jack, Ronald C Petersen, Michelle M Mielke. Serum Adiponectin Levels, Neuroimaging, and Cognition in the Mayo Clinic Study of Aging.
Journal of Alzheimer's disease : JAD.
2016 05; 53(2):573-81. doi:
10.3233/jad-151201. [PMID: 27163809] - Sarah Westwood, Emanuela Leoni, Abdul Hye, Steven Lynham, Mizanur R Khondoker, Nicholas J Ashton, Steven J Kiddle, Alison L Baird, Ricardo Sainz-Fuertes, Rufina Leung, John Graf, Cristina Tan Hehir, David Baker, Cristina Cereda, Chantal Bazenet, Malcolm Ward, Madhav Thambisetty, Simon Lovestone. Blood-Based Biomarker Candidates of Cerebral Amyloid Using PiB PET in Non-Demented Elderly.
Journal of Alzheimer's disease : JAD.
2016 03; 52(2):561-72. doi:
10.3233/jad-151155. [PMID: 27031486] - Anna Rieckmann, Trey Hedden, Alayna P Younger, Reisa A Sperling, Keith A Johnson, Randy L Buckner. Dopamine transporter availability in clinically normal aging is associated with individual differences in white matter integrity.
Human brain mapping.
2016 Feb; 37(2):621-31. doi:
10.1002/hbm.23054. [PMID: 26542307] - Hyo Jung Choi, Eun Hyun Seo, Dahyun Yi, Bo Kyung Sohn, Young Min Choe, Min Soo Byun, Jong Min Lee, Jong Inn Woo, Dong Young Lee. Amyloid-Independent Amnestic Mild Cognitive Impairment and Serum Apolipoprotein A1 Levels.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.
2016 Feb; 24(2):144-53. doi:
10.1016/j.jagp.2015.06.004. [PMID: 26238231] - B S Diniz, E Sibille, Y Ding, G Tseng, H J Aizenstein, F Lotrich, J T Becker, O L Lopez, M T Lotze, W E Klunk, C F Reynolds, M A Butters. Plasma biosignature and brain pathology related to persistent cognitive impairment in late-life depression.
Molecular psychiatry.
2015 May; 20(5):594-601. doi:
10.1038/mp.2014.76. [PMID: 25092249] - Nicola Voyle, David Baker, Samantha C Burnham, Antonia Covin, Zhanpan Zhang, Dipen P Sangurdekar, Cristina A Tan Hehir, Chantal Bazenet, Simon Lovestone, Steven Kiddle, Richard J B Dobson. Blood Protein Markers of Neocortical Amyloid-β Burden: A Candidate Study Using SOMAscan Technology.
Journal of Alzheimer's disease : JAD.
2015; 46(4):947-61. doi:
10.3233/jad-150020. [PMID: 25881911] - Seung-Pyo Lee, Eun Seong Lee, Hongyoon Choi, Hyung-Jun Im, Youngil Koh, Min-Ho Lee, Ji-Hyun Kwon, Jin Chul Paeng, Hyung-Kwan Kim, Gi Jeong Cheon, Yong-Jin Kim, Inho Kim, Sung-Soo Yoon, Jeong-Wook Seo, Dae-Won Sohn. 11C-Pittsburgh B PET imaging in cardiac amyloidosis.
JACC. Cardiovascular imaging.
2015 Jan; 8(1):50-59. doi:
10.1016/j.jcmg.2014.09.018. [PMID: 25499132] - Oscar L Lopez, William E Klunk, Chester Mathis, Rhaven L Coleman, Julie Price, James T Becker, Howard J Aizenstein, Beth Snitz, Ann Cohen, Milos Ikonomovic, Eric McDade, Steven T DeKosky, Lisa Weissfeld, Lewis H Kuller. Amyloid, neurodegeneration, and small vessel disease as predictors of dementia in the oldest-old.
Neurology.
2014 Nov; 83(20):1804-11. doi:
10.1212/wnl.0000000000000977. [PMID: 25305156] - Sergey V Matveev, Hans Peter Spielmann, Brittney M Metts, Jing Chen, Fredrick Onono, Haining Zhu, Stephen W Scheff, Lary C Walker, Harry LeVine. A distinct subfraction of Aβ is responsible for the high-affinity Pittsburgh compound B-binding site in Alzheimer's disease brain.
Journal of neurochemistry.
2014 Nov; 131(3):356-68. doi:
10.1111/jnc.12815. [PMID: 24995708] - Kai-Yuan Tzen, Shieh-Yueh Yang, Ta-Fu Chen, Ting-Wen Cheng, Herng-Er Horng, Hsiang-Ping Wen, Ya-Yao Huang, Chyng-Yann Shiue, Ming-Jang Chiu. Plasma Aβ but not tau is related to brain PiB retention in early Alzheimer's disease.
