Monatepil (BioDeep_00000181055)

   

human metabolite blood metabolite


代谢物信息卡片


4-[4-(4-fluorophenyl)piperazin-1-yl]-N-{9-thiatricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,11,13-hexaen-2-yl}butanimidic acid

化学式: C28H30FN3OS (475.2093502)
中文名称: 莫那匹尔
谱图信息: 最多检出来源 Mus musculus(blood) 15.38%

分子结构信息

SMILES: C1CN(CCN1CCCC(=O)NC2C3=CC=CC=C3CSC4=CC=CC=C24)C5=CC=C(C=C5)F
InChI: InChI=1S/C28H30FN3OS/c29-22-11-13-23(14-12-22)32-18-16-31(17-19-32)15-5-10-27(33)30-28-24-7-2-1-6-21(24)20-34-26-9-4-3-8-25(26)28/h1-4,6-9,11-14,28H,5,10,15-20H2,(H,30,33)

描述信息

C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker

同义名列表

11 个代谢物同义名

4-[4-(4-fluorophenyl)piperazin-1-yl]-N-{9-thiatricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,11,13-hexaen-2-yl}butanimidic acid; 4-[4-(4-Fluorophenyl)piperazin-1-yl]-N-{9-thiatricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,11,13-hexaen-2-yl}butanimidate; 4-[4-(4-Fluorophenyl)piperazin-1-yl]-N-{9-thiatricyclo[9.4.0.0,]pentadeca-1(15),3,5,7,11,13-hexaen-2-yl}butanimidate; 11-((4-(4-(4-Fluorophenyl)-1-piperazinyl)butyryl)amino)-6,11-dihydrodibenzo(b,e)thiepin maleate; N-(6,11-DIHYDRODIBENZO[B,E]THIEPIN-11-YL)-4-(4-(4-FLUOROPHENYL)PIPERAZIN-1-YL)BUTANAMIDE; Monatepil, (+-) monatepil; Monatepil, (R)-isomer; Monatepil, (S)-isomer; Monatepil X maleate; Monatepil maleate; Monatepil



