Bromazepam (BioDeep_00000018111)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


7-bromo-5-(pyridin-2-yl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one

化学式: C14H10BrN3O (315.000719)
中文名称: 溴西泮
谱图信息: 最多检出来源 Homo sapiens(blood) 75%

Reviewed

Last reviewed on 2024-09-14.

Cite this Page

Bromazepam. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/bromazepam (retrieved 2024-11-08) (BioDeep RN: BioDeep_00000018111). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: BrC1=CC2=C(NC(=O)CN=C2C2=CC=CC=N2)C=C1
InChI: InChI=1S/C14H10BrN3O/c15-9-4-5-11-10(7-9)14(17-8-13(19)18-11)12-3-1-2-6-16-12/h1-7H,8H2,(H,18,19)

描述信息

Bromazepam is only found in individuals that have used or taken this drug. It is one of the benzodiazepines that is used in the treatment of anxiety disorders. [PubChem] It is a Schedule IV drug in the U.S. and Canada and under the Convention on Psychotropic Substances.Bromazepam binds to the GABA receptor GABAA, causing a conformational change and increasing inhibitory effects of GABA. Other neurotransmitters are not influenced.
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
N - Nervous system > N05 - Psycholeptics > N05B - Anxiolytics > N05BA - Benzodiazepine derivatives
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C1012 - Benzodiazepine
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018757 - GABA Modulators
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent

同义名列表

45 个代谢物同义名

7-bromo-5-(pyridin-2-yl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one; 7-Bromo-5-(2-pyridyl)-3H-1,4-benzodiaxepin-2(1H)-one; 7-Bromo-5-(2-pyridyl)-3H-1,4-benzodiazepin-2(1H)-one; CT Arzneimittel brand OF bromazepam; CT-Arzneimittel brand OF bromazepam; Lichtenstein brand OF bromazepam; Neuraxpharm brand OF bromazepam; Ratiopharm brand OF bromazepam; Merck dura brand OF bromazepam; Bromazepam lichtenstein brand; Betapharm brand OF bromazepam; Genpharm brand OF bromazepam; Heumann brand OF bromazepam; Apotex brand OF bromazepam; Hexal brand OF bromazepam; Aliud brand OF bromazepam; Roche brand OF bromazepam; Irex brand OF bromazepam; 1a Brand OF bromazepam; Bromazepam neuraxpharm; Bromazepam roche brand; Bromazepam-neuraxpharm; Bromazepam ratiopharm; Bromazepam-ratiopharm; Bromazepam heumann; Von CT, bromazep; Bromaz 1a pharma; Beta, Bromazepam; Bromazep von CT; Bromazepam beta; Gen bromazepam; Apo-bromazepam; Apo bromazepam; Gen-bromazepam; Bromazepam al; bromazepam; Bromazanil; Lexotanil; BromaLich; Durazanil; Lectopam; Lexotan; Anxyrex; Lexomil; Lexatin



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Donata Favretto, Sindi Visentin, Alan W Jones. Prevalence and concentrations of sedative-hypnotic drugs in blood of drivers involved in road traffic crashes in the Padova region of Italy - not so easy to interpret. Forensic science international. 2022 Jan; 330(?):111097. doi: 10.1016/j.forsciint.2021.111097. [PMID: 34814082]
  • Darinka Purg, Andrej Markota, Damjan Grenc, Andreja Sinkovič. Low-dose intravenous lipid emulsion for the treatment of severe quetiapine and citalopram poisoning. Arhiv za higijenu rada i toksikologiju. 2016 Jun; 67(2):164-6. doi: 10.1515/aiht-2016-67-2802. [PMID: 27331303]
  • Filip Zmuda, Gaurav Malviya, Adele Blair, Marie Boyd, Anthony J Chalmers, Andrew Sutherland, Sally L Pimlott. Synthesis and Evaluation of a Radioiodinated Tracer with Specificity for Poly(ADP-ribose) Polymerase-1 (PARP-1) in Vivo. Journal of medicinal chemistry. 2015 Nov; 58(21):8683-93. doi: 10.1021/acs.jmedchem.5b01324. [PMID: 26469301]
  • Kyoko Uekusa, Makiko Hayashida, Youkichi Ohno. Forensic toxicological analyses of drugs in tissues in formalin solutions and in fixatives. Forensic science international. 2015 Apr; 249(?):165-72. doi: 10.1016/j.forsciint.2015.01.028. [PMID: 25700112]