ACS chemical neuroscience.
2014 Sep; 5(9):830-6. doi:
10.1021/cn500101j. [PMID: 25054847] - S C Burnham, N G Faux, W Wilson, S M Laws, D Ames, J Bedo, A I Bush, J D Doecke, K A Ellis, R Head, G Jones, H Kiiveri, R N Martins, A Rembach, C C Rowe, O Salvado, S L Macaulay, C L Masters, V L Villemagne. A blood-based predictor for neocortical Aβ burden in Alzheimer's disease: results from the AIBL study.
Molecular psychiatry.
2014 Apr; 19(4):519-26. doi:
10.1038/mp.2013.40. [PMID: 23628985] - Ewa Hellström-Lindahl, Per Westermark, Gunnar Antoni, Sergio Estrada. In vitro binding of [³H]PIB to human amyloid deposits of different types.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.
2014 Mar; 21(1):21-7. doi:
10.3109/13506129.2013.860895. [PMID: 24286359] - André F Martins, Jean-François Morfin, Carlos F G C Geraldes, Eva Tóth. Gd(3+) complexes conjugated to Pittsburgh compound B: potential MRI markers of β-amyloid plaques.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry.
2014 Feb; 19(2):281-95. doi:
10.1007/s00775-013-1055-8. [PMID: 24297602] - Shanker Swaminathan, Shannon L Risacher, Karmen K Yoder, John D West, Li Shen, Sungeun Kim, Mark Inlow, Tatiana Foroud, William J Jagust, Robert A Koeppe, Chester A Mathis, Leslie M Shaw, John Q Trojanowski, Holly Soares, Paul S Aisen, Ronald C Petersen, Michael W Weiner, Andrew J Saykin. Association of plasma and cortical amyloid beta is modulated by APOE ε4 status.
Alzheimer's & dementia : the journal of the Alzheimer's Association.
2014 Jan; 10(1):e9-e18. doi:
10.1016/j.jalz.2013.01.007. [PMID: 23541187] - Kenji Ishibashi, Yoshiharu Miura, Keiichi Oda, Kiichi Ishiwata, Kenji Ishii. Alzheimer's disease-like pattern of (18)F-FDG uptake during a hyperglycemic state and negative (11)C-PiB binding in a patient with mild cognitive impairment.
Journal of Alzheimer's disease : JAD.
2014; 42(2):385-9. doi:
10.3233/jad-140639. [PMID: 24898648] - G Verdile, S M Laws, D Henley, D Ames, A I Bush, K A Ellis, N G Faux, V B Gupta, Q-X Li, C L Masters, K E Pike, C C Rowe, C Szoeke, K Taddei, V L Villemagne, R N Martins. Associations between gonadotropins, testosterone and β amyloid in men at risk of Alzheimer's disease.
Molecular psychiatry.
2014 Jan; 19(1):69-75. doi:
10.1038/mp.2012.147. [PMID: 23089633] - Alan Rembach, Andrew D Watt, William J Wilson, Victor L Villemagne, Samantha C Burnham, Kathryn A Ellis, Paul Maruff, David Ames, Christopher C Rowe, S Lance Macaulay, Ashley I Bush, Ralph N Martins, Colin L Masters, James D Doecke. Plasma amyloid-β levels are significantly associated with a transition toward Alzheimer's disease as measured by cognitive decline and change in neocortical amyloid burden.
Journal of Alzheimer's disease : JAD.
2014; 40(1):95-104. doi:
10.3233/jad-131802. [PMID: 24334723] - Taher Darreh-Shori, Swetha Vijayaraghavan, Shahin Aeinehband, Fredrik Piehl, Rickard P F Lindblom, Bo Nilsson, Kristina N Ekdahl, Bengt Långström, Ove Almkvist, Agneta Nordberg. Functional variability in butyrylcholinesterase activity regulates intrathecal cytokine and astroglial biomarker profiles in patients with Alzheimer's disease.
Neurobiology of aging.
2013 Nov; 34(11):2465-81. doi:
10.1016/j.neurobiolaging.2013.04.027. [PMID: 23759148] - Beth E Snitz, Lisa A Weissfeld, Oscar L Lopez, Lewis H Kuller, Judith Saxton, Dilrukshika M Singhabahu, William E Klunk, Chester A Mathis, Julie C Price, Diane G Ives, Ann D Cohen, Eric McDade, Steven T Dekosky. Cognitive trajectories associated with β-amyloid deposition in the oldest-old without dementia.
Neurology.
2013 Apr; 80(15):1378-84. doi:
10.1212/wnl.0b013e31828c2fc8. [PMID: 23516317] - Trey Hedden, Hwamee Oh, Alayna P Younger, Tanu A Patel. Meta-analysis of amyloid-cognition relations in cognitively normal older adults.
Neurology.
