Montirelin (BioDeep_00000181079)
human metabolite blood metabolite
代谢物信息卡片
化学式: C17H24N6O4S (408.1579664)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 61.54%
分子结构信息
SMILES: CC1C(=O)NC(CS1)C(=O)NC(CC2=CN=CN2)C(=O)N3CCCC3C(=O)N
InChI: InChI=1S/C17H24N6O4S/c1-9-15(25)22-12(7-28-9)16(26)21-11(5-10-6-19-8-20-10)17(27)23-4-2-3-13(23)14(18)24/h6,8-9,11-13H,2-5,7H2,1H3,(H2,18,24)(H,19,20)(H,21,26)(H,22,25)
描述信息
同义名列表
5 个代谢物同义名
5-Hydroxy-N-{1-[2-(C-hydroxycarbonimidoyl)pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl}-6-methyl-3,6-dihydro-2H-1,4-thiazine-3-carboximidate; N-[1-(2-carbamoylpyrrolidin-1-yl)-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-6-methyl-5-oxothiomorpholine-3-carboxamide; N-[1-(2-carbamoylpyrrolidin-1-yl)-3-(3H-imidazol-4-yl)-1-oxopropan-2-yl]-6-methyl-5-oxothiomorpholine-3-carboxamide; N-(6-Methyl-5-oxothiomorpholine-3-carbonyl)histidylprolinamide; Montirelin
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- A Urayama, S Yamada, K Hirano, Y Deguchi, R Kimura. Brain receptor binding characteristics and pharmacokinetic-pharmacodynamic analysis of thyrotropin-releasing hormone analogues.
Life sciences.
2001 Dec; 70(6):647-57. doi:
10.1016/s0024-3205(01)01445-x. [PMID: 11833715] - S Nishino, J Arrigoni, J Shelton, T Kanbayashi, W C Dement, E Mignot. Effects of thyrotropin-releasing hormone and its analogs on daytime sleepiness and cataplexy in canine narcolepsy.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
1997 Aug; 17(16):6401-8. doi:
10.1523/jneurosci.17-16-06401.1997. [PMID: 9236248] - K Shinozuka, K Shimoura, K Hattori. Effects of thyrotropin-releasing hormone and its analogue, NS-3, on blood pressure, heart rate, and serum catecholamine levels in rats.
General pharmacology.
1997 Feb; 28(2):209-14. doi:
10.1016/s0306-3623(96)00219-4. [PMID: 9013196] - T Momiyama, K Ishihara, K Kimura, N Todo, Y Fujita, T Serikawa, M Sasa. Long-term antiepileptic effects of chronic intake of CNK-602A, a thyrotropin-releasing hormone analogue, on spontaneously epileptic rats.
Epilepsia.
1996 Apr; 37(4):328-31. doi:
10.1111/j.1528-1157.1996.tb00567.x. [PMID: 8603636] - T Sugimoto, T Hayashi, A Okita, A Morino. Pharmacokinetics of the new thyrotropin releasing hormone analogue montirelin hydrate. 3rd communication: identification of metabolites in rat urine.
Arzneimittel-Forschung.
1996 Feb; 46(2):127-33. doi:
. [PMID: 8720300] - T Sugimoto, T Hayashi, A Okita, A Morino. Pharmacokinetics of the new thyrotropin releasing hormone analogue montirelin hydrate. 1st communication: plasma concentrations, metabolism and excretion after a single intravenous administration to rats, dogs and monkeys.
Arzneimittel-Forschung.
1996 Feb; 46(2):106-13. doi:
NULL. [PMID: 8720298] - T Sugimoto, T Hayashi, A Okita, A Morino. Pharmacokinetics of the new thyrotropin releasing hormone analogue montirelin hydrate. 2nd communication: distribution and transfer into the fetus and milk after a single intravenous administration and pharmacokinetics and enzyme induction after repeated intravenous administration to rats.
Arzneimittel-Forschung.
1996 Feb; 46(2):114-27. doi:
NULL. [PMID: 8720299] - M Kikumori, I Nishida, M Kojima, Y Taniguchi, K Yasuhira, S Ishibashi, K Iwakura, N Sumi. [Five-week intravenous toxicity study of montirelin hydrate (NS-3) in rats followed by 4-week recovery test].
The Journal of toxicological sciences.
1995 Dec; 20 Suppl 2(?):171-89. doi:
10.2131/jts.20.supplementii_171. [PMID: 9019557] - T Ogasawara, Y Ukai, M Tamura, K Kimura. NS-3 (CG3703), an analog of thyrotropin-releasing hormone, ameliorates cognitive impairment in rats.
Pharmacology, biochemistry, and behavior.
1995 Apr; 50(4):499-503. doi:
10.1016/0091-3057(94)00312-2. [PMID: 7617693] - M B Youdim, S Yehuda. Iron deficiency induces reversal of dopamine dependent circadian cycles: differential response to d-amphetamine and TRH.
Peptides.
1985 Sep; 6(5):851-5. doi:
10.1016/0196-9781(85)90313-4. [PMID: 3936024]