  • P Kintz. Contribution of in utero drug exposure when interpreting hair results in young children. Forensic science international. 2015 Apr; 249(?):314-7. doi: 10.1016/j.forsciint.2014.09.014. [PMID: 25450508]
  • Martin Juebner, Mathias Fietzke, Justus Beike, Markus A Rothschild, Katja Bender. Assisted suicide by fentanyl intoxication due to excessive transdermal application. International journal of legal medicine. 2014 Nov; 128(6):949-56. doi: 10.1007/s00414-014-0982-4. [PMID: 24577713]
  • Maria Lodise, Fabio De-Giorgio, Riccardo Rossi, Ernesto d'Aloja, Nadia Fucci. Acute Ibuprofen intoxication: report on a case and review of the literature. The American journal of forensic medicine and pathology. 2012 Sep; 33(3):242-6. doi: 10.1097/paf.0b013e318253d6ff. [PMID: 22835967]
  • Ruth Verplaetse, Eva Cuypers, Jan Tytgat. The evaluation of the applicability of a high pH mobile phase in ultrahigh performance liquid chromatography tandem mass spectrometry analysis of benzodiazepines and benzodiazepine-like hypnotics in urine and blood. Journal of chromatography. A. 2012 Aug; 1249(?):147-54. doi: 10.1016/j.chroma.2012.06.023. [PMID: 22749457]
  • Sevasti Karampela, Ioanna Vardakou, Ioannis Papoutsis, Artemis Dona, Chara Spiliopoulou, Sotirios Athanaselis, Constantinos Pistos. Direct urine analysis for the identification and quantification of selected benzodiazepines for toxicology screening. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Aug; 902(?):42-6. doi: 10.1016/j.jchromb.2012.06.012. [PMID: 22790390]
  • C Miljevic, C Crnobaric, S Nikolic, D Lecic-Tosevski. A case of pregabalin intoxication. Psychiatrike = Psychiatriki. 2012 Apr; 23(2):162-5. doi: NULL. [PMID: 22796916]
  • Emmanuel Varesio, J C Yves Le Blanc, Gérard Hopfgartner. Real-time 2D separation by LC × differential ion mobility hyphenated to mass spectrometry. Analytical and bioanalytical chemistry. 2012 Mar; 402(8):2555-64. doi: 10.1007/s00216-011-5444-y. [PMID: 22006241]
  • T Kosjek, S Perko, M Zupanc, M Zanoški Hren, T Landeka Dragičević, D Zigon, B Kompare, E Heath. Environmental occurrence, fate and transformation of benzodiazepines in water treatment. Water research. 2012 Feb; 46(2):355-68. doi: 10.1016/j.watres.2011.10.056. [PMID: 22115636]
  • Netta Shoenfeld, Dana Bodnik, Oded Rosenberg, Moshe Kotler, Pinhas Dannon. [Six-month follow-up study of drug treatment for cannabis addiction: comparison study of four drugs]. Harefuah. 2011 Dec; 150(12):888-92, 937. doi: NULL. [PMID: 22352278]
  • P Cabarcos, M J Tabernero, I Álvarez, P López, P Fernández, A M Bermejo. Analysis of six benzodiazepines in vitreous humor by high-performance liquid chromatography-photodiode-array detection. Journal of analytical toxicology. 2010 Nov; 34(9):539-42. doi: 10.1093/jat/34.9.539. [PMID: 21073805]
  • Roberta G Machicote, María E Pacheco, Liliana Bruzzone. Binding of several benzodiazepines to bovine serum albumin: Fluorescence study. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2010 Oct; 77(2):466-72. doi: 10.1016/j.saa.2010.06.020. [PMID: 20621550]
  • P Fernández, C Vázquez, R A Lorenzo, A M Carro, I Alvarez, P Cabarcos. Experimental design for optimization of microwave-assisted extraction of benzodiazepines in human plasma. Analytical and bioanalytical chemistry. 2010 May; 397(2):677-85. doi: 10.1007/s00216-010-3572-4. [PMID: 20204329]
  • Alfonso Merante, Pietro Gareri, Norma Maria Marigliano, Salvatore De Fazio, Elvira Bonacci, Carlo Torchia, Gaetano Russo, Pasquale Lacroce, Roberto Lacava, Alberto Castagna, Giovambattista De Sarro, Giovanni Ruotolo. Laxative-induced rhabdomyolysis. Clinical interventions in aging. 2010 Apr; 5(?):71-3. doi: 10.2147/cia.s8832. [PMID: 20396636]
  • Radim Vrzal, Katerina Kubesova, Petr Pavek, Zdenek Dvorak. Benzodiazepines medazepam and midazolam are activators of pregnane X receptor and weak inducers of CYP3A4: investigation in primary cultures of human hepatocytes and hepatocarcinoma cell lines. Toxicology letters. 2010 Mar; 193(2):183-8. doi: 10.1016/j.toxlet.2010.01.004. [PMID: 20080160]
