Modecainide (BioDeep_00000181037)

   

human metabolite blood metabolite


代谢物信息卡片


4-hydroxy-3-methoxy-N-{2-[2-(1-methylpiperidin-2-yl)ethyl]phenyl}benzamide

化学式: C22H28N2O3 (368.20998180000004)
中文名称: 莫德卡尼德
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1CCCCC1CCC2=CC=CC=C2NC(=O)C3=CC(=C(C=C3)O)OC
InChI: InChI=1S/C22H28N2O3/c1-24-14-6-5-8-18(24)12-10-16-7-3-4-9-19(16)23-22(26)17-11-13-20(25)21(15-17)27-2/h3-4,7,9,11,13,15,18,25H,5-6,8,10,12,14H2,1-2H3,(H,23,26)

描述信息

C78274 - Agent Affecting Cardiovascular System > C47793 - Antiarrhythmic Agent
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents

同义名列表

7 个代谢物同义名

4-hydroxy-3-methoxy-N-{2-[2-(1-methylpiperidin-2-yl)ethyl]phenyl}benzamide; 3-Methoxy-O-demethylencainide, (+-)-isomer; 3-Methoxy-O-desmethylencainide; 3-Methoxy-O-demethyl-encainide; 3-Methoxy-O-demethylencainide; 3-Methoxy-4-hydroxyencainide; Modecainide



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • J S Fleming, J O Buchanan, F D Yocca, L G Iben, M J Antonaccio. Effect of encainide, ODE, MODE, and flecainide on ADP/5-HT induced platelet aggregation and in the anesthetized dog coronary artery stenosis-occlusion model of intravascular thrombosis. Cardiovascular drugs and therapy. 1991 Aug; 5(4):763-8. doi: 10.1007/bf03029752. [PMID: 1909560]
  • J M Poirier, M Lebot, G Cheymol. Analysis of encainide and its three major metabolites in plasma by column liquid chromatography. Journal of chromatography. 1990 Dec; 534(?):223-7. doi: 10.1016/s0378-4347(00)82166-0. [PMID: 2128839]
  • D M Roden, J T Lee, R L Woosley, D S Echt. Antiarrhythmic efficacy, clinical electrophysiology, and pharmacokinetics of 3-methoxy-O-desmethyl encainide (MODE) in patients with inducible ventricular tachycardia or fibrillation. Circulation. 1989 Nov; 80(5):1247-58. doi: 10.1161/01.cir.80.5.1247. [PMID: 2805262]
  • D M Roden, R L Woosley. Clinical pharmacokinetics of encainide. Clinical pharmacokinetics. 1988 Mar; 14(3):141-7. doi: 10.2165/00003088-198814030-00002. [PMID: 3131058]
  • J T Barbey, K A Thompson, D S Echt, R L Woosley, D M Roden. Antiarrhythmic activity, electrocardiographic effects and pharmacokinetics of the encainide metabolites O-desmethyl encainide and 3-methoxy-O-desmethyl encainide in man. Circulation. 1988 Feb; 77(2):380-91. doi: 10.1161/01.cir.77.2.380. [PMID: 3123092]
  • M J Bartek, R F Mayol, M P Boarman, R E Gammans, D G Gallo. Analysis of encainide and metabolites in plasma and urine by high-performance liquid chromatography. Therapeutic drug monitoring. 1988; 10(4):446-52. doi: 10.1097/00007691-198804000-00012. [PMID: 3144068]
  • P Dorian, J M Davy, R E Kates. Pharmacodynamic modeling of antiarrhythmic drug effects--application to 3-methoxy-O-demethyl encainide. Journal of cardiovascular pharmacology. 1986 Nov; 8(6):1217-22. doi: 10.1097/00005344-198611000-00018. [PMID: 2434749]
  • D M Roden, A J Wood, G R Wilkinson, R L Woosley. Disposition kinetics of encainide and metabolites. The American journal of cardiology. 1986 Aug; 58(5):4C-9C. doi: 10.1016/0002-9149(86)90097-4. [PMID: 3092618]
  • D C Harrison, R E Kates, B D Quart. Relation of blood level and metabolites to the antiarrhythmic effectiveness of encainide. The American journal of cardiology. 1986 Aug; 58(5):66C-73C. doi: 10.1016/0002-9149(86)90107-4. [PMID: 3092622]
  • A W Gomoll, J E Byrne, R F Mayol. Comparative antiarrhythmic actions of encainide and its major metabolites. Archives internationales de pharmacodynamie et de therapie. 1986 Jun; 281(2):277-97. doi: . [PMID: 3092755]
  • P Dumoulin, P Jaillon, A Kher, J M Poirier, G Cheymol, J Valty, D Flammang, P Coumel, J L Medvedowsky, C Barnay. Long-term efficacy and safety of oral encainide in the treatment of chronic ventricular ectopic activity: relationship to plasma concentrations--a French multicenter trial. American heart journal. 1985 Sep; 110(3):575-81. doi: 10.1016/0002-8703(85)90077-8. [PMID: 2412428]
  • R Latini, A M Gillis, R E Kates. Myocardial uptake of encainide and its two major metabolites, O-demethyl encainide and 3-methoxy-O-demethyl encainide, in the dog. Journal of cardiovascular pharmacology. 1984 Jul; 6(4):663-7. doi: 10.1097/00005344-198407000-00017. [PMID: 6206322]
  • E L Carey, H J Duff, D M Roden, R K Primm, G R Wilkinson, T Wang, J A Oates, R L Woosley. Encainide and its metabolites. Comparative effects in man on ventricular arrhythmia and electrocardiographic intervals. The Journal of clinical investigation. 1984 Feb; 73(2):539-47. doi: 10.1172/jci111241. [PMID: 6421879]
  • L Giuliani, G Carmignani, E Belgrano, P Puppo. Transcatheter arterial embolization in urological tumors: the use of isobutyl-2-cyanoacrylate. The Journal of urology. 1979 May; 121(5):630-4. doi: 10.1016/s0022-5347(17)56913-x. [PMID: 439260]