N-butylphenylnitrone (BioDeep_00000181255)
human metabolite blood metabolite
代谢物信息卡片
N-Benzylidene-2-methylpropylamine N-oxide
化学式: C11H15NO (177.115358)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCC[N+]([O-])=CC1=CC=CC=C1
InChI: InChI=1S/C11H15NO/c1-2-3-9-12(13)10-11-7-5-4-6-8-11/h4-8,10H,2-3,9H2,1H3
描述信息
同义名列表
16 个代谢物同义名
N-Benzylidene-2-methylpropylamine N-oxide; Phenyl-N-tert-butylnitrone, (Z)-isomer; N-butyl-1-phenylmethanimine oxide; alpha-Phenyl-N-tert-butyl nitrone; N-Tert-butyl-alpha-phenylnitrone; alpha Phenyl-tert-butyl nitrone; alpha-Phenyl-tert-butylnitrone; N-t-Butyl-alpha-phenylnitrone; alpha-Phenyl-t-butyl nitrone; Phenyl-N-tert-butylnitrone; N-Tert-butylphenylnitrone; Phenyl-tert-butylnitrone; Phenyl-butyl-nitrone; Phenyl butyl nitrone; N-butylphenylnitrone; alpha-PBN
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Feng-Ming Zhou, Ruo-Xiao Cheng, Shuai Wang, Ya Huang, Yong-Jing Gao, Yan Zhou, Teng-Teng Liu, Xue-Long Wang, Li-Hua Chen, Tong Liu. Antioxidants Attenuate Acute and Chronic Itch: Peripheral and Central Mechanisms of Oxidative Stress in Pruritus.
Neuroscience bulletin.
2017 Aug; 33(4):423-435. doi:
10.1007/s12264-016-0076-z. [PMID: 27783328] - Juewon Kim, Naoko Ishihara, Tae Ryong Lee. A DAF-16/FoxO3a-dependent longevity signal is initiated by antioxidants.
BioFactors (Oxford, England).
2014 Mar; 40(2):247-57. doi:
10.1002/biof.1146. [PMID: 24123695] - Libo Du, Saipeng Huang, Qianfen Zhuang, Hongying Jia, Antal Rockenbauer, Yangping Liu, Ke Jian Liu, Yang Liu. Highly sensitive free radical detection by nitrone-functionalized gold nanoparticles.
Nanoscale.
2014; 6(3):1646-52. doi:
10.1039/c3nr04559e. [PMID: 24336899] - Jian-Jun Wen, Nisha Jain Garg. Proteome expression and carbonylation changes during Trypanosoma cruzi infection and Chagas disease in rats.
Molecular & cellular proteomics : MCP.
2012 Apr; 11(4):M111.010918. doi:
10.1074/mcp.m111.010918. [PMID: 22199233] - Hironobu Yasui, Nozomi Ito, Tohru Yamamori, Hideo Nakamura, Jun Okano, Taketoshi Asanuma, Takayuki Nakajima, Mikinori Kuwabara, Osamu Inanami. Induction of neurite outgrowth by alpha-phenyl-N-tert-butylnitrone through nitric oxide release and Ras-ERK pathway in PC12 cells.
Free radical research.
2010 Jun; 44(6):645-54. doi:
10.3109/10715761003692537. [PMID: 20370559] - O Pinarbasli, Y Aktas, T Dalkara, K Andrieux, M J Alonso, E Fernandez-Megia, R Novoa-Carballal, R Riguera, P Couvreur, Y Capan. Preparation and evaluation of alpha-phenyl-n-tert-butyl nitrone (PBN)-encapsulated chitosan and PEGylated chitosan nanoparticles.
Die Pharmazie.
2009 Jul; 64(7):436-9. doi:
NULL. [PMID: 19694179] - Prasun K Datta, Sreenivas Reddy, Mukut Sharma, Elias A Lianos. Differential nephron HO-1 expression following glomerular epithelial cell injury.
Nephron. Experimental nephrology.
2006; 103(4):e131-8. doi:
10.1159/000092544. [PMID: 16601358] - Cristina Rota, Lino Liverani, Franco Spelta, Giuseppe Mascellani, Aldo Tomasi, Anna Iannone, Elena Vismara. Free radical generation during chemical depolymerization of heparin.
Analytical biochemistry.
