1-(4,5-Dimethylthiazol-2-yl)-3,5-diphenylformazan (BioDeep_00000181135)
human metabolite blood metabolite
代谢物信息卡片
N-[(4,5-dimethyl-1,3-thiazol-2-yl)imino]-N-(phenylamino)benzenecarboximidamide
化学式: C18H17N5S (335.1204602)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C)N=C(S1)N=NC(=NNC1=CC=CC=C1)C1=CC=CC=C1
InChI: InChI=1S/C18H17N5S/c1-13-14(2)24-18(19-13)23-22-17(15-9-5-3-6-10-15)21-20-16-11-7-4-8-12-16/h3-12,20H,1-2H3
数据库引用编号
分类词条
相关代谢途径
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PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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Experimental biology and medicine (Maywood, N.J.).
2008 Dec; 233(12):1591-601. doi:
10.3181/0805-rm-181. [PMID: 18997108] - Ye-Hong Kuang, Xiang Chen, Juan Su, Li-Sha Wu, Ji Li, Jing Chang, Ying Qiu, Zhe-Sheng Chen, Takuro Kanekura. Proteome analysis of multidrug resistance of human oral squamous carcinoma cells using CD147 silencing.
Journal of proteome research.
2008 Nov; 7(11):4784-91. doi:
10.1021/pr800355b. [PMID: 18816083] - Min Zhan, Fang Yuan, Hua Liu, Hui Chen, Xingbiao Qiu, Weiyi Fang. Inhibition of proliferation and apoptosis of vascular smooth muscle cells by ghrelin.
Acta biochimica et biophysica Sinica.
2008 Sep; 40(9):769-76. doi:
10.1093/abbs/40.9.769. [PMID: 18776988] - S Huljic, E I Bruske, N Pfitzenmaier, E O'Brien, D R Dietrich. Species-specific toxicity of aristolochic acid (AA) in vitro.
Toxicology in vitro : an international journal published in association with BIBRA.
2008 Aug; 22(5):1213-21. doi:
10.1016/j.tiv.2008.04.002. [PMID: 18499390] - I Rodeiro, M T Donato, I Martínez, I Hernández, G Garrido, J A González-Lavaut, R Menéndez, A Laguna, J V Castell, M J Gómez-Lechón. Potential hepatoprotective effects of new Cuban natural products in rat hepatocytes culture.
Toxicology in vitro : an international journal published in association with BIBRA.
2008 Aug; 22(5):1242-9. doi:
10.1016/j.tiv.2008.04.006. [PMID: 18502604] - Soo-Youn Choi, Joon-Ho Hwang, Soo-Young Park, Yeong-Jun Jin, Hee-Chul Ko, Sang-Wook Moon, Se-Jae Kim. Fermented guava leaf extract inhibits LPS-induced COX-2 and iNOS expression in Mouse macrophage cells by inhibition of transcription factor NF-kappaB.
Phytotherapy research : PTR.
2008 Aug; 22(8):1030-4. doi:
10.1002/ptr.2419. [PMID: 18618521] - Ines Bouhlel, Kita Valenti, Soumaya Kilani, Ines Skandrani, Mohamed Ben Sghaier, Anne-Marie Mariotte, Marie-Genevieve Dijoux-Franca, Kamel Ghedira, Isabelle Hininger-Favier, François Laporte, Leila Chekir-Ghedira. Antimutagenic, antigenotoxic and antioxidant activities of Acacia salicina extracts (ASE) and modulation of cell gene expression by H2O2 and ASE treatment.
Toxicology in vitro : an international journal published in association with BIBRA.
2008 Aug; 22(5):1264-72. doi:
10.1016/j.tiv.2008.04.008. [PMID: 18515041] - Weihua Liu, Peiqinq Liu, Sha Tao, Yanhui Deng, Xuejuan Li, Tian Lan, Xiaoyan Zhang, Fenfen Guo, Wenge Huang, Fengying Chen, Heqing Huang, Shu-Feng Zhou. Berberine inhibits aldose reductase and oxidative stress in rat mesangial cells cultured under high glucose.
Archives of biochemistry and biophysics.
2008 Jul; 475(2):128-34. doi:
10.1016/j.abb.2008.04.022. [PMID: 18471986] - Teruhiko Nitoda, Takahiko Isobe, Isao Kubo. Effects of phenolic compounds isolated from Rabdosia japonica on B16-F10 melanoma cells.
Phytotherapy research : PTR.
2008 Jul; 22(7):867-72. doi:
10.1002/ptr.2373. [PMID: 18567053] - Arianna Bellucci, Ginetta Collo, Ilenia Sarnico, Leontino Battistin, Cristina Missale, Pierfranco Spano. Alpha-synuclein aggregation and cell death triggered by energy deprivation and dopamine overload are counteracted by D2/D3 receptor activation.