  • K Lakhal, S Pallancher, J-C Mathieu-Daude, P Harry, X Capdevila. Protracted deep coma after bromazepam poisoning. International journal of clinical pharmacology and therapeutics. 2010 Jan; 48(1):79-83. doi: 10.5414/cpp48079. [PMID: 20040343]
  • Diogo Oliveira-Silva, Celso H Oliveira, Gustavo D Mendes, Paulo Alexandre R Galvinas, Rafael E Barrientos-Astigarraga, Gilberto De Nucci. Quantification of chlordesmethyldiazepam by liquid chromatography-tandem mass spectrometry: application to a cloxazolam bioequivalence study. Biomedical chromatography : BMC. 2009 Dec; 23(12):1266-75. doi: 10.1002/bmc.1249. [PMID: 19488979]
  • M S Attia. Spectrofluorimetric quantification of bromazepam using a highly selective optical probe based on Eu3+-bromazepam complex in pharmaceutical and serum samples. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2009 Nov; 74(4):972-6. doi: 10.1016/j.saa.2009.09.002. [PMID: 19781983]
  • Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance. Journal of medicinal chemistry. 2009 Aug; 52(15):4844-52. doi: 10.1021/jm900403j. [PMID: 19445515]
  • Gregory Podilsky, Markoulina Berger-Gryllaki, Bernard Testa, Thierry Buclin, Michel Roulet, Andre Pannatier. The bioavailability of bromazepam, omeprazole and paracetamol given by nasogastric feeding tube. European journal of clinical pharmacology. 2009 May; 65(5):435-42. doi: 10.1007/s00228-008-0613-4. [PMID: 19189088]
  • Mitsuhiro Nakamura, Tomofumi Ohmori, Yoshinori Itoh, Masato Terashita, Kazuyuki Hirano. Simultaneous determination of benzodiazepines and their metabolites in human serum by liquid chromatography-tandem mass spectrometry using a high-resolution octadecyl silica column compatible with aqueous compounds. Biomedical chromatography : BMC. 2009 Apr; 23(4):357-64. doi: 10.1002/bmc.1122. [PMID: 18937304]
  • N Assez, C Delangue, V Dherbecourt. [Efficiency digoxin-specific antibody FAB fragment (Digitot) after a late diagnosis in digitalis poisoning]. Annales francaises d'anesthesie et de reanimation. 2009 Feb; 28(2):178-9. doi: 10.1016/j.annfar.2008.12.025. [PMID: 19211216]
  • Mohammad Nasir Uddin, Victoria F Samanidou, Ioannis N Papadoyannis. Validation of SPE-HPLC determination of 1,4-benzodiazepines and metabolites in blood plasma, urine, and saliva. Journal of separation science. 2008 Dec; 31(21):3704-17. doi: 10.1002/jssc.200800342. [PMID: 19003810]
  • Vera Maresova, Jiri Chadt, Eva Novakova. Screening and semiquantitative analysis of drugs and drugs of abuse in human serum samples using gas chromatography-mass spectrometry. Neuro endocrinology letters. 2008 Oct; 29(5):749-54. doi: NULL. [PMID: 18987582]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • Marc Deveaux, Marjorie Chèze, Gilbert Pépin. The role of liquid chromatography-tandem mass spectrometry (LC-MS/MS) to test blood and urine samples for the toxicological investigation of drug-facilitated crimes. Therapeutic drug monitoring. 2008 Apr; 30(2):225-8. doi: 10.1097/ftd.0b013e3181676186. [PMID: 18367985]
  • Alberto S Pereira, Marc Schelfaut, Frédéric Lynen, Pat Sandra. Design and evaluation of a multi-detection system composed of ultraviolet, evaporative light scattering and inductively coupled plasma mass spectrometry detection for the analysis of pharmaceuticals by liquid chromatography. Journal of chromatography. A. 2008 Mar; 1185(1):78-84. doi: 10.1016/j.chroma.2008.01.030. [PMID: 18262535]
  • Guillaume Hoizey, Frédéric Canas, Laurent Binet, Matthieu L Kaltenbach, Gérard Jeunehomme, Marie-Hélène Bernard, Denis Lamiable. Thiodicarb and methomyl tissue distribution in a fatal multiple compounds poisoning. Journal of forensic sciences. 2008 Mar; 53(2):499-502. doi: 10.1111/j.1556-4029.2008.00676.x. [PMID: 18366586]