2005 Sep; 344(2):193-203. doi:
10.1016/j.ab.2005.06.043. [PMID: 16098471] - Young-Sook Kang, Kyeong-Eun Lee, Na-Young Lee, Tetsuya Terasaki. Donepezil, tacrine and alpha-phenyl-n-tert-butyl nitrone (PBN) inhibit choline transport by conditionally immortalized rat brain capillary endothelial cell lines (TR-BBB).
Archives of pharmacal research.
2005 Apr; 28(4):443-50. doi:
10.1007/bf02977674. [PMID: 15918518] - Mary E Lame, Amit S Kalgutkar, Michael LaFontaine. Intravenous pharmacokinetics and metabolism of the reactive oxygen scavenger alpha-phenyl-N-tert-butyl nitrone (PBN) in the cynomolgus monkey.
Drug metabolism and drug interactions.
2004; 20(1-2):11-24. doi:
10.1515/dmdi.2004.20.1-2.11. [PMID: 15283300] - O V Povarova, A A Timoshin, O S Medvedev. Protective effect of phenyl-t-butylnitrone in rats with focal cerebral ischemia.
Bulletin of experimental biology and medicine.
2003 Dec; 136(6):560-2. doi:
10.1023/b:bebm.0000020203.94421.d5. [PMID: 15500071] - Yashige Kotake, Danny R Moore, Angelica Vasquez-Walden, Tahereh Tabatabaie, Hong Sang. Antioxidant amplifies antibiotic protection in the cecal ligation and puncture model of microbial sepsis through interleukin-10 production.
Shock (Augusta, Ga.).
2003 Mar; 19(3):252-6. doi:
10.1097/00024382-200303000-00009. [PMID: 12630525] - Mary E Trudeau-Lame, Amit S Kalgutkar, Michael LaFontaine. Pharmacokinetics and metabolism of the reactive oxygen scavenger alpha-phenyl-N-tert-butylnitrone in the male Sprague-Dawley rat.
Drug metabolism and disposition: the biological fate of chemicals.
2003 Feb; 31(2):147-52. doi:
10.1124/dmd.31.2.147. [PMID: 12527695] - Attila Török, József Belágyi, Béla Török, Hans-Rudolf Tinneberg, József Bódis. Scavenger capacity of follicular fluid, decidua and culture medium with regard to assisted reproduction: an in vitro study using electron paramagnetic resonance spectroscopy.
Gynecologic and obstetric investigation.
2003; 55(3):178-82. doi:
10.1159/000071534. [PMID: 12865599] - Niklas Marklund, Sven Sihver, Bengt Långström, Mats Bergström, Lars Hillered. Effect of traumatic brain injury and nitrone radical scavengers on relative changes in regional cerebral blood flow and glucose uptake in rats.
Journal of neurotrauma.
2002 Oct; 19(10):1139-53. doi:
10.1089/08977150260337958. [PMID: 12427324] - Sunday O Awe, Ayotunde S O Adeagbo. Analysis of tert-butyl hydroperoxide induced constrictions of perfused vascular beds in vitro.
Life sciences.
2002 Aug; 71(11):1255-66. doi:
10.1016/s0024-3205(02)01845-3. [PMID: 12106591] - Yashige Kotake, Hong Sang, Tahereh Tabatabaie, Gemma L Wallis, Danny R Moore, Charles A Stewart. Interleukin-10 overexpression mediates phenyl-N-tert-butyl nitrone protection from endotoxemia.
Shock (Augusta, Ga.).
2002 Mar; 17(3):210-6. doi:
10.1097/00024382-200203000-00009. [PMID: 11900340] - Egidija Sakiniene, L Vincent Collins. Combined antibiotic and free radical trap treatment is effective at combating Staphylococcus-aureus-induced septic arthritis.
Arthritis research.
2002; 4(3):196-200. doi:
10.1186/ar406. [PMID: 12010570] - N Marklund, T Lewander, F Clausen, L Hillered. Effects of the nitrone radical scavengers PBN and S-PBN on in vivo trapping of reactive oxygen species after traumatic brain injury in rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2001 Nov; 21(11):1259-67. doi:
10.1097/00004647-200111000-00002. [PMID: 11702041] - S Christen, Y D Bifrare, C Siegenthaler, S L Leib, M G Täuber. Marked elevation in cortical urate and xanthine oxidoreductase activity in experimental bacterial meningitis.