2013 Apr; 80(14):1341-8. doi:
10.1212/wnl.0b013e31828ab35d. [PMID: 23547267] - Adi Alkalay, Gil D Rabinovici, Gabriel Zimmerman, Neha Agarwal, Daniela Kaufer, Bruce L Miller, William J Jagust, Hermona Soreq. Plasma acetylcholinesterase activity correlates with intracerebral β-amyloid load.
Current Alzheimer research.
2013 Jan; 10(1):48-56. doi:
NULL. [PMID: 23157337] - Alan Rembach, James D Doecke, Blaine R Roberts, Andrew D Watt, Noel G Faux, Irene Volitakis, Kelly K Pertile, Rebecca L Rumble, Brett O Trounson, Christopher J Fowler, William Wilson, Kathryn A Ellis, Ralph N Martins, Christopher C Rowe, Victor L Villemagne, David Ames, Colin L Masters, AIBL research group, Ashley I Bush. Longitudinal analysis of serum copper and ceruloplasmin in Alzheimer's disease.
Journal of Alzheimer's disease : JAD.
2013; 34(1):171-82. doi:
10.3233/jad-121474. [PMID: 23168449] - Anniina Snellman, Johanna Rokka, Francisco R Lopez-Picon, Olli Eskola, Ian Wilson, Gill Farrar, Mika Scheinin, Olof Solin, Juha O Rinne, Merja Haaparanta-Solin. Pharmacokinetics of [¹⁸F]flutemetamol in wild-type rodents and its binding to beta amyloid deposits in a mouse model of Alzheimer's disease.
European journal of nuclear medicine and molecular imaging.
2012 Nov; 39(11):1784-95. doi:
10.1007/s00259-012-2178-9. [PMID: 22801729] - Jon B Toledo, Estefanía Toledo, Michael W Weiner, Clifford R Jack, William Jagust, Virginia M Y Lee, Leslie M Shaw, John Q Trojanowski. Cardiovascular risk factors, cortisol, and amyloid-β deposition in Alzheimer's Disease Neuroimaging Initiative.
Alzheimer's & dementia : the journal of the Alzheimer's Association.
2012 Nov; 8(6):483-9. doi:
10.1016/j.jalz.2011.08.008. [PMID: 23102118] - P Edison, R Hinz, A Ramlackhansingh, J Thomas, G Gelosa, H A Archer, F E Turkheimer, D J Brooks. Can target-to-pons ratio be used as a reliable method for the analysis of [11C]PIB brain scans?.
NeuroImage.
2012 Apr; 60(3):1716-23. doi:
10.1016/j.neuroimage.2012.01.099. [PMID: 22306804] - Steven John Kiddle, Madhav Thambisetty, Andrew Simmons, Joanna Riddoch-Contreras, Abdul Hye, Eric Westman, Ian Pike, Malcolm Ward, Caroline Johnston, Michelle Katharine Lupton, Katie Lunnon, Hilkka Soininen, Iwona Kloszewska, Magda Tsolaki, Bruno Vellas, Patrizia Mecocci, Simon Lovestone, Stephen Newhouse, Richard Dobson. Plasma based markers of [11C] PiB-PET brain amyloid burden.
PloS one.
2012; 7(9):e44260. doi:
10.1371/journal.pone.0044260. [PMID: 23028511] - D P Devanand, N Schupf, Y Stern, R Parsey, G H Pelton, P Mehta, R Mayeux. Plasma Aβ and PET PiB binding are inversely related in mild cognitive impairment.
Neurology.
2011 Jul; 77(2):125-31. doi:
10.1212/wnl.0b013e318224afb7. [PMID: 21715709] - V B Gupta, S M Laws, V L Villemagne, D Ames, A I Bush, K A Ellis, J K Lui, C Masters, C C Rowe, C Szoeke, K Taddei, R N Martins. Plasma apolipoprotein E and Alzheimer disease risk: the AIBL study of aging.
Neurology.
2011 Mar; 76(12):1091-8. doi:
10.1212/wnl.0b013e318211c352. [PMID: 21422459] - Nastasia K-H Lim, Victor L Villemagne, Cynthia P W Soon, Katrina M Laughton, Christopher C Rowe, Catriona A McLean, Colin L Masters, Genevieve Evin, Qiao-Xin Li. Investigation of matrix metalloproteinases, MMP-2 and MMP-9, in plasma reveals a decrease of MMP-2 in Alzheimer's disease.
Journal of Alzheimer's disease : JAD.
2011; 26(4):779-86. doi:
10.3233/jad-2011-101974. [PMID: 21694463] - John Q Trojanowski, Hugo Vandeerstichele, Magdalena Korecka, Christopher M Clark, Paul S Aisen, Ronald C Petersen, Kaj Blennow, Holly Soares, Adam Simon, Piotr Lewczuk, Robert Dean, Eric Siemers, William Z Potter, Michael W Weiner, Clifford R Jack, William Jagust, Arthur W Toga, Virginia M-Y Lee, Leslie M Shaw. Update on the biomarker core of the Alzheimer's Disease Neuroimaging Initiative subjects.
