8-hydroxymirtazapine (BioDeep_00000018105)
human metabolite Endogenous blood metabolite
代谢物信息卡片
化学式: C17H19N3O (281.1528044)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 44.44%
分子结构信息
SMILES: CN1CCN2C(C1)C1=CC=CC=C1CC1=CC(O)=CN=C21
InChI: InChI=1S/C17H19N3O/c1-19-6-7-20-16(11-19)15-5-3-2-4-12(15)8-13-9-14(21)10-18-17(13)20/h2-5,9-10,16,21H,6-8,11H2,1H3
描述信息
8-hydroxymirtazapine is a metabolite of mirtazapine. Mirtazapine (Remeron, Avanza, Zispin) is a noradrenergic and specific serotonergic antidepressant (NaSSA) which was introduced by Organon International in the United States in 1990 and is used primarily in the treatment of depression. It is also commonly used as an anxiolytic, hypnotic, antiemetic, and appetite stimulant. Structurally, mirtazapine can also be classified as a tetracyclic antidepressant (TeCA). (Wikipedia)
同义名列表
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Masataka Shinozaki, Jason Pierce, Yuki Hayashi, Takashi Watanabe, Taro Sasaki, Hazuki Komahashi-Sasaki, Kazufumi Akiyama, Kazuko Kato, Yoshimasa Inoue, Shoko Tsuchimine, Norio Yasui-Furukori, Yuji Ozeki, Kazutaka Shimoda. 8-Hydroxylation and Glucuronidation of Mirtazapine in Japanese Psychiatric Patients: Significance of the Glucuronidation Pathway of 8-Hydroxy-Mirtazapine.
Pharmacopsychiatry.
2019 Sep; 52(5):237-244. doi:
10.1055/a-0918-6408. [PMID: 31158907] - Mahdi Ghorbani, Mahmoud Chamsaz, Gholam Hossein Rounaghi, Mohsen Aghamohammadhasani, Orkideh Seyedin, Nahid Afshar Lahoori. Development of a novel ultrasonic-assisted magnetic dispersive solid-phase microextraction method coupled with high performance liquid chromatography for determination of mirtazapine and its metabolites in human urine and water samples employing experimental design.
Analytical and bioanalytical chemistry.
2016 Nov; 408(27):7719-7729. doi:
10.1007/s00216-016-9869-1. [PMID: 27562753] - Mario Giorgi, Hyoin Yun. Pharmacokinetics of mirtazapine and its main metabolites in Beagle dogs: a pilot study.
Veterinary journal (London, England : 1997).
2012 May; 192(2):239-41. doi:
10.1016/j.tvjl.2011.05.010. [PMID: 21652240] - Fernando José Malagueño de Santana, Valquíria Aparecida Polisel Jabor, Evandro José Cesarino, Vera Lúcia Lanchote, Pierina Sueli Bonato. Enantioselective analysis of mirtazapine, demethylmirtazapine and 8-hydroxy mirtazapine in human urine after solid-phase microextraction.
Journal of separation science.
2010 Feb; 33(2):268-76. doi:
10.1002/jssc.200900534. [PMID: 20087868] - Anna-Britta Lind, Margareta Reis, Finn Bengtsson, Michele Jonzier-Perey, Kerry Powell Golay, Johan Ahlner, Pierre Baumann, Marja-Liisa Dahl. Steady-state concentrations of mirtazapine, N-desmethylmirtazapine, 8-hydroxymirtazapine and their enantiomers in relation to cytochrome P450 2D6 genotype, age and smoking behaviour.
Clinical pharmacokinetics.
2009; 48(1):63-70. doi:
10.2165/0003088-200948010-00005. [PMID: 19071885] - Fernando José Malagueño de Santana, Vera Lúcia Lanchote, Pierina Sueli Bonato. Capillary electrophoretic chiral determination of mirtazapine and its main metabolites in human urine after enzymatic hydrolysis.
Electrophoresis.
2008 Sep; 29(18):3924-32. doi:
10.1002/elps.200800053. [PMID: 18850661] - Zeineb Aturki, Valentina Scotti, Giovanni D'Orazio, Anna Rocco, Maria Augusta Raggi, Salvatore Fanali. Enantioselective separation of the novel antidepressant mirtazapine and its main metabolites by CEC.
Electrophoresis.
2007 Aug; 28(15):2717-25. doi:
10.1002/elps.200600731. [PMID: 17592613] - Ingolf Meineke, Hannelore Steinmetz, Julia Kirchheiner, Jürgen Brockmöller. Therapeutic drug monitoring of mirtazapine, desmethylmirtazapine, 8-hydroxymirtazapine, and mirtazapine-N-oxide by enantioselective HPLC with fluorescence detection.
Therapeutic drug monitoring.
2006 Dec; 28(6):760-5. doi:
10.1097/ftd.0b013e31802c0264. [PMID: 17164691] - Pierre Baumann, Michèle Jonzier-Perey, Erik Paus, Georg Nikisch. Mirtazapine enantiomers in blood and cerebrospinal fluid.
Neuropsychobiology.
2006; 54(3):179-81. doi:
10.1159/000098654. [PMID: 17230030] - Erik Paus, Michèle Jonzier-Perey, Nathalie Cochard, Chin B Eap, Pierre Baumann. Chirality in the new generation of antidepressants: stereoselective analysis of the enantiomers of mirtazapine, N-demethylmirtazapine, and 8-hydroxymirtazapine by LC-MS.
Therapeutic drug monitoring.
2004 Aug; 26(4):366-74. doi:
10.1097/00007691-200408000-00005. [PMID: 15257065]