  • Victoria F Samanidou, Anastasia P Pechlivanidou, Ioannis N Papadoyannis. Development of a validated HPLC method for the determination of four 1,4-benzodiazepines in human biological fluids. Journal of separation science. 2007 Mar; 30(5):679-87. doi: 10.1002/jssc.200600365. [PMID: 17461106]
  • F Mongenot, Y Tessier Gonthier, F Derderian, M Durand, D Blin. [Treatment of hydroxychloroquine poisoning with extracorporeal circulation]. Annales francaises d'anesthesie et de reanimation. 2007 Feb; 26(2):164-7. doi: 10.1016/j.annfar.2006.09.005. [PMID: 17092685]
  • Vasilios Kimiskidis, Marios Spanakis, Ioannis Niopas, Dimitrios Kazis, Chrysi Gabrieli, Feras Imad Kanaze, Daniil Divanoglou. Development and validation of a high performance liquid chromatographic method for the determination of oxcarbazepine and its main metabolites in human plasma and cerebrospinal fluid and its application to pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 2007 Jan; 43(2):763-8. doi: 10.1016/j.jpba.2006.07.047. [PMID: 16959463]
  • Sofia A C Lima, Anabela Cordeiro-da-Silva, Baltazar de Castro, Paula Gameiro. Sensitivity of P-glycoprotein tryptophan residues to benzodiazepines and ATP interaction. Biophysical chemistry. 2007 Jan; 125(1):143-50. doi: 10.1016/j.bpc.2006.07.006. [PMID: 16919386]
  • Franz E Dussy, Cornelia Hamberg, Thomas A Briellmann. Quantification of benzodiazepines in whole blood and serum. International journal of legal medicine. 2006 Nov; 120(6):323-30. doi: 10.1007/s00414-005-0042-1. [PMID: 16220317]
  • Hafid Belhadj-Tahar, Nouredine Sadeg. Methcathinone: a new postindustrial drug. Forensic science international. 2005 Oct; 153(1):99-101. doi: 10.1016/j.forsciint.2005.04.023. [PMID: 15919169]
  • Marjorie Chèze, Gaëlle Duffort, Marc Deveaux, Gilbert Pépin. Hair analysis by liquid chromatography-tandem mass spectrometry in toxicological investigation of drug-facilitated crimes: report of 128 cases over the period June 2003-May 2004 in metropolitan Paris. Forensic science international. 2005 Oct; 153(1):3-10. doi: 10.1016/j.forsciint.2005.04.021. [PMID: 15922526]
  • José Carlos Saraiva Gonçalves, Tânia Maria Monteiro, Claúdia Silvana de Miranda Neves, Karla Regina da Silva Gram, Nádia Maria Volpato, Vivian A Silva, Ricardo Caminha, Maria do Rocio Bencke Gonçalves, Fábio Monteiro Dos Santos, Gabriel Estolano da Silveira, François Noël. On-line solid-phase extraction coupled with high-performance liquid chromatography and tandem mass spectrometry (SPE-HPLC-MS-MS) for quantification of bromazepam in human plasma: an automated method for bioequivalence studies. Therapeutic drug monitoring. 2005 Oct; 27(5):601-7. doi: 10.1097/01.ftd.0000170027.28949.da. [PMID: 16175133]
  • Maristela H Andraus, Anthony Wong, Ovandir A Silva, Cicília Y Wada, Odaly Toffleto, Cristina P Azevedo, Myriam C Salvadori. Determination of bromazepam in human plasma by high-performance liquid chromatography with electrospray ionization tandem mass spectrometric detection: application to a bioequivalence study. Journal of mass spectrometry : JMS. 2004 Nov; 39(11):1348-55. doi: 10.1002/jms.667. [PMID: 15532067]
  • Marjorie Chèze, Marion Villain, Gilbert Pépin. Determination of bromazepam, clonazepam and metabolites after a single intake in urine and hair by LC-MS/MS. Application to forensic cases of drug facilitated crimes. Forensic science international. 2004 Oct; 145(2-3):123-30. doi: 10.1016/j.forsciint.2004.04.066. [PMID: 15451083]
  • Frédéric Marrache, Bruno Mégarbane, Stéphane Pirnay, Abdel Rhaoui, Marie Thuong. Difficulties in assessing brain death in a case of benzodiazepine poisoning with persistent cerebral blood flow. Human & experimental toxicology. 2004 Oct; 23(10):503-5. doi: 10.1191/0960327104ht478cr. [PMID: 15553176]