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • A Ikeno, T Sumiya, H Minato, B Fujitani, Y Masuda, K Hosoki, M Kurono, M Yasuba. Effects of monatepil maleate, a new Ca2+ channel antagonist with alpha1-adrenoceptor antagonistic activity, on cholesterol absorption and catabolism in high cholesterol diet-fed rabbits. Japanese journal of pharmacology. 1998 Nov; 78(3):303-12. doi: 10.1254/jjp.78.303. [PMID: 9869264]
  • T Sumiya, A Ikeno, H Kato, B Fujitani, Y Masuda, K Hosoki, M Miyazaki. Inhibitory effect of monatepil maleate on acyl-CoA:cholesterol acyltransferase activity in the liver of cholesterol-fed Japanese monkeys. American journal of hypertension. 1997 Jul; 10(7 Pt 1):779-85. doi: 10.1016/s0895-7061(97)00066-6. [PMID: 9234833]
  • M Kurono, K Suzuki, K Yoshida, S Naruto. Simultaneous determination of a novel calcium entry blocker, monatepil maleate, and its metabolites in rat plasma by means of solid-phase extraction and reversed-phase liquid chromatography with electrochemical detection. Journal of chromatography. B, Biomedical sciences and applications. 1997 Feb; 689(2):427-32. doi: 10.1016/s0378-4347(96)00346-5. [PMID: 9080333]
  • K Hayashi, Y Kuga, S Nomura, Y Okura, K Tanaka, Y Yasunobu, K Nomura, T Shingu, J Kuwashima, G Kajiyama. Inhibition of lipid hydroperoxidation of low density lipoprotein by the Ca(2+)-channel and alpha 1-adrenoceptor antagonist monatepil maleate. Arzneimittel-Forschung. 1996 Apr; 46(4):378-81. doi: ". [PMID: 8740082]
  • J R Gregoire, S G Sheps. Newer antihypertensive drugs. Current opinion in cardiology. 1995 Sep; 10(5):445-9. doi: 10.1097/00001573-199509000-00002. [PMID: 7496051]
  • M Notake, Y Kondo, H Nomura, K Nakano, K Hosoki, M Miyazaki. Up-regulation of hepatic LDL receptor gene expression by monatepil, a novel calcium antagonist, in high cholesterol diet-fed Japanese monkeys. American journal of hypertension. 1994 Nov; 7(11):1026-30. doi: 10.1093/ajh/7.11.1026. [PMID: 7848617]
  • M Miyazaki. Antihypertensive, antiatherosclerotic, and plasma lipid-lowering effects of monatepil, a novel calcium antagonist with alpha 1-adrenoceptor-blocking activity in experimental animals. American journal of hypertension. 1994 Oct; 7(10 Pt 2):131S-40S. doi: 10.1093/ajh/7.10.131s. [PMID: 7826563]
  • M Tsushima, H Koh, M Suzuki, S Kyotani, M Waki, Y Nishioeda, Y Harano, T Omae. Noninvasive quantitative evaluation of early atherosclerosis and the effect of monatepil, a new antihypertensive agent. An interim report. American journal of hypertension. 1994 Oct; 7(10 Pt 2):154S-160S. doi: 10.1093/ajh/7.10.154s. [PMID: 7826566]
  • J Sasaki, T Ogihara, M Yokoyama, G Kajiyama, H Mashiba, T Sunaga, K Nonaka, M Shichiri, N Tanaka, K Arakawa. Comparative effects of monatepil, a novel calcium antagonist with alpha 1-adrenergic-blocking activity, and nitrendipine on lipoprotein and carbohydrate metabolism in patients with hypertension. American journal of hypertension. 1994 Oct; 7(10 Pt 2):161S-166S. doi: 10.1093/ajh/7.10.161s. [PMID: 7826567]
  • M Miyazaki, K Hosoki, H Okunishi, K Ishii, A Ikeno, Y Okazaki. Anti-atherosclerotic and plasma lipid lowering effects of the novel calcium blocker with alpha 1-adrenoceptor antagonistic activity, monatepil, in high cholesterol diet-fed Japanese Macaca fuscata monkeys. Arzneimittel-Forschung. 1994 Mar; 44(3):288-97. doi: NULL. [PMID: 8192692]
  • I Nose, T Kataoka, Y Honda, T Yamada, A Ikeno, F Fukuya, H Minato, K Takeyama, K Hosoki, T Karasawa. In vitro and in vivo electrocardiographic evaluation of the novel calcium antagonist monatepil on cardiac conduction system. Arzneimittel-Forschung. 1993 Jul; 43(7):722-8. doi: NULL. [PMID: 8369002]
  • H Minato, A Ikeno, T Yamada, H Kato, K Zushi, M Kurokawa, Y Masuda, K Hosoki, T Karasawa. Inhibitory effect of the new calcium antagonist AJ-2615 on progression of atherosclerosis in cholesterol-fed rabbits. Journal of cardiovascular pharmacology. 1993 Apr; 21(4):663-9. doi: 10.1097/00005344-199304000-00022. [PMID: 7681914]
  • M Kurono, A Itogawa, K Yoshida, S Naruto, P Rudewicz, M Kanai. Identification of AJ-2615 and its S-oxidized metabolites in rat plasma by use of tandem-mass spectrometry. Biological mass spectrometry. 1992 Jan; 21(1):17-21. doi: 10.1002/bms.1200210105. [PMID: 1591277]
  • M Kurono, K Yoshida, S Arakawa, S Naruto. Determination of a novel calcium entry blocker, AJ-2615, in plasma using solid-phase extraction and high-performance liquid chromatography with electrochemical detection. Journal of chromatography. 1990 Oct; 532(1):175-80. doi: 10.1016/s0378-4347(00)83766-4. [PMID: 2079532]