Brain research.
2001 May; 900(2):244-51. doi:
10.1016/s0006-8993(01)02311-3. [PMID: 11334804] - M D Maines, N Panahian. The heme oxygenase system and cellular defense mechanisms. Do HO-1 and HO-2 have different functions?.
Advances in experimental medicine and biology.
2001; 502(?):249-72. doi:
10.1007/978-1-4757-3401-0_17. [PMID: 11950143] - J H Kramer, F G Lightfoot, W B Weglicki. Cardiac tissue iron: effects on post-ischemic function and free radical production, and its possible role during preconditioning.
Cellular and molecular biology (Noisy-le-Grand, France).
2000 Dec; 46(8):1313-27. doi:
NULL. [PMID: 11156477] - C Harms, M Lautenschlager, A Bergk, D Freyer, M Weih, U Dirnagl, J R Weber, H Hörtnagl. Melatonin is protective in necrotic but not in caspase-dependent, free radical-independent apoptotic neuronal cell death in primary neuronal cultures.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2000 Sep; 14(12):1814-24. doi:
10.1096/fj.99-0899com. [PMID: 10973931] - L A Reinke, D R Moore, H Sang, E G Janzen, Y Kotake. Aromatic hydroxylation in PBN spin trapping by hydroxyl radicals and cytochrome P-450.
Free radical biology & medicine.
2000 Feb; 28(3):345-50. doi:
10.1016/s0891-5849(99)00248-8. [PMID: 10699745] - K Carvajal, M El Hafidi, G Baños. Myocardial damage due to ischemia and reperfusion in hypertriglyceridemic and hypertensive rats: participation of free radicals and calcium overload.
Journal of hypertension.
1999 Nov; 17(11):1607-16. doi:
10.1097/00004872-199917110-00015. [PMID: 10608475] - M D Maines, V S Raju, N Panahian. Spin trap (N-t-butyl-alpha-phenylnitrone)-mediated suprainduction of heme oxygenase-1 in kidney ischemia/reperfusion model: role of the oxygenase in protection against oxidative injury.
The Journal of pharmacology and experimental therapeutics.
1999 Nov; 291(2):911-9. doi:
NULL. [PMID: 10525116] - S Cadenas, G Barja. Resveratrol, melatonin, vitamin E, and PBN protect against renal oxidative DNA damage induced by the kidney carcinogen KBrO3.
Free radical biology & medicine.
1999 Jun; 26(11-12):1531-7. doi:
10.1016/s0891-5849(99)00019-2. [PMID: 10401619] - D A Butterfield, T Koppal, B Howard, R Subramaniam, N Hall, K Hensley, S Yatin, K Allen, M Aksenov, M Aksenova, J Carney. Structural and functional changes in proteins induced by free radical-mediated oxidative stress and protective action of the antioxidants N-tert-butyl-alpha-phenylnitrone and vitamin E.
Annals of the New York Academy of Sciences.
1998 Nov; 854(?):448-62. doi:
10.1111/j.1749-6632.1998.tb09924.x. [PMID: 9928452] - J Karlsson, M Emgârd, C Rosenblad, P Brundin. Treatment with the spin-trap agent alpha-phenyl-N-tert-butyl nitrone does not enhance the survival of embryonic or adult dopamine neurons.
Brain research.
1998 Sep; 805(1-2):155-68. doi:
10.1016/s0006-8993(98)00702-1. [PMID: 9733957] - P J Bacon, J G Jones, P Taylor, S Stewart, D Wilson-Nunn, M Kerr. Impairment of gas exchange due to alveolar oedema during xylazine sedation in sheep; absence of a free radical mediated inflammatory mechanism.
Research in veterinary science.
1998 Jul; 65(1):71-5. doi:
10.1016/s0034-5288(98)90030-3. [PMID: 9769076] - H Fujii, J Koscielniak, L J Berliner. Determination and characterization of nitric oxide generation in mice by in vivo L-Band EPR spectroscopy.
Magnetic resonance in medicine.
1997 Oct; 38(4):565-8. doi:
10.1002/mrm.1910380410. [PMID: 9324323] - K Tanaka, H Nakazawa, K Okada, K Umezawa, N Fukuyama, Y Koga. Nitric oxide mediates murine cytomegalovirus-associated pneumonitis in lungs that are free of the virus.
