Crotamiton (BioDeep_00000018115)
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
化学式: C13H17NO (203.1310072)
中文名称: 克罗米通
谱图信息:
最多检出来源 Homo sapiens(blood) 78.13%
分子结构信息
SMILES: CC=CC(=O)N(CC)c1ccccc1C
InChI: InChI=1S/C13H17NO/c1-4-8-13(15)14(5-2)12-10-7-6-9-11(12)3/h4,6-10H,5H2,1-3H3
描述信息
Crotamiton is only found in individuals that have used or taken this drug. It is a scabicidal and antipruritic agent available as a cream or lotion for topical use only. It is a colorless to slightly yellowish oil, having a faint amine-like odor. It is miscible with alcohol and with methanol.Crotamiton is an antiparasitic that is toxic to the scabies mite. Crotamiton also relieves itching by producing what is called a counter-irritation. As crotamiton evaporates from the skin, it produces a cooling effect. This cooling effect helps to divert your bodys attention away from the itching.
C254 - Anti-Infective Agent > C28394 - Topical Anti-Infective Agent
D016573 - Agrochemicals
D010575 - Pesticides
同义名列表
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:31439
- PubChem: 688020
- PubChem: 2883
- HMDB: HMDB0014410
- DrugBank: DB00265
- ChEMBL: CHEMBL3183440
- ChEMBL: CHEMBL1200709
- Wikipedia: Crotamiton
- chemspider: 2780
- CAS: 124236-29-9
- CAS: 483-63-6
- PMhub: MS000002557
- RefMet: Crotamiton
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Keting Bao, Wenwen Liu, Zhouzhi Song, Jiali Feng, Zhifan Mao, Lingyuan Bao, Tianyue Sun, Zelan Hu, Jian Li. Crotamiton derivative JM03 extends lifespan and improves oxidative and hypertonic stress resistance in Caenorhabditis elegans via inhibiting OSM-9.
eLife.
2022 05; 11(?):. doi:
10.7554/elife.72410. [PMID: 35510610] - Lihua Chen, Majed Alrobaian, Obaid Afzal, Imran Kazmi, Sunil K Panda, Abdulmalik Saleh Alfawaz Altamimi, Fahad A Al-Abbasi, Waleed H Almalki, Hanadi A Katouah, Tanuja Singh, Kriti Soni, Abdul Hafeez, Sarwar Beg, Vikas Kumar, Mahfoozur Rahman. Crotamiton-loaded tea tree oil containing phospholipid-based microemulsion hydrogel for scabies treatment: in vitro, in vivo evaluation, and dermatokinetic studies.
Drug delivery.
2021 Dec; 28(1):1972-1981. doi:
10.1080/10717544.2021.1979131. [PMID: 34565260] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
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Molecular pharmacology.
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Drug metabolism and disposition: the biological fate of chemicals.
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10.1124/dmd.112.047068. [PMID: 22961681] - Rumi Tanoue, Yuri Sato, Miki Motoyama, Shuhei Nakagawa, Ryota Shinohara, Kei Nomiyama. Plant uptake of pharmaceutical chemicals detected in recycled organic manure and reclaimed wastewater.
Journal of agricultural and food chemistry.
2012 Oct; 60(41):10203-11. doi:
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PloS one.
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Environmental toxicology and chemistry.
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PLoS neglected tropical diseases.
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Environmental health perspectives.
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". [PMID: 8586862] - A Sioufi, N Sandrenan, J P Dubois. Determination of crotamiton in plasma and urine by high-performance liquid chromatography.
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