N-Acetyl-dl-penicillamine (BioDeep_00000181223)

   

human metabolite blood metabolite


代谢物信息卡片


2-[(1-Hydroxyethylidene)amino]-3-methyl-3-sulphanylbutanoic acid

化学式: C7H13NO3S (191.0616108)
中文名称: 2-(乙酰氨基)-3-巯基-3-甲基丁酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)NC(C(=O)O)C(C)(C)S
InChI: InChI=1S/C7H13NO3S/c1-4(9)8-5(6(10)11)7(2,3)12/h5,12H,1-3H3,(H,8,9)(H,10,11)

描述信息

同义名列表

8 个代谢物同义名

2-[(1-Hydroxyethylidene)amino]-3-methyl-3-sulphanylbutanoic acid; 2-[(1-Hydroxyethylidene)amino]-3-methyl-3-sulphanylbutanoate; 2-[(1-Hydroxyethylidene)amino]-3-methyl-3-sulfanylbutanoate; 2-acetamido-3-methyl-3-sulfanylbutanoic acid; N-Acetylpenicillamine, (D)-isomer; N-Acetylpenicillamine, (L)-isomer; N-Acetyl-dl-penicillamine; N-Acetylpenicillamine



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Els Keyaerts, Leen Vijgen, Luni Chen, Piet Maes, Göran Hedenstierna, Marc Van Ranst. Inhibition of SARS-coronavirus infection in vitro by S-nitroso-N-acetylpenicillamine, a nitric oxide donor compound. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2004 Jul; 8(4):223-6. doi: 10.1016/j.ijid.2004.04.012. [PMID: 15234326]
  • K Wang, Z Wen, W Zhang, M Xian, J P Cheng, P G Wang. Equilibrium and kinetics studies of transnitrosation between S-nitrosothiols and thiols. Bioorganic & medicinal chemistry letters. 2001 Feb; 11(3):433-6. doi: 10.1016/s0960-894x(00)00688-0. [PMID: 11212129]
  • M Iciek, M Polak, L Włodek. Effect of thiol drugs on the oxidative hemolysis in human erythrocytes. Acta poloniae pharmaceutica. 2000 Nov; 57(6):449-54. doi: ". [PMID: 11243251]
  • P J Srivastava, S Chandra, A J Arif, C Singh, V Panday. Metal chelators/antioxidants: approaches to protect erythrocytic oxidative stress injury during Plasmodium berghei infection in Mastomys coucha. Pharmacological research. 1999 Sep; 40(3):239-41. doi: 10.1006/phrs.1999.0505. [PMID: 10479467]
  • A C Degnim, S E Morrow, J Ku, H A Zar, D K Nakayama. Nitric oxide inhibits peroxide-mediated endothelial toxicity. The Journal of surgical research. 1998 Mar; 75(2):127-34. doi: 10.1006/jsre.1998.5270. [PMID: 9655085]
  • P Srivastava, A J Arif, C Singh, V C Pandey. N-acetyl penicillamine a protector of Plasmodium berghei induced stress organ injury in mice. Pharmacological research. 1997 Oct; 36(4):305-7. doi: 10.1006/phrs.1997.0233. [PMID: 9425620]
  • D J Meyer, H Kramer, N Ozer, B Coles, B Ketterer. Kinetics and equilibria of S-nitrosothiol-thiol exchange between glutathione, cysteine, penicillamines and serum albumin. FEBS letters. 1994 May; 345(2-3):177-80. doi: 10.1016/0014-5793(94)00429-3. [PMID: 8200453]
  • R E Bluhm, J A Breyer, R G Bobbitt, L W Welch, A J Wood, R A Branch. Elemental mercury vapour toxicity, treatment, and prognosis after acute, intensive exposure in chloralkali plant workers. Part II: Hyperchloraemia and genitourinary symptoms. Human & experimental toxicology. 1992 May; 11(3):211-5. doi: 10.1177/096032719201100309. [PMID: 1352116]
  • R E Bluhm, R G Bobbitt, L W Welch, A J Wood, J F Bonfiglio, C Sarzen, A J Heath, R A Branch. Elemental mercury vapour toxicity, treatment, and prognosis after acute, intensive exposure in chloralkali plant workers. Part I: History, neuropsychological findings and chelator effects. Human & experimental toxicology. 1992 May; 11(3):201-10. doi: 10.1177/096032719201100308. [PMID: 1352115]
  • M J Florentine, D J Sanfilippo. Elemental mercury poisoning. Clinical pharmacy. 1991 Mar; 10(3):213-21. doi: . [PMID: 1645633]
  • P A Lewis, A J Woodward, J Maddock. Improved method for the determination of N-acetylcysteine in human plasma by high-performance liquid chromatography. Journal of chromatography. 1985 Jun; 327(?):261-7. doi: 10.1016/s0021-9673(01)81655-1. [PMID: 4030959]
  • E Gonzalez-Fernandez, J Mena, M Diaz-Gonzalez, J M Martinez-Gil de Arana. A long-term survey of environmental, blood and urine mercury levels and clinical findings in workers manufacturing mercury relays. Industrial health. 1984; 22(2):97-106. doi: 10.2486/indhealth.22.97. [PMID: 6480424]
  • D O Hryhorczuk, L Meyers, G Chen. Treatment of mercury intoxication in a dentist with N-acetyl-D,L-penicillamine. Journal of toxicology. Clinical toxicology. 1982 Jun; 19(4):401-8. doi: 10.3109/15563658208992494. [PMID: 7143525]
  • J Aaseth, J Alexander, N Raknerud. Treatment of mercuric chloride poisoning with dimercaptosuccinic acid and diuretics: preliminary studies. Journal of toxicology. Clinical toxicology. 1982 Apr; 19(2):173-86. doi: 10.3109/15563658208990379. [PMID: 6180172]
  • S K Tandon, L Magos. Effect of kidney damage on the mobilisation of mercury by thiol-complexing agents. British journal of industrial medicine. 1980 May; 37(2):128-32. doi: 10.1136/oem.37.2.128. [PMID: 6252946]
  • H T Nagasawa, D J Goon, E G DeMaster. 2,5,5-Trimethylthiazolidine-4-carboxylic acid, a D(-)-penicillamine-directed pseudometabolite of ethanol. Detoxication mechanism for acetaldehyde. Journal of medicinal chemistry. 1978 Dec; 21(12):1274-9. doi: 10.1021/jm00210a019. [PMID: 364061]