Journal of neurochemistry.
2008 Jul; 106(2):560-77. doi:
10.1111/j.1471-4159.2008.05406.x. [PMID: 18410503] - Eva Rached, Dana Hoffmann, Kai Blumbach, Klaus Weber, Wolfgang Dekant, Angela Mally. Evaluation of putative biomarkers of nephrotoxicity after exposure to ochratoxin a in vivo and in vitro.
Toxicological sciences : an official journal of the Society of Toxicology.
2008 Jun; 103(2):371-81. doi:
10.1093/toxsci/kfn040. [PMID: 18308701] - Winston A Morgan, Thanh Nk, Yinuo Ding. The use of High Performance Thin-Layer Chromatography to determine the role of membrane lipid composition in bile salt-induced kidney cell damage.
Journal of pharmacological and toxicological methods.
2008 Jan; 57(1):70-3. doi:
10.1016/j.vascn.2007.08.003. [PMID: 17962048] - Minghua Wu, Chen Huang, Xiayu Li, Xiaoling Li, Kai Gan, Qiong Chen, Yunlian Tang, Ke Tang, Shourong Shen, Guiyuan Li. LRRC4 inhibits glioblastoma cell proliferation, migration, and angiogenesis by downregulating pleiotropic cytokine expression and responses.
Journal of cellular physiology.
2008 Jan; 214(1):65-74. doi:
10.1002/jcp.21163. [PMID: 17541939] - Thomas F Fuchs, Wolf Petersen, Thomas Vordemvenne, Richard Stange, Michael Raschke, Jürgen R J Paletta. Influence of synovial fluid on human osteoblasts: an in vitro study.
TheScientificWorldJournal.
2007 Dec; 7(?):2012-20. doi:
10.1100/tsw.2007.282. [PMID: 18167616] - Jae Youl Cho. Effect of L-cycloserine on cellular responses mediated by macrophages and T cells.
Biological & pharmaceutical bulletin.
2007 Nov; 30(11):2105-12. doi:
10.1248/bpb.30.2105. [PMID: 17978484] - Thomas Perrotton, Doriane Trompier, Xiu-Bao Chang, Attilio Di Pietro, Hélène Baubichon-Cortay. (R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1.
The Journal of biological chemistry.
2007 Oct; 282(43):31542-8. doi:
10.1074/jbc.m703964200. [PMID: 17646169] - Zhengwei Mao, Lie Ma, Jiang Yan, Ming Yan, Changyou Gao, Jiacong Shen. The gene transfection efficiency of thermoresponsive N,N,N-trimethyl chitosan chloride-g-poly(N-isopropylacrylamide) copolymer.
Biomaterials.
2007 Oct; 28(30):4488-500. doi:
10.1016/j.biomaterials.2007.06.033. [PMID: 17640726] - M Türk, S Dinçer, E Pişkin. Smart and cationic poly(NIPA)/PEI block copolymers as non-viral vectors: in vitro and in vivo transfection studies.
Journal of tissue engineering and regenerative medicine.
2007 Sep; 1(5):377-88. doi:
10.1002/term.47. [PMID: 18038432] - Ekta Kohli, Huai-Yun Han, Arin D Zeman, Serguei V Vinogradov. Formulations of biodegradable Nanogel carriers with 5'-triphosphates of nucleoside analogs that display a reduced cytotoxicity and enhanced drug activity.
Journal of controlled release : official journal of the Controlled Release Society.
2007 Aug; 121(1-2):19-27. doi:
10.1016/j.jconrel.2007.04.007. [PMID: 17509713] - Giacomo Diaz, M Melis, A Musin, M Piludu, M Piras, A M Falchi. Localization of MTT formazan in lipid droplets. An alternative hypothesis about the nature of formazan granules and aggregates.
European journal of histochemistry : EJH.
2007 Jul; 51(3):213-8. doi:
". [PMID: 17921117] - A S Duarte, N Rosa, E P Duarte, E Pires, M T Barros. Cardosins: a new and efficient plant enzymatic tool to dissociate neuronal cells for the establishment of cell cultures.
Biotechnology and bioengineering.
2007 Jul; 97(4):991-6. doi:
10.1002/bit.21259. [PMID: 17099909] - Guan Ye, Hai-Yan Zhu, Zhi-Xiong Li, Chun-Hui Ma, Ming-Song Fan, Zhao-Lin Sun, Cheng-Gang Huang. LC-MS characterization of efficacy substances in serum of experimental animals treated with Sophora flavescens extracts.