  • Marion Villain, Marjorie Chèze, Véronique Dumestre, Bertrand Ludes, Pascal Kintz. Hair to document drug-facilitated crimes: four cases involving bromazepam. Journal of analytical toxicology. 2004 Sep; 28(6):516-9. doi: 10.1093/jat/28.6.516. [PMID: 15516307]
  • Carsten Kratzsch, Oliver Tenberken, Frank T Peters, Armin A Weber, Thomas Kraemer, Hans H Maurer. Screening, library-assisted identification and validated quantification of 23 benzodiazepines, flumazenil, zaleplone, zolpidem and zopiclone in plasma by liquid chromatography/mass spectrometry with atmospheric pressure chemical ionization. Journal of mass spectrometry : JMS. 2004 Aug; 39(8):856-72. doi: 10.1002/jms.599. [PMID: 15329838]
  • Leyre Urigüen, Sandra Pérez-Rial, Catherine Ledent, Tomás Palomo, Jorge Manzanares. Impaired action of anxiolytic drugs in mice deficient in cannabinoid CB1 receptors. Neuropharmacology. 2004 Jun; 46(7):966-73. doi: 10.1016/j.neuropharm.2004.01.003. [PMID: 15081793]
  • A A Salem, B N Barsoum, E L Izake. Spectrophotometric and fluorimetric determination of diazepam, bromazepam and clonazepam in pharmaceutical and urine samples. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2004 Mar; 60(4):771-80. doi: 10.1016/s1386-1425(03)00300-7. [PMID: 15036087]
  • Franco Lombardo, R Scott Obach, Marina Y Shalaeva, Feng Gao. Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry. 2004 Feb; 47(5):1242-50. doi: 10.1021/jm030408h. [PMID: 14971904]
  • Tiago L Laurito, Gustavo D Mendes, Vincenzo Santagada, Giuseppe Caliendo, Maria Elisabete A de Moraes, Gilberto De Nucci. Bromazepam determination in human plasma by high-performance liquid chromatography coupled to tandem mass spectrometry: a highly sensitive and specific tool for bioequivalence studies. Journal of mass spectrometry : JMS. 2004 Feb; 39(2):168-76. doi: 10.1002/jms.590. [PMID: 14991686]
  • S G O'Brien, P Meinhardt, E Bond, J Beck, B Peng, C Dutreix, G Mehring, S Milosavljev, C Huber, R Capdeville, T Fischer. Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia. British journal of cancer. 2003 Nov; 89(10):1855-9. doi: 10.1038/sj.bjc.6601152. [PMID: 14612892]
  • Manami Oda, Tsutomu Kotegawa, Kimiko Tsutsumi, Yasukiyo Ohtani, Keiji Kuwatani, Shigeyuki Nakano. The effect of itraconazole on the pharmacokinetics and pharmacodynamics of bromazepam in healthy volunteers. European journal of clinical pharmacology. 2003 Nov; 59(8-9):615-9. doi: 10.1007/s00228-003-0681-4. [PMID: 14517708]
  • Kazuhiro Koyama, Yoko Shimazu, Takaaki Kikuno, Hirosi Kaziwara, Hisanori Sekiguti. [Pharmacokinetics of bromazepam in 57 patients with acute drug intoxication]. Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology. 2003 Jan; 16(1):51-6. doi: NULL. [PMID: 12712542]
  • Maria Elisa Capella-Peiró, Devasish Bose, Adrià Martinavarro-Domínguez, Mayte Gil-Agustí, Josep Esteve-Romero. Direct injection micellar liquid chromatographic determination of benzodiazepines in serum. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2002 Nov; 780(2):241-9. doi: 10.1016/s1570-0232(02)00523-8. [PMID: 12401349]
  • Franco Lombardo, R Scott Obach, Marina Y Shalaeva, Feng Gao. Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry. 2002 Jun; 45(13):2867-76. doi: 10.1021/jm0200409. [PMID: 12061889]
  • Stephane Pirnay, Ivan Ricordel, Danielle Libong, Stéphane Bouchonnet. Sensitive method for the detection of 22 benzodiazepines by gas chromatography-ion trap tandem mass spectrometry. Journal of chromatography. A. 2002 Apr; 954(1-2):235-45. doi: 10.1016/s0021-9673(02)00190-5. [PMID: 12058908]
  • V Dumestre-Toulet, V Cirimele, S Gromb, T Belooussoff, D Lavault, B Ludes, P Kintz. Last performance with VIAGRA: post-mortem identification of sildenafil and its metabolites in biological specimens including hair sample. Forensic science international. 2002 Mar; 126(1):71-6. doi: 10.1016/s0379-0738(02)00012-9. [PMID: 11955836]