The Journal of clinical investigation.
1997 Oct; 100(7):1822-30. doi:
10.1172/jci119710. [PMID: 9312183] - G Gidö, T Kristián, B K Siesjö. Extracellular potassium in a neocortical core area after transient focal ischemia.
Stroke.
1997 Jan; 28(1):206-10. doi:
10.1161/01.str.28.1.206. [PMID: 8996513] - J B Schulz, D R Henshaw, U MacGarvey, M F Beal. Involvement of oxidative stress in 3-nitropropionic acid neurotoxicity.
Neurochemistry international.
1996 Aug; 29(2):167-71. doi:
10.1016/0197-0186(95)00122-0. [PMID: 8837046] - M Kadkhodaee, G R Hanson, R A Towner, Z H Endre. Detection of hydroxyl and carbon-centred radicals by EPR spectroscopy after ischaemia and reperfusion of the rat kidney.
Free radical research.
1996 Jul; 25(1):31-42. doi:
10.3109/10715769609145654. [PMID: 8814442] - N Nakao, E M Grasbon-Frodl, H Widner, P Brundin. Antioxidant treatment protects striatal neurons against excitotoxic insults.
Neuroscience.
1996 Jul; 73(1):185-200. doi:
10.1016/0306-4522(96)00034-6. [PMID: 8783241] - G W Winston, M N Moore, M A Kirchin, C Soverchia. Production of reactive oxygen species by hemocytes from the marine mussel, Mytilus edulis: lysosomal localization and effect of xenobiotics.
Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology.
1996 Feb; 113(2):221-9. doi:
10.1016/0742-8413(95)02091-8. [PMID: 8646615] - C F Schaefer, E G Janzen, M S West, J L Poyer, S D Kosanke. Blood chemistry changes in the rat induced by high doses of nitronyl free radical spin traps.
Free radical biology & medicine.
1996; 21(4):427-36. doi:
10.1016/0891-5849(96)00039-1. [PMID: 8886792] - J Pincemail, O Detry, C Philippart, J O Defraigne, C Franssen, K Burhop, C Deby, M Meurisse, M Lamy. Diaspirin crosslinked hemoglobin (DCLHb): absence of increased free radical generation following administration in a rabbit model of renal ischemia and reperfusion.
Free radical biology & medicine.
1995 Jul; 19(1):1-9. doi:
10.1016/0891-5849(94)00219-a. [PMID: 7635350] - X L Tang, P B McCay, J Z Sun, C J Hartley, M Schleman, R Bolli. Inhibitory effect of a hydrophilic alpha-tocopherol analogue, MDL 74,405, on generation of free radicals in stunned myocardium in dogs.
Free radical research.
1995 Apr; 22(4):293-302. doi:
10.3109/10715769509145641. [PMID: 7633559] - E Monti, E Prosperi, R Supino, G Bottiroli. Free radical-dependent DNA lesions are involved in the delayed cardiotoxicity induced by adriamycin in the rat.
Anticancer research.
1995 Jan; 15(1):193-7. doi:
NULL. [PMID: 7733633] - R M Gatti, R Radi, O Augusto. Peroxynitrite-mediated oxidation of albumin to the protein-thiyl free radical.
FEBS letters.
1994 Jul; 348(3):287-90. doi:
10.1016/0014-5793(94)00625-3. [PMID: 8034056] - E Patterson, R D Burow, C Y Hung, B J Scherlag. Coronary vascular injury after transient coronary artery occlusion.
Laboratory investigation; a journal of technical methods and pathology.
1993 Oct; 69(4):471-82. doi:
NULL. [PMID: 8231114] - X Y Li, P B McCay, M Zughaib, M O Jeroudi, J F Triana, R Bolli. Demonstration of free radical generation in the 'stunned' myocardium in the conscious dog and identification of major differences between conscious and open-chest dogs.
The Journal of clinical investigation.
1993 Aug; 92(2):1025-41. doi:
10.1172/jci116608. [PMID: 8394382] - A J Tortolani, S R Powell, V Misík, W B Weglicki, G J Pogo, J H Kramer. Detection of alkoxyl and carbon-centered free radicals in coronary sinus blood from patients undergoing elective cardioplegia.
Free radical biology & medicine.
