N-Acetylsulfamethazine (BioDeep_00000181236)
human metabolite blood metabolite
代谢物信息卡片
化学式: C14H16N4O3S (320.0943066)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)N(C1=NC(C)=CC(C)=N1)S(=O)(=O)C1=CC=C(N)C=C1
InChI: InChI=1S/C14H16N4O3S/c1-9-8-10(2)17-14(16-9)18(11(3)19)22(20,21)13-6-4-12(15)5-7-13/h4-8H,15H2,1-3H3
描述信息
D000890 - Anti-Infective Agents > D013424 - Sulfanilamides
同义名列表
数据库引用编号
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- P Hubert, P Chiap, B Evrard, L Delattre, J Crommen. Fully automated determination of sulfamethazine in ovine plasma using solid-phase extraction on disposable cartridges and liquid chromatography.
Journal of chromatography.
1993 Dec; 622(1):53-60. doi:
10.1016/0378-4347(93)80249-4. [PMID: 8120113] - R P Shrewsbury, D D Hong, L G White, T R Gordon. The effect of moderate haemodilution with Fluosol-DA or Hespan on the nonmicrosomal acetylation of sulphadimidine in the rat.
The Journal of pharmacy and pharmacology.
1992 Feb; 44(2):84-8. doi:
10.1111/j.2042-7158.1992.tb03566.x. [PMID: 1378493] - G A Van 't Klooster, P B van Seeventer, H J Kolker, L A Smit, R F Witkamp. High-performance liquid chromatographic method for the routine determination of sulphadimidine, its hydroxy metabolites and N4-acetylsulphadimidine in body fluids and cell culture media.
Journal of chromatography.
1991 Nov; 571(1-2):157-68. doi:
10.1016/0378-4347(91)80442-f. [PMID: 1810944] - P T Reeves, B F Kinnear, R F Minchin, K F Ilett. Immunological evidence for N-acetyltransferase isozymes in the rabbit.
Molecular pharmacology.
1991 Jan; 39(1):42-8. doi:
NULL. [PMID: 1987451] - A Bozkurt, N E Basci, S Kalan, M Tuncer, S O Kayaalp. N-acetylation phenotyping with sulphadimidine in a Turkish population.
European journal of clinical pharmacology.
1990; 38(1):53-6. doi:
10.1007/bf00314803. [PMID: 2328748] - Y C Tsang, J J Thiessen. Competitive binding of sulfamethazine and its N-acetylated metabolite.
Biopharmaceutics & drug disposition.
1989 Sep; 10(5):465-79. doi:
10.1002/bdd.2510100505. [PMID: 2804251] - J F Nouws, D Mevius, T B Vree, M Degen. Pharmacokinetics and renal clearance of sulphadimidine, sulphamerazine and sulphadiazine and their N4-acetyl and hydroxy metabolites in pigs.
The veterinary quarterly.
1989 Apr; 11(2):78-86. doi:
10.1080/01652176.1989.9694203. [PMID: 2741297] - J M Ladero, F J Jimenez, J Benitez, M J Fernandez-Gundin, C Martinez, A Llerena, J Cobaleda, J J Muñoz. Acetylator polymorphism in Parkinson's disease.
European journal of clinical pharmacology.
1989; 37(4):391-3. doi:
10.1007/bf00558506. [PMID: 2598972] - N Haagsma, H G Pluijmakers, M M Aerts, W M Beek. Rapid sample preparation methods for analysis of residues of sulfamethazine and its N4-acetyl and desamino metabolites in swine tissue by HPLC.
Biomedical chromatography : BMC.
1987 Feb; 2(1):41-5. doi:
10.1002/bmc.1130020112. [PMID: 3508095] - J F Nouws, T B Vree, M Baakman, F Driessens, L Vellenga, D J Mevius. Pharmacokinetics, renal clearance, tissue distribution, and residue aspects of sulphadimidine and its N4-acetyl metabolite in pigs.
The veterinary quarterly.
1986 Apr; 8(2):123-35. doi:
10.1080/01652176.1986.9694031. [PMID: 3727336] - T B Vree, Y A Hekster, J F Nouws, M Baakman. Pharmacokinetics, metabolism, and renal excretion of sulfadimidine and its N4-acetyl and hydroxy metabolites in humans.
Therapeutic drug monitoring.
1986; 8(4):434-9. doi:
10.1097/00007691-198612000-00010. [PMID: 3824429] - J F Nouws, T B Vree, M Baakman, F Driessens, A Smulders, J Holtkamp. Disposition of sulfadimidine and its N4-acetyl and hydroxy metabolites in horse plasma.
Journal of veterinary pharmacology and therapeutics.
1985 Sep; 8(3):303-11. doi:
10.1111/j.1365-2885.1985.tb00960.x. [PMID: 4057349] - J F Nouws, T B Vree, H J Breukink, M Baakman, F Driessens, A Smulders. Dose dependent disposition of sulphadimidine and of its N4-acetyl and hydroxy metabolites in plasma and milk of dairy cows.
The veterinary quarterly.
1985 Jul; 7(3):177-86. doi:
10.1080/01652176.1985.9693980. [PMID: 4049715] - M E Miller, J M Cosgriff. No effect of smoking on sulfamethazine acetylation.
Drug intelligence & clinical pharmacy.
1984 Jul; 18(7-8):620-2. doi:
10.1177/106002808401800714. [PMID: 6745090] - J F Nouws, T B Vree, M Baakman, M Tijhuis. Effect of age on the acetylation and deacetylation reactions of sulphadimidine and N4-acetylsulphadimidine in calves.
Journal of veterinary pharmacology and therapeutics.
1983 Mar; 6(1):13-22. doi:
10.1111/j.1365-2885.1983.tb00450.x. [PMID: 6854729] - R Whelpton, G Watkins, S H Curry. Bratton-Marshall and liquid-chromatographic methods compared for determination of sulfamethazine acetylator status.
Clinical chemistry.
1981 Nov; 27(11):1911-4. doi:
. [PMID: 7296843]