  • Yasukiyo Ohtani, Tsutomu Kotegawa, Kimiko Tsutsumi, Takuya Morimoto, Yumiko Hirose, Shigeyuki Nakano. Effect of fluconazole on the pharmacokinetics and pharmacodynamics of oral and rectal bromazepam: an application of electroencephalography as the pharmacodynamic method. Journal of clinical pharmacology. 2002 Feb; 42(2):183-91. doi: 10.1177/00912700222011229. [PMID: 11831541]
  • P Pozzoni, F Tentori, M Corti, C Pozzi. [Rhabdomyolysis as a complication of Parkinson's disease]. Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia. 2002 Jan; 19(1):13-7. doi: NULL. [PMID: 12165940]
  • K Michaud, N Romain, C Giroud, C Brandt, P Mangin. Hypothermia and undressing associated with non-fatal bromazepam intoxication. Forensic science international. 2001 Dec; 124(2-3):112-4. doi: 10.1016/s0379-0738(01)00584-9. [PMID: 11792498]
  • B M El-Haj, A M Al-Amri, M H Hassan, R K Bin-Khadem. Investigation into some aspects of EMIT d.a.u., TLC, and GC-MS urinalysis of bromazepam. Journal of analytical toxicology. 2001 Jul; 25(5):316-22. doi: 10.1093/jat/25.5.316. [PMID: 11499884]
  • M Köster, T Wege, C Ganzemüller, W Lengfelder. [44-year-old patient with thrombocytopenia, multiple organ failure and disseminated intravascular coagulation caused by drug poisoning with paracetamol, metamizole, benzodiazepines and alcohol in attempted suicide]. Der Internist. 2001 Jun; 42(6):905-9. doi: 10.1007/s001080170134. [PMID: 11449637]
  • F E Lerner, D Schere, N Batafarano, F Casas, R Glancszpigel. Comparative bioavailability of two oral formulations of bromazepam in healthy volunteers. Arzneimittel-Forschung. 2001; 51(12):955-8. doi: 10.1055/s-0031-1300144. [PMID: 11799841]
  • U E Busto, H L Kaplan, C E Wright, B Gomez-Mancilla, L Zawertailo, D J Greenblatt, E M Sellers. A comparative pharmacokinetic and dynamic evaluation of alprazolam sustained-release, bromazepam, and lorazepam. Journal of clinical psychopharmacology. 2000 Dec; 20(6):628-35. doi: 10.1097/00004714-200012000-00008. [PMID: 11106134]
  • F Divanon, D Debruyne, M Moulin, R Leroyer. Benzodiazepines: toxic serum concentrations in positive enzyme immunoassay responses. Journal of analytical toxicology. 1998 Nov; 22(7):559-66. doi: 10.1093/jat/22.7.559. [PMID: 9847005]
  • J Rudolf, H Käferstein, M Neveling, C Stenzel. [Protracted course of bromazepam poisoning in advanced age]. Deutsche medizinische Wochenschrift (1946). 1998 Jul; 123(27):832-4. doi: 10.1055/s-2007-1024075. [PMID: 9685842]
  • M Schmitz, M Jäckel. [Comparative study for assessing quality of life of patients with exogenous sleep disorders (temporary sleep onset and sleep interruption disorders) treated with a hops-valarian preparation and a benzodiazepine drug]. Wiener medizinische Wochenschrift (1946). 1998; 148(13):291-8. doi: ". [PMID: 9757514]
  • E Tanaka, M Terada, S Misawa, C Wakasugi. Simultaneous determination of twelve benzodiazepines in human serum using a new reversed-phase chromatographic column on a 2-microns porous microspherical silica gel. Journal of chromatography. B, Biomedical applications. 1996 Jun; 682(1):173-8. doi: 10.1016/0378-4347(96)00121-1. [PMID: 8832439]
  • M Tomita, T Okuyama. Application of capillary electrophoresis to the simultaneous screening and quantitation of benzodiazepines. Journal of chromatography. B, Biomedical applications. 1996 Apr; 678(2):331-7. doi: 10.1016/0378-4347(95)00512-9. [PMID: 8738039]
  • J van Harten. Overview of the pharmacokinetics of fluvoxamine. Clinical pharmacokinetics. 1995; 29 Suppl 1(?):1-9. doi: 10.2165/00003088-199500291-00003. [PMID: 8846617]
  • A Belmadani, I Combourieu, M Bonini, E E Creppy. High performance liquid chromatography with ultraviolet detection used for laboratory routine determination of fluvoxamine in human plasma. Human & experimental toxicology. 1995 Jan; 14(1):34-7. doi: 10.1177/096032719501400108. [PMID: 7748614]
