Motolimod (BioDeep_00000181105)
human metabolite blood metabolite
代谢物信息卡片
化学式: C28H34N4O2 (458.2681624)
中文名称: 莫托莫德
谱图信息:
最多检出来源 Homo sapiens(blood) 1.79%
分子结构信息
SMILES: CCCN(CCC)C(=O)C1=CC2=C(C=C(C=C2)C3=CC=C(C=C3)C(=O)N4CCCC4)N=C(C1)N
InChI: InChI=1S/C28H34N4O2/c1-3-13-31(14-4-2)28(34)24-17-23-12-11-22(18-25(23)30-26(29)19-24)20-7-9-21(10-8-20)27(33)32-15-5-6-16-32/h7-12,17-18H,3-6,13-16,19H2,1-2H3,(H2,29,30)
描述信息
C308 - Immunotherapeutic Agent > C2139 - Immunostimulant > C177174 - Toll-like Receptor Agonist
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- PubChem: 16049404
- HMDB: HMDB0254904
- DrugBank: DB12303
- ChEMBL: CHEMBL3301618
- Wikipedia: Array BioPharma
- CAS: 926927-61-9
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Wei Yang, Xiongfei Sun, Shuai Liu, Ying Xu, Yunlei Li, Xiaoru Huang, Kaiqing Liu, Longyi Mao, Shasha Min, Linjiang Liu, Shi Li, Yuqi Zhu, Yu Zhang, Xina Xie, Kui Xu, Changqing Sun, Jie Yan, Zesong Li. TLR8 agonist Motolimod-induced inflammatory death for treatment of acute myeloid leukemia.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Apr; 163(?):114759. doi:
10.1016/j.biopha.2023.114759. [PMID: 37105077] - Yu-Geun Ji, Yu-Mi Shin, Jong-Woo Jeong, Hae-In Choi, Seung-Won Lee, Jong-Hwa Lee, Kyeong-Ryoon Lee, Tae-Sung Koo. Determination of motolimod concentration in rat plasma by liquid chromatography-tandem mass spectrometry and its application in a pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis.
2020 Feb; 179(?):112987. doi:
10.1016/j.jpba.2019.112987. [PMID: 31761376] - Laura Q M Chow, Chihiro Morishima, Keith D Eaton, Christina S Baik, Bernardo H Goulart, Leslie N Anderson, Kristi L Manjarrez, Gregory N Dietsch, James Kyle Bryan, Robert M Hershberg, Mary L Disis, Renato G Martins. Phase Ib Trial of the Toll-like Receptor 8 Agonist, Motolimod (VTX-2337), Combined with Cetuximab in Patients with Recurrent or Metastatic SCCHN.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2017 May; 23(10):2442-2450. doi:
10.1158/1078-0432.ccr-16-1934. [PMID: 27810904] - Gregory N Dietsch, Hailing Lu, Yi Yang, Chihiro Morishima, Laura Q Chow, Mary L Disis, Robert M Hershberg. Coordinated Activation of Toll-Like Receptor8 (TLR8) and NLRP3 by the TLR8 Agonist, VTX-2337, Ignites Tumoricidal Natural Killer Cell Activity.
PloS one.
2016; 11(2):e0148764. doi:
10.1371/journal.pone.0148764. [PMID: 26928328] - Gregory N Dietsch, Tressa D Randall, Raphael Gottardo, Donald W Northfelt, Ramesh K Ramanathan, Peter A Cohen, Kristi L Manjarrez, Mona Newkirk, James Kyle Bryan, Robert M Hershberg. Late-Stage Cancer Patients Remain Highly Responsive to Immune Activation by the Selective TLR8 Agonist Motolimod (VTX-2337).
Clinical cancer research : an official journal of the American Association for Cancer Research.
2015 Dec; 21(24):5445-52. doi:
10.1158/1078-0432.ccr-15-0578. [PMID: 26152744] - Donald W Northfelt, Ramesh K Ramanathan, Peter A Cohen, Daniel D Von Hoff, Glen J Weiss, Gregory N Dietsch, Kristi L Manjarrez, Tressa D Randall, Robert M Hershberg. A phase I dose-finding study of the novel Toll-like receptor 8 agonist VTX-2337 in adult subjects with advanced solid tumors or lymphoma.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2014 Jul; 20(14):3683-91. doi:
10.1158/1078-0432.ccr-14-0392. [PMID: 24807889]