Biomedical chromatography : BMC.
2007 Jun; 21(6):655-60. doi:
10.1002/bmc.805. [PMID: 17370298] - M A Aderogba, L J McGaw, A O Ogundaini, J N Eloff. Antioxidant activity and cytotoxicity study of the flavonol glycosides from Bauhinia galpinii.
Natural product research.
2007 Jun; 21(7):591-9. doi:
10.1080/14786410701369557. [PMID: 17613816] - Xing-Jiang Cao, Rui Chen, Ai-Ping Li, Jian-Wei Zhou. JWA gene is involved in cadmium-induced growth inhibition and apoptosis in HEK-293T cells.
Journal of toxicology and environmental health. Part A.
2007 Jun; 70(11):931-7. doi:
10.1080/15287390701290212. [PMID: 17479408] - Ping Yang, Xiao-Qing He, Lei Peng, Ai-Ping Li, Xin-Ru Wang, Jian-Wei Zhou, Qi-Zhan Liu. The role of oxidative stress in hormesis induced by sodium arsenite in human embryo lung fibroblast (HELF) cellular proliferation model.
Journal of toxicology and environmental health. Part A.
2007 Jun; 70(11):976-83. doi:
10.1080/15287390701290832. [PMID: 17479414] - Yuba Raj Pokharel, Qing-He Liu, Jae Wook Oh, Eun-Rhan Woo, Keon Wook Kang. 4-Hydroxykobusin inhibits the induction of nitric oxide synthase by inhibiting NF-kappaB and AP-1 activation.
Biological & pharmaceutical bulletin.
2007 Jun; 30(6):1097-101. doi:
10.1248/bpb.30.1097. [PMID: 17541160] - Jinyong Peng, Qiwei Xu, Youwei Xu, Yan Qi, Xu Han, Lina Xu. A new anticancer dihydroflavanoid from the root of Spiranthes australis (R. Brown) Lindl.
Natural product research.
2007 Jun; 21(7):641-5. doi:
10.1080/14786410701371165. [PMID: 17613822] - Parida Yamada, Hiroko Isoda, Jun Kyu Han, Terence P N Talorete, Yukuo Abe. Inhibitory effect of fulvic acid extracted from Canadian sphagnum peat on chemical mediator release by RBL-2H3 and KU812 cells.
Bioscience, biotechnology, and biochemistry.
2007 May; 71(5):1294-305. doi:
10.1271/bbb.60702. [PMID: 17485833] - Maria Davoren, Eva Herzog, Alan Casey, Benjamin Cottineau, Gordon Chambers, Hugh J Byrne, Fiona M Lyng. In vitro toxicity evaluation of single walled carbon nanotubes on human A549 lung cells.
Toxicology in vitro : an international journal published in association with BIBRA.
2007 Apr; 21(3):438-48. doi:
10.1016/j.tiv.2006.10.007. [PMID: 17125965] - Wei-Ping Mao, Ji-Lin Ye, Zheng-Bing Guan, Jie-Ming Zhao, Chao Zhang, Na-Na Zhang, Ping Jiang, Ting Tian. Cadmium induces apoptosis in human embryonic kidney (HEK) 293 cells by caspase-dependent and -independent pathways acting on mitochondria.
Toxicology in vitro : an international journal published in association with BIBRA.
2007 Apr; 21(3):343-54. doi:
10.1016/j.tiv.2006.09.004. [PMID: 17052885] - Zhuoyu Li, Yanfeng Qu, Hanqing Li, Jingming Yuan. Truncations of gelonin lead to a reduction in its cytotoxicity.
Toxicology.
2007 Mar; 231(2-3):129-36. doi:
10.1016/j.tox.2006.11.074. [PMID: 17222956] - Bastiaan P Krom, Jesse B Cohen, Gail E McElhaney Feser, Ronald L Cihlar. Optimized candidal biofilm microtiter assay.
Journal of microbiological methods.
2007 Feb; 68(2):421-3. doi:
10.1016/j.mimet.2006.08.003. [PMID: 17005276] - Yong Feng, Dong Zheng, Shuhua Yang, Jing Li. Construction of eukaryotic expression plasmid of bFGF gene in rats and its expression in tenocytes.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban.
2007 Feb; 27(1):27-30. doi:
10.1007/s11596-007-0108-z. [PMID: 17393102] - Jia-li Wei, You-ming Peng, Fuyou Liu. Connective tissue growth factor and fibronectin secretion in renal tubular epithelial cells induced by TGF-beta1: suppressive effects of troglitazone.
Cell biology international.
2007 Jan; 31(1):30-4. doi:
10.1016/j.cellbi.2006.09.004. [PMID: 17056281]