2-Methoxy-5-(2,4-dioxo-5-thiazolidinyl)-N-((4-(trifluoromethyl)phenyl)methyl)benzamide (BioDeep_00000181013)

   

human metabolite blood metabolite


代谢物信息卡片


5-[(2,4-dioxo-1,3-oxazolidin-5-yl)methyl]-2-methoxy-N-{[4-(trifluoromethyl)phenyl]methyl}benzamide

化学式: C20H17F3N2O5 (422.1089508)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=C(C=C(C=C1)CC2C(=O)NC(=O)O2)C(=O)NCC3=CC=C(C=C3)C(F)(F)F
InChI: InChI=1S/C20H17F3N2O5/c1-29-15-7-4-12(9-16-18(27)25-19(28)30-16)8-14(15)17(26)24-10-11-2-5-13(6-3-11)20(21,22)23/h2-8,16H,9-10H2,1H3,(H,24,26)(H,25,27,28)

描述信息

同义名列表

3 个代谢物同义名

5-[(2,4-dioxo-1,3-oxazolidin-5-yl)methyl]-2-methoxy-N-{[4-(trifluoromethyl)phenyl]methyl}benzamide; 2-Methoxy-5-(2,4-dioxo-5-thiazolidinyl)-N-((4-(trifluoromethyl)phenyl)methyl)benzamide; 5-((2,4-Dioxothiazolidin-5-yl)-2-methoxy-N-((4-trifluoromethyl)phenyl)methyl)benzamide



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ronda K Rippley, Kerri X Yan, Natalie D Matthews, Howard E Greenberg, Gary A Herman, John A Wagner. Human pharmacokinetics and interconversion of enantiomers of MK-0767, a dual PPARalpha/gamma agonist. Journal of clinical pharmacology. 2007 Mar; 47(3):323-33. doi: 10.1177/0091270006297141. [PMID: 17322144]
  • Christopher J Kochansky, Ronda K Rippley, Kerri X Yan, Hengchang Song, Michael A Wallace, Dennis Dean, Allen N Jones, Kenneth Lasseter, Jules Schwartz, Stella H Vincent, Ronald B Franklin, John Wagner. Absorption, metabolism, and excretion of [14C]MK-0767 (2-methoxy-5-(2,4-dioxo-5-thiazolidinyl)-N-[[4-(trifluoromethyl)phenyl] methyl]benzamide) in humans. Drug metabolism and disposition: the biological fate of chemicals. 2006 Sep; 34(9):1457-61. doi: 10.1124/dmd.106.010231. [PMID: 16772365]
  • Katelijn Decochez, Ronda K Rippley, Jutta L Miller, Marina De Smet, Kerri X Yan, Zissi Matthijs, Kerry A Riffel, Hengchang Song, Haiyuan Zhu, Hannah O Maynor, Wesley Tanaka, Amy O Johnson-Levonas, Michael J Davies, Keith M Gottesdiener, Bart Keymeulen, John A Wagner. A dual PPAR alpha/gamma agonist increases adiponectin and improves plasma lipid profiles in healthy subjects. Drugs in R&D. 2006; 7(2):99-110. doi: 10.2165/00126839-200607020-00004. [PMID: 16542056]
  • Zhongzhou Shen, Ray Bakhtiar, Masakatsu Komuro, Katsuya Awano, Fukutaro Taga, Adria Colletti, Don Hora, William Feeney, Susan Iliff, Ronald B Franklin, Stella Vincent. Enantiomer ratio of MK-0767 in humans and nonclinical species. Rapid communications in mass spectrometry : RCM. 2005; 19(9):1125-9. doi: 10.1002/rcm.1897. [PMID: 15799073]
  • Kerri X Yan, Hengchang Song, Man-Wai Lo. Determination of MK-0767 enantiomers in human plasma by normal phase LC-MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2004 Dec; 813(1-2):95-102. doi: 10.1016/j.jchromb.2004.09.016. [PMID: 15556521]
  • Hengchang Song, Kerri Yan, Xiaohui Xu, Man-Wai Lo. Quantitative determination of MK-0767, a dual alpha/gamma peroxisome proliferator-activated receptor (PPAR) agonist, in human plasma by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2004 Oct; 810(1):7-13. doi: 10.1016/j.jchromb.2004.07.003. [PMID: 15358302]
  • Thomas W Doebber, Linda J Kelly, Gaochao Zhou, Roger Meurer, Chhabi Biswas, Ying Li, Margaret S Wu, Marc C Ippolito, Yu-Sheng Chao, Pei-Ran Wang, Samuel D Wright, David E Moller, Joel P Berger. MK-0767, a novel dual PPARalpha/gamma agonist, displays robust antihyperglycemic and hypolipidemic activities. Biochemical and biophysical research communications. 2004 May; 318(2):323-8. doi: 10.1016/j.bbrc.2004.04.032. [PMID: 15120604]
  • Zhongzhou Shen, Christopher Kochansky, Ray Bakhtiar, Ronald B Franklin, Stella H Vincent. Simultaneous determination of MK-0767 and seven metabolites in rat urine using liquid chromatography/tandem mass spectrometry. Rapid communications in mass spectrometry : RCM. 2004; 18(18):2113-20. doi: 10.1002/rcm.1597. [PMID: 15317046]