  • P R Martens. A sudden infant death like syndrome possibly induced by a benzodiazepine in breast-feeding. European journal of emergency medicine : official journal of the European Society for Emergency Medicine. 1994 Jun; 1(2):86-7. doi: NULL. [PMID: 9422145]
  • H Le Solleu, F Demotes-Mainard, G Vinçon, B Bannwarth. The determination of bromazepam in plasma by reversed-phase high-performance liquid chromatography. Journal of pharmaceutical and biomedical analysis. 1993 Aug; 11(8):771-5. doi: 10.1016/0731-7085(93)80187-6. [PMID: 8257743]
  • H K Hundt, R Schall, H G Luus, F O Müller. Considerable cost savings through the analysis of pooled plasma samples in bioequivalence studies that fail to show bioequivalence. International journal of clinical pharmacology, therapy, and toxicology. 1993 Jul; 31(7):331-6. doi: NULL. [PMID: 8370632]
  • F Rodríguez-Huertas, M S Carrasco, A García-Baquero, F D Coq, J Freire. [Changes in plasma cortisol and ACTH caused by diazepam, bromazepam, triazolam, and alprazolam in oral premedication]. Revista espanola de anestesiologia y reanimacion. 1992 May; 39(3):145-8. doi: NULL. [PMID: 1329159]
  • T Maruyama, M A Furuie, S Hibino, M Otagiri. Comparative study of interaction mode of diazepines with human serum albumin and alpha 1-acid glycoprotein. Journal of pharmaceutical sciences. 1992 Jan; 81(1):16-20. doi: 10.1002/jps.2600810104. [PMID: 1352350]
  • U Gerhard, V Hobi, R Kocher, C König. [Acute sedative effect of a herbal relaxation tablet as compared to that of bromazepam]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis. 1991 Dec; 80(52):1481-6. doi: ". [PMID: 1815310]
  • J Fujii, N Inotsume, M Nakano. Effect of food on the bioavailability of bromazepam following oral administration in healthy volunteers. Journal of pharmacobio-dynamics. 1990 May; 13(5):269-71. doi: 10.1248/bpb1978.13.269. [PMID: 2273442]
  • P Kintz, A Tracqui, B Ludes, J Waller, A Boukhabza, P Mangin, A A Lugnier, A J Chaumont. Fly larvae and their relevance in forensic toxicology. The American journal of forensic medicine and pathology. 1990 Mar; 11(1):63-5. doi: 10.1097/00000433-199003000-00008. [PMID: 1968313]
  • A Boukhabza, A A Lugnier, P Kintz, A Tracqui, P Mangin, A J Chaumont. High-performance liquid chromatographic determination of bromazepam in human plasma. The Analyst. 1989 May; 114(5):639-41. doi: 10.1039/an9891400639. [PMID: 2569276]
  • T G Clausen, K Boysen, J Wolff, F Larsen. Plasma concentrations of bromazepam following peroral and sublingual administration. Pharmacology & toxicology. 1989 Apr; 64(4):389-90. doi: 10.1111/j.1600-0773.1989.tb00673.x. [PMID: 2568632]
  • A A Jansen, M N Verbaten, J L Slangen. Acute effects of bromazepam on signal detection performance, digit symbol substitution test and smooth pursuit eye movements. Neuropsychobiology. 1988; 20(2):91-5. doi: 10.1159/000118481. [PMID: 2908134]
  • J Lopez Valdeón, M T Sevilla Escribano, L Hernandez Hernandez. Determination of bromazepam and its urinary metabolites, with a previous hydrolysis reaction, by voltammetric and spectrophotometric techniques. The Analyst. 1987 Oct; 112(10):1365-8. doi: 10.1039/an9871201365. [PMID: 2893562]
  • L Hernández, A Zapardiel, J A Pérez López, E Bermejo. Determination of camazepam and bromazepam in human serum by adsorptive stripping voltammetry. The Analyst. 1987 Aug; 112(8):1149-53. doi: 10.1039/an9871201149. [PMID: 2889399]
  • H R Ochs, D J Greenblatt, H Friedman, E S Burstein, A Locniskar, J S Harmatz, R I Shader. Bromazepam pharmacokinetics: influence of age, gender, oral contraceptives, cimetidine, and propranolol. Clinical pharmacology and therapeutics. 1987 May; 41(5):562-70. doi: 10.1038/clpt.1987.72. [PMID: 2882883]
  • R Fontaine, P Mercier, P Beaudry, L Annable, G Chouinard. Bromazepam and lorazepam in generalized anxiety: a placebo-controlled study with measurement of drug plasma concentrations. Acta psychiatrica Scandinavica. 1986 Nov; 74(5):451-8. doi: 10.1111/j.1600-0447.1986.tb06268.x. [PMID: 2880459]