1993 Apr; 14(4):421-6. doi:
10.1016/0891-5849(93)90091-8. [PMID: 8385646] - H W Pogrebniak, M J Merino, S M Hahn, J B Mitchell, H I Pass. Spin trap salvage from endotoxemia: the role of cytokine down-regulation.
Surgery.
1992 Aug; 112(2):130-9; discussion 138. doi:
NULL. [PMID: 1641756] - T Sata, E Kubota, H P Misra, M Mojarad, H Pakbaz, S I Said. Paraquat-induced lung injury: prevention by N-tert-butyl-alpha-phenylnitrone, a free-radical spin-trapping agent.
The American journal of physiology.
1992 Feb; 262(2 Pt 1):L147-52. doi:
10.1152/ajplung.1992.262.2.l147. [PMID: 1311515] - J Pedraza-Chaverri, E Tapia, N Bobadilla. Ischemia-reperfusion induced acute renal failure in the rat is ameliorated by the spin-trapping agent alpha-phenyl-N-tert-butyl nitrone (PBN).
Renal failure.
1992; 14(4):467-71. doi:
10.3109/08860229209047654. [PMID: 1461997] - L A Reinke, R A Towner, E G Janzen. Spin trapping of free radical metabolites of carbon tetrachloride in vitro and in vivo: effect of acute ethanol administration.
Toxicology and applied pharmacology.
1992 Jan; 112(1):17-23. doi:
10.1016/0041-008x(92)90274-v. [PMID: 1310168] - G W Mergner, W B Weglicki, J H Kramer. Postischemic free radical production in the venous blood of the regionally ischemic swine heart. Effect of deferoxamine.
Circulation.
1991 Nov; 84(5):2079-90. doi:
10.1161/01.cir.84.5.2079. [PMID: 1657449] - G M Chen, T M Bray, E G Janzen, P B McCay. The role of mixed function oxidase (MFO) in the metabolism of the spin trapping agent alpha-phenyl-N-tert-butyl-nitrone (PBN) in rats.
Free radical research communications.
1991; 14(1):9-16. doi:
10.3109/10715769109088936. [PMID: 2022348] - L A Reinke, E G Janzen. Detection of spin adducts in blood after administration of carbon tetrachloride to rats.
Chemico-biological interactions.
1991; 78(2):155-65. doi:
10.1016/0009-2797(91)90011-u. [PMID: 1645621] - G Chen, M Griffin, J L Poyer, P B McCay. HPLC procedure for the pharmacokinetic study of the spin-trapping agent, alpha-phenyl-N-tert-butyl nitrone (PBN).
Free radical biology & medicine.
1990; 9(2):93-8. doi:
10.1016/0891-5849(90)90110-5. [PMID: 2227531] - R Bolli, P B McCay. Use of spin traps in intact animals undergoing myocardial ischemia/reperfusion: a new approach to assessing the role of oxygen radicals in myocardial 'stunning'.
Free radical research communications.
1990; 9(3-6):169-80. doi:
10.3109/10715769009145674. [PMID: 2167254] - G M Chen, T M Bray, E G Janzen, P B McCay. Excretion, metabolism and tissue distribution of a spin trapping agent, alpha-phenyl-N-tert-butyl-nitrone (PBN) in rats.
Free radical research communications.
1990; 9(3-6):317-23. doi:
10.3109/10715769009145690. [PMID: 2387499] - J Pincemail, J O Defraigne, C Franssen, T Defechereux, J L Canivet, C Philippart, M Meurisse. Evidence of in vivo free radical generation by spin trapping with alpha-phenyl N-tert-butyl nitrone during ischemia/reperfusion in rabbit kidneys.
Free radical research communications.
1990; 9(3-6):181-6. doi:
10.3109/10715769009145675. [PMID: 2167255] - H D Connor, R G Thurman, M D Galizi, R P Mason. The formation of a novel free radical metabolite from CCl4 in the perfused rat liver and in vivo.
The Journal of biological chemistry.
1986 Apr; 261(10):4542-8. doi:
10.1016/s0021-9258(17)38535-6. [PMID: 3007463] - K McKechnie, B L Furman, J R Parratt. Modification by oxygen free radical scavengers of the metabolic and cardiovascular effects of endotoxin infusion in conscious rats.
Circulatory shock.
1986; 19(4):429-39. doi:
NULL. [PMID: 3742740]