Alzheimer's & dementia : the journal of the Alzheimer's Association.
2010 May; 6(3):230-8. doi:
10.1016/j.jalz.2010.03.008. [PMID: 20451871] - M Degerman Gunnarsson, M Lindau, A Wall, K Blennow, T Darreh-Shori, S Basu, A Nordberg, A Larsson, L Lannfelt, H Basun, L Kilander. Pittsburgh compound-B and Alzheimer's disease biomarkers in CSF, plasma and urine: An exploratory study.
Dementia and geriatric cognitive disorders.
2010; 29(3):204-12. doi:
10.1159/000281832. [PMID: 20332638] - Anne M Fagan, Mark A Mintun, Aarti R Shah, Patricia Aldea, Catherine M Roe, Robert H Mach, Daniel Marcus, John C Morris, David M Holtzman. Cerebrospinal fluid tau and ptau(181) increase with cortical amyloid deposition in cognitively normal individuals: implications for future clinical trials of Alzheimer's disease.
EMBO molecular medicine.
2009 Nov; 1(8-9):371-80. doi:
10.1002/emmm.200900048. [PMID: 20049742] - Paul Edison, David J Brooks, Federico E Turkheimer, Hilary A Archer, Rainer Hinz. Strategies for the generation of parametric images of [11C]PIB with plasma input functions considering discriminations and reproducibility.
NeuroImage.
2009 Nov; 48(2):329-38. doi:
10.1016/j.neuroimage.2009.06.079. [PMID: 19591948] - Nelleke Tolboom, Maqsood Yaqub, Ronald Boellaard, Gert Luurtsema, Albert D Windhorst, Philip Scheltens, Adriaan A Lammertsma, Bart N M van Berckel. Test-retest variability of quantitative [11C]PIB studies in Alzheimer's disease.
European journal of nuclear medicine and molecular imaging.
2009 Oct; 36(10):1629-38. doi:
10.1007/s00259-009-1129-6. [PMID: 19384547] - Anne M Fagan, Denise Head, Aarti R Shah, Daniel Marcus, Mark Mintun, John C Morris, David M Holtzman. Decreased cerebrospinal fluid Abeta(42) correlates with brain atrophy in cognitively normal elderly.
Annals of neurology.
2009 Feb; 65(2):176-83. doi:
10.1002/ana.21559. [PMID: 19260027] - Mika Naganawa, Yuichi Kimura, Junichi Yano, Masahiro Mishina, Masao Yanagisawa, Kenji Ishii, Keiichi Oda, Kiichi Ishiwata. Robust estimation of the arterial input function for Logan plots using an intersectional searching algorithm and clustering in positron emission tomography for neuroreceptor imaging.
NeuroImage.
2008 Mar; 40(1):26-34. doi:
10.1016/j.neuroimage.2007.11.035. [PMID: 18187345] - Yun Zhou, Susan M Resnick, Weiguo Ye, Hong Fan, Daniel P Holt, William E Klunk, Chester A Mathis, Robert Dannals, Dean F Wong. Using a reference tissue model with spatial constraint to quantify [11C]Pittsburgh compound B PET for early diagnosis of Alzheimer's disease.
NeuroImage.
2007 Jun; 36(2):298-312. doi:
10.1016/j.neuroimage.2007.03.004. [PMID: 17449282] - Noora M Scheinin, Tuula K Tolvanen, Ian A Wilson, Eveliina M Arponen, Kjell A Någren, Juha O Rinne. Biodistribution and radiation dosimetry of the amyloid imaging agent 11C-PIB in humans.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2007 Jan; 48(1):128-33. doi:
NULL. [PMID: 17204709] - Brian J Lopresti, William E Klunk, Chester A Mathis, Jessica A Hoge, Scott K Ziolko, Xueling Lu, Carolyn C Meltzer, Kurt Schimmel, Nicholas D Tsopelas, Steven T DeKosky, Julie C Price. Simplified quantification of Pittsburgh Compound B amyloid imaging PET studies: a comparative analysis.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2005 Dec; 46(12):1959-72. doi:
NULL. [PMID: 16330558] - Nicolaas P L G Verhoeff, Alan A Wilson, Shinichiro Takeshita, Liat Trop, Doug Hussey, Kernjit Singh, Hank F Kung, Mei-Ping Kung, Sylvain Houle. In-vivo imaging of Alzheimer disease beta-amyloid with [11C]SB-13 PET.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.
2004 Nov; 12(6):584-95. doi:
10.1176/appi.ajgp.12.6.584. [PMID: 15545326]