  • A C Tas, J van der Greef, M C ten Noever de Brauw, T A Plomp, R A Maes, M Hohn, U Rapp. LC/MS determination of bromazepam, clopenthixol, and reserpine in serum of a non-fatal case of intoxication. Journal of analytical toxicology. 1986 Mar; 10(2):46-8. doi: 10.1093/jat/10.2.46. [PMID: 2871228]
  • T Vu Duc, A Vernay. [Validation of a method for detecting benzodiazepines in the urine by acid extraction of their benzophenones and thin layer chromatography]. Annales de biologie clinique. 1985; 43(3):261-5. doi: NULL. [PMID: 2862815]
  • G Ziegler, L Ludwig, U Klotz. Stress protective effects during steady-state conditions of bromazepam. Pharmacopsychiatry. 1984 Nov; 17(6):194-8. doi: 10.1055/s-2007-1017437. [PMID: 6151200]
  • P Heizmann, R Geschke, K Zinapold. Determination of bromazepam in plasma and of its main metabolites in urine by reversed-phase high-performance liquid chromatography. Journal of chromatography. 1984 Sep; 310(1):129-37. doi: 10.1016/0378-4347(84)80074-2. [PMID: 6150047]
  • T Yajima, T Ohno, K Nakamura, K Nakamura. [Effects of bromazepam on responses of mucosal blood flow of the gastrointestinal tract and the gastric motility to stimulation of the amygdala and hypothalamus in conscious cats]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1984 Mar; 83(3):237-48. doi: 10.1254/fpj.83.237. [PMID: 6144617]
  • R Jochemsen, D D Breimer. Pharmacokinetics of benzodiazepines: metabolic pathways and plasma level profiles. Current medical research and opinion. 1984; 8 Suppl 4(?):60-79. doi: 10.1185/03007998409109545. [PMID: 6144464]
  • H Hirayama, Y Kasuya, T Suga. High-performance liquid chromatographic determination of bromazepam in human plasma. Journal of chromatography. 1983 Oct; 277(?):414-8. doi: 10.1016/s0378-4347(00)84868-9. [PMID: 6139385]
  • R Fontaine, L Annable, G Chouinard, R I Ogilvie. Bromazepam and diazepam in generalized anxiety: a placebo-controlled study with measurement of drug plasma concentrations. Journal of clinical psychopharmacology. 1983 Apr; 3(2):80-7. doi: NULL. [PMID: 6132936]
  • O von Stetten, K D Rehm, E Fenzl, M F Barkworth, K I Johnson. [Comparative studies on biologic availability and pharmacokinetics of bromazepam in tablets]. Arzneimittel-Forschung. 1983; 33(12):1699-702. doi: NULL. [PMID: 6141797]
  • D Schohn, R Schmitt, H Jahn. [Bromazepam in the treatment of anxiety in nephrology and haemodialysis (author's transl)]. La Nouvelle presse medicale. 1982 May; 11(22):1718-21. doi: NULL. [PMID: 6124941]
  • Z Duraković, F Plavsić, D Ivanović, V Gasparović, M Gjurasin. Resin hemoperfusion in the treatment of tricyclic antidepressant overdose. Artificial organs. 1982 May; 6(2):205-7. doi: 10.1111/j.1525-1594.1982.tb04084.x. [PMID: 7125964]
  • C Papageorgiou, G Levis, I Kondou, S Moulopoulos. Free fatty acids, central nervous system and bromazepam. Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie. 1982 Jan; 20(1):49-55. doi: 10.1515/cclm.1982.20.1.49. [PMID: 6121836]
  • V Hobi, U C Dubach, M Skreta, I Forgo, H Riggenbach. The subacute effect of bromazepam on psychomotor activity and subjective mood. The Journal of international medical research. 1982; 10(3):140-6. doi: 10.1177/030006058201000302. [PMID: 6124470]
  • T Kaniewska, W Wejman. Gas chromatographic determination of bromo and fluoro derivatives of benzodiazepine in human body fluids. Journal of chromatography. 1980 Apr; 182(1):81-7. doi: 10.1016/s0378-4347(00)81653-9. [PMID: 6103898]
  • H Sawada, A Hara. Studies on metabolism of bromazepam. VI. Reduction of 2-(2-amino-5-bromobenzoyl)pyridine, a metabolite of bromazepam, in the rabbit, rat, and guinea pig. Drug metabolism and disposition: the biological fate of chemicals. 1978 May; 6(3):205-12. doi: NULL. [PMID: 26538]